{ "model": { "rank": 11704, "code": "thing-q6058862", "model_id": "vr.tr.fatty-liver-disease", "name": "fatty liver disease", "purpose": "Let an agent explain fatty liver disease in general terms, relay types, new nomenclature, risk factors, assessment and management from hepatology sources, route emergencies including acute fatty liver of pregnancy, point people to clinicians and alcohol support, describe the named forms, and distinguish fatty liver disease from viral hepatitis, cirrhosis as an end stage, gallbladder disease and foie gras production, without diagnosing individuals.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q6058862/", "tier": 2, "score": 41, "payload": { "layer": "wikidata", "aliases": [ "acute fatty liver of pregnancy", "alcoholic fatty liver", "metabolic dysfunction–associated steatotic liver disease", "steatohepatitis", "Focal fatty liver", "non-alcoholic steatohepatitis", "non-alcoholic fatty liver" ], "aliasCount": 7, "merged": 7, "knownIn": 41, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q6058862", "url": "https://www.wikidata.org/wiki/Q6058862", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T23:23:27Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q6058862", "registryId": "vr.tr.fatty-liver-disease", "name": "fatty liver disease", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q6058862/", "model": { "registry_id": "vr.tr.fatty-liver-disease", "name": "fatty liver disease", "purpose": "Let an agent explain fatty liver disease in general terms, relay types, new nomenclature, risk factors, assessment and management from hepatology sources, route emergencies including acute fatty liver of pregnancy, point people to clinicians and alcohol support, describe the named forms, and distinguish fatty liver disease from viral hepatitis, cirrhosis as an end stage, gallbladder disease and foie gras production, without diagnosing individuals.", "definition": "A condition in which excess fat accumulates in liver cells, including metabolic dysfunction-associated steatotic liver disease, MASLD, the name adopted in 2023 by international liver societies to replace non-alcoholic fatty liver disease, linked to obesity, type 2 diabetes and metabolic risk factors, its inflammatory form metabolic dysfunction-associated steatohepatitis, formerly non-alcoholic steatohepatitis or NASH, alcoholic fatty liver from heavy drinking, focal fatty liver seen on imaging, and acute fatty liver of pregnancy, a rare obstetric emergency in the third trimester; steatohepatitis can progress to fibrosis, cirrhosis and liver cancer. Management centres on weight loss, exercise, reducing alcohol and treating risk factors, and jaundice, confusion, vomiting blood or severe abdominal pain, including in late pregnancy, needs emergency care.", "what_it_is_for": "Not applicable; a group of liver conditions.", "affordances": [ "explain types and nomenclature", "relay risk factors and management in general terms", "describe named forms", "route emergencies" ], "distinguishing_features": [ "Fat accumulation", "Often silent", "Metabolic and alcohol causes", "Risk of progression" ], "appearance": "Usually no visible signs early; seen on ultrasound as a bright liver.", "visual_identification": [ "Excess fat in the liver", "Acute fatty liver of pregnancy, alcoholic fatty liver, metabolic dysfunction-associated steatotic liver disease, steatohepatitis, focal fatty liver, non-alcoholic steatohepatitis", "Viral hepatitis is infectious; cirrhosis is scarring; gallbladder disease affects bile storage; foie gras is fattened animal liver" ], "physical_properties": [ { "quantity": "MASLD nomenclature adopted", "typical_range": "2023", "unit": "year", "note": "multi-society Delphi consensus" }, { "quantity": "steatosis threshold", "typical_range": "fat in at least 5 percent of hepatocytes", "unit": "note", "note": "" }, { "quantity": "first US-approved MASH drug", "typical_range": "resmetirom, 2024", "unit": "note", "note": "check current options" } ], "families_and_kinds": [ "MASLD", "MASH", "alcohol-related fatty liver", "MetALD overlap", "acute fatty liver of pregnancy", "focal fatty change" ], "related_models": [ { "relation": "is a kind of", "target": "lipid storage disease", "why": "in registry terms" }, { "relation": "can progress to", "target": "cirrhosis", "why": "" }, { "relation": "is related to", "target": "metabolic syndrome", "why": "" }, { "relation": "is contrasted with", "target": "viral hepatitis", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "AASLD and EASL guidelines", "Alcohol health guidance", "Obstetric guidelines for acute fatty liver of pregnancy" ], "failure_modes_and_hazards": [ "Missing acute fatty liver of pregnancy", "Stigmatising weight", "Diagnosing individuals" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What fatty liver disease is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "Is someone vomiting blood, confused, deeply jaundiced or a pregnant woman in late pregnancy with vomiting and abdominal pain, in which case seek emergency care now?", "kind": "boundary" }, { "text": "What is fatty liver disease, and how does it differ from viral hepatitis, cirrhosis, gallbladder disease and foie gras?", "kind": "definition" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Named forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are MASLD, MASH, alcoholic fatty liver, focal fatty liver and acute fatty liver of pregnancy?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "medicine", "name": "Medicine", "description": "Causes and assessment.", "rationale": "Science.", "layers": [ { "id": "nomenclature", "name": "Nomenclature", "description": "Renaming.", "findings": [ { "id": "nomenclature-finding", "name": "Nomenclature", "description": "Nomenclature.", "questions": [ { "text": "Why did liver societies rename NAFLD to MASLD in 2023?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "assessment", "name": "Assessment", "description": "Assessment.", "findings": [ { "id": "assessment-finding", "name": "Assessment", "description": "Assessment.", "questions": [ { "text": "How are fibrosis scores and elastography used, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Management.", "rationale": "Regulation.", "layers": [ { "id": "lifestyle", "name": "Lifestyle", "description": "Lifestyle measures.", "findings": [ { "id": "lifestyle-finding", "name": "Lifestyle", "description": "Lifestyle.", "questions": [ { "text": "What do guidelines say about weight loss, exercise and alcohol, in general terms?", "kind": "provenance" }, { "text": "Which entry fits weight management?", "kind": "action" } ] } ] }, { "id": "drugs", "name": "Drugs", "description": "Medicines.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "Which medicines are approved or studied for MASH, checked against current sources?", "kind": "provenance" }, { "text": "Is the information current?", "kind": "boundary" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Public health.", "rationale": "Attribution.", "layers": [ { "id": "prevalence", "name": "Prevalence", "description": "Global burden.", "findings": [ { "id": "prevalence-finding", "name": "Prevalence", "description": "Prevalence.", "questions": [ { "text": "What do studies estimate about global prevalence, with figures attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral and non-stigmatising?", "kind": "boundary" } ] } ] }, { "id": "children", "name": "Children", "description": "Paediatric fatty liver.", "findings": [ { "id": "children-finding", "name": "Children", "description": "Children.", "questions": [ { "text": "How does fatty liver disease affect children and adolescents?", "kind": "provenance" }, { "text": "Which entry fits childhood obesity?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should acute fatty liver of pregnancy be a separate entry?", "How should the MASLD renaming be reflected across aliases?", "How should treatment approvals be kept current?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a fatty liver disease, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain fatty liver disease in general terms, relay types, new nomenclature, risk factors, assessment and management from hepatology sources, route emergencies including acute fatty liver of pregnancy, point people to clinicians and alcohol support, describe the named forms, and distinguish fatty liver disease from viral hepatitis, cirrhosis as an end stage, gallbladder disease and foie gras production, without diagnosing individuals.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: acute fatty liver of pregnancy, alcoholic fatty liver, metabolic dysfunction–associated steatotic liver disease, steatohepatitis, Focal fatty liver, non-alcoholic steatohepatitis, non-alcoholic fatty liver.", "7 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 41 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a fatty liver disease, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "acute fatty liver of pregnancy", "alcoholic fatty liver", "metabolic dysfunction–associated steatotic liver disease", "steatohepatitis", "Focal fatty liver", "non-alcoholic steatohepatitis", "non-alcoholic fatty liver" ] } ], "standing": "Described in 41 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 7 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one fatty liver disease from another, and a fatty liver disease from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a fatty liver disease sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a fatty liver disease from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a fatty liver disease passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a fatty liver disease between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a fatty liver disease, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a fatty liver disease is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of fatty liver disease a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define fatty liver disease, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover fatty liver disease, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How fatty liver disease develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does fatty liver disease typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for fatty liver disease, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a fatty liver disease came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a fatty liver disease and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a fatty liver disease is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a fatty liver disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a fatty liver disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a fatty liver disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }