{
    "model": {
        "rank": 5254,
        "code": "thing-q8084905",
        "model_id": "vr.tr.autoimmune-disease",
        "name": "autoimmune disease",
        "purpose": "Let an agent explain autoimmune diseases as a category and their main mechanisms in general terms, relay diagnosis, treatment and support information from health authorities, distinguish autoimmunity from immunodeficiency and allergy, and route personal questions to clinicians.",
        "family": "Thing Registry",
        "category": "Information and virtual systems",
        "status": "research-draft",
        "kind": "thing",
        "plane": "INF",
        "domain": "INF.KNW",
        "industry": "",
        "version": "",
        "url": "/models/thing/q8084905/",
        "tier": 2,
        "score": 68,
        "payload": {
            "layer": "wikidata",
            "aliases": [
                "autoimmune connective tissue disorder",
                "familial Mediterranean fever",
                "Autoimmune Bullous Skin Diseases",
                "Felty's syndrome",
                "common variable immunodeficiency",
                "Lupus pernio",
                "autoimmune disease of endocrine system",
                "autoimmune disease of exocrine system",
                "autoimmune disease of gastrointestinal tract",
                "autoimmune disease of musculoskeletal system",
                "autoimmune disease of urogenital tract",
                "autoimmune disease of blood",
                "autoimmune disease of the nervous system",
                "Autoimmune Oophoritis",
                "Autoimmune/inflammatory syndrome induced by adjuvants",
                "autosomal dominant familial periodic fever",
                "Autoimmune disease in women",
                "spondyloarthropathy",
                "Autoimmune GFAP Astrocytopathy",
                "postural orthostatic tachycardia syndrome",
                "Anti-AQP4 disease",
                "overlap syndrome",
                "CINCA syndrome",
                "Jaccoud's syndrome",
                "secondary neonatal autoimmune disease",
                "familial chilblain lupus",
                "autoimmune lymphoproliferative syndrome type 3",
                "immunodeficiency, common variable, 12",
                "pancytopenia due to IKZF1 mutations",
                "hypermobility of coccyx",
                "Baastrup's syndrome",
                "seronegative spondyloarthritis",
                "Kummell's disease",
                "spondylosis and allied disorder",
                "scleromyositis"
            ],
            "aliasCount": 35,
            "merged": 35,
            "knownIn": 68,
            "facets": null,
            "markers": [],
            "lexicalClass": "",
            "senseRank": null,
            "alsoRegisteredAs": "vr.tr.autoimmune-disease",
            "source": {
                "dataset": "wikidata",
                "item": "Q8084905",
                "url": "https://www.wikidata.org/wiki/Q8084905",
                "license": "CC0 1.0"
            }
        },
        "research": {
            "vercy": "1.0-draft",
            "publication": {
                "status": "research-draft",
                "adjudicationStatus": "unreviewed",
                "publishableCanonical": false,
                "generatedAt": "2026-09-12T21:17:38Z",
                "providers": [
                    "Claude"
                ],
                "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
                "pass": 2,
                "wave": 3,
                "engine": "claude"
            },
            "metaModel": {
                "id": "THING-Q8084905",
                "registryId": "vr.tr.autoimmune-disease",
                "name": "autoimmune disease",
                "version": "0.2.0-wave.3",
                "entryKind": "thing",
                "family": "Thing Registry",
                "domain": [
                    "INF.KNW"
                ],
                "status": "research-draft"
            },
            "canonicalUrl": "https://ver.cy/models/thing/q8084905/",
            "model": {
                "registry_id": "vr.tr.autoimmune-disease",
                "name": "autoimmune disease",
                "purpose": "Let an agent explain autoimmune diseases as a category and their main mechanisms in general terms, relay diagnosis, treatment and support information from health authorities, distinguish autoimmunity from immunodeficiency and allergy, and route personal questions to clinicians.",
                "definition": "A condition in which the immune system attacks the body own cells and tissues, producing inflammation and damage in one organ or throughout the body; more than 80 autoimmune diseases are recognised, including type 1 diabetes, rheumatoid arthritis, lupus, multiple sclerosis, coeliac disease and autoimmune thyroid disease, and they are managed with immune-modifying treatments and specialist care.",
                "what_it_is_for": "Not applicable; a category of disease.",
                "affordances": [
                    "explain the category and mechanisms",
                    "list major diseases and their features in general terms",
                    "relay treatment and support information",
                    "route personal questions to clinicians"
                ],
                "distinguishing_features": [
                    "Loss of self-tolerance",
                    "Organ-specific and systemic forms",
                    "Chronic and often relapsing",
                    "Treated by immune modulation"
                ],
                "appearance": "Not visible as a category; each disease has its own signs, from joint swelling to rashes and fatigue.",
                "visual_identification": [
                    "Immune attack on the body own tissues",
                    "Organ-specific or systemic",
                    "Immunodeficiency is failure of immunity; allergy is reaction to external substances"
                ],
                "physical_properties": [
                    {
                        "quantity": "recognised diseases",
                        "typical_range": "over 80",
                        "unit": "conditions",
                        "note": ""
                    },
                    {
                        "quantity": "population affected",
                        "typical_range": "about 5-10",
                        "unit": "percent",
                        "note": "estimates vary; more common in women"
                    }
                ],
                "families_and_kinds": [
                    "organ-specific diseases such as type 1 diabetes and autoimmune thyroiditis",
                    "systemic diseases such as lupus and rheumatoid arthritis",
                    "autoimmune skin diseases",
                    "neurological autoimmune diseases such as multiple sclerosis",
                    "autoinflammatory diseases, a related but distinct group",
                    "immunodeficiencies with autoimmune features"
                ],
                "related_models": [
                    {
                        "relation": "is a kind of",
                        "target": "immune system disorder",
                        "why": "the category"
                    },
                    {
                        "relation": "is contrasted with",
                        "target": "immunodeficiency",
                        "why": "failure rather than misdirection of immunity"
                    },
                    {
                        "relation": "includes",
                        "target": "rheumatoid arthritis",
                        "why": "a major example"
                    },
                    {
                        "relation": "is treated by",
                        "target": "immunosuppressive drug",
                        "why": "and targeted therapies"
                    }
                ],
                "identifiers": [
                    {
                        "scheme": "ICD-11",
                        "value_or_pattern": "chapter 4 and organ chapters",
                        "note": "by disease"
                    },
                    {
                        "scheme": "MeSH",
                        "value_or_pattern": "D001327",
                        "note": "autoimmune diseases"
                    }
                ],
                "standards_and_regulation": [
                    "Clinical guidelines by disease from specialist societies",
                    "Medicines regulation for biologics and immunosuppressants",
                    "Disability and workplace accommodation law"
                ],
                "failure_modes_and_hazards": [
                    "Delayed diagnosis",
                    "Infection risk from immunosuppression",
                    "Unproven treatments and diets",
                    "Agents giving personal medical advice"
                ],
                "in_scope": [],
                "out_of_scope": [],
                "characteristics": []
            },
            "sources": [],
            "structure": {
                "bundles": [
                    {
                        "id": "understand",
                        "name": "Understand",
                        "description": "What autoimmune disease is.",
                        "rationale": "General information.",
                        "layers": [
                            {
                                "id": "mechanism",
                                "name": "Mechanism",
                                "description": "Mechanism and category.",
                                "findings": [
                                    {
                                        "id": "mechanism-finding",
                                        "name": "Mechanism",
                                        "description": "Mechanism.",
                                        "questions": [
                                            {
                                                "text": "What goes wrong in autoimmunity, and how does it differ from immunodeficiency and allergy?",
                                                "kind": "definition"
                                            },
                                            {
                                                "text": "Is the user asking about their own symptoms or results, which needs a clinician?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "diseases",
                                "name": "Diseases",
                                "description": "Major diseases.",
                                "findings": [
                                    {
                                        "id": "diseases-finding",
                                        "name": "Diseases",
                                        "description": "Diseases.",
                                        "questions": [
                                            {
                                                "text": "What are the major autoimmune diseases and their general features?",
                                                "kind": "definition"
                                            },
                                            {
                                                "text": "Which entry fits the specific disease?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "diagnose",
                        "name": "Diagnose",
                        "description": "Diagnosis.",
                        "rationale": "Clinical.",
                        "layers": [
                            {
                                "id": "tests",
                                "name": "Tests",
                                "description": "Tests and criteria.",
                                "findings": [
                                    {
                                        "id": "tests-finding",
                                        "name": "Tests",
                                        "description": "Tests.",
                                        "questions": [
                                            {
                                                "text": "How are autoimmune diseases diagnosed, and what do autoantibody tests mean, in general terms?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Which entry fits immunology tests?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "causes",
                                "name": "Causes",
                                "description": "Causes and risk.",
                                "findings": [
                                    {
                                        "id": "causes-finding",
                                        "name": "Causes",
                                        "description": "Causes.",
                                        "questions": [
                                            {
                                                "text": "What is known about genetic and environmental causes, with findings attributed?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Which references are standard?",
                                                "kind": "provenance"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "treat",
                        "name": "Treat",
                        "description": "Treatment and living.",
                        "rationale": "Care.",
                        "layers": [
                            {
                                "id": "treatment",
                                "name": "Treatment",
                                "description": "Treatment.",
                                "findings": [
                                    {
                                        "id": "treatment-finding",
                                        "name": "Treatment",
                                        "description": "Treatment.",
                                        "questions": [
                                            {
                                                "text": "What treatments do guidelines describe, from immunosuppressants to biologics?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Is the presentation free of personal treatment advice?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "living",
                                "name": "Living",
                                "description": "Living with the condition.",
                                "findings": [
                                    {
                                        "id": "living-finding",
                                        "name": "Living",
                                        "description": "Living.",
                                        "questions": [
                                            {
                                                "text": "What support, rights and self-management information do health bodies provide?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Which entry fits patient support?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "study",
                        "name": "Study",
                        "description": "Research and teaching.",
                        "rationale": "Study.",
                        "layers": [
                            {
                                "id": "research",
                                "name": "Research",
                                "description": "Research.",
                                "findings": [
                                    {
                                        "id": "research-finding",
                                        "name": "Research",
                                        "description": "Research.",
                                        "questions": [
                                            {
                                                "text": "What research is under way on causes and therapies, with attribution?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Which entry fits immunology?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "teach",
                                "name": "Teach",
                                "description": "Teaching.",
                                "findings": [
                                    {
                                        "id": "teach-finding",
                                        "name": "Teach",
                                        "description": "Teaching.",
                                        "questions": [
                                            {
                                                "text": "How is autoimmunity taught, and which misconceptions arise?",
                                                "kind": "provenance"
                                            },
                                            {
                                                "text": "Which entry fits medical education?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    }
                ]
            },
            "openQuestions": [
                "Should each disease be a separate entry only?",
                "How should guidelines be linked by disease?",
                "The registry entry has merged aliases for immunodeficiencies and autoinflammatory diseases; should they be split off?"
            ],
            "statistics": {
                "bundles": 4,
                "layers": 8,
                "findings": 8,
                "questions": 16
            }
        },
        "draft": {
            "generator": "vr.draft.v3",
            "status": "draft-generated",
            "researched": false,
            "archetype": "disease or condition",
            "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.",
            "facetsInferred": true,
            "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.",
            "purpose": "Give an agent a durable, checkable way to recognise a autoimmune disease, record what state it is in, and decide what may be done with it.",
            "whatItIs": "Let an agent explain autoimmune diseases as a category and their main mechanisms in general terms, relay diagnosis, treatment and support information from health authorities, distinguish autoimmunity from immunodeficiency and allergy, and route personal questions to clinicians.",
            "characteristics": {
                "substance": "information",
                "origin": "conceptual",
                "agency": "inert"
            },
            "whatYouCanDoWithIt": [
                "read and interpreted"
            ],
            "distinguishingFeatures": [
                "Names folded into this entry, which a task may need to split apart again: autoimmune connective tissue disorder, familial Mediterranean fever, Autoimmune Bullous Skin Diseases, Felty's syndrome, common variable immunodeficiency, Lupus pernio, autoimmune disease of endocrine system, autoimmune disease of exocrine system, autoimmune disease of gastrointestinal tract, autoimmune disease of musculoskeletal system, autoimmune disease of urogenital tract, autoimmune disease of blood.",
                "35 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.",
                "Described in 68 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is."
            ],
            "openQuestionsForResearch": [
                "Which of the bundles below does a real task actually need, and which are ceremony?",
                "What does this thing have that the facets do not capture at all?",
                "Which neighbouring kind is most often confused with a autoimmune disease, and on what evidence are they told apart?"
            ],
            "whatItIsMadeOf": "content that has to be carried by something else",
            "physicalCharacter": [
                "Does nothing on its own; everything it does, something else did to it.",
                "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing."
            ],
            "whatCanBeDoneWithIt": [
                "read it and act on what it says"
            ],
            "howItIsRecognised": [
                "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test."
            ],
            "relatedModels": [
                {
                    "relation": "covers",
                    "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.",
                    "targets": [
                        "autoimmune connective tissue disorder",
                        "familial Mediterranean fever",
                        "Autoimmune Bullous Skin Diseases",
                        "Felty's syndrome",
                        "common variable immunodeficiency",
                        "Lupus pernio",
                        "autoimmune disease of endocrine system",
                        "autoimmune disease of exocrine system",
                        "autoimmune disease of gastrointestinal tract",
                        "autoimmune disease of musculoskeletal system",
                        "autoimmune disease of urogenital tract",
                        "autoimmune disease of blood"
                    ]
                }
            ],
            "standing": "Described in 68 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 35 finer distinctions are held inside this entry as names rather than as separate models.",
            "structure": {
                "bundles": [
                    {
                        "id": "identity-and-classification",
                        "name": "Identity, naming and classification",
                        "description": "How an agent tells one autoimmune disease from another, and a autoimmune disease from things that resemble it.",
                        "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.",
                        "layers": [
                            {
                                "id": "naming-and-identifiers",
                                "name": "Names and identifiers",
                                "description": "The names this thing goes by and the identifiers that survive translation and time.",
                                "findings": [
                                    {
                                        "id": "preferred-name-and-aliases",
                                        "name": "Preferred name, aliases and local names",
                                        "description": "Which name to use, which names mean the same thing, and which merely sound similar.",
                                        "questions": [
                                            {
                                                "id": "preferred-name-and-aliases-q01",
                                                "text": "What identifies and describes the name of a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "preferred-name-and-aliases-q02",
                                                "text": "Who or what asserted this about the name of a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "preferred-name-and-aliases-q03",
                                                "text": "What may an agent decide or do once the name of a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    },
                                    {
                                        "id": "stable-identifiers",
                                        "name": "Stable identifiers and external keys",
                                        "description": "Identifiers that keep pointing at this kind of thing across systems and languages.",
                                        "questions": [
                                            {
                                                "id": "stable-identifiers-q01",
                                                "text": "What identifies and describes an identifier for a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "stable-identifiers-q02",
                                                "text": "Who or what asserted this about an identifier for a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "stable-identifiers-q03",
                                                "text": "What may an agent decide or do once an identifier for a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "classification-and-granularity",
                                "name": "Classification and granularity",
                                "description": "Where a autoimmune disease sits among kinds, and how finely a task needs to cut it.",
                                "findings": [
                                    {
                                        "id": "kind-and-parents",
                                        "name": "Kind, parents and neighbouring kinds",
                                        "description": "The classes this thing belongs to and the ones it is next to.",
                                        "questions": [
                                            {
                                                "id": "kind-and-parents-q01",
                                                "text": "What identifies and describes the kind of a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "kind-and-parents-q02",
                                                "text": "Who or what asserted this about the kind of a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "kind-and-parents-q03",
                                                "text": "What may an agent decide or do once the kind of a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    },
                                    {
                                        "id": "distinguishing-features",
                                        "name": "Distinguishing features",
                                        "description": "What separates a autoimmune disease from the things most often confused with it.",
                                        "questions": [
                                            {
                                                "id": "distinguishing-features-q01",
                                                "text": "What identifies and describes what distinguishes a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "distinguishing-features-q02",
                                                "text": "Who or what asserted this about what distinguishes a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "distinguishing-features-q03",
                                                "text": "What may an agent decide or do once what distinguishes a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "state-and-lifecycle",
                        "name": "State and lifecycle",
                        "description": "The states a autoimmune disease passes through and the events that move it between them.",
                        "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.",
                        "layers": [
                            {
                                "id": "lifecycle-stages",
                                "name": "Lifecycle stages",
                                "description": "From coming into existence to ceasing to be one of these.",
                                "findings": [
                                    {
                                        "id": "stages-and-transitions",
                                        "name": "Stages and transitions",
                                        "description": "The stages worth naming and what moves a autoimmune disease between them.",
                                        "questions": [
                                            {
                                                "id": "stages-and-transitions-q01",
                                                "text": "What identifies and describes the lifecycle of a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "stages-and-transitions-q02",
                                                "text": "Who or what asserted this about the lifecycle of a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "stages-and-transitions-q03",
                                                "text": "What may an agent decide or do once the lifecycle of a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "observations-and-status",
                                "name": "Observations and current status",
                                "description": "What is observed about a autoimmune disease, how often and by whom.",
                                "findings": [
                                    {
                                        "id": "observation-record",
                                        "name": "Observation record",
                                        "description": "How an observation of a autoimmune disease is recorded so that it can be superseded rather than overwritten.",
                                        "questions": [
                                            {
                                                "id": "observation-record-q01",
                                                "text": "What identifies and describes an observation of a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "observation-record-q02",
                                                "text": "Who or what asserted this about an observation of a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "observation-record-q03",
                                                "text": "What may an agent decide or do once an observation of a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "content-and-access",
                        "name": "Content, encoding and access",
                        "description": "What a autoimmune disease says, how it is encoded and who may read it.",
                        "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.",
                        "layers": [
                            {
                                "id": "content-and-encoding",
                                "name": "Content and encoding",
                                "description": "The content itself, its format and its language.",
                                "findings": [
                                    {
                                        "id": "content-and-format",
                                        "name": "Content, format and language",
                                        "description": "What a autoimmune disease contains and in what form it is held.",
                                        "questions": [
                                            {
                                                "id": "content-and-format-q01",
                                                "text": "What identifies and describes the content of a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "content-and-format-q02",
                                                "text": "Who or what asserted this about the content of a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "content-and-format-q03",
                                                "text": "What may an agent decide or do once the content of a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "access-and-rights",
                                "name": "Access, rights and retention",
                                "description": "Who may read, copy or change it, and for how long it is kept.",
                                "findings": [
                                    {
                                        "id": "access-rules",
                                        "name": "Access rules and retention",
                                        "description": "The permissions attached to a autoimmune disease and the period it survives.",
                                        "questions": [
                                            {
                                                "id": "access-rules-q01",
                                                "text": "What identifies and describes access to a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "access-rules-q02",
                                                "text": "Who or what asserted this about access to a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "access-rules-q03",
                                                "text": "What may an agent decide or do once access to a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "diagnosis-and-criteria",
                        "name": "Diagnosis, criteria and coding",
                        "description": "What makes a case of autoimmune disease a case, and under which revision.",
                        "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.",
                        "layers": [
                            {
                                "id": "criteria",
                                "name": "Diagnostic criteria",
                                "description": "The criteria in force and who issues them.",
                                "findings": [
                                    {
                                        "id": "criteria-record",
                                        "name": "Criteria, issuer and revision",
                                        "description": "What must be true for a diagnosis, according to whom.",
                                        "questions": [
                                            {
                                                "id": "criteria-record-q01",
                                                "text": "What criteria define autoimmune disease, issued by which body, in which revision?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "criteria-record-q02",
                                                "text": "What changed between revisions that would reclassify existing cases?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "coding",
                                "name": "Coding and terminology",
                                "description": "The codes used to record it and their mapping.",
                                "findings": [
                                    {
                                        "id": "coding-record",
                                        "name": "Codes and mappings",
                                        "description": "Which classification codes apply and how they map.",
                                        "questions": [
                                            {
                                                "id": "coding-record-q01",
                                                "text": "Which classification and terminology codes cover autoimmune disease, and how do they map to each other?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "coding-record-q02",
                                                "text": "What is lost when a case is mapped from one scheme to another?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "course-and-population",
                        "name": "Course, population and care",
                        "description": "How autoimmune disease develops, whom it affects, and what is done about it.",
                        "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.",
                        "layers": [
                            {
                                "id": "course",
                                "name": "Course and stages",
                                "description": "Onset, progression, remission and outcome.",
                                "findings": [
                                    {
                                        "id": "course-record",
                                        "name": "Stages and transitions",
                                        "description": "The stages recorded and what moves a case between them.",
                                        "questions": [
                                            {
                                                "id": "course-record-q01",
                                                "text": "What course does autoimmune disease typically take, and what marks each stage?",
                                                "kind": "definition"
                                            },
                                            {
                                                "id": "course-record-q02",
                                                "text": "What separates the condition itself from an episode of care for it?",
                                                "kind": "boundary"
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "population",
                                "name": "Affected populations",
                                "description": "Who is affected, how often, and on what evidence.",
                                "findings": [
                                    {
                                        "id": "epidemiology",
                                        "name": "Prevalence and its basis",
                                        "description": "Rates with their population, period and source.",
                                        "questions": [
                                            {
                                                "id": "epidemiology-q01",
                                                "text": "What prevalence or incidence is reported for autoimmune disease, in which population and period?",
                                                "kind": "measurement"
                                            },
                                            {
                                                "id": "epidemiology-q02",
                                                "text": "What may an agent not conclude about an individual from a population rate?",
                                                "kind": "action"
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "id": "provenance-and-evidence",
                        "name": "Provenance, evidence and time",
                        "description": "Where every claim about a autoimmune disease came from and when it held.",
                        "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.",
                        "layers": [
                            {
                                "id": "source-and-authority",
                                "name": "Source and authority",
                                "description": "Who said it, on what evidence, and how strongly.",
                                "findings": [
                                    {
                                        "id": "claim-provenance",
                                        "name": "Claim provenance and confidence",
                                        "description": "The authority behind each claim about a autoimmune disease and how confident it is.",
                                        "questions": [
                                            {
                                                "id": "claim-provenance-q01",
                                                "text": "What identifies and describes a claim about a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "claim-provenance-q02",
                                                "text": "Who or what asserted this about a claim about a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "claim-provenance-q03",
                                                "text": "What may an agent decide or do once a claim about a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "id": "time-and-versions",
                                "name": "Time, versions and supersession",
                                "description": "When a claim was true, when it was learnt, and what replaced it.",
                                "findings": [
                                    {
                                        "id": "validity-and-supersession",
                                        "name": "Validity period and supersession",
                                        "description": "How an old claim about a autoimmune disease is retired without being erased.",
                                        "questions": [
                                            {
                                                "id": "validity-and-supersession-q01",
                                                "text": "What identifies and describes the validity of a claim about a autoimmune disease, and in what units or vocabulary?",
                                                "kind": "definition",
                                                "answer_data": [
                                                    "identifiers",
                                                    "types and classes",
                                                    "values with units",
                                                    "explicit unknowns"
                                                ]
                                            },
                                            {
                                                "id": "validity-and-supersession-q02",
                                                "text": "Who or what asserted this about the validity of a claim about a autoimmune disease, by which method, and when was it true?",
                                                "kind": "provenance",
                                                "answer_data": [
                                                    "authority",
                                                    "method",
                                                    "evidence",
                                                    "event time",
                                                    "knowledge time"
                                                ]
                                            },
                                            {
                                                "id": "validity-and-supersession-q03",
                                                "text": "What may an agent decide or do once the validity of a claim about a autoimmune disease is known, and what must it refuse?",
                                                "kind": "action",
                                                "answer_data": [
                                                    "permitted actions",
                                                    "preconditions",
                                                    "refusals",
                                                    "escalation"
                                                ]
                                            }
                                        ]
                                    }
                                ]
                            }
                        ]
                    }
                ]
            },
            "statistics": {
                "bundles": 6,
                "layers": 12,
                "findings": 14,
                "questions": 38
            }
        }
    }
}