{ "model": { "rank": 2691, "code": "thing-q42844", "model_id": "vr.tr.major-depressive-disorder", "name": "major depressive disorder", "purpose": "Let an agent give neutral, non-diagnostic information about depression, point to professional care, and give crisis contacts first when someone may be at risk.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q42844/", "tier": 2, "score": 99, "payload": { "layer": "wikidata", "aliases": [ "Dorian Gray syndrome", "depression in autism", "treatment-resistant depression", "double depression", "melancholic depression", "moderate recurrent major depression", "mild recurrent major depression", "melancholia", "masked depression", "anxiety/aggression-driven depression", "depression of Alzheimer disease", "recurrent major depression in complete remission", "major depressive disorder 1", "major depressive disorder 2", "subcortical ischemic depression", "Antidepressant treatment tachyphylaxis", "involutional melancholia" ], "aliasCount": 17, "merged": 17, "knownIn": 99, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q42844", "url": "https://www.wikidata.org/wiki/Q42844", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T06:57:21Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 1, "engine": "claude" }, "metaModel": { "id": "THING-Q42844", "registryId": "vr.tr.major-depressive-disorder", "name": "major depressive disorder", "version": "0.2.0-wave.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q42844/", "model": { "registry_id": "vr.tr.major-depressive-disorder", "name": "major depressive disorder", "purpose": "Let an agent give neutral, non-diagnostic information about depression, point to professional care, and give crisis contacts first when someone may be at risk.", "definition": "A common mental health condition characterised by persistent low mood or loss of interest or pleasure for at least two weeks, with changes in sleep, appetite, energy, concentration and self-worth, causing significant distress or impairment; it is treatable.", "what_it_is_for": "A recognised clinical condition, diagnosed and treated by health professionals.", "affordances": [ "seek assessment from a doctor or mental health professional", "access evidence-based treatments such as talking therapies and medication", "contact crisis services when at risk", "support someone who is struggling" ], "distinguishing_features": [ "Lasts at least two weeks", "Differs from ordinary sadness or grief in duration and impact", "Treatable", "Diagnosis needs a professional" ], "appearance": "Not visible; experienced as persistent low mood, loss of interest and other symptoms.", "visual_identification": [ "Diagnosed with criteria such as DSM-5 or ICD-11", "Severity: mild, moderate, severe", "Recurrent and persistent forms" ], "physical_properties": [], "families_and_kinds": [ "single episode and recurrent depression", "persistent depressive disorder", "depression with melancholic or other features", "perinatal depression", "treatment-resistant depression" ], "related_models": [ { "relation": "is a kind of", "target": "depressive disorder and mental health condition", "why": "category" }, { "relation": "is treated by", "target": "psychotherapy and medication", "why": "treatment" }, { "relation": "is diagnosed by", "target": "health professional", "why": "assessment" }, { "relation": "is related to", "target": "anxiety", "why": "co-occurring" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "6A70-6A71", "note": "depressive episode and recurrent disorder" }, { "scheme": "DSM-5", "value_or_pattern": "296.2x / 296.3x", "note": "major depressive disorder" } ], "standards_and_regulation": [ "NICE guideline NG222 depression in adults", "WHO mhGAP guidance", "Mental health law and patient rights" ], "failure_modes_and_hazards": [ "Self-diagnosis or diagnosis by an agent", "Missing signs that someone is at risk of harming themselves", "Stigmatising language", "Stopping medication without medical advice" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "safety", "name": "Safety", "description": "Crisis first.", "rationale": "Safety comes before anything else.", "layers": [ { "id": "risk", "name": "Risk", "description": "Immediate danger.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Immediate risk.", "questions": [ { "text": "Is the person in immediate danger, and should emergency services or a crisis line be contacted now?", "kind": "boundary" }, { "text": "Which crisis line serves their country?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Someone to talk to.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Immediate support.", "questions": [ { "text": "Is there a trusted person who can be with them?", "kind": "action" }, { "text": "How can the agent stay supportive without advising on treatment?", "kind": "boundary" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Professional help.", "rationale": "Diagnosis and treatment are professional.", "layers": [ { "id": "assessment", "name": "Assessment", "description": "Seeing a professional.", "findings": [ { "id": "assessment-finding", "name": "Assessment", "description": "Assessment.", "questions": [ { "text": "How can someone get assessed by a doctor or mental health professional?", "kind": "action" }, { "text": "What can they expect?", "kind": "definition" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Options.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment options.", "questions": [ { "text": "Which treatments do clinical guidelines describe?", "kind": "provenance" }, { "text": "Who decides on treatment with the person?", "kind": "boundary" } ] } ] } ] }, { "id": "information", "name": "Information", "description": "Understanding.", "rationale": "Accurate information reduces stigma.", "layers": [ { "id": "symptoms", "name": "Symptoms", "description": "What it is.", "findings": [ { "id": "symptoms-finding", "name": "Symptoms", "description": "General information.", "questions": [ { "text": "What does reliable health information say about depression?", "kind": "provenance" }, { "text": "How does it differ from sadness or grief?", "kind": "definition" } ] } ] }, { "id": "language", "name": "Language", "description": "Stigma.", "findings": [ { "id": "language-finding", "name": "Language", "description": "Respectful language.", "questions": [ { "text": "Is the language respectful and non-stigmatising?", "kind": "boundary" }, { "text": "Is recovery described as possible?", "kind": "boundary" } ] } ] } ] }, { "id": "others", "name": "Supporting others", "description": "Family and friends.", "rationale": "Supporters need guidance too.", "layers": [ { "id": "helping", "name": "Helping", "description": "What to do.", "findings": [ { "id": "helping-finding", "name": "Helping", "description": "Helping someone.", "questions": [ { "text": "How can a friend or family member help?", "kind": "action" }, { "text": "When should they seek urgent help?", "kind": "boundary" } ] } ] }, { "id": "rights", "name": "Rights", "description": "Work and study.", "findings": [ { "id": "rights-finding", "name": "Rights", "description": "Rights.", "questions": [ { "text": "What adjustments at work or study may be available?", "kind": "boundary" }, { "text": "Who can advise?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "How should crisis contacts be localised on the page?", "Should subtypes be separate entries?", "How should treatment guidance be linked to authoritative sources?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a major depressive disorder, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent give neutral, non-diagnostic information about depression, point to professional care, and give crisis contacts first when someone may be at risk.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Dorian Gray syndrome, depression in autism, treatment-resistant depression, double depression, melancholic depression, moderate recurrent major depression, mild recurrent major depression, melancholia, masked depression, anxiety/aggression-driven depression, depression of Alzheimer disease, recurrent major depression in complete remission.", "17 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 99 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a major depressive disorder, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Dorian Gray syndrome", "depression in autism", "treatment-resistant depression", "double depression", "melancholic depression", "moderate recurrent major depression", "mild recurrent major depression", "melancholia", "masked depression", "anxiety/aggression-driven depression", "depression of Alzheimer disease", "recurrent major depression in complete remission" ] } ], "standing": "Described in 99 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 17 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one major depressive disorder from another, and a major depressive disorder from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a major depressive disorder sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a major depressive disorder from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a major depressive disorder passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a major depressive disorder between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a major depressive disorder, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a major depressive disorder is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of major depressive disorder a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define major depressive disorder, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover major depressive disorder, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How major depressive disorder develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does major depressive disorder typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for major depressive disorder, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a major depressive disorder came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a major depressive disorder and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a major depressive disorder is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a major depressive disorder, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a major depressive disorder, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a major depressive disorder is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }