{ "model": { "rank": 3037, "code": "thing-q81225", "model_id": "vr.tr.morphine", "name": "morphine", "purpose": "Enable an AI agent to recognise material represented as morphine, assess its documented identity and usable state, and determine which handling or use decisions require further evidence or authority.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.OBJ", "industry": "", "version": "", "url": "/models/thing/q81225/", "tier": 2, "score": 92, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 92, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.morphine", "source": { "dataset": "wikidata", "item": "Q81225", "url": "https://www.wikidata.org/wiki/Q81225", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T14:21:09Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.03244438, "turns": 2, "seconds": 140.6, "error": null }, "codex": { "seconds": 71.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07c3c-6ad9-7e62-9fe8-5b04b8f1f50b\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: morphine\nRegistry id: vr.tr.morphine\nPlane / domain: PHY / PHY.OBJ\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA Vercy" } } }, "metaModel": { "id": "THING-Q81225", "registryId": "vr.tr.morphine", "name": "morphine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.OBJ" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q81225/", "model": { "registry_id": "vr.tr.morphine", "name": "morphine", "purpose": "Enable an AI agent to recognise material represented as morphine, assess its documented identity and usable state, and determine which handling or use decisions require further evidence or authority.", "definition": "Morphine is the principal morphinan alkaloid of opium latex from Papaver somniferum and a prototypical μ-opioid receptor agonist used as the reference strong opioid analgesic and chemical parent of many semi-synthetic opioids.", "scope_statement": "This model owns morphine as a registered substance and the morphine-specific identity, composition, condition, evidence and constraints of material containing it; it references neighbouring product, patient, laboratory and regulatory models.", "in_scope": [ "Evidence establishing morphine identity and distinguishing related substances", "Chemical form and the basis on which morphine content is expressed", "Morphine content, relevant impurities and uncertainty in analytical results", "Material condition, storage history and suitability for an explicitly stated purpose", "Provenance and applicable restrictions on possession, transfer, handling and use" ], "out_of_scope": [ "Patient diagnosis, prescribing, dose selection and treatment monitoring", "Complete medicinal-product specifications, delivery devices and packaging designs", "Manufacturing or extraction procedures and process optimisation", "Complete models of related opioids, metabolites and degradation products", "Laboratory instrument operation and analytical-method implementation", "Jurisdiction-wide controlled-substance legislation and licensing systems" ], "distinguishing_features": [ "Require identity evidence that distinguishes morphine from related substances such as codeine and diamorphine; an opioid designation alone does not establish morphine identity.", "Separate the morphine chemical entity from its named salt or hydrate form and from a formulated medicine containing it.", "Check whether a reported quantity describes morphine on a stated equivalent basis, a particular salt form, or the total mass of a preparation.", "Distinguish a specimen shown to contain morphine from material whose identity and specification are established as morphine.", "Treat a label, supplier claim or screening result as a stated level of evidence rather than automatically as confirmed identity." ], "characteristics": [ { "name": "Morphine identity status", "kind": "state", "unit_or_values": "claimed | provisionally supported | confirmed for stated purpose | contradicted | unresolved", "why_it_matters": "Determines whether downstream decisions can rely on the material being morphine." }, { "name": "Chemical form", "kind": "category", "unit_or_values": "free base or identified salt; hydration or solvation state where established; unknown", "why_it_matters": "Prevents different material forms from being treated as interchangeable without supporting evidence." }, { "name": "Material context", "kind": "category", "unit_or_values": "bulk substance | reference material | medicinal preparation | mixture | specimen containing morphine | unknown", "why_it_matters": "Separates substance identity from the requirements of the material in which it occurs." }, { "name": "Measured morphine content", "kind": "measurement", "unit_or_values": "mass fraction, mg/g, mg/mL or amount per unit, with explicit chemical basis, method and uncertainty", "why_it_matters": "Allows quantities to be interpreted without confusing salt mass, morphine-equivalent content and preparation mass." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "identified analytes and measured amounts or fractions, including reporting limits and unresolved signals", "why_it_matters": "Supports assessment of identity, contamination and change during storage." }, { "name": "Physical condition", "kind": "state", "unit_or_values": "observed appearance and physical state, compared with the applicable material specification", "why_it_matters": "Records changes that may require investigation without treating appearance as proof of identity or acceptability." }, { "name": "Storage exposure", "kind": "measurement", "unit_or_values": "recorded temperature, humidity and light exposure where relevant, with duration and gaps", "why_it_matters": "Supports a form-specific assessment of whether storage history compromises suitability." }, { "name": "Lot and evidence linkage", "kind": "relation", "unit_or_values": "links to source, lot, sampled portion, analytical records and custody events", "why_it_matters": "Establishes which physical material a certificate or result actually describes." }, { "name": "Suitability disposition", "kind": "state", "unit_or_values": "unassessed | acceptable for named purpose | restricted | quarantined | rejected", "why_it_matters": "Avoids treating identity confirmation as permission for every possible use." }, { "name": "Applicable authority", "kind": "relation", "unit_or_values": "current jurisdiction, responsible actor, permitted activity and supporting authority", "why_it_matters": "Makes possession, transfer and use decisions dependent on the relevant legal and institutional context." } ], "affordances": [ "Compare identity evidence with a morphine-specific reference and flag unresolved distinctions.", "Interpret and compare reported content only when chemical form and quantity basis are explicit.", "Link analytical results and provenance to the particular lot or sampled portion they support.", "Flag condition changes, storage excursions or evidence gaps for qualified assessment.", "Determine whether a proposed handling, transfer or use action has sufficient evidence and applicable authority.", "Record quarantine, release or disposal decisions with their purpose, responsible authority and supporting evidence." ] }, "sources": [ { "id": "wikipedia-morphine", "title": "Morphine", "url": "https://en.wikipedia.org/wiki/Morphine", "what_it_supports": "Definition, identifiers, legal scheduling, pharmacokinetics, salts, clinical use, and essential-medicine status.", "url_status": "live" }, { "id": "pubchem-5288826", "title": "Morphine | C17H19NO3 | CID 5288826", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/morphine", "what_it_supports": "CAS, UNII, formula, molecular weight, related salt CAS numbers, and DEA Schedule II status.", "url_status": "live" }, { "id": "who-eml-morphine", "title": "WHO Model List of Essential Medicines: Morphine (section 2.2 Opioid analgesics)", "url": "https://list.essentialmeds.org/recommendations/19/print?ln=EN&format=pdf", "what_it_supports": "EML/EMLc listing, ATC N02AA01, and authorised oral and parenteral salt formulations.", "url_status": "live" }, { "id": "un-1961-schedules", "title": "Schedules of the Single Convention on Narcotic Drugs of 1961 as amended by the 1972 Protocol (ST/CND/1/Add.1/Rev.9)", "url": "https://documents.un.org/api/symbol/access?s=st/CND/1/Add.1/Rev.9&l=en&t=pdf", "what_it_supports": "International control of morphine in Schedule I of the 1961 Convention, distinct from codeine in Schedule II.", "url_status": "live" }, { "id": "incb-yellow-list", "title": "Yellow List: List of Narcotic Drugs under International Control", "url": "https://www.incb.org/documents/Narcotic-Drugs/Yellow_List/56th_Edition/YL_56_edition_EN.pdf", "what_it_supports": "INCB identification of morphine as the principal alkaloid of opium, with CAS 57-27-2 and IDS code NM 009.", "url_status": "live" }, { "id": "who-cancer-pain-annex", "title": "Opioid Analgesics and International Conventions, in WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents", "url": "https://www.ncbi.nlm.nih.gov/books/NBK537494/", "what_it_supports": "That morphine and other strong opioids are Schedule I narcotics under the 1961 Convention, with medical-use control requirements.", "url_status": "live" }, { "id": "mayo-morphine-oral", "title": "Morphine (oral route)", "url": "https://www.mayoclinic.org/drugs-supplements/morphine-oral-route/description/drg-20074216", "what_it_supports": "Typical oral immediate- and extended-release adult doses and overdose signs (respiratory depression, miosis).", "url_status": "blocked" }, { "id": "drugs-com-international", "title": "Morphine (International database)", "url": "https://www.drugs.com/international/morphine.html", "what_it_supports": "INN/BAN/JAN names, ATC N02AA01, and pharmacopoeial salt monographs (USP, BP, Ph. Eur., Ph. Int., JP).", "url_status": "blocked" }, { "id": "medscape-equianalgesic", "title": "Equianalgesic opioid dosing tables", "url": "https://emedicine.medscape.com/article/2138678-print", "what_it_supports": "10 mg parenteral morphine as the conventional equianalgesic reference, with oral morphine about threefold less potent.", "url_status": "live" }, { "id": "nejm-overdose", "title": "Prevention of Opioid Overdose", "url": "https://www.nejm.org/doi/full/10.1056/NEJMra1807054", "what_it_supports": "Dose-related overdose risk and CDC/Canadian caution against chronic morphine-equivalent doses above 50-90 mg/day.", "url_status": "blocked" } ], "structure": { "bundles": [ { "id": "morphine-identity", "name": "Morphine identity", "description": "Establishes what the material is and how strongly its identification is supported.", "rationale": "An opioid label, a morphine-containing specimen and an identified morphine substance support different decisions.", "layers": [ { "id": "chemical-entity", "name": "Chemical entity", "description": "Defines the entity represented by the registry entry and its nearby boundaries.", "findings": [ { "id": "entity-and-form-boundary", "name": "Entity and form boundary", "description": "Record whether the identification denotes morphine itself, a specified chemical form or a preparation containing it.", "questions": [ { "text": "Which authoritative chemical identity, including stereochemical identity where relevant, anchors the name morphine?", "kind": "definition", "id": "entity-and-form-boundary-q01" }, { "text": "Does this material represent morphine, a morphine salt or hydrate, or a preparation or specimen containing morphine?", "kind": "boundary", "id": "entity-and-form-boundary-q02" } ] } ] }, { "id": "identity-evidence", "name": "Identity evidence", "description": "Connects identity claims to evidence capable of resolving relevant alternatives.", "findings": [ { "id": "discriminating-identification", "name": "Discriminating identification", "description": "Record the evidential strength and limitations of the identification.", "questions": [ { "text": "What examined evidence supports morphine identity for this lot or sampled portion?", "kind": "provenance", "id": "discriminating-identification-q01" }, { "text": "Which plausible alternatives, including codeine, diamorphine or mixed material, does that evidence distinguish or leave unresolved?", "kind": "boundary", "id": "discriminating-identification-q02" } ] } ] } ] }, { "id": "form-and-content", "name": "Form and content", "description": "Makes morphine quantities interpretable across chemical forms and material contexts.", "rationale": "A quantity labelled morphine is ambiguous unless its chemical basis and preparation context are known.", "layers": [ { "id": "chemical-form", "name": "Chemical form", "description": "Records the form associated with the measured or labelled material.", "findings": [ { "id": "salt-and-hydration-basis", "name": "Salt and hydration basis", "description": "Make the stated free-base, salt and hydration or solvation basis explicit without inferring it from a shortened name.", "questions": [ { "text": "What chemical form is stated, and what evidence establishes its counterion and hydration or solvation state where applicable?", "kind": "definition", "id": "salt-and-hydration-basis-q01" }, { "text": "Does the content declaration use that form's mass or a specified morphine-equivalent basis?", "kind": "measurement", "id": "salt-and-hydration-basis-q02" } ] } ] }, { "id": "content-expression", "name": "Content expression", "description": "Distinguishes measured substance content from total preparation quantity.", "findings": [ { "id": "assay-and-quantity-interpretation", "name": "Assay and quantity interpretation", "description": "Record content with the denominator, chemical basis and limitations needed to interpret it.", "questions": [ { "text": "What morphine content was measured, in which units and matrix, using which method and uncertainty or reporting limits?", "kind": "measurement", "id": "assay-and-quantity-interpretation-q01" }, { "text": "Can two reported quantities be compared directly, or is a documented chemical-form conversion or product-level interpretation required?", "kind": "boundary", "id": "assay-and-quantity-interpretation-q02" } ] } ] } ] }, { "id": "purity-and-condition", "name": "Purity and condition", "description": "Assesses whether the morphine material remains consistent with a stated specification and purpose.", "rationale": "Morphine identity alone does not establish purity, stability or suitability.", "layers": [ { "id": "related-substances", "name": "Related substances", "description": "Records relevant non-morphine constituents and the evidence for their significance.", "findings": [ { "id": "impurity-profile", "name": "Impurity profile", "description": "Separate identified impurities, possible degradation products and unresolved analytical signals.", "questions": [ { "text": "Which related substances or contaminants were examined, detected or left unresolved, and at what reporting limits?", "kind": "measurement", "id": "impurity-profile-q01" }, { "text": "Which applicable specification establishes whether these results are acceptable for this chemical form and intended purpose?", "kind": "provenance", "id": "impurity-profile-q02" } ] } ] }, { "id": "stability-and-storage", "name": "Stability and storage", "description": "Relates observed condition and exposure history to evidence applicable to the actual form or preparation.", "findings": [ { "id": "condition-change-assessment", "name": "Condition change assessment", "description": "Record changes and storage deviations without inventing a universal morphine shelf life.", "questions": [ { "text": "What physical or analytical changes and storage excursions have been recorded since the relevant baseline assessment?", "kind": "measurement", "id": "condition-change-assessment-q01" }, { "text": "What form-specific or product-specific evidence supports continued use, retesting or quarantine after those changes?", "kind": "action", "id": "condition-change-assessment-q02" } ] } ] } ] }, { "id": "provenance-and-control", "name": "Provenance and control", "description": "Connects morphine material to its evidence, custody and applicable permissions.", "rationale": "An agent must establish both which material its evidence describes and whether a proposed activity is authorised.", "layers": [ { "id": "lot-provenance", "name": "Lot provenance", "description": "Maintains the connection between source material, samples and supporting records.", "findings": [ { "id": "evidence-to-material-link", "name": "Evidence-to-material link", "description": "Record whether identity and quality documents apply to the material currently under consideration.", "questions": [ { "text": "How are the current container or portion, originating lot and examined sample linked to the identity and assay records?", "kind": "provenance", "id": "evidence-to-material-link-q01" }, { "text": "Which transfers, repackaging events or custody gaps limit reliance on those records?", "kind": "provenance", "id": "evidence-to-material-link-q02" } ] } ] }, { "id": "activity-authority", "name": "Activity authority", "description": "Resolves permissions for the particular actor, location, material and proposed activity.", "findings": [ { "id": "permitted-morphine-activity", "name": "Permitted morphine activity", "description": "Reference current legal and institutional authority rather than embedding a universal permission rule.", "questions": [ { "text": "Which current jurisdictional and institutional requirements apply to this morphine material and proposed activity?", "kind": "boundary", "id": "permitted-morphine-activity-q01" }, { "text": "What evidence establishes that the responsible actor may possess, transfer, use or dispose of it in this context?", "kind": "action", "id": "permitted-morphine-activity-q02" } ] } ] } ] }, { "id": "purpose-and-disposition", "name": "Purpose and disposition", "description": "Connects evidence about morphine to a bounded decision about its next permitted use.", "rationale": "Acceptance for analytical work, pharmaceutical manufacture and administration requires different evidence and neighbouring models.", "layers": [ { "id": "intended-use-boundary", "name": "Intended-use boundary", "description": "States the purpose against which material suitability is being assessed.", "findings": [ { "id": "purpose-specific-suitability", "name": "Purpose-specific suitability", "description": "Prevent a general identity or purity result from becoming an unsupported claim of clinical usability.", "questions": [ { "text": "For which explicit purpose is this morphine material being assessed, and what acceptance requirements follow?", "kind": "definition", "id": "purpose-specific-suitability-q01" }, { "text": "Which decisions require a medicinal-product, patient-care or other neighbouring model before use can proceed?", "kind": "boundary", "id": "purpose-specific-suitability-q02" } ] } ] }, { "id": "handling-and-disposition", "name": "Handling and disposition", "description": "Records justified next actions and unresolved conditions preventing them.", "findings": [ { "id": "evidence-supported-next-action", "name": "Evidence-supported next action", "description": "Tie release, restriction, quarantine or disposal to morphine-specific evidence and responsible authority.", "questions": [ { "text": "Which handling requirements apply to the actual morphine form and concentration, and what authoritative material-specific guidance supports them?", "kind": "action", "id": "evidence-supported-next-action-q01" }, { "text": "Given the identity, content, condition and authority evidence, what disposition is justified and which unresolved issues prevent the proposed action?", "kind": "action", "id": "evidence-supported-next-action-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "morphine free base", "morphine sulfate (anhydrous and pentahydrate)", "morphine hydrochloride (anhydrous and trihydrate)", "morphine tartrate", "immediate-release oral morphine", "extended-release oral morphine", "parenteral morphine (IV, IM, SC)", "neuraxial morphine (epidural or intrathecal)" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q81225", "note": "Item for the chemical compound morphine." }, { "scheme": "CAS Registry Number", "value_or_pattern": "57-27-2", "note": "Free base." }, { "scheme": "CAS Registry Number", "value_or_pattern": "64-31-3", "note": "Morphine sulfate, anhydrous (2:1)." }, { "scheme": "CAS Registry Number", "value_or_pattern": "6211-15-0", "note": "Morphine sulfate pentahydrate, the usual pharmaceutical sulfate." }, { "scheme": "CAS Registry Number", "value_or_pattern": "52-26-6", "note": "Morphine hydrochloride, anhydrous." }, { "scheme": "CAS Registry Number", "value_or_pattern": "6055-06-7", "note": "Morphine hydrochloride trihydrate, common European injectable salt." }, { "scheme": "UNII", "value_or_pattern": "76I7G6D29C", "note": "FDA Global Substance Registration System identifier for morphine." }, { "scheme": "PubChem CID", "value_or_pattern": "5288826", "note": "NCBI PubChem compound record." }, { "scheme": "ATC", "value_or_pattern": "N02AA01", "note": "WHO Anatomical Therapeutic Chemical code, natural opium alkaloids." }, { "scheme": "INN", "value_or_pattern": "morphine", "note": "WHO International Nonproprietary Name; BAN morphine; DCIT morfina; Latin morphinum." }, { "scheme": "DrugBank", "value_or_pattern": "DB00295", "note": "DrugBank accession." }, { "scheme": "ChEBI", "value_or_pattern": "CHEBI:17303", "note": "Chemical Entities of Biological Interest." }, { "scheme": "EC number", "value_or_pattern": "200-320-2", "note": "ECHA European Community number." }, { "scheme": "INCB IDS", "value_or_pattern": "NM 009", "note": "International Narcotics Control Board drug-system code on the Yellow List." }, { "scheme": "IUPHAR/BPS", "value_or_pattern": "1627", "note": "Guide to Pharmacology ligand identifier." }, { "scheme": "InChIKey", "value_or_pattern": "BQJCRHHNABKAKU-KBQPJGBKSA-N", "note": "Stereospecific key for the natural (−)-enantiomer." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Single Convention on Narcotic Drugs, 1961, as amended 1972 - United Nations: morphine in Schedule I; some dilute preparations may fall under Schedule III.", "INCB Yellow List of narcotic drugs under international control - International Narcotics Control Board.", "WHO Model List of Essential Medicines (core EML and EMLc), first listed 1977 - World Health Organization.", "WHO ATC/DDD index, N02AA01 - WHO Collaborating Centre for Drug Statistics Methodology.", "United States Controlled Substances Act Schedule II (selected low-dose combinations Schedule III) - DEA/FDA.", "Misuse of Drugs Act 1971 Class A and POM prescription control - United Kingdom.", "Controlled Drugs and Substances Act Schedule I - Canada.", "Standard for the Uniform Scheduling of Medicines and Poisons Schedule 8 - Australia.", "Betäubungsmittelgesetz Anlage III (special prescription form) - Germany.", "Pharmacopoeial monographs: USP Morphine Sulfate; Ph. Eur./BP Morphine hydrochloride and Morphine sulfate; Ph. Int. Morphine Hydrochloride / Morphine Sulfate; JP Morphine Hydrochloride Hydrate - USP, EDQM, MHRA, WHO, PMDA." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "First-line strong opioid for severe acute pain (post-operative, trauma, burns) given IV in 2-5 mg titrated increments or IM/SC about 10 mg in opioid-naïve adults.", "WHO step-3 analgesic for cancer and other palliative pain, as oral immediate-release solution or tablets and as 12- or 24-hour modified-release tablets, capsules or granules.", "Neuraxial (epidural or intrathecal) morphine for peri-operative and labour analgesia, at microgram-to-low-milligram doses.", "Reference opioid for morphine milligram equivalent (MME) conversion tables used in chronic-pain prescribing.", "Hospital procedural sedation and, in some services, treatment of neonatal opioid withdrawal.", "Isolation from dried opium-poppy latex (typically about 10% morphine by mass) and as the industrial starting point for codeine, hydromorphone and diacetylmorphine (heroin).", "Illicit injection or oral use of diverted pharmaceutical morphine, and forensic detection of morphine as both a drug of abuse and a heroin metabolite." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "molecular mass (free base)", "typical_range": "285.34", "unit": "g/mol" }, { "quantity": "oral bioavailability", "typical_range": "20-40", "unit": "%" }, { "quantity": "plasma elimination half-life", "typical_range": "2-3", "unit": "h" }, { "quantity": "duration of analgesia (immediate-release)", "typical_range": "3-7", "unit": "h" }, { "quantity": "equianalgesic adult dose (parenteral vs oral)", "typical_range": "10 parenteral ≈ 30 oral", "unit": "mg" }, { "quantity": "typical adult oral immediate-release dose", "typical_range": "10-30 every 4 h", "unit": "mg" }, { "quantity": "typical adult IV titration increment", "typical_range": "2-5", "unit": "mg" }, { "quantity": "chronic oral morphine-equivalent caution threshold (CDC/Canada)", "typical_range": "50-90", "unit": "mg/day" }, { "quantity": "morphine content of raw opium", "typical_range": "about 10", "unit": "% w/w" }, { "quantity": "aqueous solubility of free base at 20 °C", "typical_range": "149", "unit": "mg/L" }, { "quantity": "protein binding", "typical_range": "30-40", "unit": "%" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Dose-dependent opioid-induced respiratory depression progressing to apnoea, hypoxia and death; risk rises sharply with benzodiazepines, alcohol or high MME.", "Rapid tolerance and physical dependence; abrupt cessation produces a withdrawal syndrome (cramps, lacrimation, sweating, tremor, insomnia).", "Accumulation of the active metabolite morphine-6-glucuronide in renal impairment, prolonging sedation and respiratory depression.", "Histamine release causing pruritus, flushing, bronchospasm and transient hypotension, especially after IV bolus.", "Crushing or chewing extended-release tablets causes dose dumping and overdose.", "Constipation, urinary retention, myoclonus and delirium at high or rapidly escalating doses.", "Diversion, unsafe injection, and infectious complications; pregnancy exposure can cause neonatal opioid withdrawal.", "Incomplete cross-tolerance when rotating to another opioid, so converted doses can be unexpectedly potent." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "US and USP practice centres on morphine sulfate (often the pentahydrate); much of Europe, the BP, Ph. Eur. and Japan commonly use morphine hydrochloride (often the trihydrate).", "INN/BAN morphine versus German Morphin/Morphium, French morphine, Italian morfina, Latin morphinum; older English morphia is obsolete.", "United Kingdom still uses pharmaceutical diamorphine (heroin) as a hospital alternative to morphine; the United States does not.", "National scheduling labels differ (US Schedule II, UK Class A, Canada Schedule I, Australia S8, Germany Anlage III, Brazil A1) though all implement 1961 Convention Schedule I.", "Medical availability is highly uneven: morphine is on the WHO Essential Medicines List, yet many low- and middle-income countries have very low licit consumption and tight narcotic-import rules.", "Japan lists Morphine Hydrochloride Hydrate as a Japanese Accepted Name; Russian control places morphine and its salts in List II of restricted narcotics." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "codeine (3-methylmorphine)", "difference": "Codeine is the 3-O-methyl ether and a CYP2D6 prodrug of morphine, roughly one-tenth as potent orally; LC-MS or the free 3-phenol versus 3-methoxy group separates them, and codeine is 1961 Convention Schedule II rather than Schedule I." }, { "name": "diamorphine / heroin (3,6-diacetylmorphine)", "difference": "Heroin is the diacetyl ester of morphine; 6-monoacetylmorphine (6-MAM) in blood or urine is the forensic marker of heroin use, whereas morphine alone does not prove heroin." }, { "name": "hydromorphone", "difference": "Hydromorphone is 7,8-dihydro-6-ketomorphine, about five to seven times more potent than morphine; distinct chromatographic retention and mass spectrum, not a morphine salt." }, { "name": "oxycodone", "difference": "Oxycodone is a 14-hydroxy-3-methoxy-6-keto morphinan, not morphine; oral equianalgesic dose is about 20 mg versus 30 mg morphine, confirmed by specific immunoassay or LC-MS." }, { "name": "morphine-6-glucuronide", "difference": "Polar 6-O-glucuronide metabolite that is itself a μ agonist; separated from parent morphine by polarity on LC-MS and accumulates when GFR is low." }, { "name": "papaveretum / opium alkaloid mixtures", "difference": "Contain morphine plus other poppy alkaloids (codeine, papaverine, noscapine); a morphine-only assay understates the mixture, and INCB treats such mixtures as morphine preparations when not made directly from opium." }, { "name": "thebaine", "difference": "Same morphinan skeleton but a non-analgesic, highly unsaturated poppy alkaloid used to make oxycodone and buprenorphine; distinguished by unsaturation pattern and lack of μ-agonist analgesia." }, { "name": "fentanyl", "difference": "A synthetic anilidopiperidine, not a morphinan; immunoassay panels may cross-react poorly, so a morphine-positive result does not identify fentanyl, and vice versa." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of morphine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already own morphine or its chemical-form distinctions, requiring this registry entry to link to it?", "Which authoritative identity references and analytical criteria should establish morphine identity for each supported material context?", "Which salts, hydrates and content-expression conventions must this entry cover, and where should medicinal-product models take ownership?", "Which current specifications and stability evidence apply to each supported form and intended purpose, including impurity limits and retest criteria?", "Which jurisdictions and institutional settings must the model support, and how will activity permissions and handling references be kept current?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "device, machine or tool", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a morphine, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise material represented as morphine, assess its documented identity and usable state, and determine which handling or use decisions require further evidence or authority.", "characteristics": { "substance": "material", "origin": "manufactured", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Described in 92 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a morphine, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by form, by the arrangement of its controls, and by markings - a plate, a model number, a certification mark. Form alone rarely separates two models that do very different things." ], "relatedModels": [], "standing": "Described in 92 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one morphine from another, and a morphine from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a morphine sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a morphine from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a morphine is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a morphine is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a morphine is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a morphine is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a morphine is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a morphine is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a morphine passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a morphine between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a morphine, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a morphine is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "function-and-principle", "name": "Function and operating principle", "description": "What morphine is for and how it achieves it.", "rationale": "Two devices with the same name can work on different principles, and the principle is what predicts failure and constrains use.", "layers": [ { "id": "intended-function", "name": "Intended function", "description": "The job it does, and the jobs it is used for anyway.", "findings": [ { "id": "function-record", "name": "Function, principle and variants", "description": "What it does, how, and which variants do it differently.", "questions": [ { "id": "function-record-q01", "text": "What function does morphine perform, on what operating principle, and which variants differ in that principle?", "kind": "definition" }, { "id": "function-record-q02", "text": "What use falls outside the intended function but happens in practice?", "kind": "boundary" } ] } ] }, { "id": "capacity-and-rating", "name": "Capacity and rating", "description": "The numbers that say what it can do and where it stops.", "findings": [ { "id": "ratings", "name": "Ratings and their conditions", "description": "Rated capacity, power, throughput and the conditions each assumes.", "questions": [ { "id": "ratings-q01", "text": "What ratings characterise morphine, in what units, and under what stated conditions?", "kind": "measurement" }, { "id": "ratings-q02", "text": "What happens beyond the rating - degradation, refusal, damage - and how is that detected?", "kind": "action" } ] } ] } ] }, { "id": "operation-and-state", "name": "Operation, controls and state", "description": "How morphine is operated and what state it is in right now.", "rationale": "An agent acting on a device needs its current state and the controls that change it, not just its specification.", "layers": [ { "id": "controls-and-modes", "name": "Controls and modes", "description": "What can be set, what that changes, and what is interlocked.", "findings": [ { "id": "control-surface", "name": "Control surface and interlocks", "description": "The settings available and the conditions that block them.", "questions": [ { "id": "control-surface-q01", "text": "What controls and modes does morphine have, and what does each change?", "kind": "definition" }, { "id": "control-surface-q02", "text": "Which actions are interlocked or forbidden in which state, and what must be true before acting?", "kind": "action" } ] } ] }, { "id": "condition-and-maintenance", "name": "Condition and maintenance", "description": "Wear, service intervals, consumables and the line between working and broken.", "findings": [ { "id": "service-record", "name": "Condition, service and consumables", "description": "What is consumed, what is serviced, and how condition is judged.", "questions": [ { "id": "service-record-q01", "text": "What consumables and service does morphine need, at what interval, and on whose authority?", "kind": "measurement" }, { "id": "service-record-q02", "text": "What evidence separates a unit that is working from one that is out of service?", "kind": "boundary" } ] } ] } ] }, { "id": "kind-model-unit", "name": "Kind, model and unit", "description": "Whether a claim about morphine is about the kind, a product line, or one physical unit.", "rationale": "This is the boundary most often got wrong for made things, and getting it wrong mixes a catalogue entry with the machine in the yard.", "layers": [ { "id": "level-of-reference", "name": "Level of reference", "description": "The three levels and what belongs at each.", "findings": [ { "id": "level-rules", "name": "What belongs to kind, model and unit", "description": "Which properties are shared by all of them and which are not.", "questions": [ { "id": "level-rules-q01", "text": "Which facts about morphine hold for every one of them, which for a model, and which only for one unit?", "kind": "boundary" }, { "id": "level-rules-q02", "text": "What identifies an individual unit, and what should an agent do when it has only the kind?", "kind": "action" } ] } ] }, { "id": "standards-and-conformity", "name": "Standards and conformity", "description": "The standards a working example must meet and who attests it.", "findings": [ { "id": "conformity", "name": "Standards, marks and attestation", "description": "Which standard applies, who certifies, and what the mark means.", "questions": [ { "id": "conformity-q01", "text": "Which standards govern morphine, issued by whom, and what does conformity actually assert?", "kind": "provenance" }, { "id": "conformity-q02", "text": "What may an agent conclude from a certification mark, and what may it not?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a morphine came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a morphine and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a morphine is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a morphine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a morphine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a morphine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 8, "layers": 17, "findings": 19, "questions": 51 } } } }