{ "model": { "rank": 8088, "code": "thing-q372701", "model_id": "vr.tr.esophageal-cancer", "name": "esophageal cancer", "purpose": "Let an agent explain oesophageal cancer and its types in general terms from oncology guidelines, describe risk factors, symptoms, diagnosis and treatment approaches, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q372701/", "tier": 2, "score": 52, "payload": { "layer": "wikidata", "aliases": [ "malignant neoplasm of thoracic esophagus", "malignant granular cell esophageal tumor", "esophagus melanoma", "esophagus sarcoma", "esophageal adenosquamous carcinoma", "esophageal neuroendocrine tumor", "esophageal basaloid squamous cell carcinoma", "neurofibroma of the esophagus", "malignant neoplasm of cervical part of esophagus", "recurrent esophagus cancer", "oesophagogastric junctional adenocarcinoma" ], "aliasCount": 11, "merged": 11, "knownIn": 52, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q372701", "url": "https://www.wikidata.org/wiki/Q372701", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T02:25:37Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q372701", "registryId": "vr.tr.esophageal-cancer", "name": "esophageal cancer", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q372701/", "model": { "registry_id": "vr.tr.esophageal-cancer", "name": "esophageal cancer", "purpose": "Let an agent explain oesophageal cancer and its types in general terms from oncology guidelines, describe risk factors, symptoms, diagnosis and treatment approaches, and route personal questions to clinicians.", "definition": "Cancer arising in the oesophagus, chiefly squamous cell carcinoma, common in parts of Asia and Africa and linked to tobacco, alcohol and hot beverages, and adenocarcinoma, rising in Western countries and linked to reflux, Barrett oesophagus and obesity, with rare types such as neuroendocrine tumours, adenosquamous carcinoma, melanoma, sarcoma and granular cell tumours; oesophageal cancer often presents late with swallowing difficulty and is treated with surgery, chemotherapy, radiotherapy and immunotherapy.", "what_it_is_for": "Not applicable; a cancer.", "affordances": [ "explain types and risk factors", "relay symptoms and diagnosis", "relay treatment approaches", "route personal questions" ], "distinguishing_features": [ "Two main histologies", "Geographic variation", "Late presentation", "Multimodal treatment" ], "appearance": "Not a visible object; a tumour seen at endoscopy.", "visual_identification": [ "Malignant tumour of the oesophagus", "Squamous cell carcinoma, adenocarcinoma and rare types", "Barrett oesophagus is a precursor; gastric cancer arises in the stomach" ], "physical_properties": [ { "quantity": "new cases worldwide", "typical_range": "about 510000", "unit": "per year", "note": "GLOBOCAN 2022" }, { "quantity": "five-year survival", "typical_range": "about 20", "unit": "percent", "note": "overall, varies by stage" } ], "families_and_kinds": [ "squamous cell carcinoma", "adenocarcinoma", "adenosquamous carcinoma", "neuroendocrine tumours", "rare types such as melanoma, sarcoma and granular cell tumours", "cancers by site such as the thoracic oesophagus" ], "related_models": [ { "relation": "is a kind of", "target": "esophageal neoplasm", "why": "in registry terms" }, { "relation": "is a kind of", "target": "gastrointestinal system cancer", "why": "in registry terms" }, { "relation": "is preceded by", "target": "Barrett esophagus", "why": "for adenocarcinoma" }, { "relation": "is diagnosed by", "target": "endoscopy", "why": "with biopsy" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "2B70", "note": "malignant neoplasms of oesophagus" }, { "scheme": "MeSH", "value_or_pattern": "D004938", "note": "esophageal neoplasms" } ], "standards_and_regulation": [ "ESMO, NCCN and other oncology guidelines", "Cancer registration standards", "Drug approvals for targeted and immunotherapies" ], "failure_modes_and_hazards": [ "Late diagnosis", "Agents giving personal medical advice", "Confusing types and sites", "Treatment complications" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Getting help first.", "rationale": "Safety.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What symptoms such as difficulty swallowing or weight loss need prompt assessment?", "kind": "action" }, { "text": "Is the user describing such symptoms, which need a clinician promptly?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Specialist care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is oesophageal cancer diagnosed and staged by specialists, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis, which needs their oncology team?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The cancer.", "rationale": "Clinical.", "layers": [ { "id": "types", "name": "Types", "description": "Types and risk factors.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What types of oesophageal cancer exist, and what are the risk factors for each?", "kind": "definition" }, { "text": "Is the question about oesophageal cancer, Barrett oesophagus or gastric cancer?", "kind": "boundary" } ] } ] }, { "id": "geography", "name": "Geography", "description": "Epidemiology.", "findings": [ { "id": "geography-finding", "name": "Geography", "description": "Geography.", "questions": [ { "text": "How does incidence vary worldwide, and why, with sources?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines recommend by stage and type, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "outcomes", "name": "Outcomes", "description": "Outcomes and support.", "findings": [ { "id": "outcomes-finding", "name": "Outcomes", "description": "Outcomes.", "questions": [ { "text": "What are the outcomes, and what nutritional and supportive care exists?", "kind": "provenance" }, { "text": "Which entry fits cancer supportive care?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Prevention and research.", "rationale": "Context.", "layers": [ { "id": "prevention", "name": "Prevention", "description": "Prevention and screening.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "What prevention advice and screening exist, including surveillance of Barrett oesophagus?", "kind": "provenance" }, { "text": "Which entry fits Barrett esophagus?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is advancing early detection and treatment, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits oncology research?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should squamous cell carcinoma and adenocarcinoma be separate primary entries?", "How should guidelines be linked?", "The registry entry has merged aliases naming rare types and sites; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a esophageal cancer, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain oesophageal cancer and its types in general terms from oncology guidelines, describe risk factors, symptoms, diagnosis and treatment approaches, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: malignant neoplasm of thoracic esophagus, malignant granular cell esophageal tumor, esophagus melanoma, esophagus sarcoma, esophageal adenosquamous carcinoma, esophageal neuroendocrine tumor, esophageal basaloid squamous cell carcinoma, neurofibroma of the esophagus, malignant neoplasm of cervical part of esophagus, recurrent esophagus cancer, oesophagogastric junctional adenocarcinoma.", "11 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 52 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a esophageal cancer, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "malignant neoplasm of thoracic esophagus", "malignant granular cell esophageal tumor", "esophagus melanoma", "esophagus sarcoma", "esophageal adenosquamous carcinoma", "esophageal neuroendocrine tumor", "esophageal basaloid squamous cell carcinoma", "neurofibroma of the esophagus", "malignant neoplasm of cervical part of esophagus", "recurrent esophagus cancer", "oesophagogastric junctional adenocarcinoma" ] } ], "standing": "Described in 52 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 11 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one esophageal cancer from another, and a esophageal cancer from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a esophageal cancer sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a esophageal cancer from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a esophageal cancer passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a esophageal cancer between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a esophageal cancer, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a esophageal cancer is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of esophageal cancer a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define esophageal cancer, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover esophageal cancer, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How esophageal cancer develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does esophageal cancer typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for esophageal cancer, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a esophageal cancer came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a esophageal cancer and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a esophageal cancer is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a esophageal cancer, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a esophageal cancer, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a esophageal cancer is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }