kidney failure
Let an agent explain kidney failure and its acute and chronic forms in general terms from nephrology guidelines, describe causes, staging, treatment and prevention, identify emergencies, and route personal questions to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain kidney failure and its acute and chronic forms in general terms from nephrology guidelines, describe causes, staging, treatment and prevention, identify emergencies, and route personal questions to clinicians.
A condition in which the kidneys lose the ability to filter waste and regulate fluid and electrolytes, occurring acutely as acute kidney injury from causes such as dehydration, sepsis, toxins or muscle breakdown as in myoglobinuric renal failure, or chronically as chronic kidney disease and chronic renal insufficiency from diabetes, hypertension, glomerular disease or chronic tubulointerstitial nephritis, progressing in the worst cases to end-stage kidney disease requiring dialysis or transplantation; kidney failure is diagnosed by blood and urine tests and staged by filtration rate.
What it is for: Not applicable; a disease state.
It can be explain acute and chronic forms; relay causes and staging; relay treatment and prevention; route emergencies and personal questions.
Distinguishing features
Reduced filtration
Acute and chronic forms
Staged by eGFR
Dialysis and transplant
What it looks like
Not a visible object; abnormal blood tests, swelling and reduced urine.
Physical character
chronic kidney disease prevalence: about 10 percent - of adults worldwide
CKD stages: 5 count - by eGFR
people on dialysis worldwide: about 3-4 million - estimates
How it is recognised
Loss of kidney filtering function
Acute kidney injury, chronic kidney disease, end-stage kidney disease; myoglobinuric and other specific causes
Kidney stones and infections may cause but are not failure; some registry aliases such as lipodermatosclerosis are unrelated skin conditions
Related models
is a kind of - in registry terms
is a kind of - in registry terms, in its chronic form
is a kind of - in registry terms
is treated by - and kidney transplantation
In practice
Families and kinds
acute kidney injury including prerenal, intrinsic and postrenal causes and myoglobinuric renal failure
chronic kidney disease stages 1 to 5
end-stage kidney disease
causes such as diabetic and hypertensive nephropathy, glomerulonephritis and chronic tubulointerstitial nephritis
kidney failure in pregnancy and after obstetric complications
Identifiers
ICD-11 GB60-GB61 acute kidney failure and chronic kidney disease
MeSH D051437 renal insufficiency
Standards and regulation
KDIGO guidelines on acute kidney injury and chronic kidney disease
National nephrology guidelines
Organ donation and transplant regulation
Failure modes and hazards
Missed acute kidney injury
Nephrotoxic drug use
Agents giving personal medical advice
Registry aliases naming unrelated conditions
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Help Urgent signs first.
Safety.
Urgent
Emergency signs.
Urgent
Urgent.
- Which signs, such as very little urine, severe swelling, breathlessness, confusion or chest pain, need emergency care? action
- Is the user describing such signs, which need emergency services now? boundary
Care
Getting assessed.
Care
Care.
- How is kidney function assessed with eGFR, creatinine and urine tests, in general terms? provenance
- Is the user asking about their own results, which need a clinician? boundary
Understand The condition.
Clinical.
Forms
Acute and chronic.
Forms
Forms.
- What are acute kidney injury and chronic kidney disease, and how are they staged? definition
- Is the question about kidney failure or another kidney condition? boundary
Causes
Causes.
Causes
Causes.
- What causes kidney failure, from diabetes and hypertension to sepsis, toxins and myoglobinuria? provenance
- Which entry fits the specific cause? action
Treat Treatment and prevention.
Clinical.
Treatment
Treatment.
Treatment
Treatment.
- What treatments do guidelines recommend, from managing causes and medication to dialysis and transplant, in general terms? provenance
- Which references are standard? provenance
Prevention
Prevention and slowing.
Prevention
Prevention.
- How can kidney failure be prevented or slowed, per guidelines? provenance
- Which sources are cited? provenance
Context Epidemiology and research.
Context.
Epidemiology
Epidemiology.
Epidemiology
Epidemiology.
- How common is kidney disease worldwide, and how does access to dialysis vary? provenance
- Which entry fits global kidney health? action
Research
Research.
Research
Research.
- What research addresses new drugs, artificial kidneys and xenotransplantation, with findings attributed? provenance
- Which entry fits nephrology research? action
What the second pass must settle
- Should acute kidney injury and chronic kidney disease be separate primary entries?
- How should guidelines be linked?
- The registry entry has merged aliases including an unrelated skin condition; should they be corrected?