{ "model": { "rank": 18237, "code": "thing-q659446", "model_id": "vr.tr.therapeutic-index", "name": "therapeutic index", "purpose": "Let an agent explain the therapeutic index in pharmacology in general terms, why narrow-index drugs are monitored, and refer all personal dosing questions to clinicians and pharmacists.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.REL", "industry": "", "version": "", "url": "/models/thing/q659446/", "tier": 2, "score": 30, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 30, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q659446", "url": "https://www.wikidata.org/wiki/Q659446", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T13:26:00Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 1, "engine": "claude" }, "metaModel": { "id": "THING-Q659446", "registryId": "vr.tr.therapeutic-index", "name": "therapeutic index", "version": "0.2.0-wave.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.REL" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q659446/", "model": { "registry_id": "vr.tr.therapeutic-index", "name": "therapeutic index", "purpose": "Let an agent explain the therapeutic index in pharmacology in general terms, why narrow-index drugs are monitored, and refer all personal dosing questions to clinicians and pharmacists.", "definition": "A quantitative measure comparing the dose of a drug that causes toxicity with the dose that produces the desired effect, often expressed as a ratio such as TD50 to ED50; drugs with a narrow therapeutic index, such as some anticoagulants, lithium and digoxin, need careful dosing and monitoring.", "what_it_is_for": "Pharmacology, drug development and patient safety.", "affordances": [ "explain what the therapeutic index measures", "describe why narrow-index drugs need monitoring", "find official product information", "route overdose concerns to emergency help" ], "distinguishing_features": [ "Compares toxic and effective doses", "Indicates margin of safety", "Narrow for some important drugs", "Guides monitoring" ], "appearance": "Not physical; a ratio or range reported in pharmacology.", "visual_identification": [ "Ratios such as TD50/ED50", "Narrow therapeutic index labelling", "Therapeutic window is a related concept" ], "physical_properties": [], "families_and_kinds": [ "therapeutic index", "therapeutic window", "margin of safety", "narrow therapeutic index drugs" ], "related_models": [ { "relation": "is a kind of", "target": "factor of safety", "why": "category" }, { "relation": "is used in", "target": "pharmacology", "why": "field" }, { "relation": "is related to", "target": "medication", "why": "product" }, { "relation": "is related to", "target": "therapeutic drug monitoring", "why": "practice" } ], "identifiers": [], "standards_and_regulation": [ "Medicines regulatory guidance on narrow therapeutic index drugs", "Generic substitution rules for such drugs" ], "failure_modes_and_hazards": [ "Toxicity from small dosing changes", "Interactions altering drug levels", "Agents giving personal dosing advice" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "emergency", "name": "Emergency", "description": "Overdose.", "rationale": "Safety comes first.", "layers": [ { "id": "overdose", "name": "Overdose", "description": "Too much taken.", "findings": [ { "id": "overdose-finding", "name": "Overdose", "description": "Overdose.", "questions": [ { "text": "Has someone taken too much of a narrow-index medicine or shows signs of toxicity?", "kind": "boundary" }, { "text": "Should a poison centre or emergency services be contacted now?", "kind": "action" } ] } ] }, { "id": "interaction", "name": "Interaction", "description": "New medicines.", "findings": [ { "id": "interaction-finding", "name": "Interaction", "description": "Interactions.", "questions": [ { "text": "Has a new medicine or supplement been started alongside a narrow-index drug?", "kind": "boundary" }, { "text": "Should the person check with their pharmacist promptly?", "kind": "action" } ] } ] } ] }, { "id": "concept", "name": "Concept", "description": "What it measures.", "rationale": "Definitions vary.", "layers": [ { "id": "ratio", "name": "Ratio", "description": "Calculation.", "findings": [ { "id": "ratio-finding", "name": "Ratio", "description": "Ratio.", "questions": [ { "text": "How is the therapeutic index calculated in pharmacology texts?", "kind": "definition" }, { "text": "How does it differ from the therapeutic window?", "kind": "definition" } ] } ] }, { "id": "limits", "name": "Limits", "description": "Interpretation.", "findings": [ { "id": "limits-finding", "name": "Limits", "description": "Interpretation limits.", "questions": [ { "text": "Why can animal-derived indices mislead for humans?", "kind": "boundary" }, { "text": "Which measures are used clinically?", "kind": "provenance" } ] } ] } ] }, { "id": "practice", "name": "Practice", "description": "Monitoring.", "rationale": "Monitoring keeps patients safe.", "layers": [ { "id": "monitoring", "name": "Monitoring", "description": "Drug levels.", "findings": [ { "id": "monitoring-finding", "name": "Monitoring", "description": "Monitoring.", "questions": [ { "text": "Why are blood levels monitored for some narrow-index drugs, in general terms?", "kind": "provenance" }, { "text": "Which official guidance describes it?", "kind": "provenance" } ] } ] }, { "id": "personal", "name": "Personal", "description": "Personal questions.", "findings": [ { "id": "personal-finding", "name": "Personal", "description": "Personal advice limits.", "questions": [ { "text": "Is the user asking about their own dose or test result?", "kind": "boundary" }, { "text": "How should the agent refer them to their prescriber or pharmacist?", "kind": "action" } ] } ] } ] }, { "id": "development", "name": "Development", "description": "Drug development.", "rationale": "Safety margins guide development.", "layers": [ { "id": "trials", "name": "Trials", "description": "Dose finding.", "findings": [ { "id": "trials-finding", "name": "Trials", "description": "Dose finding.", "questions": [ { "text": "How do early trials establish safe and effective doses, in general terms?", "kind": "definition" }, { "text": "Which regulators oversee them?", "kind": "provenance" } ] } ] }, { "id": "generics", "name": "Generics", "description": "Substitution.", "findings": [ { "id": "generics-finding", "name": "Generics", "description": "Generic substitution.", "questions": [ { "text": "Are special rules applied when switching brands of narrow-index drugs here?", "kind": "provenance" }, { "text": "Who decides?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should therapeutic window be a separate entry?", "How should drug lists be sourced?", "How should monitoring guidance be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a therapeutic index, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain the therapeutic index in pharmacology in general terms, why narrow-index drugs are monitored, and refer all personal dosing questions to clinicians and pharmacists.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Described in 30 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a therapeutic index, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [], "standing": "Described in 30 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one therapeutic index from another, and a therapeutic index from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a therapeutic index sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a therapeutic index from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a therapeutic index passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a therapeutic index between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a therapeutic index, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a therapeutic index is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What therapeutic index is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of therapeutic index are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is therapeutic index operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of therapeutic index and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of therapeutic index?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as therapeutic index?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a therapeutic index came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a therapeutic index and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a therapeutic index is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a therapeutic index, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a therapeutic index, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a therapeutic index is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }