icosanoid
Let an agent explain eicosanoids and their pathways, relay classes, functions and drug targets from biochemistry and pharmacology references, describe their roles in disease, and distinguish eicosanoids from other lipid mediators.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain eicosanoids and their pathways, relay classes, functions and drug targets from biochemistry and pharmacology references, describe their roles in disease, and distinguish eicosanoids from other lipid mediators.
A class of signalling molecules derived from twenty-carbon polyunsaturated fatty acids, chiefly arachidonic acid, through cyclooxygenase, lipoxygenase and cytochrome P450 pathways, including prostaglandins, thromboxanes, leukotrienes, lipoxins, hydroxy and hydroperoxy eicosatetraenoic acids such as 20-HETE and 15-HPETE, and epoxy and dihydroxy derivatives; eicosanoids act locally to regulate inflammation, immunity, blood flow, blood clotting and many other processes, and are targets of aspirin, NSAIDs and asthma drugs.
What it is for: Not applicable; a class of signalling lipids.
It can be explain pathways and classes; relay functions; describe drug targets and disease; distinguish from other lipid mediators.
Distinguishing features
Arachidonic acid origin
Three enzyme pathways
Local hormone action
Drug targets
What it looks like
Not a visible object; lipid molecules acting locally.
Physical character
carbon skeleton: 20 carbons
main precursor: arachidonic acid compound
Nobel Prize: 1982 year - Bergstrom, Samuelsson, Vane
How it is recognised
Twenty-carbon fatty acid derived mediators
Prostaglandins, thromboxanes, leukotrienes, lipoxins, HETEs, HPETEs, EETs and DHETs
Endocannabinoids and resolvins are related lipid mediators; steroids are different lipids
Related models
is a kind of - in registry terms, as derivatives
is a kind of - in registry terms
includes - as a major class
is inhibited by - through cyclooxygenase
In practice
Families and kinds
prostaglandins and prostacyclin
thromboxanes
leukotrienes
lipoxins
hydroxyeicosatetraenoic and hydroperoxyeicosatetraenoic acids such as 20-HETE and 15-HPETE
epoxyeicosatrienoic and dihydroxyeicosatrienoic acids
isoprostanes formed non-enzymatically
Identifiers
MeSH D015786 eicosanoids
ChEBI CHEBI:23899 icosanoid
Standards and regulation
IUPAC lipid nomenclature
Drug regulation of NSAIDs, leukotriene antagonists and prostaglandin analogues
Failure modes and hazards
Agents giving personal medication advice
Confusing eicosanoid classes
Registry aliases with unwieldy systematic names
Also called
+129
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What eicosanoids are.
Science.
Definition
Definition and pathways.
Definition
Definition.
- What are eicosanoids, and how do the cyclooxygenase, lipoxygenase and cytochrome P450 pathways produce them? definition
- Is the question about eicosanoids in general, a class such as prostaglandins, or a specific compound? boundary
Classes
Classes.
Classes
Classes.
- How do prostaglandins, thromboxanes, leukotrienes, lipoxins, HETEs and EETs differ? definition
- Which entry fits the specific class? action
Biology Functions.
Science.
Roles
Physiological roles.
Roles
Roles.
- How do eicosanoids regulate inflammation, immunity, blood flow, clotting and kidney function? provenance
- Which references are standard? provenance
Disease
Disease.
Disease
Disease.
- What roles do eicosanoids play in asthma, cardiovascular disease, pain and cancer, in general terms? provenance
- Which entry fits the specific disease? action
Medicine Drugs.
Clinical.
Drugs
Drug targets.
Drugs
Drugs.
- How do aspirin, NSAIDs, leukotriene antagonists and prostaglandin analogues act on eicosanoid pathways? provenance
- Is the user asking about their own medication, which needs a clinician or pharmacist? boundary
Research
Research.
Research
Research.
- What research explores resolvins, 20-HETE and new eicosanoid targets, with findings attributed? provenance
- Which sources are cited? provenance
Context History and methods.
Context.
History
History.
History
History.
- How were eicosanoids discovered and characterised, with Nobel recognition? provenance
- Which entry fits the history of pharmacology? action
Methods
Analysis.
Methods
Methods.
- How are eicosanoids measured by mass spectrometry and immunoassay? provenance
- Which entry fits lipidomics? action
What the second pass must settle
- Should leukotriene and thromboxane be separate primary entries?
- How should pharmacology references be linked?
- The registry entry has merged aliases with systematic names; should they be split off?