blood plasma
Let an agent explain blood plasma and its composition, relay functions, donation, transfusion and plasma-derived medicines from haematology and blood service sources, describe convalescent and platelet-rich plasma with evidence attributed, and distinguish plasma from serum, whole blood and interstitial fluid, routing personal treatment questions to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain blood plasma and its composition, relay functions, donation, transfusion and plasma-derived medicines from haematology and blood service sources, describe convalescent and platelet-rich plasma with evidence attributed, and distinguish plasma from serum, whole blood and interstitial fluid, routing personal treatment questions to clinicians.
The pale yellow liquid component of blood, about 55 percent of its volume, consisting mostly of water with proteins such as albumin, globulins and clotting factors, electrolytes, nutrients, hormones and waste products, in which blood cells are suspended; plasma is collected by donation and used for transfusion, as convalescent plasma containing antibodies from recovered patients, and to manufacture medicines, while platelet-rich plasma is a concentrate used in some treatments whose evidence is debated.
What it is for: Carrying cells, proteins and substances in blood.
It can be explain composition and function; relay donation and uses; describe special preparations with attribution; distinguish related fluids.
Distinguishing features
Cell-free blood liquid
Contains clotting factors
Donated and fractionated
Transfusion product
What it looks like
A clear pale yellow liquid separated from blood cells.
Physical character
share of blood volume: about 55 percent
water content: about 92 percent
main protein: albumin note
frozen storage: about 1 year or more note - fresh frozen plasma, per standards
How it is recognised
Liquid part of blood
Human plasma, convalescent plasma, platelet-rich plasma
Serum is plasma without clotting factors; whole blood includes cells; interstitial fluid surrounds tissues
Related models
is a kind of - in registry terms
is a component of -
is contrasted with - which lacks clotting factors
is collected by -
In practice
Families and kinds
fresh frozen plasma
convalescent plasma
plasma for fractionation
plasma-derived medicines such as immunoglobulins and albumin
platelet-rich plasma preparations
Identifiers
MeSH D010949 Plasma
UBERON UBERON:0001969 blood plasma
Standards and regulation
Blood safety regulations and donor eligibility rules
Pharmaceutical rules for plasma-derived products
WHO and national transfusion guidelines
Failure modes and hazards
Agents giving personal medical advice
Overstating evidence for platelet-rich plasma or convalescent plasma
Transfusion reactions
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What blood plasma is.
Science.
Definition
Definition.
Definition
Definition.
- What is blood plasma, and how does it differ from serum, whole blood and interstitial fluid? definition
- Is the question about physiology, donation, a treatment or a personal medical decision needing a clinician? boundary
Preparations
Preparations.
Preparations
Preparations.
- What are fresh frozen, convalescent and platelet-rich plasma? definition
- Which entry fits the specific preparation? action
Physiology Physiology.
Science.
Composition
Composition.
Composition
Composition.
- What proteins, electrolytes and other substances does plasma contain? provenance
- Which references are standard? provenance
Function
Function.
Function
Function.
- How does plasma transport substances, maintain pressure and support clotting and immunity? provenance
- Which sources are cited? provenance
Medicine Donation and medicine.
Attribution.
Donation
Donation.
Donation
Donation.
- How is plasma donated, and what eligibility rules do blood services describe? provenance
- Which entry fits blood donation? action
Evidence
Evidence on treatments.
Evidence
Evidence.
- What do trials show for convalescent plasma and platelet-rich plasma, with findings attributed? provenance
- Is the presentation attributed and not overstated? boundary
Context Industry and history.
Context.
Industry
Plasma industry.
Industry
Industry.
- How are plasma-derived medicines made, and what debates exist about paid donation, with positions attributed? provenance
- Which entry fits plasma fractionation? action
History
History.
History
History.
- How did plasma transfusion develop, including Charles Drew s work? provenance
- Which entry fits the history of blood transfusion? action
What the second pass must settle
- Should convalescent plasma and platelet-rich plasma be separate primary entries?
- How should blood service sources be linked?
- How should the registry present debated treatments?