{ "model": { "rank": 13690, "code": "thing-q536269", "model_id": "vr.tr.phaeochromocytoma", "name": "phaeochromocytoma", "purpose": "Let an agent explain phaeochromocytoma and paraganglioma, relay symptoms, genetics, diagnosis and general treatment from endocrinology sources, describe the tumour sites the registry aliases name, and distinguish these tumours from other adrenal tumours, from anxiety or panic and from essential hypertension, routing crises to emergency care.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q536269/", "tier": 2, "score": 37, "payload": { "layer": "wikidata", "aliases": [ "adrenal gland pheochromocytoma", "sporadic pheochromocytoma/secreting paraganglioma", "paraganglioma", "extra-adrenal retroperitoneal paraganglioma", "extra-adrenal paraganglioma", "glomus jugulare tumor", "Gangliocytic paraganglioma", "Abdominal chemodectomas with cutaneous angiolipomas", "parasympathetic paraganglioma", "sympathetic paraganglioma", "paragangliomas 1" ], "aliasCount": 11, "merged": 11, "knownIn": 37, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q536269", "url": "https://www.wikidata.org/wiki/Q536269", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T18:46:32Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q536269", "registryId": "vr.tr.phaeochromocytoma", "name": "phaeochromocytoma", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q536269/", "model": { "registry_id": "vr.tr.phaeochromocytoma", "name": "phaeochromocytoma", "purpose": "Let an agent explain phaeochromocytoma and paraganglioma, relay symptoms, genetics, diagnosis and general treatment from endocrinology sources, describe the tumour sites the registry aliases name, and distinguish these tumours from other adrenal tumours, from anxiety or panic and from essential hypertension, routing crises to emergency care.", "definition": "A rare neuroendocrine tumour of the adrenal medulla that produces catecholamines such as adrenaline and noradrenaline, causing episodes of high blood pressure, headache, sweating and palpitations, closely related to paragangliomas, which arise from extra-adrenal paraganglia in the abdomen, retroperitoneum or head and neck, such as the glomus jugulare tumour; many cases are hereditary, and although often classed as benign, all such tumours are now considered to have metastatic potential. A hypertensive crisis needs emergency care. The model routes people to clinicians.", "what_it_is_for": "Not applicable; a tumour.", "affordances": [ "route crises first", "explain tumour and symptoms", "relay diagnosis and treatment", "distinguish related conditions" ], "distinguishing_features": [ "Catecholamine excess", "Episodic symptoms", "Strong genetic link", "Adrenal or extra-adrenal" ], "appearance": "Not a visible object; an adrenal or paraganglion mass.", "visual_identification": [ "Catecholamine-producing neuroendocrine tumour", "Adrenal phaeochromocytoma, paraganglioma, extra-adrenal retroperitoneal paraganglioma, glomus jugulare tumour", "Adrenal adenomas are usually non-functioning; panic attacks lack a tumour; essential hypertension has no single cause" ], "physical_properties": [ { "quantity": "incidence", "typical_range": "about 2-8 per million", "unit": "per year", "note": "estimates" }, { "quantity": "hereditary share", "typical_range": "about 30-40", "unit": "percent", "note": "" }, { "quantity": "classic triad", "typical_range": "headache, sweating, palpitations", "unit": "list", "note": "" }, { "quantity": "WHO 2017", "typical_range": "all considered potentially metastatic", "unit": "note", "note": "" } ], "families_and_kinds": [ "adrenal phaeochromocytoma", "sympathetic abdominal paragangliomas", "head and neck paragangliomas such as glomus jugulare", "hereditary syndromes such as MEN2, VHL and SDH-related", "metastatic disease" ], "related_models": [ { "relation": "is a kind of", "target": "neuroendocrine tumor", "why": "in registry terms" }, { "relation": "arises from", "target": "adrenal medulla", "why": "" }, { "relation": "is related to", "target": "paraganglioma", "why": "" }, { "relation": "produces", "target": "norepinephrine", "why": "and epinephrine" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "D35.0", "note": "benign neoplasm of adrenal gland" }, { "scheme": "MeSH", "value_or_pattern": "D010673", "note": "Pheochromocytoma" } ], "standards_and_regulation": [ "Endocrine Society clinical practice guidelines", "Genetic testing recommendations" ], "failure_modes_and_hazards": [ "Hypertensive crisis", "Agents giving personal medical advice", "Registry parent benign neoplasm understating metastatic potential" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What phaeochromocytoma is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is phaeochromocytoma, and how does it differ from paraganglioma, other adrenal tumours, panic attacks and essential hypertension?", "kind": "definition" }, { "text": "Is someone having a severe headache with very high blood pressure, chest pain or confusion, which needs emergency services?", "kind": "boundary" } ] } ] }, { "id": "sites", "name": "Sites", "description": "Sites.", "findings": [ { "id": "sites-finding", "name": "Sites", "description": "Sites.", "questions": [ { "text": "What are adrenal, retroperitoneal and head and neck paragangliomas such as glomus jugulare?", "kind": "definition" }, { "text": "Which entry fits the specific site?", "kind": "action" } ] } ] } ] }, { "id": "biology", "name": "Biology", "description": "Biology and genetics.", "rationale": "Science.", "layers": [ { "id": "hormones", "name": "Hormones", "description": "Catecholamines.", "findings": [ { "id": "hormones-finding", "name": "Hormones", "description": "Hormones.", "questions": [ { "text": "How do catecholamines cause the symptoms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "genetics", "name": "Genetics", "description": "Genetics.", "findings": [ { "id": "genetics-finding", "name": "Genetics", "description": "Genetics.", "questions": [ { "text": "Which hereditary syndromes are involved, and why is genetic testing recommended?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is it diagnosed with metanephrine tests and imaging, in general terms?", "kind": "provenance" }, { "text": "Which entry fits metanephrine?", "kind": "action" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What general treatment approaches, including pre-operative preparation and surgery, do guidelines describe?", "kind": "provenance" }, { "text": "Which entry fits adrenalectomy?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Classification and support.", "rationale": "Context.", "layers": [ { "id": "classification", "name": "Classification", "description": "Classification.", "findings": [ { "id": "classification-finding", "name": "Classification", "description": "Classification.", "questions": [ { "text": "Why did WHO stop classifying these tumours as benign or malignant?", "kind": "provenance" }, { "text": "Which entry fits WHO classification of tumours?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What patient organisations support people and families?", "kind": "provenance" }, { "text": "Which entry fits rare disease support organisations?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should paraganglioma be a separate primary entry?", "How should endocrinology sources be linked?", "The registry parent endocrine organ benign neoplasm conflicts with the current view of metastatic potential; should it be reviewed?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a phaeochromocytoma, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain phaeochromocytoma and paraganglioma, relay symptoms, genetics, diagnosis and general treatment from endocrinology sources, describe the tumour sites the registry aliases name, and distinguish these tumours from other adrenal tumours, from anxiety or panic and from essential hypertension, routing crises to emergency care.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: adrenal gland pheochromocytoma, sporadic pheochromocytoma/secreting paraganglioma, paraganglioma, extra-adrenal retroperitoneal paraganglioma, extra-adrenal paraganglioma, glomus jugulare tumor, Gangliocytic paraganglioma, Abdominal chemodectomas with cutaneous angiolipomas, parasympathetic paraganglioma, sympathetic paraganglioma, paragangliomas 1.", "11 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 37 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a phaeochromocytoma, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "adrenal gland pheochromocytoma", "sporadic pheochromocytoma/secreting paraganglioma", "paraganglioma", "extra-adrenal retroperitoneal paraganglioma", "extra-adrenal paraganglioma", "glomus jugulare tumor", "Gangliocytic paraganglioma", "Abdominal chemodectomas with cutaneous angiolipomas", "parasympathetic paraganglioma", "sympathetic paraganglioma", "paragangliomas 1" ] } ], "standing": "Described in 37 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 11 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one phaeochromocytoma from another, and a phaeochromocytoma from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a phaeochromocytoma sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a phaeochromocytoma from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a phaeochromocytoma passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a phaeochromocytoma between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a phaeochromocytoma, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a phaeochromocytoma is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What phaeochromocytoma is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of phaeochromocytoma are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is phaeochromocytoma operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of phaeochromocytoma and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of phaeochromocytoma?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as phaeochromocytoma?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a phaeochromocytoma came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a phaeochromocytoma and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a phaeochromocytoma is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a phaeochromocytoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a phaeochromocytoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a phaeochromocytoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }