{ "model": { "rank": 5569, "code": "thing-q61233", "model_id": "vr.tr.histamine", "name": "histamine", "purpose": "Enable an agent to recognise histamine, assess its chemical and biological context, and determine appropriate measurement, handling and use.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q61233/", "tier": 2, "score": 66, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 66, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q61233", "url": "https://www.wikidata.org/wiki/Q61233", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T22:40:09Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 17.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08853-286f-7921-8abe-2d497ed798b2\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: histamine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 188 things:\n# Batch 006: 1001 regist", "usd": 0, "recall": true }, "codex": { "seconds": 63.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08853-2864-7b90-b99a-d6e2f6fe9651\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: histamine\nRegistry id: vr.tr.histamine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCont" } } }, "metaModel": { "id": "THING-Q61233", "registryId": "vr.tr.histamine", "name": "histamine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q61233/", "model": { "registry_id": "vr.tr.histamine", "name": "histamine", "purpose": "Enable an agent to recognise histamine, assess its chemical and biological context, and determine appropriate measurement, handling and use.", "definition": "Histamine is a biogenic amine formed by decarboxylation of histidine that acts through histamine receptors as a mediator of immune responses, gastric acid secretion and neurotransmission.", "scope_statement": "This model owns histamine as a chemical substance, including its identity, material forms, sample quality, context-dependent biological activity and evidence needed for decisions about its presence or use.", "in_scope": [ "Histamine identity, molecular structure, protonation state and distinction from salts and formulated products", "Composition, purity, concentration and physical condition of histamine-containing samples", "Histamine formation, metabolism and receptor-mediated activity as relations to biological processes", "Measurement of histamine in chemical, biological and food matrices", "Evidence governing storage, handling and interpretation of histamine exposure" ], "out_of_scope": [ "Complete models of histidine, antihistamines and other biogenic amines", "Diseases and clinical diagnoses associated with histamine", "Foods, medicines and laboratory products as complete products", "Full models of histamine receptors, cells, organisms and microbial species", "Manufacturing processes and clinical treatment protocols" ], "distinguishing_features": [ "Histamine has an imidazole ring with an aminoethyl side chain; a candidate identity must match this connectivity rather than merely contain an imidazole group.", "Histamine lacks the carboxyl group present in its precursor histidine, so histidine content cannot be recorded as histamine content.", "A histamine salt includes counterions and has a different formula mass from histamine free base; its weighed mass cannot be treated as an equal mass of free base.", "An antihistamine is identified through its own chemical identity and pharmacological action, not classified as histamine because its name or use refers to histamine.", "Histamine detected in food and histamine released by cells share a chemical identity, but their origin and exposure context require separate records." ], "characteristics": [ { "name": "Chemical identity", "kind": "category", "unit_or_values": "Verified structure, molecular formula and form-specific CAS, PubChem and EC identifiers where available", "why_it_matters": "Prevents confusion between histamine, its salts, precursors and similarly named compounds." }, { "name": "Material form and protonation context", "kind": "state", "unit_or_values": "Free base or named salt; counterion stoichiometry; hydration state; solution pH", "why_it_matters": "Determines mass conversion, solution behaviour and applicability of reference properties." }, { "name": "Histamine concentration", "kind": "measurement", "unit_or_values": "mol/L, mass/volume or mass/mass with matrix and free-base-equivalent or salt basis specified", "why_it_matters": "Makes quantities comparable and supports preparation, exposure assessment and interpretation." }, { "name": "Purity and impurity profile", "kind": "measurement", "unit_or_values": "Assay percentage with method and reporting basis; identified impurities and their amounts", "why_it_matters": "Determines suitability for analytical or experimental use and identifies potential confounders." }, { "name": "Physical properties under stated conditions", "kind": "measurement", "unit_or_values": "Phase; melting or decomposition temperature in °C; solubility in g/L or mol/L with solvent, pH and temperature", "why_it_matters": "Supports preparation and storage without transferring properties between incompatible material forms." }, { "name": "Sample matrix", "kind": "category", "unit_or_values": "Neat material, prepared solution, food, biological fluid, tissue or other specified matrix", "why_it_matters": "Controls sampling, extraction, analytical interference and interpretation." }, { "name": "Formation and removal context", "kind": "relation", "unit_or_values": "Documented links to histidine decarboxylation, cellular release, uptake or metabolic degradation", "why_it_matters": "Helps explain whether a measured amount represents accumulation, release or clearance." }, { "name": "Receptor and response context", "kind": "relation", "unit_or_values": "H1, H2, H3 or H4 receptor; species, tissue, assay and measured response", "why_it_matters": "Prevents biological effects observed in one system from being treated as universal properties." }, { "name": "Analytical confidence", "kind": "measurement", "unit_or_values": "Detection and quantification limits, recovery, precision and uncertainty in method-appropriate units", "why_it_matters": "Distinguishes reliable quantification from tentative identification or an unquantifiable signal." }, { "name": "Applicable hazard and decision status", "kind": "category", "unit_or_values": "Verified form-specific hazard classification and context-specific criteria, with source, jurisdiction and date", "why_it_matters": "Connects actions to applicable evidence rather than assuming one universal histamine safety threshold." } ], "affordances": [ "Resolve whether a record describes histamine free base, a named salt or histamine within a mixture.", "Convert reported amounts to a common histamine basis when composition and reporting conventions are verified.", "Select and assess sampling and analytical methods appropriate to the matrix and required sensitivity.", "Relate changes in histamine concentration to supported formation, release or degradation pathways.", "Evaluate whether a histamine sample is suitable for a specified analytical or biological experiment.", "Determine applicable handling instructions and flag measurements requiring specialist interpretation." ] }, "sources": [], "structure": { "bundles": [ { "id": "histamine-identity-and-form", "name": "Histamine identity and form", "description": "Establishes the chemical entity and the material form actually represented.", "rationale": "Histamine, histidine and histamine salts can be confused in names, identifiers and quantity calculations.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Recognises histamine through chemical structure and supported identifiers.", "findings": [ { "id": "histamine-structural-boundary", "name": "Histamine structural boundary", "description": "Recognition requires histamine connectivity and explicit exclusion of precursors, metabolites and receptor-blocking compounds.", "questions": [ { "text": "What verified structure and identifiers establish that the entity is histamine?", "kind": "definition", "id": "histamine-structural-boundary-q01" }, { "text": "Does this record instead describe histidine, a histamine metabolite or an antihistamine?", "kind": "boundary", "id": "histamine-structural-boundary-q02" } ] } ] }, { "id": "salt-and-solution-form", "name": "Salt and solution form", "description": "Separates supplied material identity from histamine species present in solution.", "findings": [ { "id": "histamine-quantity-basis", "name": "Histamine quantity basis", "description": "Amounts must distinguish free base, salt mass and histamine-equivalent content, with solution conditions recorded separately.", "questions": [ { "text": "Is the material free base or a specified salt, and what counterion, hydration state and stoichiometry are documented?", "kind": "definition", "id": "histamine-quantity-basis-q01" }, { "text": "Are reported quantities based on the supplied material or histamine equivalents, and what verified conversion applies?", "kind": "measurement", "id": "histamine-quantity-basis-q02" } ] } ] } ] }, { "id": "histamine-material-fitness", "name": "Histamine material fitness", "description": "Assesses the composition and condition of histamine material intended for measurement or use.", "rationale": "Form, impurities and solution conditions can change the meaning of a nominal histamine amount and the suitability of a sample.", "layers": [ { "id": "assay-and-impurities", "name": "Assay and impurities", "description": "Establishes how much histamine is present and what accompanies it.", "findings": [ { "id": "usable-histamine-content", "name": "Usable histamine content", "description": "Sample fitness depends on an assay with a clear reporting basis and relevant impurity information.", "questions": [ { "text": "What assay establishes histamine content, and does its percentage refer to dry material, supplied material or another basis?", "kind": "measurement", "id": "usable-histamine-content-q01" }, { "text": "Which residual precursors, other amines, solvents or counterions could interfere with the intended use?", "kind": "action", "id": "usable-histamine-content-q02" } ] } ] }, { "id": "physical-condition-and-storage", "name": "Physical condition and storage", "description": "Records properties and storage evidence for the particular histamine form or preparation.", "findings": [ { "id": "form-specific-property-evidence", "name": "Form-specific property evidence", "description": "Solubility, phase transitions and stability claims must identify material form and experimental conditions.", "questions": [ { "text": "What measured phase, solubility and melting or decomposition behaviour apply to this histamine form under stated conditions?", "kind": "measurement", "id": "form-specific-property-evidence-q01" }, { "text": "What evidence supports the storage conditions and usable lifetime of this solid or prepared histamine solution?", "kind": "provenance", "id": "form-specific-property-evidence-q02" } ] } ] } ] }, { "id": "histamine-biological-context", "name": "Histamine biological context", "description": "Connects histamine to its formation, removal and receptor-dependent effects.", "rationale": "Chemical identity alone cannot explain where histamine came from or what a particular concentration means biologically.", "layers": [ { "id": "formation-release-and-removal", "name": "Formation, release and removal", "description": "Distinguishes production from release of existing stores and subsequent metabolism.", "findings": [ { "id": "histamine-origin-and-fate", "name": "Histamine origin and fate", "description": "Changes in histamine amount require context about histidine conversion, cellular release and removal pathways.", "questions": [ { "text": "What evidence attributes the histamine to endogenous synthesis, cellular release, microbial formation or external addition?", "kind": "provenance", "id": "histamine-origin-and-fate-q01" }, { "text": "Which formation or removal processes could change histamine between the event of interest and measurement?", "kind": "measurement", "id": "histamine-origin-and-fate-q02" } ] } ] }, { "id": "receptor-dependent-response", "name": "Receptor-dependent response", "description": "Locates biological activity within a defined receptor, tissue and experimental system.", "findings": [ { "id": "bounded-histamine-effect", "name": "Bounded histamine effect", "description": "An observed histamine response belongs to its tested concentration, duration and biological context.", "questions": [ { "text": "Which histamine receptor subtype, species, tissue and response endpoint are implicated by the evidence?", "kind": "definition", "id": "bounded-histamine-effect-q01" }, { "text": "What concentration and exposure duration produced the response, and what limits transfer to another biological setting?", "kind": "boundary", "id": "bounded-histamine-effect-q02" } ] } ] } ] }, { "id": "histamine-detection-and-quantification", "name": "Histamine detection and quantification", "description": "Establishes whether analytical results identify and quantify histamine reliably.", "rationale": "Histamine measurements depend on matrix, sampling history, selectivity and reporting conventions.", "layers": [ { "id": "sampling-and-matrix", "name": "Sampling and matrix", "description": "Captures the origin and handling of the portion submitted for analysis.", "findings": [ { "id": "representative-histamine-sample", "name": "Representative histamine sample", "description": "A result must retain its matrix and sampling history to represent the intended material or biological event.", "questions": [ { "text": "What food portion, fluid, tissue or chemical preparation was sampled, and how representative is it of the target?", "kind": "provenance", "id": "representative-histamine-sample-q01" }, { "text": "How were collection timing, temperature, preservation and extraction controlled to limit changes in histamine content?", "kind": "measurement", "id": "representative-histamine-sample-q02" } ] } ] }, { "id": "analytical-selectivity-and-reporting", "name": "Analytical selectivity and reporting", "description": "Evaluates identification, calibration and uncertainty in the reported histamine result.", "findings": [ { "id": "defensible-histamine-result", "name": "Defensible histamine result", "description": "A defensible result distinguishes histamine from interfering compounds and states the limits of quantification.", "questions": [ { "text": "How does the method distinguish histamine from histidine, other biogenic amines and matrix interference?", "kind": "measurement", "id": "defensible-histamine-result-q01" }, { "text": "What calibration traceability, recovery, quantification limit and uncertainty support the reported value and units?", "kind": "measurement", "id": "defensible-histamine-result-q02" } ] } ] } ] }, { "id": "histamine-handling-and-decisions", "name": "Histamine handling and decisions", "description": "Connects material hazards and measured histamine to justified actions in a specific use context.", "rationale": "Laboratory handling, food assessment and biological interpretation require different evidence and cannot share an assumed universal threshold.", "layers": [ { "id": "material-hazard-and-use", "name": "Material hazard and use", "description": "Establishes handling requirements for the supplied form and intended operation.", "findings": [ { "id": "applicable-histamine-handling", "name": "Applicable histamine handling", "description": "Handling decisions require a current safety source that matches the actual substance form or mixture.", "questions": [ { "text": "Which safety data and hazard classification apply to this histamine form, concentration and jurisdiction?", "kind": "provenance", "id": "applicable-histamine-handling-q01" }, { "text": "What handling, storage and disposal measures follow for the intended preparation or experiment?", "kind": "action", "id": "applicable-histamine-handling-q02" } ] } ] }, { "id": "exposure-and-interpretation", "name": "Exposure and interpretation", "description": "Separates analytical observations from conclusions about exposure, compliance or health.", "findings": [ { "id": "context-specific-histamine-decision", "name": "Context-specific histamine decision", "description": "A histamine measurement supports a decision only when the relevant matrix, exposure and interpretation criteria are established.", "questions": [ { "text": "What route, amount, timing and sample context connect the measured histamine to the proposed decision?", "kind": "boundary", "id": "context-specific-histamine-decision-q01" }, { "text": "Which verified regulatory criterion, validated reference interval or experimental acceptance rule applies, and what action does it support?", "kind": "action", "id": "context-specific-histamine-decision-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled knowledge, not a source-verified account.", "Physical constants, purity specifications and hazard classifications must be checked for the particular free base or salt.", "Applicable food limits, analytical methods and medicinal preparation requirements need jurisdiction-specific verification." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Histamine free base", "Histamine dihydrochloride, a salt form" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "51-45-6", "note": "Identifies histamine free base; salts have separate identifiers." }, { "scheme": "PubChem CID", "value_or_pattern": "774", "note": "Compound record for histamine." }, { "scheme": "Molecular formula", "value_or_pattern": "C5H9N3", "note": "Formula of the neutral molecule; not a unique structural identifier." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Positive control in allergy skin testing using formulated histamine preparations.", "Experimental reagent for studying histamine receptors and their physiological effects.", "Analytical reference material for measuring histamine in food and biological samples.", "Food safety testing target, particularly in fish susceptible to histamine accumulation." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of histamine free base", "typical_range": "111.15", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Excess histamine exposure can produce flushing, headache, itching, gastrointestinal symptoms and cardiovascular effects.", "Microbial conversion of histidine to histamine in improperly stored fish can cause scombroid poisoning.", "Histamine already present in food is not reliably eliminated by ordinary cooking.", "Confusing free-base and salt masses produces concentration errors when preparing solutions." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Food safety limits and sampling requirements for histamine vary by jurisdiction and food category." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Histidine", "difference": "Histidine is an amino acid with a carboxyl group; its decarboxylation produces histamine." }, { "name": "Histamine receptor", "difference": "A receptor is a protein that responds to histamine; histamine is its small-molecule ligand." }, { "name": "Antihistamine", "difference": "An antihistamine modifies or blocks histamine receptor activity rather than being histamine itself." }, { "name": "Histamine-containing food", "difference": "A food is a mixture whose histamine concentration can vary; histamine is the individual chemical constituent." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of histamine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative identifiers and reference records should anchor histamine free base and link its salts without conflating their material properties?", "What reliable form-specific measurements establish solubility, acid-base behaviour, phase transitions and storage stability, including whether reported boiling values describe meaningful experimental behaviour?", "Which validated methods and sampling controls are appropriate for the intended food, biological and laboratory matrices, and what interference or recovery limitations remain?", "Which current hazard classifications, occupational exposure limits if any, and food criteria apply in the target jurisdictions and to which forms or matrices?", "What evidence supports interpretation of histamine measurements in each biological setting, and which conclusions remain unsupported by a concentration measurement alone?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a histamine, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an agent to recognise histamine, assess its chemical and biological context, and determine appropriate measurement, handling and use.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 66 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a histamine, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 66 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one histamine from another, and a histamine from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a histamine sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a histamine from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a histamine is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a histamine is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a histamine is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a histamine is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a histamine is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a histamine is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a histamine passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a histamine between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a histamine, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a histamine is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a histamine and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a histamine is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a histamine performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a histamine.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a histamine at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a histamine there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What histamine is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name histamine unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of histamine exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How histamine behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of histamine, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is histamine incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How histamine can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is histamine classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover histamine, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a histamine came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a histamine and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a histamine is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a histamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a histamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a histamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }