{ "model": { "rank": 13169, "code": "thing-q549534", "model_id": "vr.tr.osteosarcoma", "name": "osteosarcoma", "purpose": "Let an agent explain osteosarcoma in general terms from oncology guidelines, describe symptoms, diagnosis, treatment and outcomes, distinguish it from other bone sarcomas and benign bone conditions, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q549534/", "tier": 2, "score": 38, "payload": { "layer": "wikidata", "aliases": [ "metastatic osteosarcoma", "fibrosarcoma of bone", "pediatric osteosarcoma", "bone angioendothelial sarcoma", "malignant fibrous histiocytoma of bone", "localized osteosarcoma", "extraosseous osteosarcoma", "multifocal osteogenic sarcoma", "bone leiomyosarcoma", "chondroblastic osteosarcoma", "bone osteosarcoma", "metachronous osteosarcoma of the bone", "liposarcoma of bone", "recurrent osteosarcoma", "parosteal osteosarcoma", "low grade central osteosarcoma", "OSLAM syndrome" ], "aliasCount": 17, "merged": 17, "knownIn": 38, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q549534", "url": "https://www.wikidata.org/wiki/Q549534", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T03:32:00Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q549534", "registryId": "vr.tr.osteosarcoma", "name": "osteosarcoma", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q549534/", "model": { "registry_id": "vr.tr.osteosarcoma", "name": "osteosarcoma", "purpose": "Let an agent explain osteosarcoma in general terms from oncology guidelines, describe symptoms, diagnosis, treatment and outcomes, distinguish it from other bone sarcomas and benign bone conditions, and route personal questions to clinicians.", "definition": "The most common primary malignant bone tumour, arising from bone-forming cells, most often in the long bones around the knee and shoulder in adolescents and young adults as pediatric osteosarcoma and with a second peak in older adults, presenting as localized or metastatic disease, and grouped with rarer bone sarcomas such as fibrosarcoma of bone, malignant fibrous histiocytoma of bone and vascular sarcomas; osteosarcoma is treated with chemotherapy and surgery, and survival for localized disease has improved to about 60 to 70 percent.", "what_it_is_for": "Not applicable; a cancer.", "affordances": [ "explain the disease", "relay symptoms and diagnosis", "relay treatment and outcomes", "route personal questions" ], "distinguishing_features": [ "Bone-forming tumour", "Adolescent peak", "Chemotherapy and surgery", "Metastasis to lungs" ], "appearance": "Not a visible object; a bone tumour seen on imaging.", "visual_identification": [ "Malignant bone-forming tumour", "Localized and metastatic osteosarcoma; pediatric and adult forms; related bone sarcomas", "Ewing sarcoma and chondrosarcoma are other bone sarcomas; bone metastases from other cancers differ" ], "physical_properties": [ { "quantity": "incidence", "typical_range": "about 3-4", "unit": "per million per year", "note": "" }, { "quantity": "five-year survival, localized", "typical_range": "about 60-70", "unit": "percent", "note": "" }, { "quantity": "peak age", "typical_range": "10-20", "unit": "years", "note": "" } ], "families_and_kinds": [ "conventional high-grade osteosarcoma", "localized osteosarcoma", "metastatic osteosarcoma", "pediatric osteosarcoma", "secondary osteosarcoma in Paget disease or after radiation", "related bone sarcomas such as fibrosarcoma of bone, malignant fibrous histiocytoma of bone and angiosarcoma of bone" ], "related_models": [ { "relation": "is a kind of", "target": "bone sarcoma", "why": "in registry terms" }, { "relation": "is a kind of", "target": "osteogenic neoplasm", "why": "in registry terms" }, { "relation": "is a kind of", "target": "paediatric oncology", "why": "in registry terms, as a paediatric cancer" }, { "relation": "is treated by", "target": "chemotherapy", "why": "and limb-sparing surgery" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "2B51", "note": "osteosarcoma of bone and articular cartilage" }, { "scheme": "MeSH", "value_or_pattern": "D012516", "note": "osteosarcoma" } ], "standards_and_regulation": [ "ESMO and NCCN bone sarcoma guidelines", "Paediatric oncology protocols such as EURAMOS", "Cancer registration standards" ], "failure_modes_and_hazards": [ "Delayed diagnosis mistaken for growing pains or injury", "Agents giving personal medical advice", "Confusing with other bone tumours" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Getting help first.", "rationale": "Safety.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What signs, such as persistent bone pain, swelling or a fracture without cause, need prompt assessment?", "kind": "action" }, { "text": "Is the user describing such symptoms, which need a clinician promptly?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Specialist care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is osteosarcoma diagnosed and staged by specialist sarcoma teams, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis, which needs their oncology team?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The cancer.", "rationale": "Clinical.", "layers": [ { "id": "disease", "name": "Disease", "description": "Disease and types.", "findings": [ { "id": "disease-finding", "name": "Disease", "description": "Disease.", "questions": [ { "text": "What is osteosarcoma, who is affected, and what types exist?", "kind": "definition" }, { "text": "Is the question about osteosarcoma or another bone tumour?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes and risk.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What is known about causes and risk factors, such as growth, genetics, Paget disease and radiation?", "kind": "provenance" }, { "text": "Which entry fits the specific risk factor?", "kind": "action" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines recommend, from chemotherapy to limb-sparing surgery, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "outcomes", "name": "Outcomes", "description": "Outcomes and follow-up.", "findings": [ { "id": "outcomes-finding", "name": "Outcomes", "description": "Outcomes.", "questions": [ { "text": "What outcomes are seen for localized and metastatic disease, and what follow-up and rehabilitation exist?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and support.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses new therapies and biology, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits sarcoma research?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What organisations support patients and families?", "kind": "provenance" }, { "text": "Which entry fits the specific organisation?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should bone sarcoma be the primary linked entry?", "How should guidelines be linked?", "The registry entry has merged aliases naming distinct rare sarcomas; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a osteosarcoma, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain osteosarcoma in general terms from oncology guidelines, describe symptoms, diagnosis, treatment and outcomes, distinguish it from other bone sarcomas and benign bone conditions, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: metastatic osteosarcoma, fibrosarcoma of bone, pediatric osteosarcoma, bone angioendothelial sarcoma, malignant fibrous histiocytoma of bone, localized osteosarcoma, extraosseous osteosarcoma, multifocal osteogenic sarcoma, bone leiomyosarcoma, chondroblastic osteosarcoma, bone osteosarcoma, metachronous osteosarcoma of the bone.", "17 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 38 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a osteosarcoma, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "metastatic osteosarcoma", "fibrosarcoma of bone", "pediatric osteosarcoma", "bone angioendothelial sarcoma", "malignant fibrous histiocytoma of bone", "localized osteosarcoma", "extraosseous osteosarcoma", "multifocal osteogenic sarcoma", "bone leiomyosarcoma", "chondroblastic osteosarcoma", "bone osteosarcoma", "metachronous osteosarcoma of the bone" ] } ], "standing": "Described in 38 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 17 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one osteosarcoma from another, and a osteosarcoma from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a osteosarcoma sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a osteosarcoma from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a osteosarcoma passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a osteosarcoma between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a osteosarcoma, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a osteosarcoma is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What osteosarcoma is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of osteosarcoma are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is osteosarcoma operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of osteosarcoma and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of osteosarcoma?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as osteosarcoma?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a osteosarcoma came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a osteosarcoma and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a osteosarcoma is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a osteosarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a osteosarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a osteosarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }