{ "model": { "rank": 10538, "code": "thing-q38173", "model_id": "vr.tr.g-protein-coupled-recepteishon", "name": "G protein-coupled recepteishon", "purpose": "Let an agent explain G protein-coupled receptors, their structure, classes and signalling, relay their roles in physiology and drug action from reference sources, and distinguish them from other receptor families.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q38173/", "tier": 2, "score": 44, "payload": { "layer": "wikidata", "aliases": [ "G protein-coupled receptor 98", "GPCR, family 2, glucagon-like peptide-1/glucagon receptor", "7TM GPCR, serpentine receptor class a (Sra)", "taste receptor type 2", "GPCR, family 2, growth hormone-releasing hormone receptor", "G-protein coupled receptor 143", "TSH/LHCG/FSH receptor", "Methuselah, N-terminal domain superfamily", "Taste receptor type 2 member 38", "Taste receptor type 2 member 4", "Taste receptor type 2 member 7", "leukotriene receptor", "Prostanoid receptor", "G protein-coupled receptor 176, rhodopsin-like, 7TM, protein family", "Adhesion G protein-coupled receptor B, N-terminal domain, protein family", "GPCR, family 3", "Gonadotrophin-releasing hormone receptor family", "Thyrotropin-releasing hormone receptor", "Thyrotropin receptor", "Formyl peptide receptor 1", "melatonin receptor family", "melanocortin receptor", "Adhesion G protein-coupled receptor", "GPCR family 2, extracellular hormone receptor domain superfamily", "Frizzled cysteine-rich domain superfamily", "tachykinin receptor", "anaphylatoxin receptors", "fungal mating pheromone receptors", "GPCR, family 3, extracellular calcium-sensing receptor-related", "lysophospholipid receptor", "G protein-coupled receptor, rhodopsin-like", "GPCR, family 2, secretin-like", "pituitary adenylate cyclase-activating polypeptide receptors", "islet amyloid polypeptide receptors", "Methuselah, N-terminal domain, protein family", "GPCR, family 3, nine cysteines domain, protein family", "GPCR family 3, C-terminal domain, protein family", "GPCR, family 2, latrophilin, C-terminal domain, protein family", "GPCR, family 2, extracellular hormone receptor domain, protein family", "GPCR, cAMP-type, protein family" ], "aliasCount": 162, "merged": 163, "knownIn": 44, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q38173", "url": "https://www.wikidata.org/wiki/Q38173", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T22:02:06Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q38173", "registryId": "vr.tr.g-protein-coupled-recepteishon", "name": "G protein-coupled recepteishon", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q38173/", "model": { "registry_id": "vr.tr.g-protein-coupled-recepteishon", "name": "G protein-coupled recepteishon", "purpose": "Let an agent explain G protein-coupled receptors, their structure, classes and signalling, relay their roles in physiology and drug action from reference sources, and distinguish them from other receptor families.", "definition": "A large family of cell surface receptors with seven transmembrane helices that detect molecules outside the cell, from hormones, neurotransmitters and odorants to light and tastants, and activate intracellular G proteins to trigger signalling; G protein-coupled receptors number about 800 in humans, are grouped into classes A to F, and are the targets of roughly a third of approved drugs.", "what_it_is_for": "Transmitting signals from outside cells to the inside.", "affordances": [ "explain structure and signalling", "classify receptor families", "relay roles in physiology and pharmacology", "distinguish from other receptor types" ], "distinguishing_features": [ "Seven transmembrane helices", "G protein activation", "Largest receptor family", "Major drug targets" ], "appearance": "Not visible; a protein with seven membrane-spanning helices, shown in structural models.", "visual_identification": [ "Seven transmembrane helices coupled to G proteins", "Classes A to F by sequence and structure", "Ion channel and enzyme-linked receptors are other families" ], "physical_properties": [ { "quantity": "human GPCR genes", "typical_range": "about 800", "unit": "count", "note": "including olfactory receptors" }, { "quantity": "share of drug targets", "typical_range": "about 30-35", "unit": "percent", "note": "of approved drugs" } ], "families_and_kinds": [ "class A rhodopsin-like receptors including adrenergic, opioid and olfactory receptors", "class B secretin family including glucagon-like peptide-1 and growth hormone-releasing hormone receptors", "class C glutamate family", "adhesion and frizzled receptors", "taste receptors", "orphan receptors with unknown ligands" ], "related_models": [ { "relation": "is a kind of", "target": "cell surface receptor", "why": "the category" }, { "relation": "is a kind of", "target": "transmembrane signaling receptor", "why": "in registry terms" }, { "relation": "activates", "target": "G protein", "why": "the transducer" }, { "relation": "is targeted by", "target": "drug", "why": "a third of approved medicines" } ], "identifiers": [ { "scheme": "Pfam", "value_or_pattern": "PF00001 and others", "note": "7tm families" }, { "scheme": "IUPHAR", "value_or_pattern": "GPCR list", "note": "nomenclature" } ], "standards_and_regulation": [ "IUPHAR receptor nomenclature", "No regulation of the receptors themselves" ], "failure_modes_and_hazards": [ "Confusing receptor classes", "Overstating drug selectivity", "Mutations causing disease" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "structure", "name": "Structure", "description": "Structure and signalling.", "rationale": "Science.", "layers": [ { "id": "structure", "name": "Structure", "description": "Structure.", "findings": [ { "id": "structure-finding", "name": "Structure", "description": "Structure.", "questions": [ { "text": "What is the structure of a GPCR, and how does ligand binding change it?", "kind": "definition" }, { "text": "Is the receptor a GPCR or another receptor family?", "kind": "boundary" } ] } ] }, { "id": "signalling", "name": "Signalling", "description": "Signalling.", "findings": [ { "id": "signalling-finding", "name": "Signalling", "description": "Signalling.", "questions": [ { "text": "How do GPCRs activate G proteins and arrestins, and how is signalling terminated?", "kind": "definition" }, { "text": "Which entry fits G protein?", "kind": "action" } ] } ] } ] }, { "id": "classify", "name": "Classify", "description": "Families.", "rationale": "Classification.", "layers": [ { "id": "classes", "name": "Classes", "description": "Classes.", "findings": [ { "id": "classes-finding", "name": "Classes", "description": "Classes.", "questions": [ { "text": "What are the GPCR classes, and what receptors belong to each?", "kind": "definition" }, { "text": "Which entry fits the specific receptor?", "kind": "action" } ] } ] }, { "id": "nomenclature", "name": "Nomenclature", "description": "Nomenclature.", "findings": [ { "id": "nomenclature-finding", "name": "Nomenclature", "description": "Nomenclature.", "questions": [ { "text": "How are GPCRs named and catalogued?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] } ] }, { "id": "function", "name": "Function", "description": "Physiology and medicine.", "rationale": "Application.", "layers": [ { "id": "physiology", "name": "Physiology", "description": "Roles.", "findings": [ { "id": "physiology-finding", "name": "Physiology", "description": "Physiology.", "questions": [ { "text": "What roles do GPCRs play in sensing, hormones and neurotransmission?", "kind": "provenance" }, { "text": "Which entry fits the specific system?", "kind": "action" } ] } ] }, { "id": "drugs", "name": "Drugs", "description": "Drug targets.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "How do drugs act on GPCRs, and what does biased signalling mean for drug design?", "kind": "provenance" }, { "text": "Which entry fits pharmacology?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "History and research.", "rationale": "Context.", "layers": [ { "id": "history", "name": "History", "description": "Discovery.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How were GPCRs discovered and characterised, including the 2012 Nobel Prize?", "kind": "provenance" }, { "text": "Which entry fits the history of molecular biology?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What are current research directions, such as cryo-EM structures and orphan receptors?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should each receptor class be a separate entry?", "How should nomenclature databases be linked?", "The registry entry has merged aliases naming individual receptors and families; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a G protein-coupled recepteishon, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain G protein-coupled receptors, their structure, classes and signalling, relay their roles in physiology and drug action from reference sources, and distinguish them from other receptor families.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: G protein-coupled receptor 98, GPCR, family 2, glucagon-like peptide-1/glucagon receptor, 7TM GPCR, serpentine receptor class a (Sra), taste receptor type 2, GPCR, family 2, growth hormone-releasing hormone receptor, G-protein coupled receptor 143, TSH/LHCG/FSH receptor, Methuselah, N-terminal domain superfamily, Taste receptor type 2 member 38, Taste receptor type 2 member 4, Taste receptor type 2 member 7, leukotriene receptor.", "163 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 44 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a G protein-coupled recepteishon, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "G protein-coupled receptor 98", "GPCR, family 2, glucagon-like peptide-1/glucagon receptor", "7TM GPCR, serpentine receptor class a (Sra)", "taste receptor type 2", "GPCR, family 2, growth hormone-releasing hormone receptor", "G-protein coupled receptor 143", "TSH/LHCG/FSH receptor", "Methuselah, N-terminal domain superfamily", "Taste receptor type 2 member 38", "Taste receptor type 2 member 4", "Taste receptor type 2 member 7", "leukotriene receptor" ] } ], "standing": "Described in 44 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 163 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one G protein-coupled recepteishon from another, and a G protein-coupled recepteishon from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a G protein-coupled recepteishon sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a G protein-coupled recepteishon from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a G protein-coupled recepteishon is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a G protein-coupled recepteishon is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a G protein-coupled recepteishon is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a G protein-coupled recepteishon is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a G protein-coupled recepteishon is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a G protein-coupled recepteishon is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a G protein-coupled recepteishon passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a G protein-coupled recepteishon between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a G protein-coupled recepteishon, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a G protein-coupled recepteishon is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a G protein-coupled recepteishon and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a G protein-coupled recepteishon is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a G protein-coupled recepteishon performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a G protein-coupled recepteishon.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a G protein-coupled recepteishon at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a G protein-coupled recepteishon there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What G protein-coupled recepteishon is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name G protein-coupled recepteishon unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of G protein-coupled recepteishon exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How G protein-coupled recepteishon behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of G protein-coupled recepteishon, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is G protein-coupled recepteishon incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How G protein-coupled recepteishon can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is G protein-coupled recepteishon classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover G protein-coupled recepteishon, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a G protein-coupled recepteishon came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a G protein-coupled recepteishon and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a G protein-coupled recepteishon is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a G protein-coupled recepteishon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a G protein-coupled recepteishon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a G protein-coupled recepteishon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }