{ "model": { "rank": 6186, "code": "thing-q66590068", "model_id": "vr.tr.prolactin", "name": "prolactin", "purpose": "Enable an AI agent to recognise prolactin, assess its molecular and measured state, and determine which analytical, handling or interpretive actions the available evidence supports.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q66590068/", "tier": 2, "score": 62, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 62, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.prolactin", "source": { "dataset": "wikidata", "item": "Q66590068", "url": "https://www.wikidata.org/wiki/Q66590068", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T12:01:18Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00278256, "turns": 1, "seconds": 31, "error": null }, "codex": { "seconds": 95.4, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07bbd-1342-7933-bafc-92b8a51e8e4c\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: prolactin\nRegistry id: vr.tr.prolactin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA Ver" } } }, "metaModel": { "id": "THING-Q66590068", "registryId": "vr.tr.prolactin", "name": "prolactin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q66590068/", "model": { "registry_id": "vr.tr.prolactin", "name": "prolactin", "purpose": "Enable an AI agent to recognise prolactin, assess its molecular and measured state, and determine which analytical, handling or interpretive actions the available evidence supports.", "definition": "Prolactin is a 199-residue anterior-pituitary peptide hormone (human PRL, UniProt P01236) whose circulating monomeric form acts via the prolactin receptor-JAK2/STAT5 axis to drive mammary lactogenesis and modulate reproduction and immunity.", "scope_statement": "This model owns prolactin as a biological substance under vr.tr.prolactin, including species-specific identity, molecular forms, biological context, measured abundance, activity and preparation condition; it links to organism, specimen, assay and disease models.", "in_scope": [ "Species-specific prolactin protein identity and distinction from its encoding gene and receptor.", "Mature, precursor, modified, aggregated and complexed prolactin forms.", "Endogenous production, biological compartment and physiological context.", "Prolactin concentration, biological activity and analytical reliability.", "Isolated or recombinant prolactin preparation quality and fitness for intended use." ], "out_of_scope": [ "PRL gene organisation, inheritance and transcriptional regulation as standalone genetic models.", "Prolactin receptor structure and complete downstream signalling networks.", "Pituitary anatomy, tumour classification and prolactinoma management.", "Patient diagnosis, prescribing and treatment protocols.", "Whole lactation, reproductive or endocrine-system models.", "General specimen logistics and laboratory instrument operation." ], "distinguishing_features": [ "Require a species-linked protein identity: human prolactin maps to UniProt P01236; a PRL gene record or PRLR receptor record does not identify the hormone substance. [UniProt](https://www.uniprot.org/uniprotkb/P01236)", "Distinguish prolactin from growth hormone and placental lactogens using sequence identity or demonstrated analytical specificity; a shared biological response alone is insufficient.", "Distinguish monomeric prolactin from prolactin-containing complexes using molecular-form evidence rather than treating total immunoreactivity as proof of monomer abundance.", "Distinguish the prolactin substance from a concentration result, hyperprolactinaemia or a prolactinoma: those describe an observation, a physiological state and a lesion respectively." ], "characteristics": [ { "name": "Species and protein identity", "kind": "relation", "unit_or_values": "Organism, protein accession and sequence version", "why_it_matters": "Prevents human-specific identity, assays or interpretation from being applied automatically to another species." }, { "name": "Molecular form", "kind": "category", "unit_or_values": "Precursor, mature monomer, modified form, fragment, aggregate, complex, mixed or unresolved", "why_it_matters": "Different forms require separate evidence for detection and biological activity." }, { "name": "Production origin and compartment", "kind": "relation", "unit_or_values": "Producing tissue or expression system; circulation, tissue, culture medium or purified preparation", "why_it_matters": "Connects the material to the context in which its amount and effects can be interpreted." }, { "name": "Measured concentration", "kind": "measurement", "unit_or_values": "ng/mL, µg/L or mIU/L, with analyte definition, method and calibration", "why_it_matters": "Makes abundance interpretable without assuming a universal conversion between mass and activity-based units." }, { "name": "Monomeric prolactin estimate", "kind": "measurement", "unit_or_values": "Concentration and recovery percentage with separation procedure and method-specific interpretation", "why_it_matters": "Keeps total prolactin results separate from estimates obtained after removing larger molecular forms." }, { "name": "Biological activity", "kind": "measurement", "unit_or_values": "Assay-defined response, potency or specific activity with receptor system and reference material", "why_it_matters": "Prevents antibody recognition from being treated as sufficient evidence of functional activity." }, { "name": "Sampling context", "kind": "relation", "unit_or_values": "Collection time linked to sleep, pregnancy, lactation, stimulation, stress and relevant exposures", "why_it_matters": "Allows an agent to assess whether observations were obtained under comparable conditions." }, { "name": "Analytical validity", "kind": "state", "unit_or_values": "Supported, provisional, interference suspected, outside measuring range or unresolved", "why_it_matters": "Controls whether a result supports interpretation or needs laboratory clarification." }, { "name": "Preparation fitness", "kind": "state", "unit_or_values": "Fit for specified use, restricted, degraded, expired or unassessed", "why_it_matters": "Connects identity, purity, activity and storage evidence to a particular experimental use." } ], "affordances": [ "Resolve a prolactin mention or preparation to its species, protein identity and molecular form.", "Request or interpret a prolactin measurement with its specimen, calibration and collection context attached.", "Flag results needing laboratory review for molecular-form effects, interference or dilution checks.", "Compare repeated prolactin observations when assay and physiological contexts support comparison.", "Select, aliquot, store or use a prolactin preparation according to documented stability and activity requirements.", "Route unresolved findings to the appropriate laboratory, organism or clinical model with the supporting evidence." ] }, "sources": [], "structure": { "bundles": [ { "id": "prolactin-identity-and-forms", "name": "Prolactin identity and forms", "description": "Establish which prolactin substance is represented and which molecular forms it contains.", "rationale": "A hormone name alone does not establish species, sequence, processing state or complex composition.", "layers": [ { "id": "species-and-sequence", "name": "Species and sequence", "description": "Anchor prolactin identity to the organism and protein product.", "findings": [ { "id": "protein-identity-evidence", "name": "Protein identity evidence", "description": "Record evidence identifying the prolactin protein independently of gene names or functional resemblance.", "questions": [ { "text": "Which organism, protein accession and sequence identify this prolactin?", "kind": "definition", "id": "protein-identity-evidence-q01" }, { "text": "What evidence distinguishes it from growth hormone, placental lactogens and other related proteins?", "kind": "boundary", "id": "protein-identity-evidence-q02" } ] } ] }, { "id": "processing-and-complexes", "name": "Processing and complexes", "description": "Separate protein processing and modification from aggregation or binding to other molecules.", "findings": [ { "id": "molecular-form-assignment", "name": "Molecular-form assignment", "description": "Record mature or precursor status and evidence for modified, fragmented, aggregated or complexed prolactin.", "questions": [ { "text": "Which molecular forms are demonstrated, and which remain unresolved?", "kind": "definition", "id": "molecular-form-assignment-q01" }, { "text": "What separation or characterisation method supports the distinction between monomeric prolactin and larger prolactin-containing forms?", "kind": "measurement", "id": "molecular-form-assignment-q02" } ] } ] } ] }, { "id": "prolactin-biological-context", "name": "Prolactin biological context", "description": "Locate prolactin production and observation within an organism and physiological timeline.", "rationale": "An observed amount cannot be judged without its biological compartment and collection context.", "layers": [ { "id": "production-and-compartment", "name": "Production and compartment", "description": "Distinguish the place of measurement from the demonstrated source of production.", "findings": [ { "id": "origin-and-location", "name": "Origin and location", "description": "Record whether the material is endogenous or produced experimentally, and where it was observed.", "questions": [ { "text": "Was this prolactin produced endogenously, isolated from biological material or expressed recombinantly?", "kind": "provenance", "id": "origin-and-location-q01" }, { "text": "Which tissue or expression system produced it, and is that origin demonstrated or inferred from its measurement compartment?", "kind": "provenance", "id": "origin-and-location-q02" } ] } ] }, { "id": "physiological-timing", "name": "Physiological timing", "description": "Connect each observation to relevant physiological states and recent events.", "findings": [ { "id": "collection-context", "name": "Collection context", "description": "Record the temporal and physiological circumstances needed to compare prolactin observations.", "questions": [ { "text": "What were the pregnancy or lactation state, sleep timing, recent stimulation and stress context at collection?", "kind": "measurement", "id": "collection-context-q01" }, { "text": "Which medications, interventions or linked organism conditions could affect interpretation, and when did they occur?", "kind": "provenance", "id": "collection-context-q02" } ] } ] } ] }, { "id": "prolactin-measurement-validity", "name": "Prolactin measurement validity", "description": "Define what a prolactin result measures and whether the analytical evidence supports its use.", "rationale": "Reported immunoreactivity, monomeric concentration and functional activity are different observations.", "layers": [ { "id": "analyte-and-calibration", "name": "Analyte and calibration", "description": "Specify the result's molecular target, specimen matrix, units and reference framework.", "findings": [ { "id": "result-definition", "name": "Result definition", "description": "Attach the measurement procedure and applicable reference interval to the numerical result.", "questions": [ { "text": "Does the result represent total immunoreactive prolactin, a post-separation estimate or another explicitly defined analyte?", "kind": "definition", "id": "result-definition-q01" }, { "text": "Which specimen matrix, assay, calibrator, units and population-specific reference interval accompany the result?", "kind": "measurement", "id": "result-definition-q02" } ] } ] }, { "id": "interference-and-resolution", "name": "Interference and resolution", "description": "Capture analytical discrepancies and the checks used to investigate them.", "findings": [ { "id": "analytical-discrepancy", "name": "Analytical discrepancy", "description": "Record unresolved molecular-form or assay effects. High-dose hook effects have produced falsely low prolactin results in immunoradiometric assays. [Primary study](https://pubmed.ncbi.nlm.nih.gov/8729527/)", "questions": [ { "text": "What evidence raises or resolves concern about macroprolactin, high-dose hook effect or platform-specific interference?", "kind": "measurement", "id": "analytical-discrepancy-q01" }, { "text": "Which laboratory-validated dilution, separation or alternative-method check is appropriate before this result is used?", "kind": "action", "id": "analytical-discrepancy-q02" } ] } ] } ] }, { "id": "prolactin-activity-and-state", "name": "Prolactin activity and state", "description": "Assess functional evidence and contextual changes without converting a hormone observation into a disease diagnosis.", "rationale": "An agent must distinguish measured abundance, demonstrated activity and interpretation within a particular organism.", "layers": [ { "id": "functional-response", "name": "Functional response", "description": "Link prolactin material to an explicitly defined biological assay or response.", "findings": [ { "id": "activity-evidence", "name": "Activity evidence", "description": "Record the strength and limits of evidence that the identified material produces a prolactin-associated response.", "questions": [ { "text": "Which receptor system, species, endpoint and reference preparation define the activity measurement?", "kind": "measurement", "id": "activity-evidence-q01" }, { "text": "What controls support attribution of the response to prolactin rather than another component of the sample?", "kind": "boundary", "id": "activity-evidence-q02" } ] } ] }, { "id": "contextual-state-and-trend", "name": "Contextual state and trend", "description": "Interpret individual observations and changes using explicit comparability criteria.", "findings": [ { "id": "state-assessment", "name": "State assessment", "description": "Record whether the observation is interpretable relative to an applicable reference and whether repeated results establish a change.", "questions": [ { "text": "Is this result below, within or above the applicable reference interval, or currently uninterpretable?", "kind": "measurement", "id": "state-assessment-q01" }, { "text": "Do serial results use sufficiently comparable assays, molecular-form definitions and collection conditions to support a trend?", "kind": "boundary", "id": "state-assessment-q02" }, { "text": "What unresolved evidence requires laboratory or clinical review before a consequential decision?", "kind": "action", "id": "state-assessment-q03" } ] } ] } ] }, { "id": "prolactin-preparation-and-use", "name": "Prolactin preparation and use", "description": "Determine whether isolated or recombinant prolactin material is suitable for a specified application.", "rationale": "Protein identity alone does not establish that a prolactin preparation has suitable purity, activity or stability.", "layers": [ { "id": "preparation-qualification", "name": "Preparation qualification", "description": "Characterise the supplied material and the evidence supporting its intended role.", "findings": [ { "id": "material-suitability", "name": "Material suitability", "description": "Record production-specific features and qualification evidence relevant to a standard, assay reagent or biological experiment.", "questions": [ { "text": "Which expression host, sequence changes, tags, formulation and lot identify this preparation?", "kind": "provenance", "id": "material-suitability-q01" }, { "text": "What identity, purity, aggregation, contaminant and activity evidence supports its intended application?", "kind": "measurement", "id": "material-suitability-q02" } ] } ] }, { "id": "stability-and-permitted-use", "name": "Stability and permitted use", "description": "Connect handling history and current condition to documented use requirements.", "findings": [ { "id": "handling-and-use-decision", "name": "Handling and use decision", "description": "Determine whether the preparation can be used as supplied or requires further qualification.", "questions": [ { "text": "What documented temperature, formulation, reconstitution, storage-duration and freeze-thaw limits apply to this prolactin preparation?", "kind": "provenance", "id": "handling-and-use-decision-q01" }, { "text": "Does its handling history support the planned use, or is requalification, replacement or restricted use required?", "kind": "action", "id": "handling-and-use-decision-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "monomeric (little) prolactin", "big prolactin", "macroprolactin (big-big prolactin)", "glycosylated prolactin", "pituitary prolactin", "extra-pituitary (decidual/lymphocyte) prolactin", "recombinant human prolactin" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of prolactin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend prolactin across species, and which species-specific identity and physiology extensions are required?", "Which prolactin-derived fragments and complexes should remain forms within this entry, and which should link to separately registered substances?", "Which assay-specific calibrations, reference intervals and macroprolactin procedures should be supported in the intended deployment?", "What evidence is sufficient to relate immunoreactive concentration to biological activity for each molecular form and specimen context?", "Which preparation-specific stability evidence and review responsibilities are required before an agent can authorise experimental use or escalate a clinical observation?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 11, "questions": 22 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a prolactin, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise prolactin, assess its molecular and measured state, and determine which analytical, handling or interpretive actions the available evidence supports.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 62 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a prolactin, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 62 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one prolactin from another, and a prolactin from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a prolactin sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a prolactin from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a prolactin is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a prolactin is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a prolactin is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a prolactin is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a prolactin is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a prolactin is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a prolactin passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a prolactin between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a prolactin, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a prolactin is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a prolactin and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a prolactin is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a prolactin performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a prolactin.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a prolactin at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a prolactin there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What prolactin is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name prolactin unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of prolactin exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How prolactin behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of prolactin, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is prolactin incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How prolactin can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is prolactin classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover prolactin, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a prolactin came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a prolactin and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a prolactin is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a prolactin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a prolactin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a prolactin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }