{ "model": { "rank": 14220, "code": "thing-q378681", "model_id": "vr.tr.peripheral-artery-disease", "name": "peripheral artery disease", "purpose": "Let an agent explain peripheral artery disease in general terms from cardiovascular guidelines, describe symptoms, diagnosis and treatment, route urgent limb-threatening presentations to emergency care, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q378681/", "tier": 2, "score": 36, "payload": { "layer": "wikidata", "aliases": [ "lower limb ischemia", "critical limb ischemia", "deafness, sensorineural, with peripheral neuropathy and arterial disease", "peripheral arterial occlusive disease 1", "carotid artery occlusion", "Aortoiliac occlusive disease", "carotid artery stenosis", "internal carotid artery stenosis" ], "aliasCount": 8, "merged": 8, "knownIn": 36, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q378681", "url": "https://www.wikidata.org/wiki/Q378681", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T02:44:35Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q378681", "registryId": "vr.tr.peripheral-artery-disease", "name": "peripheral artery disease", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q378681/", "model": { "registry_id": "vr.tr.peripheral-artery-disease", "name": "peripheral artery disease", "purpose": "Let an agent explain peripheral artery disease in general terms from cardiovascular guidelines, describe symptoms, diagnosis and treatment, route urgent limb-threatening presentations to emergency care, and route personal questions to clinicians.", "definition": "A circulatory condition in which narrowed or blocked arteries, usually from atherosclerosis, reduce blood flow to the limbs, most often the legs, causing leg pain on walking, and in severe cases critical limb ischemia with rest pain, ulcers and gangrene, including aortoiliac occlusive disease and related arterial occlusions such as carotid artery occlusion, and rare inherited forms; peripheral artery disease shares risk factors with heart disease and is treated with risk factor control, exercise, medication and revascularisation.", "what_it_is_for": "Not applicable; a disease.", "affordances": [ "explain the disease", "relay symptoms and diagnosis", "relay treatment approaches", "route urgent and personal questions" ], "distinguishing_features": [ "Atherosclerotic cause", "Claudication symptom", "Ankle-brachial index", "Limb threat when severe" ], "appearance": "Not a visible object; in advanced cases cool, pale limbs with ulcers.", "visual_identification": [ "Narrowed limb arteries from atherosclerosis", "Intermittent claudication, critical limb ischemia, aortoiliac occlusive disease", "Venous disease affects veins; neuropathy causes different leg symptoms; carotid disease affects the brain" ], "physical_properties": [ { "quantity": "global prevalence", "typical_range": "about 230", "unit": "million people", "note": "estimates" }, { "quantity": "ankle-brachial index threshold", "typical_range": "0.9 or below", "unit": "ratio", "note": "diagnostic" } ], "families_and_kinds": [ "asymptomatic peripheral artery disease", "intermittent claudication", "critical or chronic limb-threatening ischemia", "aortoiliac occlusive disease", "acute limb ischemia", "rare inherited arterial diseases", "related occlusions such as carotid artery occlusion" ], "related_models": [ { "relation": "is a kind of", "target": "artery disease", "why": "in registry terms" }, { "relation": "is a kind of", "target": "Peripheral vasculopathy", "why": "in registry terms" }, { "relation": "is caused by", "target": "atherosclerosis", "why": "in most cases" }, { "relation": "is diagnosed by", "target": "ankle-brachial index", "why": "and imaging" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "BD40", "note": "chronic arterial occlusive disease" }, { "scheme": "MeSH", "value_or_pattern": "D058729", "note": "peripheral arterial disease" } ], "standards_and_regulation": [ "ESC, AHA/ACC and other cardiovascular guidelines", "Drug approvals for antiplatelet and lipid therapies" ], "failure_modes_and_hazards": [ "Missed diagnosis", "Limb loss from delayed care", "Agents giving personal medical advice", "Confusing arterial and venous disease" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Urgent signs first.", "rationale": "Safety.", "layers": [ { "id": "urgent", "name": "Urgent", "description": "Emergency signs.", "findings": [ { "id": "urgent-finding", "name": "Urgent", "description": "Urgent.", "questions": [ { "text": "Which signs, such as sudden cold, painful or pale limb, need emergency care?", "kind": "action" }, { "text": "Is the user describing such signs, which need emergency services now?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Getting assessed.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is PAD assessed by clinicians, including the ankle-brachial index?", "kind": "provenance" }, { "text": "Is the user asking about their own symptoms, which need a clinician?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and causes.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is peripheral artery disease, and what causes it?", "kind": "definition" }, { "text": "Is the question about PAD, venous disease or neuropathy?", "kind": "boundary" } ] } ] }, { "id": "stages", "name": "Stages", "description": "Stages.", "findings": [ { "id": "stages-finding", "name": "Stages", "description": "Stages.", "questions": [ { "text": "How does PAD progress from asymptomatic disease to claudication and limb-threatening ischemia?", "kind": "definition" }, { "text": "Which entry fits the specific stage?", "kind": "action" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines recommend, from exercise and medication to revascularisation, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "prevention", "name": "Prevention", "description": "Prevention.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "How do smoking cessation, diabetes control and lipid management reduce risk?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Epidemiology and research.", "rationale": "Context.", "layers": [ { "id": "epidemiology", "name": "Epidemiology", "description": "Epidemiology.", "findings": [ { "id": "epidemiology-finding", "name": "Epidemiology", "description": "Epidemiology.", "questions": [ { "text": "How common is PAD, and how does it relate to heart disease and stroke?", "kind": "provenance" }, { "text": "Which entry fits cardiovascular disease?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is advancing PAD treatment, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits vascular research?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should critical limb ischemia be a separate primary entry?", "How should guidelines be linked?", "The registry entry has merged aliases naming rare syndromes and carotid disease; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a peripheral artery disease, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain peripheral artery disease in general terms from cardiovascular guidelines, describe symptoms, diagnosis and treatment, route urgent limb-threatening presentations to emergency care, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: lower limb ischemia, critical limb ischemia, deafness, sensorineural, with peripheral neuropathy and arterial disease, peripheral arterial occlusive disease 1, carotid artery occlusion, Aortoiliac occlusive disease, carotid artery stenosis, internal carotid artery stenosis.", "8 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 36 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a peripheral artery disease, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "lower limb ischemia", "critical limb ischemia", "deafness, sensorineural, with peripheral neuropathy and arterial disease", "peripheral arterial occlusive disease 1", "carotid artery occlusion", "Aortoiliac occlusive disease", "carotid artery stenosis", "internal carotid artery stenosis" ] } ], "standing": "Described in 36 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 8 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one peripheral artery disease from another, and a peripheral artery disease from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a peripheral artery disease sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a peripheral artery disease from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a peripheral artery disease passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a peripheral artery disease between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a peripheral artery disease, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a peripheral artery disease is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of peripheral artery disease a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define peripheral artery disease, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover peripheral artery disease, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How peripheral artery disease develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does peripheral artery disease typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for peripheral artery disease, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a peripheral artery disease came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a peripheral artery disease and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a peripheral artery disease is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a peripheral artery disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a peripheral artery disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a peripheral artery disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }