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Klatskin's tumor

vr.tr.klatskin-s-tumor · thing-q475260

Enable an agent to recognize Klatskin's tumor, represent uncertainty about its perihilar origin and extent, and support specialist review of diagnostic and treatment options.

Thing Registry Cross-cutting context XCT.STA

Bundle → Layer → Finding → Questions Filled

6 bundles · 11 layers · 18 findings · 30 questions

Perihilar identity Establish why this lesion belongs to the Klatskin tumor concept.

Primary site

Anchor the diagnostic label to the biliary anatomy.

Perihilar origin

Record the attributed site of origin separately from the full territory subsequently involved.

  1. Where is the lesion's apparent origin relative to the right-left hepatic duct confluence and adjacent ducts? boundary
  2. Which imaging, operative or pathology report supports that attribution, and with what certainty? provenance

Malignancy and mimics

Represent the evidence distinguishing a primary malignancy from alternative causes of hilar narrowing.

Diagnostic basis

Preserve pathology results, clinical interpretation and unresolved alternatives as separate assertions.

  1. Is the diagnosis suspected, clinically established or pathologically confirmed, and who made that determination? provenance
  2. What evidence addresses inflammatory strictures, IgG4-related disease, stones or secondary involvement by another cancer? boundary
  3. Was an inconclusive sample recorded as inconclusive rather than as proof of benign disease? definition
Hilar extension Represent ductal and vascular anatomy supporting local treatment assessment.

Ductal map

Describe extension along individual ducts and branches.

Longitudinal involvement

Keep the reported Bismuth-Corlette type alongside the anatomical observations from which it was assigned.

  1. Which common hepatic, right, left and second-order ducts are involved or remain assessable as uninvolved? measurement
  2. What ductal classification was assigned, and do anatomical variants or incomplete visualization limit it? boundary

Vessels and liver territories

Relate the lesion to blood supply and the liver tissue a proposed operation would retain.

Territorial feasibility

Record vascular relationships, lobar atrophy and proposed remnant assessments without automatically inferring operability.

  1. Which portal vein and hepatic artery segments have suspected involvement, and what observation supports each assessment? measurement
  2. For the proposed operation, what liver territory would remain and how were its volume, function and drainage assessed? action
Obstruction and drainage Connect hilar narrowing to physiological effects and territory-specific intervention history.

Obstruction state

Describe the clinical consequences attributed to impaired bile flow.

Cholestasis and infection assessment

Track dated symptoms, laboratory findings and clinician assessments of suspected cholangitis.

  1. What are the bilirubin trend, jaundice and pruritus burden before and after biliary interventions? measurement
  2. Is cholangitis suspected or confirmed, and what documented escalation or treatment plan addresses it? action

Drainage topology

Map the functional target and observed result of each drainage intervention.

Drained territories

Record which ducts each drain or stent serves, its current status and the specialist plan for reassessment.

  1. Which liver territories are drained, remain obstructed or have uncertain communication with a drain? measurement
  2. What was the intervention's intended purpose, and what evidence shows that purpose was achieved? action
Staging and treatment gates Organize evidence needed before a specialist team commits to a treatment pathway.

Oncological extent

Record regional and distant disease separately from longitudinal duct involvement.

Stage evidence

Perihilar staging includes local invasion, lymph nodes and distant spread. [NCI stages](https://www.cancer.gov/types/liver/bile-duct-cancer/stages)

  1. What evidence supports each T, N and M assignment under the recorded staging edition? provenance
  2. Which suspicious nodes or distant lesions remain indeterminate, and could resolving them change the proposed pathway? action

Pathway preservation

Keep specialist decisions and intervention sequencing explicit.

Specialist intervention review

BSG recommends specialist HPB discussion before perihilar endotherapy and describes transplantation for selected patients. Record the team's sampling, drainage and eligibility decisions. [BSG guideline](https://pmc.ncbi.nlm.nih.gov/articles/PMC10715509/)

  1. Has the specialist team reviewed the proposed sampling route and drainage plan against possible resection or transplant pathways? action
  2. What dated reasons support resection feasibility, transplant referral or a nonoperative pathway, including patient preferences? provenance
  3. Which eligibility judgments depend on a named center's current protocol rather than a universal rule? boundary
Treated disease and reassessment Maintain the tumor's identity and uncertainty through treatment and follow-up.

Post-treatment baseline

Capture the evidence available after the selected treatment.

Residual disease assessment

Link operative pathology or nonoperative response assessments to the original perihilar lesion.

  1. After resection, what do the specimen report, ductal and radial margins, and examined nodes establish? provenance
  2. After nonoperative treatment, what dated observations define the baseline for subsequent comparison? measurement

Longitudinal interpretation

Separate observed change from conclusions about recurrence or progression.

Recurrent obstruction interpretation

Record competing explanations for new hilar narrowing, laboratory changes or symptoms and the evidence resolving them.

  1. Does new obstruction reflect suspected tumor recurrence, an anastomotic stricture, drain dysfunction or an unresolved combination? boundary
  2. What corroborating evidence and specialist review support changing the recorded disease state or treatment plan? action
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.

Reported evidence

Findings from the breadth pass, kept separate from the structural claims.

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these check these first hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Kinds and varieties

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these kinds and varieties hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these identifiers and schemes hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Standards and regulation

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these standards and regulation hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these real-world use hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these failure modes and hazards hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Regional variation

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these regional variation hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these neighbouring kinds and how to tell them apart hold for the sense of Klatskin's tumor this model covers, and on what evidence? provenance

Classifiers Filled

Family
Thing Registry
Category
Cross-cutting context
Entry kind
thing
Plane
XCT
Domain
XCT.STA

What it is Filled

Klatskin's tumor is a perihilar cholangiocarcinoma arising in the bile ducts at or near the junction of the right and left hepatic ducts, usually with adenocarcinoma histology.

In scope

  • Evidence that a suspected or confirmed bile duct malignancy originates in the perihilar region
  • Longitudinal ductal extension and relationships to hilar vessels and liver territories
  • Diagnostic uncertainty and competing explanations for a hilar stricture
  • Tumor-associated biliary obstruction and the territories affected by drainage
  • Perihilar staging, specialist treatment feasibility and subsequent disease state

Out of scope

  • The general cholangiocarcinoma model and features shared across all its anatomical subtypes
  • Intrahepatic and distal cholangiocarcinoma as separate primary diseases
  • Gallbladder cancer, pancreatic cancer and metastases causing secondary hilar obstruction
  • Primary sclerosing cholangitis, IgG4-related disease and benign strictures as independent conditions
  • Detailed surgical techniques, drainage-device specifications and drug-regimen protocols

Why it exists Filled

Enable an agent to recognize Klatskin's tumor, represent uncertainty about its perihilar origin and extent, and support specialist review of diagnostic and treatment options.

Distinguishing features Filled

  • Locate the primary lesion relative to the hepatic duct confluence; a liver mass or distal bile duct lesion does not establish perihilar origin.
  • Separate malignant hilar narrowing from benign or inflammatory narrowing using attributable diagnostic evidence rather than obstruction alone.
  • Distinguish a primary bile duct malignancy from another tumor extending into or compressing the hilum.
  • Treat Klatskin tumor as an anatomical designation, not a histological grade or a stage label.
  • Record ductal spread separately from vascular involvement and metastatic spread; one anatomical classification must not substitute for the others.

What robots and AI may and may not do Filled

Must not

  • Diagnose the tumour or judge whether it can be removed for a specific person.
  • Give a prognosis to a specific patient.
  • Disclose a person's diagnosis without consent.
  • Promote unproven cures or discourage evidence-based treatment.

Only with a human decision

  • Any treatment, surgery, stenting or transplant decision.

May

  • Explain the cancer in general terms from reputable medical sources.
  • Advise a person with jaundice or itching without cause to seek medical care promptly.

Moral aspects Filled

  • A hard prognosis calls for honesty, compassion and respect for patients' choices.
  • Some risk factors, such as liver fluke infection, reflect poverty and lack of sanitation.

Who is affected

  • Patients
  • Families and carers
  • Communities with high rates of liver fluke infection

Owners Filled

Steward

Nobody owns the disease; patients and their clinicians answer for care.

Master systems

  • Cancer registries

Links to other meta-models Filled

parent

  • Q18556554 - registry parent class

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.klatskin-s-tumor
  • Wikidata: Q475260 (https://www.wikidata.org/wiki/Q475260)

Direct properties not applicable Not applicable

  • Primary-site attribution: perihilar origin supported; alternative origin supported; indeterminate
  • Diagnostic confidence: suspected; clinically diagnosed; pathologically confirmed; disputed; excluded
  • Ductal extension: Affected named ducts and branches, with imaging date and report reference
  • Bismuth-Corlette classification: I; II; IIIa; IIIb; IV; indeterminate; not assessed
  • Hilar vascular relationship: Named portal vein or hepatic artery segment; reported contact, narrowing, occlusion or invasion; certainty
  • Perihilar TNM assessment: T, N and M categories plus system, edition, clinical or pathological basis, and assessment date
  • Bilirubin trajectory: Total and direct bilirubin in µmol/L or mg/dL, with dates and drainage context
  • Future liver remnant assessment: Volume in mL and percentage with denominator specified; functional assessment and method where available
  • Specialist treatment feasibility: under assessment; resection considered feasible; resection considered infeasible; transplant evaluation proposed; nonoperative pathway agreed

Plane XCT: no invented physical properties.

Recognition optional Filled

  • Imaging may show narrowing or irregular thickening of the bile ducts near the junction of the right and left hepatic ducts.
  • Dilation of intrahepatic bile ducts upstream of a hilar obstruction can support suspicion of this location.
  • A discrete mass may be absent, and imaging appearances can overlap with benign strictures and inflammatory disease.

Capabilities and actions required Filled

  • Assemble a source-linked case summary separating suspected diagnosis, confirmed observations and unresolved interpretations.
  • Map involved ducts, vessels and drainage territories for hepatobiliary multidisciplinary review.
  • Identify missing evidence behind a stage or resectability label.
  • Flag proposed sampling or drainage for specialist review when it could affect the intended treatment pathway.
  • Compare serial assessments while distinguishing tumor change from obstruction, infection and intervention effects.

Hazards and failure modes required Filled

  • Blocked bile ducts cause jaundice, infection and liver damage.
  • Often found when it can no longer be removed by surgery.

Standards and interfaces required Filled

  • AJCC Cancer Staging Manual, American Joint Committee on Cancer.

Context of use required Filled

  • Klatskin's tumor is encountered in specialist assessment of suspected cancer near the junction of the right and left hepatic ducts.
  • The term helps clinicians communicate the anatomical location of disease when reviewing imaging, pathology and treatment options.

Sources Filled

  1. Wikidata item Q475260: Klatskin's tumor - identity and sense of the item
  2. Wikipedia: Klatskin tumor - general description of the item

Open questions

  • Does an existing Vercy world model already own perihilar cholangiocarcinoma, requiring this registry entry to link to it instead of creating another publication?
  • Should registry usage follow the broad synonymy between Klatskin tumor and perihilar cholangiocarcinoma, or document a narrower historical confluence-based meaning?
  • Which anatomical boundary convention and staging edition should govern ambiguous lesions spanning perihilar and adjacent bile duct regions?
  • Which current center-specific criteria should be referenced for transplant evaluation, sampling restrictions and remnant adequacy?
  • What evidence standard should distinguish clinical diagnosis, pathological confirmation and persistent diagnostic uncertainty when tissue sampling is inconclusive?

Machine files

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q475260/spec.json