{ "model": { "rank": 6114, "code": "thing-q49989", "model_id": "vr.tr.creutzfeldt-jakob-disease", "name": "Creutzfeldt-Jakob disease", "purpose": "Enable an AI agent to recognise a suspected or established Creutzfeldt-Jakob disease case, track diagnostic confidence and progression, and identify appropriate clinical, care and prion-safety actions.", "family": "Thing Registry", "category": "Information and virtual systems", "status": "research-draft", "kind": "thing", "plane": "INF", "domain": "INF.KNW", "industry": "", "version": "", "url": "/models/thing/q49989/", "tier": 2, "score": 62, "payload": { "layer": "wikidata", "aliases": [ "inherited Creutzfeldt–Jakob disease", "acquired Creutzfeldt-Jakob disease" ], "aliasCount": 2, "merged": 2, "knownIn": 62, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q49989", "url": "https://www.wikidata.org/wiki/Q49989", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T11:36:10Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00574634, "turns": 1, "seconds": 12.8, "error": null }, "codex": { "seconds": 78.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07ba6-5336-7bc1-9985-74931e0660be\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: Creutzfeldt-Jakob disease\nRegistry id: vr.tr.creutzfeldt-jakob-disease\nPlane / domain: XCT / XCT.STA\nRegistry definition: (none recorded)\nNames folde" } } }, "metaModel": { "id": "THING-Q49989", "registryId": "vr.tr.creutzfeldt-jakob-disease", "name": "Creutzfeldt-Jakob disease", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q49989/", "model": { "registry_id": "vr.tr.creutzfeldt-jakob-disease", "name": "Creutzfeldt-Jakob disease", "purpose": "Enable an AI agent to recognise a suspected or established Creutzfeldt-Jakob disease case, track diagnostic confidence and progression, and identify appropriate clinical, care and prion-safety actions.", "definition": "string", "scope_statement": "This model owns the disease-specific identity, evidence, clinical course and action constraints of Creutzfeldt-Jakob disease under vr.tr.creutzfeldt-jakob-disease, distinguishing sporadic, genetic, iatrogenic and variant presentations without creating separate registry entries.", "in_scope": [ "Evidence supporting or challenging a CJD diagnosis and its documented certainty.", "Clinical onset, neurological phenotype, progression and functional consequences.", "Sporadic, genetic, iatrogenic or variant classification and its supporting evidence.", "CJD-specific tissue, procedure and instrument exposure concerns.", "Specialist review, supportive care, surveillance and diagnostic follow-up needs." ], "out_of_scope": [ "The person's complete longitudinal health record.", "Full models of alternative causes of rapidly progressive neurological decline.", "Other human prion diseases, including kuru, fatal familial insomnia and Gerstmann-Sträussler-Scheinker disease.", "Animal prion diseases and food-chain management.", "Laboratory operating procedures and instrument decontamination protocols.", "Relatives' independent genetic-risk assessments and medical records." ], "distinguishing_features": [ "Assess whether cognitive and neurological deterioration progresses over weeks or months rather than the usual slower course of common dementias; tempo supports recognition but cannot establish CJD alone. [CDC clinical overview](https://www.cdc.gov/creutzfeldt-jakob/hcp/clinical-overview/index.html)", "Evaluate prion-seeding evidence from RT-QuIC alongside the clinical syndrome; a positive result supports probable sporadic CJD under applicable criteria rather than independently establishing definite disease. [CDC diagnostic criteria](https://www.cdc.gov/creutzfeldt-jakob/hcp/clinical-overview/index.html)", "Check MRI distribution, EEG findings and alternative explanations together; characteristic cortical or striatal MRI abnormalities and periodic sharp-wave complexes contribute evidence rather than acting as stand-alone diagnoses. [CDC diagnostic criteria](https://www.cdc.gov/creutzfeldt-jakob/hcp/clinical-overview/index.html)", "Distinguish a possible variant presentation through its combination of early psychiatric symptoms, persistent painful sensory symptoms and characteristic pulvinar MRI findings; apply variant-specific assessment rather than assuming sporadic-CJD criteria transfer. [CDC variant CJD overview](https://www.cdc.gov/variant-creutzfeldt-jakob/hcp/clinical-overview/index.html)", "Require documented neuropathological or disease-specific brain-tissue evidence for a definite classification under the selected criteria, keeping it separate from clinical probability. [CDC clinical overview](https://www.cdc.gov/creutzfeldt-jakob/hcp/clinical-overview/index.html)" ], "characteristics": [ { "name": "Diagnostic classification", "kind": "state", "unit_or_values": "Under investigation, possible, probable, definite, alternative diagnosis established; criteria system and version required", "why_it_matters": "Separates suspicion from established evidence and makes classification changes auditable." }, { "name": "Disease form", "kind": "category", "unit_or_values": "Sporadic, genetic, iatrogenic, variant, unresolved; supporting evidence recorded separately", "why_it_matters": "Selects relevant diagnostic, exposure and family-assessment pathways." }, { "name": "Time since clinical onset", "kind": "measurement", "unit_or_values": "Days or weeks, with onset estimate and uncertainty interval", "why_it_matters": "Makes the observed rate of decline interpretable." }, { "name": "Neurological phenotype", "kind": "state", "unit_or_values": "Dated presence, absence or unknown status for cognitive, cerebellar, visual, movement, pyramidal and psychiatric manifestations", "why_it_matters": "Supports recognition of typical and atypical presentations." }, { "name": "Prion-seeding assay evidence", "kind": "category", "unit_or_values": "Positive, negative, indeterminate, pending or not performed; specimen, assay, laboratory and date", "why_it_matters": "Preserves the actual result and testing context for specialist interpretation." }, { "name": "MRI and EEG evidence", "kind": "relation", "unit_or_values": "Links to dated reports, images or recordings and specialist interpretations", "why_it_matters": "Allows reported patterns and disagreements to be examined rather than reduced to a diagnostic checkbox." }, { "name": "PRNP evidence", "kind": "relation", "unit_or_values": "Link to consented genetic report, variant classification and phenotype interpretation, or not assessed", "why_it_matters": "Separates genetic findings from an unsupported assumption of inherited CJD." }, { "name": "Functional dependence", "kind": "state", "unit_or_values": "Dated communication, mobility, swallowing and daily-care abilities; named scale and score when used", "why_it_matters": "Connects progression to immediate support needs." }, { "name": "Potential prion exposure", "kind": "relation", "unit_or_values": "Links to implicated procedures, biological products, tissues or instruments; suspected, documented or excluded", "why_it_matters": "Supports exposure investigation without confusing exposure with causation." }, { "name": "Procedure-specific precaution status", "kind": "state", "unit_or_values": "Assessment needed, precautions specified, implemented, reviewed or closed; responsible service and governing guidance", "why_it_matters": "Connects suspected disease to the relevant handling decisions and their accountable owners." } ], "affordances": [ "Assemble a dated CJD evidence summary for specialist review.", "Compare recorded evidence with a named diagnostic framework and identify missing or contradictory information.", "Track neurological decline and surface changes requiring reassessment of support needs.", "Flag relevant tissue or instrument exposures for infection-prevention review.", "Route genetic, surveillance and post-mortem questions to the responsible services.", "Record clinician-approved care decisions and distinguish routine care from investigational interventions." ] }, "sources": [ { "id": "string", "title": "string", "url": "", "what_it_supports": "string" } ], "structure": { "bundles": [ { "id": "cjd-identity-and-classification", "name": "CJD identity and classification", "description": "Represent which CJD concept is being considered and how confidently the case is classified.", "rationale": "A disease name alone obscures differences between clinical suspicion, confirmed disease and disease form.", "layers": [ { "id": "disease-form", "name": "Disease form", "description": "Separate etiological attribution from the presence of a CJD-compatible illness.", "findings": [ { "id": "form-attribution", "name": "Form attribution", "description": "Record the proposed sporadic, genetic, iatrogenic or variant form, its evidence and unresolved alternatives.", "questions": [ { "text": "Which CJD form is proposed, and what findings support that attribution?", "kind": "definition", "id": "form-attribution-q01" }, { "text": "Does the evidence indicate CJD, another prion disease or an unresolved prion syndrome?", "kind": "boundary", "id": "form-attribution-q02" } ] } ] }, { "id": "diagnostic-certainty", "name": "Diagnostic certainty", "description": "Make the applicable criteria and the basis of classification explicit.", "findings": [ { "id": "criteria-based-status", "name": "Criteria-based status", "description": "Preserve the criteria version, assessor, assessment date and evidence behind each diagnostic status.", "questions": [ { "text": "Which diagnostic framework and version apply to this proposed CJD form?", "kind": "provenance", "id": "criteria-based-status-q01" }, { "text": "Which required elements are met, missing or contradicted, and who assigned the current status?", "kind": "measurement", "id": "criteria-based-status-q02" } ] } ] } ] }, { "id": "neurological-course-and-dependence", "name": "Neurological course and dependence", "description": "Describe the evolving syndrome and the abilities it affects.", "rationale": "The sequence and speed of deterioration influence recognition, reassessment and care planning.", "layers": [ { "id": "onset-and-phenotype", "name": "Onset and phenotype", "description": "Capture the first manifestations and the subsequent neurological pattern.", "findings": [ { "id": "dated-syndrome-trajectory", "name": "Dated syndrome trajectory", "description": "Separate observed symptoms from retrospective reports and document uncertainty in onset.", "questions": [ { "text": "What were the earliest cognitive, visual, cerebellar, psychiatric or movement changes, and when did they begin?", "kind": "measurement", "id": "dated-syndrome-trajectory-q01" }, { "text": "Which changes were directly examined, reported by caregivers or inferred retrospectively?", "kind": "provenance", "id": "dated-syndrome-trajectory-q02" } ] } ] }, { "id": "functional-progression", "name": "Functional progression", "description": "Connect serial neurological assessments to dependence and communication.", "findings": [ { "id": "changing-care-needs", "name": "Changing care needs", "description": "Record losses of mobility, swallowing, communication and daily-care ability without imposing an unsupported universal stage.", "questions": [ { "text": "How have mobility, swallowing, communication and daily-care abilities changed between dated assessments?", "kind": "measurement", "id": "changing-care-needs-q01" }, { "text": "Which changes require prompt clinical review or revision of the support plan?", "kind": "action", "id": "changing-care-needs-q02" } ] } ] } ] }, { "id": "diagnostic-evidence-and-mimics", "name": "Diagnostic evidence and mimics", "description": "Organise investigations, their limitations and competing explanations.", "rationale": "CJD assessment requires converging evidence while preserving opportunities to identify alternative diagnoses.", "layers": [ { "id": "investigation-interpretation", "name": "Investigation interpretation", "description": "Keep prion assays, imaging, electrophysiology and tissue findings individually interpretable.", "findings": [ { "id": "test-results-in-context", "name": "Test results in context", "description": "Record results with specimen quality, timing, method and specialist interpretation, including discordance.", "questions": [ { "text": "What do RT-QuIC, MRI, EEG, CSF injury markers and any tissue examination show, and when were they obtained?", "kind": "measurement", "id": "test-results-in-context-q01" }, { "text": "What assay, specimen or interpretation limitations could explain negative, indeterminate or conflicting results?", "kind": "boundary", "id": "test-results-in-context-q02" } ] } ] }, { "id": "alternative-diagnoses", "name": "Alternative diagnoses", "description": "Maintain explicit competing explanations for the rapidly progressive syndrome.", "findings": [ { "id": "mimic-evaluation", "name": "Mimic evaluation", "description": "Track clinician assessment of autoimmune, infectious, seizure-related, toxic-metabolic, vascular and other degenerative explanations.", "questions": [ { "text": "Which alternative explanations remain plausible, and what evidence supports or weakens each?", "kind": "boundary", "id": "mimic-evaluation-q01" }, { "text": "Which unresolved alternative requires further investigation or clinician-directed treatment before diagnostic closure?", "kind": "action", "id": "mimic-evaluation-q02" } ] } ] } ] }, { "id": "origin-and-prion-exposure", "name": "Origin and prion exposure", "description": "Represent inherited or acquired attribution and procedure-specific transmission concerns.", "rationale": "The origins of a case and the risks arising from particular tissue contacts require separate evidence and decisions.", "layers": [ { "id": "genetic-and-acquired-attribution", "name": "Genetic and acquired attribution", "description": "Assess family, molecular and exposure evidence without treating an association as proof.", "findings": [ { "id": "attribution-evidence", "name": "Attribution evidence", "description": "Link PRNP interpretation, family history and relevant medical or other exposure histories to the proposed disease form.", "questions": [ { "text": "What verified family history, PRNP findings or exposure records support the proposed origin?", "kind": "provenance", "id": "attribution-evidence-q01" }, { "text": "What evidence distinguishes a causal attribution from an incidental variant or historical exposure?", "kind": "boundary", "id": "attribution-evidence-q02" } ] } ] }, { "id": "procedure-and-tissue-risk", "name": "Procedure and tissue risk", "description": "Associate handling decisions with the actual procedure, tissues and diagnostic context.", "findings": [ { "id": "prion-safety-disposition", "name": "Prion-safety disposition", "description": "Record specialist decisions for potentially contaminated instruments and materials; tissue contact and diagnostic suspicion affect handling requirements. [CDC infection control](https://www.cdc.gov/creutzfeldt-jakob/hcp/infection-control/index.html)", "questions": [ { "text": "Which procedures, tissues, specimens or instruments are implicated, and how certain is the contact history?", "kind": "measurement", "id": "prion-safety-disposition-q01" }, { "text": "Which current local prion guidance governs handling, and who authorises instrument quarantine, reprocessing, disposal or release?", "kind": "action", "id": "prion-safety-disposition-q02" } ] } ] } ] }, { "id": "care-decisions-and-case-follow-through", "name": "Care decisions and case follow-through", "description": "Connect the disease assessment to supportive care, accountable communication and eventual case resolution.", "rationale": "Rapid deterioration makes timely care decisions and continuity of responsibility central to the model.", "layers": [ { "id": "symptom-support-and-preferences", "name": "Symptom support and preferences", "description": "Record disease-related burdens, care goals and the people authorised to make decisions.", "findings": [ { "id": "individualised-care-plan", "name": "Individualised care plan", "description": "Link symptom burden and functional decline to agreed care measures, decision-making capacity and documented preferences.", "questions": [ { "text": "Which symptoms or functional losses currently cause distress, and what benefit or burden follows the agreed interventions?", "kind": "measurement", "id": "individualised-care-plan-q01" }, { "text": "What preferences, capacity assessment and authorised decision-maker govern changes to supportive or end-of-life care?", "kind": "action", "id": "individualised-care-plan-q02" } ] } ] }, { "id": "specialist-surveillance-and-confirmation", "name": "Specialist, surveillance and confirmation", "description": "Track responsible services, reporting decisions and further diagnostic opportunities.", "findings": [ { "id": "case-follow-through", "name": "Case follow-through", "description": "Record referral, jurisdiction-specific notification, consented post-mortem assessment and updates to the final classification.", "questions": [ { "text": "Which specialist or surveillance service is responsible, and what notification requirements apply in this jurisdiction?", "kind": "action", "id": "case-follow-through-q01" }, { "text": "Has post-mortem diagnostic assessment been discussed and consent documented, and how will resulting evidence update the case?", "kind": "action", "id": "case-follow-through-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "string" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "string", "value_or_pattern": "string", "note": "string" } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "string" ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "string" ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "string", "typical_range": "string", "unit": "string" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "string" ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "string" ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "string", "difference": "string" } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of Creutzfeldt-Jakob disease this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend this entry to encompass variant CJD, or does an existing authoritative model require a cross-reference instead?", "Which diagnostic and surveillance frameworks should govern classification across the intended jurisdictions, including genetic and variant cases?", "What assay-specific evidence is needed to represent the meaning of negative or discordant RT-QuIC results across disease forms and stages?", "Which functional assessment instrument and reassessment triggers best represent CJD progression in the intended care setting?", "Which local rules govern prion precautions, exposure investigation, notification, genetic consent and post-mortem confirmation?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a Creutzfeldt-Jakob disease, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise a suspected or established Creutzfeldt-Jakob disease case, track diagnostic confidence and progression, and identify appropriate clinical, care and prion-safety actions.", "characteristics": { "substance": "information", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "read and interpreted" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: inherited Creutzfeldt–Jakob disease, acquired Creutzfeldt-Jakob disease.", "2 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 62 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a Creutzfeldt-Jakob disease, and on what evidence are they told apart?" ], "whatItIsMadeOf": "content that has to be carried by something else", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "read it and act on what it says" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "inherited Creutzfeldt–Jakob disease", "acquired Creutzfeldt-Jakob disease" ] } ], "standing": "Described in 62 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 2 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one Creutzfeldt-Jakob disease from another, and a Creutzfeldt-Jakob disease from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a Creutzfeldt-Jakob disease sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a Creutzfeldt-Jakob disease from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a Creutzfeldt-Jakob disease passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a Creutzfeldt-Jakob disease between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a Creutzfeldt-Jakob disease, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a Creutzfeldt-Jakob disease is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "content-and-access", "name": "Content, encoding and access", "description": "What a Creutzfeldt-Jakob disease says, how it is encoded and who may read it.", "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.", "layers": [ { "id": "content-and-encoding", "name": "Content and encoding", "description": "The content itself, its format and its language.", "findings": [ { "id": "content-and-format", "name": "Content, format and language", "description": "What a Creutzfeldt-Jakob disease contains and in what form it is held.", "questions": [ { "id": "content-and-format-q01", "text": "What identifies and describes the content of a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "content-and-format-q02", "text": "Who or what asserted this about the content of a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "content-and-format-q03", "text": "What may an agent decide or do once the content of a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "access-and-rights", "name": "Access, rights and retention", "description": "Who may read, copy or change it, and for how long it is kept.", "findings": [ { "id": "access-rules", "name": "Access rules and retention", "description": "The permissions attached to a Creutzfeldt-Jakob disease and the period it survives.", "questions": [ { "id": "access-rules-q01", "text": "What identifies and describes access to a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "access-rules-q02", "text": "Who or what asserted this about access to a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "access-rules-q03", "text": "What may an agent decide or do once access to a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of Creutzfeldt-Jakob disease a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define Creutzfeldt-Jakob disease, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover Creutzfeldt-Jakob disease, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How Creutzfeldt-Jakob disease develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does Creutzfeldt-Jakob disease typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for Creutzfeldt-Jakob disease, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a Creutzfeldt-Jakob disease came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a Creutzfeldt-Jakob disease and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a Creutzfeldt-Jakob disease is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a Creutzfeldt-Jakob disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a Creutzfeldt-Jakob disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a Creutzfeldt-Jakob disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }