{ "model": { "rank": 6123, "code": "thing-q484583", "model_id": "vr.tr.dl-proline", "name": "DL-proline", "purpose": "Enable an agent to recognise DL-proline, assess the identity and condition of a material sample, and determine whether its stereochemical composition and quality permit an intended use.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q484583/", "tier": 2, "score": 62, "payload": { "layer": "wikidata", "aliases": [ "L-proline", "D-proline", "L-proline zwitterion", "D-proline zwitterion", "L-prolinate", "L-prolinium", "D-prolinate", "D-prolinium", "prolinate", "prolinium", "L-(¹³C)Proline" ], "aliasCount": 11, "merged": 11, "knownIn": 62, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q484583", "url": "https://www.wikidata.org/wiki/Q484583", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T11:42:10Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.0056933, "turns": 1, "seconds": 84.7, "error": null }, "codex": { "seconds": 83.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07ba9-6d8d-7b13-a640-6d21f8f3f0b5\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: DL-proline\nRegistry id: vr.tr.dl-proline\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA V" } } }, "metaModel": { "id": "THING-Q484583", "registryId": "vr.tr.dl-proline", "name": "DL-proline", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q484583/", "model": { "registry_id": "vr.tr.dl-proline", "name": "DL-proline", "purpose": "Enable an agent to recognise DL-proline, assess the identity and condition of a material sample, and determine whether its stereochemical composition and quality permit an intended use.", "definition": "DL-proline is the racemic mixture of the cyclic α-amino acid pyrrolidine-2-carboxylic acid, i.e. equimolar D- and L-proline, typically isolated or supplied as the zwitterionic solid rather than as a resolved enantiomer.", "scope_statement": "This model owns the material identity, racemic composition, physical presentation, sample quality and use eligibility of DL-proline under registry entry vr.tr.dl-proline in PHY / PHY.MAT.", "in_scope": [ "Recognition of free DL-proline and separation of verified identity from supplier naming", "D-proline and L-proline proportions and evidence supporting a racemic designation", "Solid or dissolved presentation, water content and material-form qualification", "Proline assay, relevant impurities and changes during storage or preparation", "Suitability of a particular sample for an explicitly specified laboratory use" ], "out_of_scope": [ "Independent models of enantiopure D-proline and L-proline", "Proline residues incorporated into peptides, proteins or polyproline", "Hydroxyproline, protected prolines, proline esters and other covalent derivatives", "Complete formulations, reaction systems and separation equipment", "Organism-level proline metabolism, nutritional requirements and therapeutic effects" ], "distinguishing_features": [ "Confirm the pyrrolidine-2-carboxylic acid connectivity; formula or nominal mass alone cannot establish this structure. Reference identity: [PubChem DL-proline](https://pubchem.ncbi.nlm.nih.gov/compound/%28%2B%2F-%29-Proline).", "Use an enantiomer-resolving measurement to distinguish racemic DL-proline from D-proline, L-proline or an unequally mixed sample; record the permitted departure from an equimolar mixture.", "Require free proline identity rather than a peptide-bound residue, protected amine or esterified carboxyl group.", "Determine water and counterion content before treating a sample as the anhydrous parent material; a separate DL-proline monohydrate record exists in [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/18474102).", "Treat a near-zero optical rotation as supporting evidence only, with solvent, concentration, temperature and wavelength recorded; require sufficient identity and composition evidence to exclude misleading cancellation or inadequate sensitivity." ], "characteristics": [ { "name": "Chemical identity assignment", "kind": "category", "unit_or_values": "Confirmed free proline; derivative; unresolved identity", "why_it_matters": "Prevents a matching label or nominal mass from substituting for structural identification." }, { "name": "D-proline mole fraction", "kind": "measurement", "unit_or_values": "mol% of total D-proline plus L-proline, with uncertainty", "why_it_matters": "Tests the racemic designation independently of total chemical purity." }, { "name": "Racemic designation status", "kind": "state", "unit_or_values": "Declared; analytically supported within stated tolerance; nonconforming; unresolved", "why_it_matters": "Separates a supplier claim from demonstrated stereochemical composition." }, { "name": "Total free-proline assay", "kind": "measurement", "unit_or_values": "Mass%, explicitly as received or corrected to a stated dry basis", "why_it_matters": "Supports dose and concentration calculations without confusing chromatographic area with material content." }, { "name": "Water content", "kind": "measurement", "unit_or_values": "Mass%, with method and sampling date", "why_it_matters": "Affects weighed proline content and helps investigate hydration or moisture uptake." }, { "name": "Material presentation", "kind": "category", "unit_or_values": "Solid with qualified hydration state; solution with specified solvent; unresolved", "why_it_matters": "Determines which preparation, identity and concentration assumptions are valid." }, { "name": "Solution concentration", "kind": "measurement", "unit_or_values": "mol/L of total free proline, with solvent and preparation basis", "why_it_matters": "Makes solution use traceable to assay, water correction and dilution." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Identified impurity concentrations in mass%, mg/kg or method-specific units, with detection limits", "why_it_matters": "Determines whether apparently acceptable proline content conceals application-relevant contaminants." }, { "name": "Lot evidence linkage", "kind": "relation", "unit_or_values": "Sample linked to supplier lot, certificate, analytical results and applicable safety data sheet", "why_it_matters": "Prevents properties from another proline grade or enantiomer being assigned to this sample." }, { "name": "Intended-use disposition", "kind": "state", "unit_or_values": "Eligible; conditionally eligible; hold for testing; unsuitable for specified use", "why_it_matters": "Expresses a decision against explicit chemical and stereochemical requirements." } ], "affordances": [ "Identify and qualify a sample as DL-proline using structural and stereochemical evidence.", "Calculate usable proline amount or prepare a solution using the measured assay and water basis.", "Select a lot against application-specific impurity and D:L composition limits.", "Aliquot, store and retest material under conditions supported by its product documentation and observations.", "Route material to a specified synthesis, analysis or enantiomer-separation workflow when its requirements are met.", "Hold or reclassify material whose composition no longer supports the DL-proline designation." ] }, "sources": [ { "id": "pubchem-614", "title": "Proline (CID 614) compound summary", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/614", "what_it_supports": "Identity of the racemic/unspecified-stereochemistry proline record, molecular formula C5H9NO2, InChIKey without stereo, and the associated CAS/synonym set.", "url_status": "live" }, { "id": "iupac-nomenclature", "title": "Nomenclature and symbolism for amino acids and peptides", "url": "https://iupac.qmul.ac.uk/AminoAcid/", "what_it_supports": "IUPAC/IUBMB naming of proline as pyrrolidine-2-carboxylic acid and the DL-/RS- convention for unresolved stereochemistry.", "url_status": "live" }, { "id": "echa-proline", "title": "Proline substance information", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.009.264", "what_it_supports": "EC inventory identity for racemic/unspecified proline (EC 210-189-3) used in REACH listings.", "url_status": "unverified" } ], "structure": { "bundles": [ { "id": "proline-identity", "name": "Proline identity", "description": "Establish that the material contains free proline with the intended chemical connectivity.", "rationale": "The DL prefix specifies stereochemical composition but cannot establish chemical identity or exclude a derivative.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Connect the sample designation to evidence for the proline parent structure.", "findings": [ { "id": "parent-structure-confirmation", "name": "Parent structure confirmation", "description": "Record the evidence distinguishing free proline from similar compounds and identity based only on a label.", "questions": [ { "text": "Which structural measurements or authenticated reference comparisons establish pyrrolidine-2-carboxylic acid in this sample?", "kind": "measurement", "id": "parent-structure-confirmation-q01" }, { "text": "Which lot-specific documents support the DL-proline identity, and do their identifiers agree?", "kind": "provenance", "id": "parent-structure-confirmation-q02" } ] } ] }, { "id": "chemical-boundaries", "name": "Chemical boundaries", "description": "Separate the parent material from derivatives and proline incorporated into larger molecules.", "findings": [ { "id": "free-proline-boundary", "name": "Free proline boundary", "description": "Make explicit whether the named material is free proline, a salt or a covalently modified substance.", "questions": [ { "text": "Is proline present as the free amino acid, an externally counterion-containing salt, a protected derivative or a peptide residue?", "kind": "boundary", "id": "free-proline-boundary-q01" }, { "text": "If another chemical entity is present, which neighbouring model owns it and what relation connects it to DL-proline?", "kind": "boundary", "id": "free-proline-boundary-q02" } ] } ] } ] }, { "id": "racemic-composition", "name": "Racemic composition", "description": "Establish and maintain the evidence for the DL designation.", "rationale": "A chemically pure proline sample can still have the wrong enantiomeric composition for DL-proline use.", "layers": [ { "id": "enantiomer-quantification", "name": "Enantiomer quantification", "description": "Record separate D and L measurements and their analytical limitations.", "findings": [ { "id": "d-l-ratio", "name": "D:L ratio", "description": "Represent measured enantiomer proportions rather than inferring them from total proline assay.", "questions": [ { "text": "What D:L molar ratio was measured, with what uncertainty and enantiomer-resolving method?", "kind": "measurement", "id": "d-l-ratio-q01" }, { "text": "How were D and L peak identities, separation adequacy and quantitative response established?", "kind": "provenance", "id": "d-l-ratio-q02" } ] } ] }, { "id": "racemate-acceptance", "name": "Racemate acceptance", "description": "Translate stereochemical evidence into a defensible material designation.", "findings": [ { "id": "racemic-qualification", "name": "Racemic qualification", "description": "Apply an explicit tolerance and distinguish direct composition measurements from supporting optical observations.", "questions": [ { "text": "What departure from an equimolar D:L mixture is acceptable for the stated DL-proline specification?", "kind": "definition", "id": "racemic-qualification-q01" }, { "text": "Does the available evidence justify the designation, or must the sample remain unresolved or be reclassified?", "kind": "action", "id": "racemic-qualification-q02" } ] } ] } ] }, { "id": "material-form-and-preparation", "name": "Material form and preparation", "description": "Describe the physical material being weighed, sampled or dissolved.", "rationale": "Water, solid form and solution conditions affect how much proline is delivered and which observations are comparable.", "layers": [ { "id": "solid-and-water-state", "name": "Solid and water state", "description": "Qualify hydration and physical presentation without treating appearance as chemical proof.", "findings": [ { "id": "water-basis", "name": "Water basis", "description": "Distinguish measured water content from a demonstrated hydrate assignment.", "questions": [ { "text": "What water content is measured, and is there evidence distinguishing a hydrate from adsorbed or residual water?", "kind": "measurement", "id": "water-basis-q01" }, { "text": "Which material-form assignment and assay basis must be used when converting a weighed portion into moles of proline?", "kind": "action", "id": "water-basis-q02" } ] } ] }, { "id": "dissolved-proline", "name": "Dissolved proline", "description": "Make solution composition and preparation conditions explicit.", "findings": [ { "id": "solution-qualification", "name": "Solution qualification", "description": "Record whether preparation delivers the intended dissolved proline concentration under the actual conditions.", "questions": [ { "text": "What solvent, temperature, pH where applicable, and assay-corrected total proline concentration describe the solution?", "kind": "measurement", "id": "solution-qualification-q01" }, { "text": "Is dissolution complete, and what evidence supports using or resampling a preparation containing precipitate?", "kind": "action", "id": "solution-qualification-q02" } ] } ] } ] }, { "id": "lot-quality-and-change", "name": "Lot quality and change", "description": "Assess chemical quality and whether handling has invalidated earlier qualification.", "rationale": "The DL designation does not establish assay, impurity limits or continued fitness after storage.", "layers": [ { "id": "assay-and-contaminants", "name": "Assay and contaminants", "description": "Separate proline content from impurities relevant to the intended application.", "findings": [ { "id": "chemical-quality-evidence", "name": "Chemical quality evidence", "description": "Record meaningful assay and impurity results with their methods and reporting bases.", "questions": [ { "text": "What total free-proline assay is supported, and is it an absolute content measurement or a chromatographic area percentage?", "kind": "measurement", "id": "chemical-quality-evidence-q01" }, { "text": "Which related compounds, residual solvents, inorganic residues or other contaminants require limits for this use?", "kind": "boundary", "id": "chemical-quality-evidence-q02" } ] } ] }, { "id": "qualification-over-time", "name": "Qualification over time", "description": "Connect exposure and observed changes to retesting requirements.", "findings": [ { "id": "sample-requalification", "name": "Sample requalification", "description": "Determine whether previous assay, water and D:L measurements still represent the available material.", "questions": [ { "text": "What storage, opening, drying, heating or solution-treatment history occurred after the last qualifying measurements?", "kind": "provenance", "id": "sample-requalification-q01" }, { "text": "Which documented excursion or observed change requires renewed identity, water, impurity or enantiomer-ratio testing?", "kind": "action", "id": "sample-requalification-q02" } ] } ] } ] }, { "id": "use-eligibility", "name": "Use eligibility", "description": "Translate the qualified material record into permitted next actions for a specified application.", "rationale": "Racemic proline cannot be assumed interchangeable with an enantiopure reagent or a differently qualified grade.", "layers": [ { "id": "stereochemical-fit", "name": "Stereochemical fit", "description": "Check whether the application accepts both proline enantiomers in the measured proportions.", "findings": [ { "id": "application-composition-match", "name": "Application composition match", "description": "Evaluate substitution and use against explicit stereochemical requirements.", "questions": [ { "text": "Does the intended reaction, assay or biological experiment require DL-proline, a particular enantiomer or a specified D:L ratio?", "kind": "boundary", "id": "application-composition-match-q01" }, { "text": "What evidence permits this lot to be used or substituted without invalidating the application's stereochemical requirements?", "kind": "action", "id": "application-composition-match-q02" } ] } ] }, { "id": "handling-and-disposition", "name": "Handling and disposition", "description": "Link sample-specific documentation and qualification to preparation, storage and release decisions.", "findings": [ { "id": "documented-next-action", "name": "Documented next action", "description": "Make the next action depend on the actual DL-proline product, material form and intended use.", "questions": [ { "text": "Which current supplier instructions and safety data sheet apply to this DL-proline grade and its solid or solution presentation?", "kind": "provenance", "id": "documented-next-action-q01" }, { "text": "Given the assay, D:L ratio, water content and impurity results, should this material be released, retested, reclassified or rejected for the specified use?", "kind": "action", "id": "documented-next-action-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "DL-proline racemate (unresolved, typically CAS 609-36-9)", "L-proline (proteinogenic S-enantiomer)", "D-proline (R-enantiomer)", "DL-proline hydrochloride and other salts", "N-protected DL-proline (Boc, Fmoc, Cbz) used in peptide chemistry", "cis/trans ring conformers of the pyrrolidine (not separately sold, but distinguished in spectroscopy)" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "609-36-9", "note": "Racemic / unspecified-stereochemistry proline (DL-proline). Distinct from L-proline 147-85-3 and D-proline 344-25-2." }, { "scheme": "PubChem CID", "value_or_pattern": "614", "note": "Parent compound record for proline without specified configuration." }, { "scheme": "EC number", "value_or_pattern": "210-189-3", "note": "EINECS/EC inventory number corresponding to CAS 609-36-9." }, { "scheme": "InChIKey", "value_or_pattern": "ONIBWKKTOPOVIA-UHFFFAOYSA-N", "note": "Non-isomeric key (racemate or unspecified stereo). Enantiomers use ONIBWKKTOPOVIA-BYPYZUCNSA-N (L) and ONIBWKKTOPOVIA-STGXRNPVSA-N (D)." }, { "scheme": "Molecular formula", "value_or_pattern": "C5H9NO2", "note": "Neutral (zwitterionic) molecular formula; MW 115.13 g/mol." }, { "scheme": "UNII", "value_or_pattern": "DCA150089W", "note": "FDA Unique Ingredient Identifier commonly cited for unspecified/DL-proline; confirm against the current UNII file before treating as authoritative." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "IUPAC/IUBMB Recommendations on amino-acid nomenclature (proline = pyrrolidine-2-carboxylic acid; DL/RS for unresolved stereo) - International Union of Pure and Applied Chemistry / International Union of Biochemistry and Molecular Biology", "Ph. Eur. / USP proline monographs - apply to L-proline as a pharmaceutical substance; DL-proline is not the pharmacopoeial article and must not be substituted for it - EDQM and United States Pharmacopeia", "REACH registration / CLP classification for proline (EC 210-189-3) as an industrial chemical - European Chemicals Agency", "Food-additive and flavouring listings for L-proline (e.g. FEMA/JECFA amino-acid flavouring use) - do not automatically cover the racemate - JECFA / FEMA / relevant food-law bodies" ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Sold as a bulk amino-acid chemical for organic synthesis, racemic building-block supply, and as a cheaper feedstock than resolved L-proline when chirality is not required.", "Starting material or reference racemate in chiral resolution, HPLC method development, and enantiomeric-excess assays for proline.", "Intermediate toward N-protected proline derivatives and proline-based organocatalysts; the racemate is used when a catalyst screen does not yet demand a single enantiomer.", "Component of some industrial fermentation or chemical amino-acid streams before optical resolution; L-proline for food, feed, and pharma is usually the resolved or biosynthesized enantiomer, not DL." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "specific optical rotation [α]D", "typical_range": "approximately 0 (racemate); L-proline is strongly levorotatory in water (order of −80 to −86 deg mL g−1 dm−1 depending on concentration and t)", "unit": "deg mL g^-1 dm^-1" }, { "quantity": "melting / decomposition point", "typical_range": "about 205-228 (decomposes; literature values scatter with purity and heating rate)", "unit": "°C" }, { "quantity": "enantiomeric excess (ee)", "typical_range": "0 for true DL; specification limits for a racemic product are typically within a few percent of 50:50", "unit": "%" }, { "quantity": "aqueous solubility (20-25 °C)", "typical_range": "high, on the order of 1-2×10^2 g per litre (freely soluble; exact figure is grade- and temperature-dependent)", "unit": "g L^-1" }, { "quantity": "pKa (α-COOH / pyrrolidinium NH2+)", "typical_range": "approximately 2.0 and 10.6", "unit": "pKa units" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Optical contamination: residual L- or D-excess in a lot labelled DL, or conversely DL material substituted for pharmacopoeial L-proline, invalidates chiral synthesis, food, and drug use.", "Racemization on heating, strong acid/base, or prolonged processing of an enantiopure proline lot, producing unintended DL-proline.", "Hygroscopic caking and discoloration of the solid on storage; amine oxidation / Maillard-type browning if mixed with reducing sugars.", "Not a high-acute-toxicity industrial chemical, but dust irritation and incorrect GRAS/food use of the racemate (only L-proline has the established nutritional/flavouring status) are the practical hazards." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Catalogues in Europe and North America usually list 'DL-Proline' with CAS 609-36-9 separately from 'L-Proline' 147-85-3; some Asian commodity listings still use 'proline' without stereo, which may mean L from fermentation or DL from chemical synthesis.", "Pharmacopoeial 'Proline' in USP/Ph. Eur./JP means L-proline; Japanese and Chinese pharmacopoeias follow the same enantiomer convention.", "Biochemical literature writes Pro/P for the L-residue in proteins and 'DL-Pro' only when the racemate is intended; chemical suppliers use DL-, (±)-, or (RS)- interchangeably." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "L-proline", "difference": "Non-zero specific rotation and a chiral HPLC/GC or enzymatic assay showing a single enantiomer; CAS 147-85-3 vs 609-36-9." }, { "name": "D-proline", "difference": "Opposite sign of [α]D relative to L; chiral chromatography vs a D-proline standard (CAS 344-25-2)." }, { "name": "4-hydroxyproline (Hyp)", "difference": "Extra ring OH (C5H9NO3 vs C5H9NO2); mass spectrometry (m/z +16) or ninhydrin/amino-acid analysis retention time." }, { "name": "pipecolic acid (piperidine-2-carboxylic acid)", "difference": "Six-membered ring (C6H11NO2); molecular mass 129 vs 115 and distinct NMR/MS." }, { "name": "prolinamide / proline esters", "difference": "Neutral amide or ester IR/NMR (no carboxylate zwitterion); not amphoteric at the same pKa pair." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of DL-proline this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "What authoritative specification, if any, defines the acceptable D:L tolerance for the grades represented by this registry entry?", "Should verified DL-proline hydrates be represented as material forms within this entry or linked to distinct existing registry entries?", "Which enantiomer-resolving methods are validated for the relevant grades and impurity matrices, and what uncertainty do they achieve?", "What experimentally supported storage and preparation conditions preserve assay and enantiomer composition for the actual products in scope?", "Which application-specific impurity limits and qualification requirements are supported by authoritative sources rather than supplier marketing?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a DL-proline, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an agent to recognise DL-proline, assess the identity and condition of a material sample, and determine whether its stereochemical composition and quality permit an intended use.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: L-proline, D-proline, L-proline zwitterion, D-proline zwitterion, L-prolinate, L-prolinium, D-prolinate, D-prolinium, prolinate, prolinium, L-(¹³C)Proline.", "11 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 62 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a DL-proline, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "L-proline", "D-proline", "L-proline zwitterion", "D-proline zwitterion", "L-prolinate", "L-prolinium", "D-prolinate", "D-prolinium", "prolinate", "prolinium", "L-(¹³C)Proline" ] } ], "standing": "Described in 62 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 11 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one DL-proline from another, and a DL-proline from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a DL-proline sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a DL-proline from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a DL-proline is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a DL-proline is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a DL-proline is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a DL-proline is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a DL-proline is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a DL-proline is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a DL-proline passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a DL-proline between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a DL-proline, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a DL-proline is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a DL-proline and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a DL-proline is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a DL-proline performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a DL-proline.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a DL-proline at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a DL-proline there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What DL-proline is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name DL-proline unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of DL-proline exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How DL-proline behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of DL-proline, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is DL-proline incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How DL-proline can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is DL-proline classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover DL-proline, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a DL-proline came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a DL-proline and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a DL-proline is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a DL-proline, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a DL-proline, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a DL-proline is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }