genome
Let an agent explain genomes and their organisation, relay sizes, sequencing and organelle genomes from genomics references, describe applications in medicine and evolution, and distinguish genomes from genes, transcriptomes and proteomes.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain genomes and their organisation, relay sizes, sequencing and organelle genomes from genomics references, describe applications in medicine and evolution, and distinguish genomes from genes, transcriptomes and proteomes.
The complete set of genetic material of an organism or virus, comprising all its DNA or, in some viruses, RNA, including chromosomes in the nucleus and separate genomes of organelles such as mitochondrial DNA and the kinetoplast DNA of trypanosomatids like Leishmania, encoding genes and regulatory and non-coding sequences; genomes range from a few thousand bases in small viruses to billions in plants and animals, and are sequenced, annotated and compared in genomics.
What it is for: Not applicable; the genetic content of an organism.
It can be explain organisation; relay sizes and sequencing; describe organelle genomes; distinguish from related concepts.
Distinguishing features
Complete genetic content
Nuclear and organelle parts
Huge size range
Sequenced and annotated
What it looks like
Not a visible object; DNA or RNA sequences.
Physical character
human genome: about 3.1 billion base pairs
human mitochondrial genome: 16569 base pairs
first complete human genome: 2022 year - telomere to telomere
How it is recognised
Complete genetic material of an organism
Nuclear genomes, mitochondrial DNA, kinetoplast DNA, viral RNA genomes
A gene is one unit; the transcriptome is expressed RNA; the proteome is the proteins
Related models
is a kind of - in registry terms, though biologists treat it as genetic material
is made of - or RNA in some viruses
is studied by - through sequencing
includes - as an organelle genome
In practice
Families and kinds
nuclear genomes of eukaryotes
bacterial and archaeal genomes
viral DNA and RNA genomes
mitochondrial genomes including those of Leishmania species
kinetoplast DNA networks of trypanosomatids
chloroplast genomes
metagenomes of communities
Identifiers
MeSH D016678 genome
GO GO:0000229 and related genome components
Standards and regulation
Genome data sharing standards such as INSDC and GA4GH
Genetic privacy and data protection laws
Biobank and research ethics rules
Failure modes and hazards
Confusing genome with gene or DNA generally
Privacy risks of genomic data
Registry parent treating the genome as a recording medium
Also called
+78
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What a genome is.
Science.
Definition
Definition and organisation.
Definition
Definition.
- What is a genome, and how are genes, regulatory and non-coding sequences organised in chromosomes? definition
- Is the question about a genome, a gene, the transcriptome or the proteome? boundary
Kinds
Kinds.
Kinds
Kinds.
- How do nuclear, bacterial, viral, mitochondrial, kinetoplast and chloroplast genomes differ? definition
- Which entry fits the specific genome? action
Study Sequencing and analysis.
Science.
Sequencing
Sequencing.
Sequencing
Sequencing.
- How are genomes sequenced, assembled and annotated? provenance
- Which references are standard? provenance
Comparison
Comparative genomics.
Comparison
Comparison.
- What do genome comparisons reveal about evolution and gene function? provenance
- Which entry fits comparative genomics? action
Apply Applications.
Application.
Medicine
Medicine.
Medicine
Medicine.
- How are genomes used in diagnosis, pharmacogenomics and personalised medicine, in general terms? provenance
- Is the user asking about their own genetic results, which need a clinician or genetic counsellor? boundary
Parasites
Parasite genomes.
Parasites
Parasites.
- What is known about Leishmania mitochondrial and kinetoplast genomes, and why do they matter? provenance
- Which sources are cited? provenance
Context Ethics and history.
Context.
Ethics
Privacy and ethics.
Ethics
Ethics.
- What privacy and ethical issues surround genomic data, with positions attributed? provenance
- Which entry fits genetic privacy? action
History
History.
History
History.
- How did genome sequencing develop from the first viral genome to the Human Genome Project and beyond? provenance
- Which entry fits the history of genomics? action
What the second pass must settle
- Should mitochondrial DNA and human genome be separate primary entries?
- How should genomics references be linked?
- The registry entry has merged aliases naming specific Leishmania genomes; should they be split off?