{ "model": { "rank": 16249, "code": "thing-q539568", "model_id": "vr.tr.angiogenesis", "name": "angiogenesis", "purpose": "Let an agent explain angiogenesis, relay mechanisms, physiological and pathological roles and therapeutic targeting from cell biology and medicine sources, describe the named forms, and distinguish angiogenesis from vasculogenesis, arteriogenesis and lymphangiogenesis.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q539568/", "tier": 2, "score": 32, "payload": { "layer": "wikidata", "aliases": [ "tumor angiogenesis", "angiogenesis involved in coronary vascular morphogenesis", "glomerular capillary formation", "sprouting angiogenesis", "angiogenesis involved in wound healing", "intussusceptive angiogenesis", "Tumor angiogenesis", "Intussusceptive angiogenesis", "metastasis angiogenesis" ], "aliasCount": 9, "merged": 9, "knownIn": 32, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q539568", "url": "https://www.wikidata.org/wiki/Q539568", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-14T02:43:53Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q539568", "registryId": "vr.tr.angiogenesis", "name": "angiogenesis", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q539568/", "model": { "registry_id": "vr.tr.angiogenesis", "name": "angiogenesis", "purpose": "Let an agent explain angiogenesis, relay mechanisms, physiological and pathological roles and therapeutic targeting from cell biology and medicine sources, describe the named forms, and distinguish angiogenesis from vasculogenesis, arteriogenesis and lymphangiogenesis.", "definition": "The formation of new blood vessels from existing ones, a process essential to growth, wound healing and the menstrual cycle, driven by signals such as vascular endothelial growth factor, with forms the registry aliases name such as sprouting and intussusceptive angiogenesis and angiogenesis in wound healing and coronary and glomerular development; tumour angiogenesis, also named, is the growth of vessels that supply tumours, a target of anti-angiogenic cancer drugs, while too little or abnormal angiogenesis features in poor healing and eye disease. Angiogenesis is distinct from vasculogenesis, the initial formation of vessels, and from arteriogenesis.", "what_it_is_for": "Forming new blood vessels.", "affordances": [ "explain mechanisms", "relay physiological and pathological roles", "describe named forms", "distinguish related processes" ], "distinguishing_features": [ "New vessels from existing ones", "VEGF-driven", "Healing and disease roles", "Drug target" ], "appearance": "Not visible to the eye; new capillaries sprouting, seen in microscopy.", "visual_identification": [ "Formation of new blood vessels from existing ones", "Tumor angiogenesis, sprouting angiogenesis, intussusceptive angiogenesis, angiogenesis in wound healing, coronary and glomerular angiogenesis", "Vasculogenesis forms the first vessels; arteriogenesis enlarges arteries; lymphangiogenesis forms lymph vessels" ], "physical_properties": [ { "quantity": "key signal", "typical_range": "vascular endothelial growth factor", "unit": "note", "note": "VEGF" }, { "quantity": "types", "typical_range": "sprouting and intussusceptive", "unit": "list", "note": "" }, { "quantity": "registry parent", "typical_range": "microvasculature remodeling", "unit": "note", "note": "" } ], "families_and_kinds": [ "sprouting angiogenesis", "intussusceptive angiogenesis", "physiological angiogenesis", "tumour angiogenesis" ], "related_models": [ { "relation": "is a kind of", "target": "vascular remodeling", "why": "in registry terms" }, { "relation": "is driven by", "target": "vascular endothelial growth factor", "why": "" }, { "relation": "is contrasted with", "target": "vasculogenesis", "why": "" }, { "relation": "is contrasted with", "target": "lymphangiogenesis", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "Drug regulation for anti-angiogenic therapies" ], "failure_modes_and_hazards": [ "Tumour growth from angiogenesis", "Poor healing from insufficient angiogenesis", "Eye disease from abnormal vessels" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What angiogenesis is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is angiogenesis, and how does it differ from vasculogenesis, arteriogenesis and lymphangiogenesis?", "kind": "definition" }, { "text": "Is the question about normal biology, cancer or eye disease?", "kind": "boundary" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Named forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are sprouting and intussusceptive angiogenesis and tumour angiogenesis?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "mechanism", "name": "Mechanism", "description": "Mechanism.", "rationale": "Science.", "layers": [ { "id": "vegf", "name": "VEGF", "description": "Signalling.", "findings": [ { "id": "vegf-finding", "name": "VEGF", "description": "VEGF.", "questions": [ { "text": "How do VEGF and other signals drive angiogenesis?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "sprouting", "name": "Sprouting", "description": "Sprouting versus intussusceptive.", "findings": [ { "id": "sprouting-finding", "name": "Sprouting", "description": "Sprouting.", "questions": [ { "text": "How do sprouting and intussusceptive angiogenesis differ?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "roles", "name": "Roles", "description": "Roles.", "rationale": "Science.", "layers": [ { "id": "physiological", "name": "Physiological", "description": "Healing and development.", "findings": [ { "id": "physiological-finding", "name": "Physiological", "description": "Physiological.", "questions": [ { "text": "How does angiogenesis support wound healing and development?", "kind": "provenance" }, { "text": "Which entry fits wound healing?", "kind": "action" } ] } ] }, { "id": "tumour", "name": "Tumour", "description": "Tumour angiogenesis.", "findings": [ { "id": "tumour-finding", "name": "Tumour", "description": "Tumour.", "questions": [ { "text": "How do tumours induce angiogenesis, and how is it targeted?", "kind": "provenance" }, { "text": "Which entry fits anti-angiogenic therapy?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Medicine.", "rationale": "Attribution.", "layers": [ { "id": "therapy", "name": "Therapy", "description": "Anti-angiogenic drugs.", "findings": [ { "id": "therapy-finding", "name": "Therapy", "description": "Therapy.", "questions": [ { "text": "What anti-angiogenic drugs are used, and for what, checked against current sources?", "kind": "provenance" }, { "text": "Is the information current?", "kind": "boundary" } ] } ] }, { "id": "eye", "name": "Eye", "description": "Eye disease.", "findings": [ { "id": "eye-finding", "name": "Eye", "description": "Eye.", "questions": [ { "text": "How does abnormal angiogenesis cause eye disease such as wet macular degeneration?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] } ] } ] }, "openQuestions": [ "Should tumour angiogenesis be a separate entry?", "How should anti-angiogenic drugs be linked?", "How should the vessel-formation processes be distinguished?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a angiogenesis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain angiogenesis, relay mechanisms, physiological and pathological roles and therapeutic targeting from cell biology and medicine sources, describe the named forms, and distinguish angiogenesis from vasculogenesis, arteriogenesis and lymphangiogenesis.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: tumor angiogenesis, angiogenesis involved in coronary vascular morphogenesis, glomerular capillary formation, sprouting angiogenesis, angiogenesis involved in wound healing, intussusceptive angiogenesis, Tumor angiogenesis, Intussusceptive angiogenesis, metastasis angiogenesis.", "9 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 32 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a angiogenesis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "tumor angiogenesis", "angiogenesis involved in coronary vascular morphogenesis", "glomerular capillary formation", "sprouting angiogenesis", "angiogenesis involved in wound healing", "intussusceptive angiogenesis", "Tumor angiogenesis", "Intussusceptive angiogenesis", "metastasis angiogenesis" ] } ], "standing": "Described in 32 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 9 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one angiogenesis from another, and a angiogenesis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a angiogenesis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a angiogenesis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a angiogenesis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a angiogenesis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a angiogenesis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a angiogenesis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What angiogenesis is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of angiogenesis are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is angiogenesis operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of angiogenesis and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of angiogenesis?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as angiogenesis?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a angiogenesis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a angiogenesis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a angiogenesis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a angiogenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a angiogenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a angiogenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }