{ "model": { "rank": 10624, "code": "thing-q431643", "model_id": "vr.tr.microcephaly", "name": "microcephaly", "purpose": "Let an agent explain microcephaly and its causes in general terms from clinical sources, describe diagnosis, outcomes and support, relay public health aspects such as the Zika epidemic with attribution, and route families to clinicians and support organisations.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q431643/", "tier": 2, "score": 44, "payload": { "layer": "wikidata", "aliases": [ "Lambotte syndrome", "Halal syndrome", "Microcephaly with spastic diplegia", "Autosomal recessive primary microcephaly", "syndrome with microcephaly as major feature", "Stimmler syndrome", "Microlissencephaly", "autosomal dominant microcephaly", "Filippi Syndrome", "postnatal microcephaly", "isolated congenital microcephaly", "primary microcephaly", "lissencephaly 6 with microcephaly", "lissencephaly 4" ], "aliasCount": 14, "merged": 14, "knownIn": 44, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q431643", "url": "https://www.wikidata.org/wiki/Q431643", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T02:58:54Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q431643", "registryId": "vr.tr.microcephaly", "name": "microcephaly", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q431643/", "model": { "registry_id": "vr.tr.microcephaly", "name": "microcephaly", "purpose": "Let an agent explain microcephaly and its causes in general terms from clinical sources, describe diagnosis, outcomes and support, relay public health aspects such as the Zika epidemic with attribution, and route families to clinicians and support organisations.", "definition": "A condition in which the head and brain are much smaller than expected for age and sex, present at birth or developing in infancy, caused by genetic disorders such as autosomal recessive primary microcephaly and syndromes in which microcephaly is a major feature, or by prenatal factors including infections such as Zika virus and rubella, alcohol, malnutrition and injury, and often associated with developmental delay, seizures and conditions such as spastic diplegia; severity and outcomes vary widely, and care is supportive and multidisciplinary.", "what_it_is_for": "Not applicable; a condition.", "affordances": [ "explain the condition and causes", "relay diagnosis and outcomes", "relay public health aspects", "route families" ], "distinguishing_features": [ "Reduced brain growth", "Genetic and acquired causes", "Variable outcomes", "Supportive care" ], "appearance": "Not a visible object; a head circumference well below the expected range.", "visual_identification": [ "Abnormally small head and brain", "Primary genetic microcephaly, syndromic forms, acquired microcephaly from infection or injury", "Craniosynostosis alters head shape from suture fusion; small stature alone is not microcephaly" ], "physical_properties": [ { "quantity": "definition threshold", "typical_range": "head circumference below -2 or -3 SD", "unit": "measure", "note": "for age and sex" }, { "quantity": "Zika-associated cases in Brazil", "typical_range": "thousands", "unit": "count", "note": "2015-2016 epidemic" } ], "families_and_kinds": [ "autosomal recessive primary microcephaly", "syndromic microcephaly, including named syndromes such as Lambotte, Halal and Stimmler syndromes", "microcephaly with spastic diplegia", "congenital infection-related microcephaly such as Zika and rubella", "acquired postnatal microcephaly" ], "related_models": [ { "relation": "is a kind of", "target": "malformation of cortical development, Group I", "why": "in registry terms" }, { "relation": "is caused by", "target": "Zika virus", "why": "among other prenatal factors" }, { "relation": "is measured by", "target": "head circumference", "why": "against growth charts" }, { "relation": "is associated with", "target": "developmental delay", "why": "in many cases" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "LD20.0", "note": "microcephaly" }, { "scheme": "MeSH", "value_or_pattern": "D008831", "note": "microcephaly" }, { "scheme": "Orphanet", "value_or_pattern": "ORPHA:2512", "note": "autosomal recessive primary microcephaly" } ], "standards_and_regulation": [ "WHO and CDC guidance on microcephaly surveillance and Zika", "Clinical guidelines on developmental assessment", "Rare disease frameworks" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Stigma and misinformation", "Overgeneralising outcomes", "Confusing with craniosynostosis" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What microcephaly is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is microcephaly, and how is it defined and measured?", "kind": "definition" }, { "text": "Is the question about microcephaly, craniosynostosis or another growth condition?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What genetic, infectious and environmental causes exist, including named syndromes and Zika virus?", "kind": "provenance" }, { "text": "Which entry fits the specific cause?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and care.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is microcephaly diagnosed before and after birth, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own child or pregnancy, which needs their clinicians?", "kind": "boundary" } ] } ] }, { "id": "support", "name": "Support", "description": "Outcomes and support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What outcomes are seen, and what therapies and support help, per guidelines?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] } ] }, { "id": "publichealth", "name": "Public health", "description": "Public health.", "rationale": "Attribution.", "layers": [ { "id": "zika", "name": "Zika", "description": "Zika epidemic.", "findings": [ { "id": "zika-finding", "name": "Zika", "description": "Zika.", "questions": [ { "text": "How did the Zika epidemic reveal the link to microcephaly, as reported by WHO and researchers?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] }, { "id": "prevention", "name": "Prevention", "description": "Prevention.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "What prevention advice exists on infections, alcohol and nutrition in pregnancy?", "kind": "provenance" }, { "text": "Which entry fits prenatal care?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and community.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research on microcephaly genes and brain development exists, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits neurodevelopment research?", "kind": "action" } ] } ] }, { "id": "community", "name": "Community", "description": "Families and organisations.", "findings": [ { "id": "community-finding", "name": "Community", "description": "Community.", "questions": [ { "text": "What organisations support families affected by microcephaly?", "kind": "provenance" }, { "text": "Which entry fits the specific organisation?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should primary microcephaly and Zika-associated microcephaly be separate entries?", "How should clinical and public health guidance be linked?", "The registry entry has merged aliases naming rare syndromes; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a microcephaly, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain microcephaly and its causes in general terms from clinical sources, describe diagnosis, outcomes and support, relay public health aspects such as the Zika epidemic with attribution, and route families to clinicians and support organisations.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Lambotte syndrome, Halal syndrome, Microcephaly with spastic diplegia, Autosomal recessive primary microcephaly, syndrome with microcephaly as major feature, Stimmler syndrome, Microlissencephaly, autosomal dominant microcephaly, Filippi Syndrome, postnatal microcephaly, isolated congenital microcephaly, primary microcephaly.", "14 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 44 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a microcephaly, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Lambotte syndrome", "Halal syndrome", "Microcephaly with spastic diplegia", "Autosomal recessive primary microcephaly", "syndrome with microcephaly as major feature", "Stimmler syndrome", "Microlissencephaly", "autosomal dominant microcephaly", "Filippi Syndrome", "postnatal microcephaly", "isolated congenital microcephaly", "primary microcephaly" ] } ], "standing": "Described in 44 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 14 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one microcephaly from another, and a microcephaly from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a microcephaly sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a microcephaly from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a microcephaly passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a microcephaly between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a microcephaly, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a microcephaly is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What microcephaly is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of microcephaly are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is microcephaly operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of microcephaly and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of microcephaly?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as microcephaly?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a microcephaly came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a microcephaly and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a microcephaly is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a microcephaly, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a microcephaly, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a microcephaly is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }