{ "model": { "rank": 2380, "code": "thing-q43656", "model_id": "vr.tr.cholesterol", "name": "cholesterol", "purpose": "Enable an AI agent to recognise cholesterol, assess its chemical and contextual state, interpret observations about it, and identify justified handling or analytical actions.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q43656/", "tier": 2, "score": 107, "payload": { "layer": "wikidata", "aliases": [ "7-dehydrocholesterol", "HDL cholesterol", "VLDL cholesterol", "LDL cholesterol" ], "aliasCount": 4, "merged": 4, "knownIn": 107, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q43656", "url": "https://www.wikidata.org/wiki/Q43656", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T11:52:44Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00720222, "turns": 1, "seconds": 56.6, "error": null }, "codex": { "seconds": 76.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07bb5-83f2-75e1-a6a2-4ce9e8d45aed\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: cholesterol\nRegistry id: vr.tr.cholesterol\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA" } } }, "metaModel": { "id": "THING-Q43656", "registryId": "vr.tr.cholesterol", "name": "cholesterol", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q43656/", "model": { "registry_id": "vr.tr.cholesterol", "name": "cholesterol", "purpose": "Enable an AI agent to recognise cholesterol, assess its chemical and contextual state, interpret observations about it, and identify justified handling or analytical actions.", "definition": "Cholesterol is a sterol lipid (C27H46O) that is both synthesized endogenously and obtained from animal-derived foods, serving as a structural component of eukaryotic membranes and a biosynthetic precursor of steroid hormones, bile acids, and vitamin D.", "scope_statement": "This model owns cholesterol as a molecular substance and as an identified constituent of materials or biological samples, including its chemical identity, free or esterified representation, physical condition, amount, location and evidential basis.", "in_scope": [ "Molecular identity and discrimination from related sterols", "Free cholesterol and explicitly distinguished cholesteryl ester contributions", "Physical form, purity and chemical alteration of cholesterol-containing material", "Cholesterol amount, concentration and distribution in a specified sample or compartment", "Measurement interpretation, traceability and justified material-handling actions" ], "out_of_scope": [ "Lipoprotein particle identity, composition and transport behaviour as complete entities", "Patient cardiovascular risk, diagnosis and treatment decisions", "Whole-cell regulation, organ physiology and complete metabolic pathways", "Food composition, dietary planning and nutritional recommendations", "Other sterols, cholesteryl esters and cholesterol oxidation products as independently characterised substances" ], "distinguishing_features": [ "Identify cholesterol by its sterol structure, including the 3β-hydroxyl group and double bond between carbons 5 and 6; the molecular formula C27H46O alone does not establish identity against isomers.", "Distinguish free cholesterol from cholesteryl esters by whether the hydroxyl group is esterified; an assay reporting total cholesterol may combine contributions from both.", "Treat LDL cholesterol and HDL cholesterol as cholesterol measurements associated with specified lipoprotein fractions, rather than different molecular species of cholesterol.", "Distinguish cholesterol from related sterols using analytical evidence capable of resolving the relevant structural differences, rather than appearance or a generic sterol-positive result.", "Distinguish intact cholesterol from oxidised derivatives; a material derived from cholesterol is not automatically chemically unchanged cholesterol." ], "characteristics": [ { "name": "Identity evidence", "kind": "relation", "unit_or_values": "Links to structural identification, reference material, analytical results or supplier documentation", "why_it_matters": "Determines whether the material is established as cholesterol or merely labelled or suspected to contain it." }, { "name": "Chemical representation", "kind": "category", "unit_or_values": "Free cholesterol; esterified cholesterol contribution; total cholesterol; unresolved", "why_it_matters": "Prevents chemically distinct forms and assay-defined totals from being treated as interchangeable." }, { "name": "Material presentation", "kind": "state", "unit_or_values": "Solid; dissolved; dispersed; membrane-associated; lipoprotein-associated; other specified presentation", "why_it_matters": "Controls what sampling, separation and handling operations are meaningful." }, { "name": "Amount or concentration", "kind": "measurement", "unit_or_values": "mol, g, mmol/L, mg/dL, mg/g or another explicitly defined basis", "why_it_matters": "Supports quantitative comparison only when the analyte definition, matrix and denominator are known." }, { "name": "Purity or constituent fraction", "kind": "measurement", "unit_or_values": "Mass fraction, mole fraction or method-defined purity with its basis stated", "why_it_matters": "Distinguishes a cholesterol reagent from a mixture containing cholesterol and constrains its suitability for use." }, { "name": "Associated matrix or compartment", "kind": "relation", "unit_or_values": "Specified solvent, material, biological sample, membrane or lipoprotein fraction", "why_it_matters": "The same cholesterol amount can have different meanings and accessibility in different surroundings." }, { "name": "Chemical integrity", "kind": "state", "unit_or_values": "Integrity supported; alteration detected; alteration suspected; unassessed", "why_it_matters": "Determines whether observations and intended uses can still be attributed to intact cholesterol." }, { "name": "Measurement qualification", "kind": "relation", "unit_or_values": "Method, calibration, uncertainty, reporting limit, sample preparation and observation time", "why_it_matters": "Establishes which conclusions a reported cholesterol result can support." } ], "affordances": [ "Verify a cholesterol identity claim against suitable structural or analytical evidence.", "Quantify cholesterol on a declared free, esterified or total basis and compare compatible observations.", "Locate cholesterol within a specified material, biological compartment or separated fraction.", "Assess whether dissolution, extraction, separation or incorporation into a preparation is supported by the material state and intended use.", "Select documented storage and handling conditions and flag evidence of chemical alteration.", "Route clinical interpretations or decisions about associated particles to the relevant neighbouring model." ] }, "sources": [ { "id": "src-iupac-goldbook-sterols", "title": "sterols (steroid alcohols)", "url": "https://goldbook.iupac.org/terms/view/S06003", "what_it_supports": "IUPAC Gold Book definition of sterols as naturally occurring steroids with a 3-hydroxy group, of which cholesterol is the principal animal example.", "url_status": "blocked" }, { "id": "src-ncbi-statpearls-physiology", "title": "Physiology, Cholesterol", "url": "https://www.ncbi.nlm.nih.gov/books/NBK470561/", "what_it_supports": "Membrane role, de novo synthesis via HMG-CoA reductase, lipoprotein transport, steroid/bile-acid/vitamin D precursor functions, and clinical lipid-panel fractions.", "url_status": "live" }, { "id": "src-nhlbi-blood-cholesterol", "title": "Blood Cholesterol", "url": "https://www.nhlbi.nih.gov/health/blood-cholesterol", "what_it_supports": "Clinical distinction of LDL, HDL, and triglycerides; atherosclerotic risk framing; and US public-health treatment of blood cholesterol as a measured quantity.", "url_status": "live" }, { "id": "src-who-cvd", "title": "Cardiovascular diseases (CVDs)", "url": "https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)", "what_it_supports": "WHO attribution of raised blood cholesterol as a major modifiable risk factor for atherosclerotic cardiovascular disease globally.", "url_status": "live" } ], "structure": { "bundles": [ { "id": "cholesterol-identity", "name": "Cholesterol identity", "description": "Establish what substance is present and what a cholesterol label actually denotes.", "rationale": "Cholesterol is easily conflated with related sterols, its esters and lipoprotein-associated measurements.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Record evidence that discriminates cholesterol from chemically similar substances.", "findings": [ { "id": "structure-supported-identity", "name": "Structure-supported identity", "description": "Record the claimed identity, its supporting evidence and whether relevant sterol alternatives were resolved.", "questions": [ { "text": "What evidence establishes the cholesterol structure, including its stereochemistry, rather than only a compatible formula or sterol class?", "kind": "definition", "id": "structure-supported-identity-q01" }, { "text": "Which reference material, analytical record or supplier record supports this identity claim?", "kind": "provenance", "id": "structure-supported-identity-q02" } ] } ] }, { "id": "chemical-form-boundary", "name": "Chemical form boundary", "description": "Separate free cholesterol from esterified contributions and other derivatives.", "findings": [ { "id": "free-versus-derived", "name": "Free cholesterol versus derived forms", "description": "Record whether cholesterol denotes the unesterified substance, a cholesterol contribution within esters or an assay-defined total.", "questions": [ { "text": "Does this record refer to free cholesterol, esterified cholesterol contributions or total cholesterol?", "kind": "definition", "id": "free-versus-derived-q01" }, { "text": "Which esters or oxidation products require linked substance records rather than being counted as intact free cholesterol?", "kind": "boundary", "id": "free-versus-derived-q02" } ] } ] } ] }, { "id": "material-state-and-integrity", "name": "Material state and integrity", "description": "Describe how cholesterol is physically presented and whether its chemical identity has been preserved.", "rationale": "A solid reagent, a solution and cholesterol incorporated into a membrane require different observations and operations.", "layers": [ { "id": "physical-presentation", "name": "Physical presentation", "description": "Characterise the phase and surroundings in which cholesterol is available.", "findings": [ { "id": "phase-and-dispersion", "name": "Phase and dispersion", "description": "Record whether cholesterol is solid, dissolved, dispersed or incorporated into an organised lipid environment.", "questions": [ { "text": "Is cholesterol present as a solid, in solution, in a dispersion or associated with a membrane or particle?", "kind": "measurement", "id": "phase-and-dispersion-q01" }, { "text": "What solvent, temperature and preparation history support that state, and is precipitation or phase separation evident?", "kind": "provenance", "id": "phase-and-dispersion-q02" } ] } ] }, { "id": "purity-and-alteration", "name": "Purity and alteration", "description": "Assess non-cholesterol constituents and changes affecting intended use.", "findings": [ { "id": "intact-cholesterol-fraction", "name": "Intact cholesterol fraction", "description": "Record purity evidence and any detected or suspected conversion to other chemical species.", "questions": [ { "text": "What fraction of the material is intact cholesterol, and does the method distinguish relevant impurities or oxidation products?", "kind": "measurement", "id": "intact-cholesterol-fraction-q01" }, { "text": "What storage or exposure history could affect integrity, and what evidence confirms or leaves that effect unresolved?", "kind": "provenance", "id": "intact-cholesterol-fraction-q02" } ] } ] } ] }, { "id": "amount-and-assay-meaning", "name": "Amount and assay meaning", "description": "Make cholesterol quantities interpretable and comparable.", "rationale": "A cholesterol number is incomplete without its analyte basis, sample matrix, denominator and measurement method.", "layers": [ { "id": "quantity-definition", "name": "Quantity definition", "description": "Specify exactly what each reported cholesterol quantity counts.", "findings": [ { "id": "declared-cholesterol-basis", "name": "Declared cholesterol basis", "description": "Bind each quantity to a free, esterified or total basis and a specified sample denominator.", "questions": [ { "text": "What cholesterol quantity is reported, in which units, and relative to what sample volume, mass or amount?", "kind": "measurement", "id": "declared-cholesterol-basis-q01" }, { "text": "If esters contribute, is the result expressed as cholesterol equivalents or as the mass of whole ester molecules?", "kind": "definition", "id": "declared-cholesterol-basis-q02" } ] } ] }, { "id": "analytical-validity", "name": "Analytical validity", "description": "Capture the analytical operations and limitations behind a cholesterol result.", "findings": [ { "id": "method-qualified-result", "name": "Method-qualified result", "description": "Record sample preparation, assay selectivity, calibration and uncertainty sufficient to assess the result.", "questions": [ { "text": "How was cholesterol measured, and did preparation include extraction, ester hydrolysis or fraction separation?", "kind": "provenance", "id": "method-qualified-result-q01" }, { "text": "What uncertainty, recovery limitations or interferences constrain comparison with another cholesterol result?", "kind": "measurement", "id": "method-qualified-result-q02" } ] } ] } ] }, { "id": "biological-and-material-location", "name": "Biological and material location", "description": "Locate cholesterol without confusing the molecule with its carrier or host system.", "rationale": "Cholesterol measurements in membranes, bulk materials and lipoprotein fractions describe different contextual populations.", "layers": [ { "id": "host-and-compartment", "name": "Host and compartment", "description": "Identify the material or biological location to which an observation applies.", "findings": [ { "id": "located-cholesterol-population", "name": "Located cholesterol population", "description": "Record the sample, compartment or material population represented by the cholesterol observation.", "questions": [ { "text": "Which material, specimen or biological compartment contains the cholesterol being described?", "kind": "definition", "id": "located-cholesterol-population-q01" }, { "text": "Was that location directly sampled, experimentally separated or inferred from a broader measurement?", "kind": "provenance", "id": "located-cholesterol-population-q02" } ] } ] }, { "id": "carrier-association", "name": "Carrier association", "description": "Represent cholesterol association with lipoproteins or membranes as a contextual relation.", "findings": [ { "id": "fraction-associated-cholesterol", "name": "Fraction-associated cholesterol", "description": "Distinguish cholesterol content attributed to a fraction from properties of the particles or membranes themselves.", "questions": [ { "text": "If the observation is labelled LDL cholesterol or HDL cholesterol, how was the fraction association measured or calculated?", "kind": "measurement", "id": "fraction-associated-cholesterol-q01" }, { "text": "Which conclusions concern cholesterol content, and which require a separate lipoprotein, membrane or patient model?", "kind": "boundary", "id": "fraction-associated-cholesterol-q02" } ] } ] } ] }, { "id": "supported-operations", "name": "Supported operations", "description": "Connect cholesterol state and evidence to justified analytical and material operations.", "rationale": "An agent must know which operations preserve the intended cholesterol identity and which deliberately change what is being measured or used.", "layers": [ { "id": "preparation-and-transformation", "name": "Preparation and transformation", "description": "Specify prerequisites and consequences of preparing cholesterol-containing material.", "findings": [ { "id": "operation-with-defined-target", "name": "Operation with a defined target", "description": "Record the target chemical form and material state for dissolution, extraction, separation or incorporation.", "questions": [ { "text": "What documented procedure supports the intended cholesterol preparation in this matrix and at this scale?", "kind": "action", "id": "operation-with-defined-target-q01" }, { "text": "Will the operation preserve free cholesterol, release cholesterol from esters or otherwise change the analyte basis?", "kind": "boundary", "id": "operation-with-defined-target-q02" } ] } ] }, { "id": "retention-and-use-readiness", "name": "Retention and use readiness", "description": "Assess whether the material remains fit for its stated analytical or experimental purpose.", "findings": [ { "id": "evidence-based-use-disposition", "name": "Evidence-based use disposition", "description": "Connect documented storage requirements, current integrity evidence and intended use to a handling decision.", "questions": [ { "text": "Which storage and handling conditions apply to this specific cholesterol preparation according to its documentation?", "kind": "provenance", "id": "evidence-based-use-disposition-q01" }, { "text": "Does the available identity, purity and integrity evidence support use, or is reanalysis or replacement needed?", "kind": "action", "id": "evidence-based-use-disposition-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Endogenous cholesterol (hepatic and extrahepatic de novo synthesis)", "Dietary cholesterol (animal-source food cholesterol)", "Free (unesterified) cholesterol", "Cholesteryl esters", "LDL cholesterol (LDL-C)", "HDL cholesterol (HDL-C)", "Non-HDL cholesterol", "Remnant cholesterol" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q43656", "note": "Wikidata item for cholesterol (the chemical substance)." }, { "scheme": "CAS Registry Number", "value_or_pattern": "57-88-5", "note": "Chemical Abstracts Service registry number for cholesterol." }, { "scheme": "ChEBI", "value_or_pattern": "CHEBI:16113", "note": "ChEBI identifier for cholesterol." }, { "scheme": "PubChem CID", "value_or_pattern": "5997", "note": "PubChem compound identifier." }, { "scheme": "InChIKey", "value_or_pattern": "HVYWMOMLDIMFJA-DPRGBGLPSA-N", "note": "Standard InChIKey for cholesterol." }, { "scheme": "ATC", "value_or_pattern": "C10A*", "note": "WHO ATC class C10A (lipid-modifying agents, plain) covers drugs that act on cholesterol metabolism, not the molecule itself." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "IUPAC Gold Book: sterols (steroid alcohols) - International Union of Pure and Applied Chemistry", "NCEP ATP III / 2018 AHA/ACC Guideline on the Management of Blood Cholesterol - US National Heart, Lung, and Blood Institute and American Heart Association / American College of Cardiology", "ESC/EAS Guidelines for the management of dyslipidaemias - European Society of Cardiology / European Atherosclerosis Society", "WHO Global Hearts / CVD risk factor guidance treating raised blood cholesterol as a modifiable cardiovascular risk factor - World Health Organization", "EU Regulation (EC) No 1924/2006 on nutrition and health claims (cholesterol-related food claims) - European Commission", "FDA food labeling rules for cholesterol content and nutrient content claims (21 CFR 101) - US Food and Drug Administration" ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Measured on a fasting or non-fasting lipid panel (total cholesterol, LDL-C, HDL-C, non-HDL-C, triglycerides) in primary care and cardiology to estimate atherosclerotic cardiovascular risk and to guide statin and other lipid-lowering therapy.", "Used as a raw material and reference standard in pharmaceutical, diagnostic, and biochemical manufacturing (e.g. lipoprotein calibrators, cell-culture media supplements, steroid-hormone synthesis feedstock).", "Encountered in food composition tables and nutrition labels as milligrams of cholesterol per serving in animal-source foods (egg yolk, offal, shellfish, meat, dairy).", "Target of public-health screening programmes (workplace, national health checks) and of over-the-counter point-of-care cholesterol meters.", "Pharmacologic target of HMG-CoA reductase inhibitors (statins), ezetimibe, PCSK9 inhibitors, bempedoic acid, and bile-acid sequestrants." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Total blood cholesterol (adult clinical)", "typical_range": "about 3.0-6.5 (desirable often <5.2; high often ≥6.2)", "unit": "mmol/L" }, { "quantity": "LDL cholesterol (LDL-C)", "typical_range": "about 1.0-4.9 (many guidelines treat <2.6 as desirable in primary prevention; very-high-risk targets can be <1.4 or <1.8)", "unit": "mmol/L" }, { "quantity": "HDL cholesterol (HDL-C)", "typical_range": "about 0.8-2.2 (low often <1.0 in men, <1.3 in women in US cut-points)", "unit": "mmol/L" }, { "quantity": "Dietary cholesterol intake (adults, mixed diets)", "typical_range": "about 200-400", "unit": "mg/day" }, { "quantity": "Molecular mass", "typical_range": "386.65", "unit": "g/mol" }, { "quantity": "Melting point (anhydrous cholesterol)", "typical_range": "about 147-150", "unit": "°C" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Elevated circulating LDL and non-HDL cholesterol drive atherosclerotic plaque formation and increase risk of coronary heart disease, ischaemic stroke, and peripheral artery disease.", "Genetic disorders of LDL-receptor pathway (familial hypercholesterolaemia) produce very high LDL-C from childhood and premature atherosclerotic disease if untreated.", "Very low circulating cholesterol can occur in malnutrition, malabsorption, hyperthyroidism, or severe liver disease and is a marker of poor prognosis rather than a primary toxin of the molecule.", "Laboratory misclassification: Friedewald-estimated LDL-C is unreliable at high triglycerides; direct LDL-C and apoB better separate particle number from cholesterol mass.", "Statin and other lipid-lowering adverse effects (myopathy, rare rhabdomyolysis, new-onset diabetes) are hazards of treating cholesterol, not of the sterol itself.", "Oxidized cholesterol species and cholesterol crystals in plaque contribute to inflammation and plaque instability." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "US practice still commonly reports cholesterol in mg/dL; most of the world, including Europe, uses mmol/L (conversion: mg/dL ÷ 38.67 ≈ mmol/L).", "US dietary guidance after 2015 no longer sets a numeric cap of 300 mg/day dietary cholesterol, while some national food-based dietary guidelines still advise limiting high-cholesterol foods.", "European ESC/EAS guidelines use risk-category LDL-C targets (including <1.4 mmol/L for very-high-risk) more aggressively than older US treat-to-target culture, which shifted toward risk-based statin intensity after 2013 and returned to explicit LDL-C thresholds in 2018 AHA/ACC.", "Japan and some East Asian populations have historically lower mean population LDL-C and different CHD event rates at a given cholesterol level, which affects local treatment thresholds.", "Food-label cholesterol claims and 'cholesterol-free' marketing are tightly regulated in the US and EU but loosely or differently defined in other markets." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "Plant sterols / phytosterols (e.g. sitosterol, campesterol)", "difference": "Same tetracyclic sterol nucleus but extra alkylation on the side chain; humans absorb them poorly. Gas chromatography or mass spectrometry of the sterol profile, not a routine lipid panel, separates cholesterol from phytosterols. Sitosterolemia is the clinical exception." }, { "name": "Cholesteryl esters", "difference": "Fatty-acyl esters of cholesterol stored in lipid droplets and in the core of lipoproteins; distinguished from free cholesterol by saponification or enzymatic free-vs-total cholesterol assays." }, { "name": "Triglycerides", "difference": "Glycerol triesters, not sterols; reported on the same lipid panel but measured by a different enzymatic assay. High triglycerides invalidate Friedewald LDL-C and raise remnant cholesterol." }, { "name": "Apolipoprotein B (apoB)", "difference": "Protein cargo of atherogenic particles, not the sterol. ApoB immunoassay counts particle number; LDL-C measures cholesterol mass inside those particles. Discordance appears in hypertriglyceridaemia and diabetes." }, { "name": "Vitamin D (cholecalciferol) and steroid hormones", "difference": "Biosynthetic products of cholesterol, not cholesterol itself; distinguished by specific immunoassays or LC-MS/MS of 25-hydroxyvitamin D, cortisol, sex steroids, etc." }, { "name": "Bile acids", "difference": "Oxidized, side-chain-shortened cholesterol metabolites that act as detergents and FXR ligands; measured as bile-acid profiles, not as blood cholesterol." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of cholesterol this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry already contain authoritative models for sterols, cholesteryl esters, lipoproteins or clinical lipid observations that should own some of these boundaries?", "Which identity methods and reference materials provide sufficient discrimination from relevant sterol isomers and impurities for each intended use?", "Which assay conventions govern total and esterified cholesterol reporting in the target sample types, including cholesterol-equivalent calculations?", "What preparation-specific storage conditions, integrity criteria and reanalysis intervals are supported by authoritative documentation?", "Which physical-state details, such as solid form or membrane accessibility, materially change decisions in the intended applications and therefore warrant finer modelling?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a cholesterol, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise cholesterol, assess its chemical and contextual state, interpret observations about it, and identify justified handling or analytical actions.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: 7-dehydrocholesterol, HDL cholesterol, VLDL cholesterol, LDL cholesterol.", "4 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 107 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a cholesterol, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "7-dehydrocholesterol", "HDL cholesterol", "VLDL cholesterol", "LDL cholesterol" ] } ], "standing": "Described in 107 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 4 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one cholesterol from another, and a cholesterol from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a cholesterol sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a cholesterol from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a cholesterol is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a cholesterol is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a cholesterol is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a cholesterol is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a cholesterol is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a cholesterol is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a cholesterol passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a cholesterol between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a cholesterol, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a cholesterol is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a cholesterol and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a cholesterol is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a cholesterol performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a cholesterol.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a cholesterol at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a cholesterol there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What cholesterol is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name cholesterol unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of cholesterol exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How cholesterol behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of cholesterol, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is cholesterol incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How cholesterol can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is cholesterol classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover cholesterol, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a cholesterol came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a cholesterol and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a cholesterol is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a cholesterol, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a cholesterol, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a cholesterol is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }