{
    "model": {
        "rank": 12674,
        "code": "thing-q423042",
        "model_id": "vr.tr.membrane-protein",
        "name": "membrane protein",
        "purpose": "",
        "family": "Thing Registry",
        "category": "Physical world and living systems",
        "status": "draft-generated",
        "kind": "thing",
        "plane": "PHY",
        "domain": "PHY.MAT",
        "industry": "",
        "version": "",
        "url": "/models/thing/q423042/",
        "tier": 2,
        "score": 39,
        "payload": {
            "layer": "wikidata",
            "aliases": [
                "heterotrimeric G protein",
                "Endothelin-converting enzyme 1, putative",
                "arrestin",
                "Frizzled-related proteins",
                "archaeosortase",
                "integral membrane protein",
                "STRN",
                "hemagglutinin",
                "Fumarate reductase, subunit C",
                "Fumarate reductase, subunit D",
                "Membrane-associated guanylate kinase",
                "Klotho",
                "peripheral membrane protein",
                "dystrophin-associated protein",
                "nuclear membrane protein",
                "membrane protein of peroxisome",
                "plasma membrane protein",
                "membrane protein of endoplasmic reticulum cistern",
                "membrane protein of golgi cistern",
                "membrane protein of golgi vesicle",
                "membrane protein of endoplasmic reticulum vesicle",
                "membrane protein of smooth endoplasmic reticulum cistern",
                "membrane protein of smooth endoplasmic reticulum vesicle",
                "membrane protein of rough endoplasmic reticulum cistern",
                "membrane protein of rough endoplasmic reticulum vesicle",
                "membrane protein of lysosome",
                "membrane protein of mitochondrion",
                "membrane protein of endosome",
                "plasma transmembrane protein",
                "MAPEG family",
                "MARVEL domain-containing proteins",
                "cornified envelope proline-rich proteins",
                "bacterial outer membrane proteins",
                "myelin proteins",
                "membrane-associated matrix metalloproteinases",
                "electron transport chain complex proteins",
                "thylakoid membrane proteins",
                "NADPH oxidases",
                "intercellular adhesion protein",
                "Arrestin-C"
            ],
            "aliasCount": 47,
            "merged": 47,
            "knownIn": 39,
            "facets": null,
            "markers": [],
            "lexicalClass": "",
            "senseRank": null,
            "alsoRegisteredAs": null,
            "source": {
                "dataset": "wikidata",
                "item": "Q423042",
                "url": "https://www.wikidata.org/wiki/Q423042",
                "license": "CC0 1.0"
            }
        },
        "draft": {
            "generator": "vr.draft.v3",
            "status": "draft-generated",
            "researched": false,
            "archetype": "chemical substance or material",
            "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.",
            "facetsInferred": true,
            "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.",
            "purpose": "Give an agent a durable, checkable way to recognise a membrane protein, record what state it is in, and decide what may be done with it.",
            "whatItIs": "A physical thing registered under PHY.MAT. The registry names it; this draft has not been given a definition yet.",
            "characteristics": {
                "substance": "material",
                "origin": "natural",
                "agency": "inert",
                "mobility": "varies"
            },
            "whatYouCanDoWithIt": [
                "observed and measured",
                "consumed or used up"
            ],
            "distinguishingFeatures": [
                "Names folded into this entry, which a task may need to split apart again: heterotrimeric G protein, Endothelin-converting enzyme 1, putative, arrestin, Frizzled-related proteins, archaeosortase, integral membrane protein, STRN, hemagglutinin, Fumarate reductase, subunit C, Fumarate reductase, subunit D, Membrane-associated guanylate kinase, Klotho.",
                "47 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.",
                "Described in 39 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is."
            ],
            "openQuestionsForResearch": [
                "Which of the bundles below does a real task actually need, and which are ceremony?",
                "What does this thing have that the facets do not capture at all?",
                "Which neighbouring kind is most often confused with a membrane protein, and on what evidence are they told apart?"
            ],
            "whatItIsMadeOf": "matter you can touch",
            "physicalCharacter": [
                "Mobility varies between examples.",
                "Does nothing on its own; everything it does, something else did to it.",
                "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing."
            ],
            "whatCanBeDoneWithIt": [
                "observe it, measure it, record its state",
                "use it up, and then need more of it"
            ],
            "howItIsRecognised": [
                "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay."
            ],
            "relatedModels": [
                {
                    "relation": "covers",
                    "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.",
                    "targets": [
                        "heterotrimeric G protein",
                        "Endothelin-converting enzyme 1, putative",
                        "arrestin",
                        "Frizzled-related proteins",
                        "archaeosortase",
                        "integral membrane protein",
                        "STRN",
                        "hemagglutinin",
                        "Fumarate reductase, subunit C",
                        "Fumarate reductase, subunit D",
                        "Membrane-associated guanylate kinase",
                        "Klotho"
                    ]
                }
            ],
            "standing": "Described in 39 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 47 finer distinctions are held inside this entry as names rather than as separate models.",
            "structure": {
                "bundles": [
                    {
                        "id": "identity-and-classification",
                        "name": "Identity, naming and classification",
                        "description": "How an agent tells one membrane protein from another, and a membrane protein from things that resemble it.",
                        "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.",
                        "layers": [
                            {
                                "id": "naming-and-identifiers",
                                "name": "Names and identifiers",
                                "description": "The names this thing goes by and the identifiers that survive translation and time.",
                                "findings": [
                                    {
                                        "id": "preferred-name-and-aliases",
                                        "name": "Preferred name, aliases and local names",
                                        "description": "Which name to use, which names mean the same thing, and which merely sound similar.",
                                        "questions": [
                                            {
                                                "id": "preferred-name-and-aliases-q01",
                                                "text": "What identifies and describes the name of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "preferred-name-and-aliases-q02",
                                                "text": "Who or what asserted this about the name of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "preferred-name-and-aliases-q03",
                                                "text": "What may an agent decide or do once the name of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    },
                                    {
                                        "id": "stable-identifiers",
                                        "name": "Stable identifiers and external keys",
                                        "description": "Identifiers that keep pointing at this kind of thing across systems and languages.",
                                        "questions": [
                                            {
                                                "id": "stable-identifiers-q01",
                                                "text": "What identifies and describes an identifier for a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "stable-identifiers-q02",
                                                "text": "Who or what asserted this about an identifier for a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "stable-identifiers-q03",
                                                "text": "What may an agent decide or do once an identifier for a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "classification-and-granularity",
                                "name": "Classification and granularity",
                                "description": "Where a membrane protein sits among kinds, and how finely a task needs to cut it.",
                                "findings": [
                                    {
                                        "id": "kind-and-parents",
                                        "name": "Kind, parents and neighbouring kinds",
                                        "description": "The classes this thing belongs to and the ones it is next to.",
                                        "questions": [
                                            {
                                                "id": "kind-and-parents-q01",
                                                "text": "What identifies and describes the kind of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "kind-and-parents-q02",
                                                "text": "Who or what asserted this about the kind of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "kind-and-parents-q03",
                                                "text": "What may an agent decide or do once the kind of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    },
                                    {
                                        "id": "distinguishing-features",
                                        "name": "Distinguishing features",
                                        "description": "What separates a membrane protein from the things most often confused with it.",
                                        "questions": [
                                            {
                                                "id": "distinguishing-features-q01",
                                                "text": "What identifies and describes what distinguishes a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "distinguishing-features-q02",
                                                "text": "Who or what asserted this about what distinguishes a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "distinguishing-features-q03",
                                                "text": "What may an agent decide or do once what distinguishes a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "form-and-composition",
                        "name": "Form, composition and condition",
                        "description": "What a membrane protein is made of, what shape and size it takes, and what state it is in.",
                        "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.",
                        "layers": [
                            {
                                "id": "form-and-dimensions",
                                "name": "Form and dimensions",
                                "description": "Shape, size, mass and the ranges these take across examples.",
                                "findings": [
                                    {
                                        "id": "measurable-dimensions",
                                        "name": "Measurable dimensions and their units",
                                        "description": "The quantities worth recording and the units they are recorded in.",
                                        "questions": [
                                            {
                                                "id": "measurable-dimensions-q01",
                                                "text": "What identifies and describes the dimensions of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "measurable-dimensions-q02",
                                                "text": "Who or what asserted this about the dimensions of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "measurable-dimensions-q03",
                                                "text": "What may an agent decide or do once the dimensions of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "material-and-composition",
                                "name": "Material and composition",
                                "description": "Materials, parts and how they are put together.",
                                "findings": [
                                    {
                                        "id": "parts-and-materials",
                                        "name": "Parts and materials",
                                        "description": "What a membrane protein is built from and which parts are replaceable.",
                                        "questions": [
                                            {
                                                "id": "parts-and-materials-q01",
                                                "text": "What identifies and describes the composition of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "parts-and-materials-q02",
                                                "text": "Who or what asserted this about the composition of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "parts-and-materials-q03",
                                                "text": "What may an agent decide or do once the composition of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "condition-and-integrity",
                                "name": "Condition and integrity",
                                "description": "Wear, damage, health and the difference between working and broken.",
                                "findings": [
                                    {
                                        "id": "condition-assessment",
                                        "name": "Condition, damage and health",
                                        "description": "How the condition of a membrane protein is judged and by whom.",
                                        "questions": [
                                            {
                                                "id": "condition-assessment-q01",
                                                "text": "What identifies and describes the condition of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "condition-assessment-q02",
                                                "text": "Who or what asserted this about the condition of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "condition-assessment-q03",
                                                "text": "What may an agent decide or do once the condition of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "place-and-movement",
                        "name": "Place and movement",
                        "description": "Where a membrane protein is, how it got there and where it may go (varies).",
                        "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.",
                        "layers": [
                            {
                                "id": "location-and-placement",
                                "name": "Location and placement",
                                "description": "Position, containment and the reference frame the position is given in.",
                                "findings": [
                                    {
                                        "id": "position-and-frame",
                                        "name": "Position, container and reference frame",
                                        "description": "Where a membrane protein is, and what that position is measured against.",
                                        "questions": [
                                            {
                                                "id": "position-and-frame-q01",
                                                "text": "What identifies and describes the location of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "position-and-frame-q02",
                                                "text": "Who or what asserted this about the location of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "position-and-frame-q03",
                                                "text": "What may an agent decide or do once the location of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "movement-and-transfer",
                                "name": "Movement and transfer",
                                "description": "How a membrane protein is carried, installed or relocated.",
                                "findings": [
                                    {
                                        "id": "movement-events",
                                        "name": "Movement events and constraints",
                                        "description": "What counts as a movement, what records it and what limits it.",
                                        "questions": [
                                            {
                                                "id": "movement-events-q01",
                                                "text": "What identifies and describes the movement of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "movement-events-q02",
                                                "text": "Who or what asserted this about the movement of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "movement-events-q03",
                                                "text": "What may an agent decide or do once the movement of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "state-and-lifecycle",
                        "name": "State and lifecycle",
                        "description": "The states a membrane protein passes through and the events that move it between them.",
                        "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.",
                        "layers": [
                            {
                                "id": "lifecycle-stages",
                                "name": "Lifecycle stages",
                                "description": "From coming into existence to ceasing to be one of these.",
                                "findings": [
                                    {
                                        "id": "stages-and-transitions",
                                        "name": "Stages and transitions",
                                        "description": "The stages worth naming and what moves a membrane protein between them.",
                                        "questions": [
                                            {
                                                "id": "stages-and-transitions-q01",
                                                "text": "What identifies and describes the lifecycle of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "stages-and-transitions-q02",
                                                "text": "Who or what asserted this about the lifecycle of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "stages-and-transitions-q03",
                                                "text": "What may an agent decide or do once the lifecycle of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "observations-and-status",
                                "name": "Observations and current status",
                                "description": "What is observed about a membrane protein, how often and by whom.",
                                "findings": [
                                    {
                                        "id": "observation-record",
                                        "name": "Observation record",
                                        "description": "How an observation of a membrane protein is recorded so that it can be superseded rather than overwritten.",
                                        "questions": [
                                            {
                                                "id": "observation-record-q01",
                                                "text": "What identifies and describes an observation of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "observation-record-q02",
                                                "text": "Who or what asserted this about an observation of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "observation-record-q03",
                                                "text": "What may an agent decide or do once an observation of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "use-and-operation",
                        "name": "Use and operation",
                        "description": "What can be done with a membrane protein and what it takes to do it.",
                        "rationale": "An agent that can recognise a thing but not act on it has only half a model.",
                        "layers": [
                            {
                                "id": "intended-use",
                                "name": "Intended use and function",
                                "description": "What a membrane protein is for, and what it is used for anyway.",
                                "findings": [
                                    {
                                        "id": "function-and-purpose",
                                        "name": "Function, purpose and misuse",
                                        "description": "The function a membrane protein performs and the uses that fall outside it.",
                                        "questions": [
                                            {
                                                "id": "function-and-purpose-q01",
                                                "text": "What identifies and describes the use of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "function-and-purpose-q02",
                                                "text": "Who or what asserted this about the use of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "function-and-purpose-q03",
                                                "text": "What may an agent decide or do once the use of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "handling-and-procedure",
                                "name": "Handling and procedure",
                                "description": "The steps, skills and tools involved in using a membrane protein.",
                                "findings": [
                                    {
                                        "id": "procedures-and-skills",
                                        "name": "Procedures, skills and required tools",
                                        "description": "What an agent needs before it can act on a membrane protein at all.",
                                        "questions": [
                                            {
                                                "id": "procedures-and-skills-q01",
                                                "text": "What identifies and describes handling a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "procedures-and-skills-q02",
                                                "text": "Who or what asserted this about handling a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "procedures-and-skills-q03",
                                                "text": "What may an agent decide or do once handling a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "supply-and-consumption",
                                "name": "Supply and consumption",
                                "description": "Quantities, rates and what running out means.",
                                "findings": [
                                    {
                                        "id": "consumption-and-stock",
                                        "name": "Consumption, stock and replenishment",
                                        "description": "How much of a membrane protein there is and how fast it goes.",
                                        "questions": [
                                            {
                                                "id": "consumption-and-stock-q01",
                                                "text": "What identifies and describes the supply of a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "consumption-and-stock-q02",
                                                "text": "Who or what asserted this about the supply of a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "consumption-and-stock-q03",
                                                "text": "What may an agent decide or do once the supply of a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "composition-and-identity",
                        "name": "Composition, grade and chemical identity",
                        "description": "What membrane protein is made of and how pure the thing in hand is.",
                        "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.",
                        "layers": [
                            {
                                "id": "chemical-identity",
                                "name": "Chemical identity",
                                "description": "Formula, structure and the registry numbers that name it unambiguously.",
                                "findings": [
                                    {
                                        "id": "identity-record",
                                        "name": "Identity and registry numbers",
                                        "description": "What identifies this substance across suppliers and regulators.",
                                        "questions": [
                                            {
                                                "id": "identity-record-q01",
                                                "text": "What formula, structure and registry identifiers name membrane protein unambiguously?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "identity-record-q02",
                                                "text": "Which related substances share a name in common use but not an identifier?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "grade-and-impurities",
                                "name": "Grade, purity and impurities",
                                "description": "The specification a batch meets and what else is in it.",
                                "findings": [
                                    {
                                        "id": "specification",
                                        "name": "Specification and assay",
                                        "description": "How purity is stated and measured, and which impurities matter.",
                                        "questions": [
                                            {
                                                "id": "specification-q01",
                                                "text": "What grades of membrane protein exist, how is purity assayed, and which impurities are limited?",
                                                "kind": "measurement"
                                            },
                                            {
                                                "id": "specification-q02",
                                                "text": "Which use requires which grade, and what happens when a lower grade is substituted?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "properties-and-behaviour",
                        "name": "Properties and behaviour",
                        "description": "How membrane protein behaves under conditions an agent can measure or change.",
                        "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.",
                        "layers": [
                            {
                                "id": "physical-constants",
                                "name": "Physical constants",
                                "description": "Values that hold for the pure substance, with their conditions.",
                                "findings": [
                                    {
                                        "id": "constants-record",
                                        "name": "Constants and conditions",
                                        "description": "The quantities worth recording and the state they apply in.",
                                        "questions": [
                                            {
                                                "id": "constants-record-q01",
                                                "text": "What are the defining physical constants of membrane protein, in what units and under what conditions?",
                                                "kind": "measurement"
                                            },
                                            {
                                                "id": "constants-record-q02",
                                                "text": "Which of these values change with grade or form rather than being fixed?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "stability-and-reactivity",
                                "name": "Stability and reactivity",
                                "description": "What it reacts with, degrades into, and how it is stored.",
                                "findings": [
                                    {
                                        "id": "incompatibilities",
                                        "name": "Incompatibilities and degradation",
                                        "description": "What must not meet it, and what it becomes over time.",
                                        "questions": [
                                            {
                                                "id": "incompatibilities-q01",
                                                "text": "What is membrane protein incompatible with, and what does it degrade into under storage?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "incompatibilities-q02",
                                                "text": "What storage and handling does that require, and who is competent to do it?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "hazard-and-regulation",
                        "name": "Hazard classification and regulation",
                        "description": "How membrane protein can harm, and what the law says about holding and moving it.",
                        "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.",
                        "layers": [
                            {
                                "id": "hazard-class",
                                "name": "Hazard classification",
                                "description": "Classified hazards, exposure limits and protective measures.",
                                "findings": [
                                    {
                                        "id": "classified-hazards",
                                        "name": "Classified hazards and limits",
                                        "description": "The classification, the scheme it belongs to, and the limits set.",
                                        "questions": [
                                            {
                                                "id": "classified-hazards-q01",
                                                "text": "How is membrane protein classified for hazard, under which scheme, and what exposure limits apply?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "classified-hazards-q02",
                                                "text": "What protection does handling require, and what must an agent refuse to do without it?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "regulatory-identity",
                                "name": "Regulatory identity and control",
                                "description": "Registration, restriction and transport rules by jurisdiction.",
                                "findings": [
                                    {
                                        "id": "controls",
                                        "name": "Controls and jurisdiction",
                                        "description": "Where it is restricted and what the restriction attaches to.",
                                        "questions": [
                                            {
                                                "id": "controls-q01",
                                                "text": "Which registrations, restrictions or transport rules cover membrane protein, and where?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "id": "controls-q02",
                                                "text": "Does the control attach to the substance, its concentration, or its intended use?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "provenance-and-evidence",
                        "name": "Provenance, evidence and time",
                        "description": "Where every claim about a membrane protein came from and when it held.",
                        "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.",
                        "layers": [
                            {
                                "id": "source-and-authority",
                                "name": "Source and authority",
                                "description": "Who said it, on what evidence, and how strongly.",
                                "findings": [
                                    {
                                        "id": "claim-provenance",
                                        "name": "Claim provenance and confidence",
                                        "description": "The authority behind each claim about a membrane protein and how confident it is.",
                                        "questions": [
                                            {
                                                "id": "claim-provenance-q01",
                                                "text": "What identifies and describes a claim about a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "claim-provenance-q02",
                                                "text": "Who or what asserted this about a claim about a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "claim-provenance-q03",
                                                "text": "What may an agent decide or do once a claim about a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "time-and-versions",
                                "name": "Time, versions and supersession",
                                "description": "When a claim was true, when it was learnt, and what replaced it.",
                                "findings": [
                                    {
                                        "id": "validity-and-supersession",
                                        "name": "Validity period and supersession",
                                        "description": "How an old claim about a membrane protein is retired without being erased.",
                                        "questions": [
                                            {
                                                "id": "validity-and-supersession-q01",
                                                "text": "What identifies and describes the validity of a claim about a membrane protein, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "validity-and-supersession-q02",
                                                "text": "Who or what asserted this about the validity of a claim about a membrane protein, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "validity-and-supersession-q03",
                                                "text": "What may an agent decide or do once the validity of a claim about a membrane protein is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    }
                ]
            },
            "statistics": {
                "bundles": 9,
                "layers": 20,
                "findings": 22,
                "questions": 60
            }
        }
    }
}