{ "model": { "rank": 11469, "code": "thing-q570197", "model_id": "vr.tr.proteinuria", "name": "proteinuria", "purpose": "Let an agent explain proteinuria and its causes in neutral clinical terms, relay detection, classification and significance from nephrology sources, describe evaluation and management in general, and route individuals with abnormal results to clinicians.", "family": "Thing Registry", "category": "Information and virtual systems", "status": "research-draft", "kind": "thing", "plane": "INF", "domain": "INF.KNW", "industry": "", "version": "", "url": "/models/thing/q570197/", "tier": 2, "score": 42, "payload": { "layer": "wikidata", "aliases": [ "orthostatic proteinuria", "nephrosis", "tubular proteinuria", "Bence Jones proteinuria", "familial visceral amyloidosis", "osmotic nephrosis", "apolipoprotein A-II amyloidosis", "AApoAI amyloidosis", "ALys amyloidosis", "AFib amyloidosis" ], "aliasCount": 10, "merged": 10, "knownIn": 42, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q570197", "url": "https://www.wikidata.org/wiki/Q570197", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T05:09:41Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q570197", "registryId": "vr.tr.proteinuria", "name": "proteinuria", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "INF.KNW" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q570197/", "model": { "registry_id": "vr.tr.proteinuria", "name": "proteinuria", "purpose": "Let an agent explain proteinuria and its causes in neutral clinical terms, relay detection, classification and significance from nephrology sources, describe evaluation and management in general, and route individuals with abnormal results to clinicians.", "definition": "The presence of excess protein in the urine, a sign of kidney disease or other conditions, detected by dipstick or laboratory measurement of albumin or total protein, arising from glomerular leakage as in nephrotic syndrome, from tubular disorders, from overflow of abnormal proteins such as Bence Jones proteins in myeloma, from benign causes such as orthostatic proteinuria in young people, or from fever and exercise; persistent proteinuria is a marker of kidney damage and cardiovascular risk.", "what_it_is_for": "Not applicable; a clinical sign.", "affordances": [ "explain causes and types", "relay detection and significance", "describe evaluation in general", "route to clinicians" ], "distinguishing_features": [ "Urine test sign", "Multiple mechanisms", "Marker of kidney damage", "Benign variants" ], "appearance": "Not a visible object; foamy urine in heavy cases, otherwise a test result.", "visual_identification": [ "Excess protein in urine", "Glomerular, tubular, overflow and orthostatic proteinuria; Bence Jones proteinuria; nephrosis", "Haematuria is blood in urine; albuminuria is the albumin-specific measure" ], "physical_properties": [ { "quantity": "normal urinary protein", "typical_range": "under 150", "unit": "mg per day", "note": "" }, { "quantity": "nephrotic range", "typical_range": "over 3.5", "unit": "g per day", "note": "" }, { "quantity": "albumin-creatinine ratio threshold", "typical_range": "30", "unit": "mg/g", "note": "for albuminuria" } ], "families_and_kinds": [ "glomerular proteinuria including nephrotic syndrome and nephrosis", "tubular proteinuria", "overflow proteinuria such as Bence Jones proteinuria", "orthostatic or postural proteinuria", "transient proteinuria from fever or exercise", "proteinuria in amyloidosis including familial forms and in osmotic nephrosis" ], "related_models": [ { "relation": "is a kind of", "target": "urological symptom", "why": "in registry terms" }, { "relation": "is a kind of", "target": "kidney disease", "why": "in registry terms, as a sign" }, { "relation": "indicates", "target": "chronic kidney disease", "why": "when persistent" }, { "relation": "is measured by", "target": "urinalysis", "why": "and albumin-creatinine ratio" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "MF98.0", "note": "proteinuria" }, { "scheme": "MeSH", "value_or_pattern": "D011507", "note": "proteinuria" } ], "standards_and_regulation": [ "KDIGO guidelines on chronic kidney disease", "Laboratory standards for urine protein measurement", "Screening recommendations in diabetes and hypertension" ], "failure_modes_and_hazards": [ "Agents interpreting personal results", "Missing serious causes behind transient findings", "Confusing proteinuria with haematuria" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Abnormal results first.", "rationale": "Safety.", "layers": [ { "id": "results", "name": "Results", "description": "Test results.", "findings": [ { "id": "results-finding", "name": "Results", "description": "Results.", "questions": [ { "text": "Why do positive protein tests need follow-up with a clinician, and when is urgent care needed, such as with swelling, high blood pressure or reduced urine?", "kind": "action" }, { "text": "Is the user asking about their own result, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "screening", "name": "Screening", "description": "Screening.", "findings": [ { "id": "screening-finding", "name": "Screening", "description": "Screening.", "questions": [ { "text": "Who is screened for proteinuria, and why, according to guidelines?", "kind": "provenance" }, { "text": "Which entry fits chronic kidney disease screening?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The sign.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and types.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is proteinuria, and how do glomerular, tubular, overflow and orthostatic types differ?", "kind": "definition" }, { "text": "Is the question about proteinuria, haematuria or a specific kidney disease?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What conditions cause proteinuria, from diabetes and glomerulonephritis to myeloma and amyloidosis?", "kind": "definition" }, { "text": "Which entry fits the specific cause?", "kind": "action" } ] } ] } ] }, { "id": "evaluate", "name": "Evaluate", "description": "Detection and evaluation.", "rationale": "Clinical.", "layers": [ { "id": "tests", "name": "Tests", "description": "Tests.", "findings": [ { "id": "tests-finding", "name": "Tests", "description": "Tests.", "questions": [ { "text": "How is proteinuria measured by dipstick, ratios and 24-hour collection?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "workup", "name": "Workup", "description": "Evaluation.", "findings": [ { "id": "workup-finding", "name": "Workup", "description": "Workup.", "questions": [ { "text": "How do clinicians evaluate persistent proteinuria, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Management and research.", "rationale": "Context.", "layers": [ { "id": "management", "name": "Management", "description": "Management.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "How is proteinuria reduced in kidney disease, in general terms?", "kind": "provenance" }, { "text": "Which entry fits nephrology?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research links proteinuria to cardiovascular risk, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits cardiorenal syndrome?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should nephrotic syndrome and albuminuria be separate primary entries?", "How should nephrology guidelines be linked?", "The registry entry has merged aliases naming distinct diseases; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "discipline or field of knowledge", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a proteinuria, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain proteinuria and its causes in neutral clinical terms, relay detection, classification and significance from nephrology sources, describe evaluation and management in general, and route individuals with abnormal results to clinicians.", "characteristics": { "substance": "information", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "read and interpreted" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: orthostatic proteinuria, nephrosis, tubular proteinuria, Bence Jones proteinuria, familial visceral amyloidosis, osmotic nephrosis, apolipoprotein A-II amyloidosis, AApoAI amyloidosis, ALys amyloidosis, AFib amyloidosis.", "10 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 42 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a proteinuria, and on what evidence are they told apart?" ], "whatItIsMadeOf": "content that has to be carried by something else", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "read it and act on what it says" ], "howItIsRecognised": [], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "orthostatic proteinuria", "nephrosis", "tubular proteinuria", "Bence Jones proteinuria", "familial visceral amyloidosis", "osmotic nephrosis", "apolipoprotein A-II amyloidosis", "AApoAI amyloidosis", "ALys amyloidosis", "AFib amyloidosis" ] } ], "standing": "Described in 42 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 10 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one proteinuria from another, and a proteinuria from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a proteinuria sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a proteinuria from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a proteinuria passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a proteinuria between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a proteinuria, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a proteinuria is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "content-and-access", "name": "Content, encoding and access", "description": "What a proteinuria says, how it is encoded and who may read it.", "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.", "layers": [ { "id": "content-and-encoding", "name": "Content and encoding", "description": "The content itself, its format and its language.", "findings": [ { "id": "content-and-format", "name": "Content, format and language", "description": "What a proteinuria contains and in what form it is held.", "questions": [ { "id": "content-and-format-q01", "text": "What identifies and describes the content of a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "content-and-format-q02", "text": "Who or what asserted this about the content of a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "content-and-format-q03", "text": "What may an agent decide or do once the content of a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "access-and-rights", "name": "Access, rights and retention", "description": "Who may read, copy or change it, and for how long it is kept.", "findings": [ { "id": "access-rules", "name": "Access rules and retention", "description": "The permissions attached to a proteinuria and the period it survives.", "questions": [ { "id": "access-rules-q01", "text": "What identifies and describes access to a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "access-rules-q02", "text": "Who or what asserted this about access to a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "access-rules-q03", "text": "What may an agent decide or do once access to a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "subject-and-method", "name": "Subject matter and method", "description": "What proteinuria studies and how it establishes anything.", "rationale": "A field is identified by its questions and its methods, and those are what distinguish it from the fields next to it.", "layers": [ { "id": "subject", "name": "Subject matter", "description": "The questions it takes as its own.", "findings": [ { "id": "subject-record", "name": "Questions and objects of study", "description": "What it is about, stated so a neighbouring field can be told apart.", "questions": [ { "id": "subject-record-q01", "text": "What questions and objects does proteinuria take as its own?", "kind": "definition" }, { "id": "subject-record-q02", "text": "Which questions does it share with a neighbouring field, and who claims them?", "kind": "boundary" } ] } ] }, { "id": "method", "name": "Method and evidence", "description": "How claims are established and what counts as evidence.", "findings": [ { "id": "method-record", "name": "Methods and standards of evidence", "description": "The methods used and what they are taken to establish.", "questions": [ { "id": "method-record-q01", "text": "By what methods does proteinuria establish claims, and what counts as sufficient evidence?", "kind": "provenance" }, { "id": "method-record-q02", "text": "What kind of claim can this field not settle, and where should an agent look instead?", "kind": "action" } ] } ] } ] }, { "id": "institutions-and-classification", "name": "Institutions and classification", "description": "Where proteinuria is practised and how catalogues place it.", "rationale": "The institutional footprint is the evidence that a field exists as a field rather than as a topic.", "layers": [ { "id": "institutions", "name": "Institutional markers", "description": "Societies, journals, degrees and departments.", "findings": [ { "id": "institution-record", "name": "Bodies and venues", "description": "Where the field organises itself.", "questions": [ { "id": "institution-record-q01", "text": "Which societies, journals or degrees mark proteinuria as an established field?", "kind": "provenance" }, { "id": "institution-record-q02", "text": "What would show that it is emerging or dissolving rather than established?", "kind": "boundary" } ] } ] }, { "id": "classification", "name": "Classification schemes", "description": "Where library and research classifications put it.", "findings": [ { "id": "classification-record", "name": "Codes and their disagreements", "description": "The classification codes that place it, and where they differ.", "questions": [ { "id": "classification-record-q01", "text": "Which classification schemes place proteinuria, under what codes?", "kind": "definition" }, { "id": "classification-record-q02", "text": "Where do those schemes disagree about its scope?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a proteinuria came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a proteinuria and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a proteinuria is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a proteinuria, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a proteinuria, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a proteinuria is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }