mpox

Supported case classification

Record the classification, its supporting observations and unresolved alternatives separately.

1. Which jurisdiction's dated mpox case definition applies, and which criteria are satisfied, absent or unknown? definition
2. How were varicella, herpes, syphilis and other plausible explanations assessed, including possible coinfection? boundary

Interpretable mpox test evidence

Link each interpretation to the actual assay, specimen and report rather than a standalone positive or negative label.

1. What specimen site, collection date, assay target and laboratory report support the result? provenance
2. Does the assay establish MPXV, broader orthopoxvirus detection or clade attribution, and what limitations qualify a negative or indeterminate result? boundary
3. What unresolved discrepancy warrants clinician or laboratory review for additional testing? action

Lesion and function profile

Record site-specific findings and distinguish unexamined areas from documented absence.

1. Which skin, oral, genital, anal or ocular sites are involved, and which were not assessed? measurement
2. What lesion evolution, pain and interference with eating, drinking, urination or defecation were recorded at each assessment? measurement

Dated clinical trajectory

Keep symptom onset, lesion onset, new lesion formation and healing as distinct observations.

1. When did systemic symptoms and lesions first appear, and which dates are recalled estimates? provenance
2. Does serial assessment show improvement, new lesions, persistent disease or deterioration, and what evidence supports that judgement? measurement

Individual risk modifiers

Use documented clinical context rather than group membership to qualify risk.

1. What current evidence describes immune function, pregnancy, age-related considerations and relevant skin disease? provenance
2. Which previous mpox episodes or vaccinations are documented, and what does the applicable guidance allow an assessor to infer from them? boundary

Escalation-relevant burden

Track ocular, neurological, respiratory, hydration, pain and secondary-infection concerns without automatically attributing each to mpox.

1. Which complications or functional impairments are observed, suspected or excluded, and how is their relationship to mpox assessed? measurement
2. Which findings meet the applicable criteria for urgent assessment, specialist consultation or inpatient care, and who must review them? action

Qualified exposure history

Capture relevant human, material and animal contacts with timing and evidential confidence.

1. What close contact, contaminated-material contact, animal contact or pregnancy-associated exposure is reported, and when? provenance
2. Is the proposed source confirmed, plausible or unknown, and what evidence would distinguish competing acquisition events? boundary

Contact window and precautions

Record the policy-defined assessment window separately from uncertain infectiousness at a particular moment.

1. Which dated guidance determines the contact-assessment interval, and how do uncertain onset dates affect its boundaries? boundary
2. Which household, intimate, healthcare or animal contacts fall within that interval, and what precautions or authorised follow-up require review? action

Care and prevention options

Support review of symptom care, additional therapies and vaccination without embedding permanent eligibility rules.

1. What symptom burden and complications determine supportive-care needs, and what response has been observed? action
2. For an exposed person, how do exposure timing, symptoms and vaccination history affect eligibility under current post-exposure guidance? action
3. If additional therapy is considered, what current evidence, eligibility criteria, local authorisation and clinician decision support it? provenance

Documented episode disposition

Record healing evidence, residual effects and the authority for closure; WHO describes infectiousness continuing until sores heal and new skin forms. [WHO mpox fact sheet](https://www.who.int/news-room/fact-sheets/detail/mpox)

1. What skin and mucosal healing evidence supports release under the applicable guidance, and who documented that determination? action
2. What residual pain, scarring, other sequelae or unresolved symptoms require follow-up after the acute episode? measurement
3. Which local reporting duties remain, and what minimum necessary information may an authorised actor disclose? action

Kinds and varieties

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these kinds and varieties hold for the sense of mpox this model covers, and on what evidence? provenance

Identifiers and schemes

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these identifiers and schemes hold for the sense of mpox this model covers, and on what evidence? provenance

Standards and regulation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these standards and regulation hold for the sense of mpox this model covers, and on what evidence? provenance

Real-world use

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these real-world use hold for the sense of mpox this model covers, and on what evidence? provenance

Typical measurements

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these typical measurements hold for the sense of mpox this model covers, and on what evidence? provenance

Failure modes and hazards

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these failure modes and hazards hold for the sense of mpox this model covers, and on what evidence? provenance

Regional variation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these regional variation hold for the sense of mpox this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of mpox this model covers, and on what evidence? provenance