{ "model": { "rank": 9248, "code": "thing-q504790", "model_id": "vr.tr.nephrotic-syndrome", "name": "nephrotic syndrome", "purpose": "Let an agent explain nephrotic syndrome and its causes in general terms from nephrology guidelines, describe diagnosis and treatment approaches, distinguish it from nephritic syndrome, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Information and virtual systems", "status": "research-draft", "kind": "thing", "plane": "INF", "domain": "INF.KNW", "industry": "", "version": "", "url": "/models/thing/q504790/", "tier": 2, "score": 48, "payload": { "layer": "wikidata", "aliases": [ "nephrotic syndrome with lesion of proliferative glomerulonephritis", "focal segmental glomerulosclerosis", "nephrotic syndrome ocular anomalies", "nephrotic syndrome with lesion of membranoproliferative glomerulonephritis", "nephrotic syndrome with lesion of endothelial glomerulonephritis", "nephrotic syndrome with lesion of segmental hyalinosis", "nephrotic syndrome with lesion of hypocomplementemic glomerulonephritis", "nephrotic syndrome with lesion of mesangiocapillary glomerulonephritis", "nephrotic syndrome with lesion of persistent glomerulonephritis", "nephrotic syndrome with lesion of membranous glomerulonephritis", "nephrotic syndrome with lesion of lobular glomerulonephritis", "nephrotic syndrome with lesion of focal glomerulosclerosis", "familial nephrotic syndrome", "nephrotic syndrome, type 3", "idiopathic nephrotic syndrome", "Leigh syndrome with nephrotic syndrome", "Primary nephrotic syndrome", "focal segmental glomerulosclerosis 1", "focal segmental glomerulosclerosis 2", "focal segmental glomerulosclerosis 5", "focal segmental glomerulosclerosis 6", "focal segmental glomerulosclerosis 7", "focal segmental glomerulosclerosis 8", "focal segmental glomerulosclerosis 9", "nephrotic syndrome type 20", "nephrotic syndrome type 22", "Sphingosine Phosphate Lyase Insufficiency Syndrome", "nephrotic syndrome 15", "nephrotic syndrome 16", "nephrotic syndrome, type 4", "nephrotic syndrome, type 6", "nephrotic syndrome, type 11", "nephrotic syndrome, type 12", "nephrotic syndrome, type 13", "nephrotic syndrome, type 9", "nephrotic syndrome, type 10", "familial idiopathic steroid-resistant nephrotic syndrome", "nephrotic syndrome type 2", "nephrotic syndrome type 5", "nephrotic syndrome type 3" ], "aliasCount": 46, "merged": 46, "knownIn": 48, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q504790", "url": "https://www.wikidata.org/wiki/Q504790", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T01:17:35Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q504790", "registryId": "vr.tr.nephrotic-syndrome", "name": "nephrotic syndrome", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "INF.KNW" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q504790/", "model": { "registry_id": "vr.tr.nephrotic-syndrome", "name": "nephrotic syndrome", "purpose": "Let an agent explain nephrotic syndrome and its causes in general terms from nephrology guidelines, describe diagnosis and treatment approaches, distinguish it from nephritic syndrome, and route personal questions to clinicians.", "definition": "A kidney disorder in which damage to the glomerular filter causes heavy loss of protein into the urine, low blood albumin, swelling and high blood lipids, arising from primary glomerular diseases such as minimal change disease, focal segmental glomerulosclerosis and membranous nephropathy, from proliferative and membranoproliferative glomerulonephritis, and from systemic conditions such as diabetes and lupus, with rare genetic forms sometimes accompanied by ocular anomalies; nephrotic syndrome is treated with steroids, immunosuppression and supportive care according to cause.", "what_it_is_for": "Not applicable; a clinical syndrome.", "affordances": [ "explain the syndrome and causes", "relay diagnosis and treatment approaches", "distinguish from nephritic syndrome", "route personal questions" ], "distinguishing_features": [ "Glomerular protein leak", "Oedema and hypoalbuminaemia", "Primary and secondary causes", "Steroid responsiveness in many children" ], "appearance": "Not a visible object; swelling and frothy urine are typical signs.", "visual_identification": [ "Heavy proteinuria with low albumin and oedema", "Minimal change, FSGS, membranous, proliferative and systemic causes", "Nephritic syndrome features blood in urine and hypertension; chronic kidney disease is the broader decline" ], "physical_properties": [ { "quantity": "proteinuria threshold", "typical_range": "over 3.5", "unit": "g per day", "note": "adults" }, { "quantity": "childhood incidence", "typical_range": "about 2-7", "unit": "per 100000 per year", "note": "" } ], "families_and_kinds": [ "minimal change disease", "focal segmental glomerulosclerosis", "membranous nephropathy", "proliferative, membranoproliferative and endothelial glomerulonephritis lesions", "secondary nephrotic syndrome in diabetes, lupus and amyloidosis", "genetic and congenital forms, including syndromes with ocular anomalies" ], "related_models": [ { "relation": "is a kind of", "target": "nephrosis", "why": "in registry terms" }, { "relation": "affects", "target": "glomerulus", "why": "the kidney filter" }, { "relation": "is diagnosed by", "target": "kidney biopsy", "why": "in many adult cases" }, { "relation": "is contrasted with", "target": "nephritic syndrome", "why": "a related presentation" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "GB41", "note": "nephrotic syndrome" }, { "scheme": "MeSH", "value_or_pattern": "D009404", "note": "" } ], "standards_and_regulation": [ "KDIGO glomerular disease guidelines", "Paediatric nephrotic syndrome guidelines", "Drug regulation for immunosuppressants" ], "failure_modes_and_hazards": [ "Infection, thrombosis and kidney failure", "Agents giving personal medical advice", "Confusing with nephritic syndrome", "Outdated classifications" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Getting help first.", "rationale": "Safety.", "layers": [ { "id": "urgent", "name": "Urgent", "description": "Urgent signs.", "findings": [ { "id": "urgent-finding", "name": "Urgent", "description": "Urgent.", "questions": [ { "text": "What signs such as severe swelling, breathlessness or fever need urgent care?", "kind": "action" }, { "text": "Is the user describing such signs, which need prompt medical care?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Specialist care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is nephrotic syndrome diagnosed and followed by nephrologists, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own condition, which needs their clinician?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The syndrome.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and causes.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is nephrotic syndrome, and what primary and secondary causes exist?", "kind": "definition" }, { "text": "Is the question about nephrotic or nephritic syndrome?", "kind": "boundary" } ] } ] }, { "id": "lesions", "name": "Lesions", "description": "Histological lesions.", "findings": [ { "id": "lesions-finding", "name": "Lesions", "description": "Lesions.", "questions": [ { "text": "What do minimal change, FSGS, membranous and proliferative lesions mean, in general terms?", "kind": "provenance" }, { "text": "Which entry fits the specific lesion?", "kind": "action" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines recommend for children and adults, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "complications", "name": "Complications", "description": "Complications.", "findings": [ { "id": "complications-finding", "name": "Complications", "description": "Complications.", "questions": [ { "text": "What complications arise, and how are they prevented?", "kind": "provenance" }, { "text": "Which entry fits the specific complication?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and epidemiology.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is ongoing on causes such as anti-nephrin antibodies and new therapies, with findings attributed?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] }, { "id": "epidemiology", "name": "Epidemiology", "description": "Epidemiology.", "findings": [ { "id": "epidemiology-finding", "name": "Epidemiology", "description": "Epidemiology.", "questions": [ { "text": "How common is nephrotic syndrome in children and adults, with sources?", "kind": "measurement" }, { "text": "Which entry fits glomerular disease?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should FSGS and minimal change disease be separate primary entries?", "How should guidelines be linked?", "The registry entry has merged aliases naming histological lesions and rare syndromes; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a nephrotic syndrome, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain nephrotic syndrome and its causes in general terms from nephrology guidelines, describe diagnosis and treatment approaches, distinguish it from nephritic syndrome, and route personal questions to clinicians.", "characteristics": { "substance": "information", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "read and interpreted" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: nephrotic syndrome with lesion of proliferative glomerulonephritis, focal segmental glomerulosclerosis, nephrotic syndrome ocular anomalies, nephrotic syndrome with lesion of membranoproliferative glomerulonephritis, nephrotic syndrome with lesion of endothelial glomerulonephritis, nephrotic syndrome with lesion of segmental hyalinosis, nephrotic syndrome with lesion of hypocomplementemic glomerulonephritis, nephrotic syndrome with lesion of mesangiocapillary glomerulonephritis, nephrotic syndrome with lesion of persistent glomerulonephritis, nephrotic syndrome with lesion of membranous glomerulonephritis, nephrotic syndrome with lesion of lobular glomerulonephritis, nephrotic syndrome with lesion of focal glomerulosclerosis.", "46 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 48 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a nephrotic syndrome, and on what evidence are they told apart?" ], "whatItIsMadeOf": "content that has to be carried by something else", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "read it and act on what it says" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "nephrotic syndrome with lesion of proliferative glomerulonephritis", "focal segmental glomerulosclerosis", "nephrotic syndrome ocular anomalies", "nephrotic syndrome with lesion of membranoproliferative glomerulonephritis", "nephrotic syndrome with lesion of endothelial glomerulonephritis", "nephrotic syndrome with lesion of segmental hyalinosis", "nephrotic syndrome with lesion of hypocomplementemic glomerulonephritis", "nephrotic syndrome with lesion of mesangiocapillary glomerulonephritis", "nephrotic syndrome with lesion of persistent glomerulonephritis", "nephrotic syndrome with lesion of membranous glomerulonephritis", "nephrotic syndrome with lesion of lobular glomerulonephritis", "nephrotic syndrome with lesion of focal glomerulosclerosis" ] } ], "standing": "Described in 48 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 46 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one nephrotic syndrome from another, and a nephrotic syndrome from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a nephrotic syndrome sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a nephrotic syndrome from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a nephrotic syndrome passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a nephrotic syndrome between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a nephrotic syndrome, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a nephrotic syndrome is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "content-and-access", "name": "Content, encoding and access", "description": "What a nephrotic syndrome says, how it is encoded and who may read it.", "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.", "layers": [ { "id": "content-and-encoding", "name": "Content and encoding", "description": "The content itself, its format and its language.", "findings": [ { "id": "content-and-format", "name": "Content, format and language", "description": "What a nephrotic syndrome contains and in what form it is held.", "questions": [ { "id": "content-and-format-q01", "text": "What identifies and describes the content of a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "content-and-format-q02", "text": "Who or what asserted this about the content of a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "content-and-format-q03", "text": "What may an agent decide or do once the content of a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "access-and-rights", "name": "Access, rights and retention", "description": "Who may read, copy or change it, and for how long it is kept.", "findings": [ { "id": "access-rules", "name": "Access rules and retention", "description": "The permissions attached to a nephrotic syndrome and the period it survives.", "questions": [ { "id": "access-rules-q01", "text": "What identifies and describes access to a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "access-rules-q02", "text": "Who or what asserted this about access to a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "access-rules-q03", "text": "What may an agent decide or do once access to a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of nephrotic syndrome a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define nephrotic syndrome, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover nephrotic syndrome, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How nephrotic syndrome develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does nephrotic syndrome typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for nephrotic syndrome, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a nephrotic syndrome came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a nephrotic syndrome and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a nephrotic syndrome is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a nephrotic syndrome, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a nephrotic syndrome, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a nephrotic syndrome is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }