{ "model": { "rank": 12205, "code": "thing-q641307", "model_id": "vr.tr.immunodeficiency", "name": "immunodeficiency", "purpose": "Let an agent give accurate general information on immunodeficiency, recognise urgent situations for immunocompromised people, explain types and management in general terms, and point to specialist care and support without individual medical advice.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q641307/", "tier": 2, "score": 40, "payload": { "layer": "wikidata", "aliases": [ "Epstein-Barr virus-associated malignant lymphoproliferative disorder", "lymphoid neoplasm", "Nijmegen breakage syndrome-like disorder", "EBV-related posttransplantation lymphoproliferative disease", "immunodeficiency syndrome with abnormal pigmentation", "autoimmune lymphoproliferative syndrome", "immunodeficiency-centromeric instability-facial anomalies syndrome 1", "familial cold autoinflammatory syndrome 3", "RAS-associated autoimmune leukoproliferative disorder", "type 1a ALPS", "autoimmune lymphoproliferative syndrome type 1b", "Type 2 Autoimmune Lymphoproliferative Syndrome", "familial cold urticaria", "familial cold autoinflammatory syndrome 2", "familial cold autoinflammatory syndrome 1", "familial cold autoinflammatory syndrome 4", "hypoproteinemia, Hypercatabolic", "immunodeficiency 47", "mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency", "autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency", "acquired immunodeficiency", "primary immunodeficiency disease", "combined immunodeficiency", "immunodeficiency with defective leukocyte and lymphocyte function and With response to Histamine-1 antagonist", "Tuftsin deficiency", "immunodeficiency with defective T-cell response to interleukin 1", "immunodeficiency without anhidrotic ectodermal dysplasia", "immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein", "immunodeficiency 65", "T cell and NK cell immunodeficiency", "immunodeficiency 51", "dendritic cell deficiency", "NK cell deficiency", "immunodeficiency 57", "immunodeficiency 66", "immunodeficiency 18", "B cell deficiency", "congenital disorder of natural immunity", "NEMO deficiency syndrome", "Mendelian susceptibility to mycobacterial disease" ], "aliasCount": 92, "merged": 92, "knownIn": 40, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.immunodeficiency", "source": { "dataset": "wikidata", "item": "Q641307", "url": "https://www.wikidata.org/wiki/Q641307", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T20:38:30Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q641307", "registryId": "vr.tr.immunodeficiency", "name": "immunodeficiency", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q641307/", "model": { "registry_id": "vr.tr.immunodeficiency", "name": "immunodeficiency", "purpose": "Let an agent give accurate general information on immunodeficiency, recognise urgent situations for immunocompromised people, explain types and management in general terms, and point to specialist care and support without individual medical advice.", "definition": "A state in which the immune system ability to fight infection and disease is reduced or absent, either primary and inherited, as in many rare genetic syndromes, or secondary and acquired through conditions such as HIV infection, cancer treatment, transplantation medicines or malnutrition; immunodeficiency increases susceptibility to infections and some cancers and is managed by specialist care.", "what_it_is_for": "A group of conditions requiring specialist care.", "affordances": [ "explain primary and secondary immunodeficiency", "recognise urgent situations", "explain management and precautions in general terms", "find specialist centres and patient organisations" ], "distinguishing_features": [ "Reduced immune function", "Primary or secondary", "Infection susceptibility", "Specialist management" ], "appearance": "Not physical; a diagnosis from history and immune testing.", "visual_identification": [ "Recurrent, severe or unusual infections", "Inherited or acquired", "Autoimmunity is an overactive rather than deficient response" ], "physical_properties": [], "families_and_kinds": [ "primary immunodeficiencies", "secondary immunodeficiency from infection such as HIV", "treatment-related immunosuppression", "immunodeficiency-associated lymphoproliferative disorders", "immunodeficiency in older age and malnutrition" ], "related_models": [ { "relation": "is a kind of", "target": "immune disorder", "why": "category" }, { "relation": "is treated by", "target": "health care", "why": "services" }, { "relation": "is related to", "target": "hemopoiesis", "why": "immune cell production" }, { "relation": "is related to", "target": "inflammatory bowel diseases", "why": "other immune disorder" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines from immunology societies", "Vaccination guidance for immunocompromised people", "Rare disease frameworks" ], "failure_modes_and_hazards": [ "Delayed treatment of infections", "Agents giving individual medical advice", "Inappropriate live vaccines" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "urgent", "name": "Urgent", "description": "Infections in immunocompromised people.", "rationale": "Act early.", "layers": [ { "id": "fever", "name": "Fever", "description": "Signs of infection.", "findings": [ { "id": "fever-finding", "name": "Fever", "description": "Infection signs.", "questions": [ { "text": "Does an immunocompromised person have fever or signs of infection?", "kind": "boundary" }, { "text": "Should they seek urgent care according to their care plan?", "kind": "action" } ] } ] }, { "id": "plan", "name": "Plan", "description": "Care plans.", "findings": [ { "id": "plan-finding", "name": "Plan", "description": "Care plans.", "questions": [ { "text": "Does the person have an emergency plan from their specialist team?", "kind": "provenance" }, { "text": "Who should be contacted?", "kind": "provenance" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "Types and causes.", "rationale": "General information.", "layers": [ { "id": "types", "name": "Types", "description": "Primary and secondary.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What are primary and secondary immunodeficiencies, and how do they arise, in general terms?", "kind": "definition" }, { "text": "Is the user asking about their own diagnosis?", "kind": "boundary" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "How diagnosed.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How are immunodeficiencies diagnosed, according to guidelines?", "kind": "provenance" }, { "text": "Which warning signs prompt testing?", "kind": "provenance" } ] } ] } ] }, { "id": "manage", "name": "Manage", "description": "Living with immunodeficiency.", "rationale": "Precautions and care.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Management options.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Management.", "questions": [ { "text": "Which treatments are used, such as immunoglobulin replacement or prophylaxis, in general terms?", "kind": "provenance" }, { "text": "Which questions should be asked of the specialist?", "kind": "action" } ] } ] }, { "id": "precautions", "name": "Precautions", "description": "Daily precautions.", "findings": [ { "id": "precautions-finding", "name": "Precautions", "description": "Precautions.", "questions": [ { "text": "What do guidelines advise on vaccination, hygiene and exposure for immunocompromised people?", "kind": "provenance" }, { "text": "Which vaccines are unsuitable?", "kind": "provenance" } ] } ] } ] }, { "id": "support", "name": "Support", "description": "Help and research.", "rationale": "Communities help.", "layers": [ { "id": "orgs", "name": "Organisations", "description": "Patient groups.", "findings": [ { "id": "orgs-finding", "name": "Organisations", "description": "Patient groups.", "questions": [ { "text": "Which patient organisations support people with immunodeficiency here?", "kind": "provenance" }, { "text": "Which services do they offer?", "kind": "provenance" } ] } ] }, { "id": "research", "name": "Research", "description": "Research and registries.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "Which registries and research programmes exist?", "kind": "provenance" }, { "text": "How can patients participate?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should primary and secondary forms be separate entries?", "How should guidelines be linked?", "How should patient organisations be localised?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a immunodeficiency, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent give accurate general information on immunodeficiency, recognise urgent situations for immunocompromised people, explain types and management in general terms, and point to specialist care and support without individual medical advice.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Epstein-Barr virus-associated malignant lymphoproliferative disorder, lymphoid neoplasm, Nijmegen breakage syndrome-like disorder, EBV-related posttransplantation lymphoproliferative disease, immunodeficiency syndrome with abnormal pigmentation, autoimmune lymphoproliferative syndrome, immunodeficiency-centromeric instability-facial anomalies syndrome 1, familial cold autoinflammatory syndrome 3, RAS-associated autoimmune leukoproliferative disorder, type 1a ALPS, autoimmune lymphoproliferative syndrome type 1b, Type 2 Autoimmune Lymphoproliferative Syndrome.", "92 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 40 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a immunodeficiency, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Epstein-Barr virus-associated malignant lymphoproliferative disorder", "lymphoid neoplasm", "Nijmegen breakage syndrome-like disorder", "EBV-related posttransplantation lymphoproliferative disease", "immunodeficiency syndrome with abnormal pigmentation", "autoimmune lymphoproliferative syndrome", "immunodeficiency-centromeric instability-facial anomalies syndrome 1", "familial cold autoinflammatory syndrome 3", "RAS-associated autoimmune leukoproliferative disorder", "type 1a ALPS", "autoimmune lymphoproliferative syndrome type 1b", "Type 2 Autoimmune Lymphoproliferative Syndrome" ] } ], "standing": "Described in 40 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 92 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one immunodeficiency from another, and a immunodeficiency from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a immunodeficiency sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a immunodeficiency from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a immunodeficiency passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a immunodeficiency between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a immunodeficiency, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a immunodeficiency is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What immunodeficiency is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of immunodeficiency are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is immunodeficiency operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of immunodeficiency and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of immunodeficiency?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as immunodeficiency?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a immunodeficiency came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a immunodeficiency and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a immunodeficiency is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a immunodeficiency, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a immunodeficiency, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a immunodeficiency is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }