{ "model": { "rank": 13092, "code": "thing-q611984", "model_id": "vr.tr.keratoconus", "name": "keratoconus", "purpose": "Let an agent explain keratoconus and its course, relay diagnosis, treatment and genetics from ophthalmology sources in general terms, describe the forms and stages the registry aliases name, and distinguish keratoconus from regular astigmatism, other corneal ectasias and corneal dystrophies, routing people to eye care professionals.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q611984/", "tier": 2, "score": 38, "payload": { "layer": "wikidata", "aliases": [ "acute hydrops keratoconus", "stable condition keratoconus", "syndromic keratoconus", "keratoconus 1", "keratoconus 3", "keratoconus 2", "keratoconus 4", "keratoconus 5", "keratoconus 6", "keratoconus 8", "keratoconus 7" ], "aliasCount": 11, "merged": 11, "knownIn": 38, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q611984", "url": "https://www.wikidata.org/wiki/Q611984", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T15:18:08Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q611984", "registryId": "vr.tr.keratoconus", "name": "keratoconus", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q611984/", "model": { "registry_id": "vr.tr.keratoconus", "name": "keratoconus", "purpose": "Let an agent explain keratoconus and its course, relay diagnosis, treatment and genetics from ophthalmology sources in general terms, describe the forms and stages the registry aliases name, and distinguish keratoconus from regular astigmatism, other corneal ectasias and corneal dystrophies, routing people to eye care professionals.", "definition": "A progressive eye condition in which the cornea thins and bulges into a cone shape, causing distorted vision and irregular astigmatism, usually beginning in adolescence, with genetic contributions mapped as keratoconus 1, 2, 3 and further loci, syndromic forms associated with conditions such as Down syndrome, a stable stage in adulthood and acute hydrops when the inner corneal layer ruptures; treatment ranges from contact lenses and corneal cross-linking to transplantation. The model routes symptoms to eye care professionals.", "what_it_is_for": "Not applicable; a condition.", "affordances": [ "explain the condition", "relay diagnosis and treatment", "route to eye care", "distinguish related conditions" ], "distinguishing_features": [ "Corneal ectasia", "Irregular astigmatism", "Genetic and environmental", "Cross-linking treatment" ], "appearance": "Not a visible object; a cone-shaped cornea on imaging.", "visual_identification": [ "Cone-shaped thinning of the cornea", "Keratoconus 1, 2 and 3 loci, syndromic keratoconus, stable keratoconus, acute hydrops", "Regular astigmatism is symmetric; pellucid marginal degeneration is another ectasia; dystrophies are different" ], "physical_properties": [ { "quantity": "prevalence", "typical_range": "about 1 in 2000", "unit": "note", "note": "estimates vary widely" }, { "quantity": "onset", "typical_range": "adolescence to early adulthood", "unit": "note", "note": "" }, { "quantity": "cross-linking approved, US", "typical_range": "2016", "unit": "year", "note": "" }, { "quantity": "keratoconus loci", "typical_range": "multiple, e.g. KTCN1-4", "unit": "note", "note": "" } ], "families_and_kinds": [ "sporadic keratoconus", "familial keratoconus with mapped loci such as keratoconus 1, 2 and 3", "syndromic keratoconus", "progressive and stable stages", "acute corneal hydrops" ], "related_models": [ { "relation": "is a kind of", "target": "corneal disease", "why": "in registry terms" }, { "relation": "is a kind of", "target": "rare genetic eye disease", "why": "in registry terms" }, { "relation": "is treated by", "target": "corneal collagen cross-linking", "why": "to halt progression" }, { "relation": "is contrasted with", "target": "astigmatism", "why": "the regular form" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "H18.6", "note": "keratoconus" }, { "scheme": "OMIM", "value_or_pattern": "148300", "note": "keratoconus 1" }, { "scheme": "MeSH", "value_or_pattern": "D007640", "note": "Keratoconus" } ], "standards_and_regulation": [ "Ophthalmology treatment guidelines", "Regulatory approval of cross-linking devices" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Eye rubbing as a risk factor", "Registry aliases mixing loci and stages" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What keratoconus is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is keratoconus, and how does it differ from regular astigmatism, other ectasias and dystrophies?", "kind": "definition" }, { "text": "Is the user describing personal vision changes, which need an eye care professional?", "kind": "boundary" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Forms and stages.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are keratoconus 1, 2 and 3, syndromic keratoconus, the stable stage and acute hydrops?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is keratoconus diagnosed with corneal topography and tomography, as guidelines describe?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How do contact lenses, cross-linking, intracorneal rings and transplantation help, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "science", "name": "Science", "description": "Science.", "rationale": "Science.", "layers": [ { "id": "genetics", "name": "Genetics", "description": "Genetics.", "findings": [ { "id": "genetics-finding", "name": "Genetics", "description": "Genetics.", "questions": [ { "text": "What is known about genetic loci and heritability?", "kind": "provenance" }, { "text": "Which entry fits the specific locus?", "kind": "action" } ] } ] }, { "id": "risk", "name": "Risk", "description": "Risk factors.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Risk.", "questions": [ { "text": "What roles do eye rubbing, allergy and connective tissue conditions play, as research reports?", "kind": "provenance" }, { "text": "Which entry fits corneal ectasia?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Living and history.", "rationale": "Context.", "layers": [ { "id": "living", "name": "Living", "description": "Living with keratoconus.", "findings": [ { "id": "living-finding", "name": "Living", "description": "Living.", "questions": [ { "text": "How does keratoconus affect daily life, and what support exists?", "kind": "provenance" }, { "text": "Which entry fits visual impairment?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did understanding and treatment of keratoconus develop?", "kind": "provenance" }, { "text": "Which entry fits the history of ophthalmology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should acute hydrops and the genetic loci be separate primary entries?", "How should ophthalmology sources be linked?", "The registry entry has merged aliases naming loci, stages and complications; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a keratoconus, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain keratoconus and its course, relay diagnosis, treatment and genetics from ophthalmology sources in general terms, describe the forms and stages the registry aliases name, and distinguish keratoconus from regular astigmatism, other corneal ectasias and corneal dystrophies, routing people to eye care professionals.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: acute hydrops keratoconus, stable condition keratoconus, syndromic keratoconus, keratoconus 1, keratoconus 3, keratoconus 2, keratoconus 4, keratoconus 5, keratoconus 6, keratoconus 8, keratoconus 7.", "11 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 38 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a keratoconus, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "acute hydrops keratoconus", "stable condition keratoconus", "syndromic keratoconus", "keratoconus 1", "keratoconus 3", "keratoconus 2", "keratoconus 4", "keratoconus 5", "keratoconus 6", "keratoconus 8", "keratoconus 7" ] } ], "standing": "Described in 38 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 11 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one keratoconus from another, and a keratoconus from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a keratoconus sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a keratoconus from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a keratoconus passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a keratoconus between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a keratoconus, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a keratoconus is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What keratoconus is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of keratoconus are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is keratoconus operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of keratoconus and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of keratoconus?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as keratoconus?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a keratoconus came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a keratoconus and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a keratoconus is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a keratoconus, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a keratoconus, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a keratoconus is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }