{ "model": { "rank": 14106, "code": "thing-q3242950", "model_id": "vr.tr.kidney-cancer", "name": "kidney cancer", "purpose": "Let an agent explain kidney cancer and its types in general terms from oncology guidelines, describe risk factors, diagnosis and treatment approaches, distinguish adult and childhood forms, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q3242950/", "tier": 2, "score": 36, "payload": { "layer": "wikidata", "aliases": [ "childhood kidney neoplasm", "renal pelvis neoplasm", "catecholamine-producing tumor", "malignant cystic nephroma", "mesoblastic nephroma", "kidney small cell carcinoma", "hereditary Wilms' tumor", "kidney hemangiopericytoma", "benign metanephric tumour", "non-amyloid monoclonal immunoglobulin deposition disease", "nephroblastoma", "congenital mesoblastic nephroma", "renal Wilms' tumor", "metachronous kidney Wilms' tumor", "mixed cell type kidney Wilms' tumor", "blastema predominant kidney Wilms' tumor", "epithelial predominant Wilms' tumor", "stromal predominant kidney Wilms' tumor", "Wilms' tumor 2", "Wilms' tumor 3", "adult kidney wilms tumor", "childhood kidney wilms tumor" ], "aliasCount": 22, "merged": 22, "knownIn": 36, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q3242950", "url": "https://www.wikidata.org/wiki/Q3242950", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T01:37:50Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q3242950", "registryId": "vr.tr.kidney-cancer", "name": "kidney cancer", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3242950/", "model": { "registry_id": "vr.tr.kidney-cancer", "name": "kidney cancer", "purpose": "Let an agent explain kidney cancer and its types in general terms from oncology guidelines, describe risk factors, diagnosis and treatment approaches, distinguish adult and childhood forms, and route personal questions to clinicians.", "definition": "Cancer arising in the kidney, chiefly renal cell carcinoma in adults, urothelial carcinoma of the renal pelvis, and in children Wilms tumour and rarer tumours such as mesoblastic nephroma and malignant cystic nephroma, with uncommon forms such as small cell carcinoma and catecholamine-producing tumours of adjacent adrenal tissue sometimes grouped with them; kidney cancer is often found incidentally on imaging, is treated by surgery, targeted therapy and immunotherapy, and has risk factors including smoking, obesity and hypertension.", "what_it_is_for": "Not applicable; a group of cancers.", "affordances": [ "explain types and risk factors", "relay diagnosis and treatment approaches", "distinguish adult and childhood forms", "route personal questions" ], "distinguishing_features": [ "Renal cell carcinoma dominance", "Incidental detection", "Surgery as main treatment", "Distinct childhood tumours" ], "appearance": "Not a visible object; a tumour seen on imaging.", "visual_identification": [ "Malignant tumours of the kidney", "Renal cell carcinoma, renal pelvis cancer, Wilms tumour and rare types", "Benign kidney tumours and cysts are not cancer; bladder cancer is a separate urinary cancer" ], "physical_properties": [ { "quantity": "new cases worldwide", "typical_range": "about 430000", "unit": "per year", "note": "GLOBOCAN 2022" }, { "quantity": "renal cell carcinoma share", "typical_range": "about 90", "unit": "percent", "note": "of adult kidney cancers" } ], "families_and_kinds": [ "renal cell carcinoma and its subtypes", "urothelial carcinoma of the renal pelvis", "Wilms tumour and other childhood kidney neoplasms", "rare tumours such as mesoblastic nephroma, malignant cystic nephroma and small cell carcinoma", "hereditary kidney cancer syndromes" ], "related_models": [ { "relation": "is a kind of", "target": "kidney neoplasm", "why": "in registry terms" }, { "relation": "is a kind of", "target": "urinary system cancer", "why": "in registry terms" }, { "relation": "is treated by", "target": "nephrectomy", "why": "among other treatments" }, { "relation": "is contrasted with", "target": "benign kidney tumour", "why": "such as oncocytoma" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "2C90", "note": "malignant neoplasms of kidney" }, { "scheme": "MeSH", "value_or_pattern": "D007680", "note": "kidney neoplasms" } ], "standards_and_regulation": [ "Oncology guidelines from ESMO, NCCN and urological associations", "Cancer registration standards", "Drug approvals for targeted and immunotherapies" ], "failure_modes_and_hazards": [ "Late diagnosis", "Agents giving personal medical advice", "Confusing kidney cancer types", "Overtreatment of small incidental masses" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Getting help first.", "rationale": "Safety.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What signs such as blood in the urine or flank pain need prompt assessment?", "kind": "action" }, { "text": "Is the user describing such signs, which need a clinician promptly?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Specialist care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is kidney cancer diagnosed and staged by specialists, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis, which needs their oncology team?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The cancers.", "rationale": "Clinical.", "layers": [ { "id": "types", "name": "Types", "description": "Types and risk factors.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What types of kidney cancer exist, and what are the risk factors?", "kind": "definition" }, { "text": "Is the question about adult kidney cancer, a childhood tumour or a benign mass?", "kind": "boundary" } ] } ] }, { "id": "childhood", "name": "Childhood", "description": "Childhood tumours.", "findings": [ { "id": "childhood-finding", "name": "Childhood", "description": "Childhood.", "questions": [ { "text": "What are Wilms tumour and other childhood kidney tumours, in general terms?", "kind": "provenance" }, { "text": "Which entry fits the specific tumour?", "kind": "action" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines recommend, from surgery to targeted and immunotherapies, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "outcomes", "name": "Outcomes", "description": "Outcomes and follow-up.", "findings": [ { "id": "outcomes-finding", "name": "Outcomes", "description": "Outcomes.", "questions": [ { "text": "What do statistics say about survival by stage, and how is follow-up organised?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and prevention.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is advancing kidney cancer treatment, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits cancer immunotherapy?", "kind": "action" } ] } ] }, { "id": "prevention", "name": "Prevention", "description": "Prevention.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "What prevention advice do guidelines give, and what hereditary syndromes need screening?", "kind": "provenance" }, { "text": "Which entry fits hereditary kidney cancer?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should renal cell carcinoma and Wilms tumour be separate primary entries?", "How should guidelines be linked?", "The registry entry has merged aliases naming rare tumours and an adrenal tumour type; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a kidney cancer, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain kidney cancer and its types in general terms from oncology guidelines, describe risk factors, diagnosis and treatment approaches, distinguish adult and childhood forms, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: childhood kidney neoplasm, renal pelvis neoplasm, catecholamine-producing tumor, malignant cystic nephroma, mesoblastic nephroma, kidney small cell carcinoma, hereditary Wilms' tumor, kidney hemangiopericytoma, benign metanephric tumour, non-amyloid monoclonal immunoglobulin deposition disease, nephroblastoma, congenital mesoblastic nephroma.", "22 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 36 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a kidney cancer, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "childhood kidney neoplasm", "renal pelvis neoplasm", "catecholamine-producing tumor", "malignant cystic nephroma", "mesoblastic nephroma", "kidney small cell carcinoma", "hereditary Wilms' tumor", "kidney hemangiopericytoma", "benign metanephric tumour", "non-amyloid monoclonal immunoglobulin deposition disease", "nephroblastoma", "congenital mesoblastic nephroma" ] } ], "standing": "Described in 36 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 22 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one kidney cancer from another, and a kidney cancer from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a kidney cancer sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a kidney cancer from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a kidney cancer passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a kidney cancer between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a kidney cancer, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a kidney cancer is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of kidney cancer a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define kidney cancer, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover kidney cancer, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How kidney cancer develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does kidney cancer typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for kidney cancer, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a kidney cancer came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a kidney cancer and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a kidney cancer is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a kidney cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a kidney cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a kidney cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }