{ "model": { "rank": 3858, "code": "thing-q8277", "model_id": "vr.tr.multiple-sclerosis", "name": "multiple sclerosis", "purpose": "Let an agent explain multiple sclerosis and its courses and mechanisms, relay general information on diagnosis, treatment and living with the condition from health bodies, support patients and families in understanding care, and route personal medical questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q8277/", "tier": 2, "score": 81, "payload": { "layer": "wikidata", "aliases": [ "Idiopathic inflammatory demyelinating disease", "pediatric multiple sclerosis", "Balo concentric sclerosis", "primary progressive multiple sclerosis", "progressive relapsing multiple sclerosis", "relapsing-remitting multiple sclerosis", "secondary progressive multiple sclerosis", "chronic progressive multiple sclerosis", "clinically isolated syndrome", "multiple sclerosis, susceptibility to", "disseminated sclerosis with narcolepsy", "tumefactive multiple sclerosis" ], "aliasCount": 12, "merged": 12, "knownIn": 81, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q8277", "url": "https://www.wikidata.org/wiki/Q8277", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T03:55:22Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q8277", "registryId": "vr.tr.multiple-sclerosis", "name": "multiple sclerosis", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q8277/", "model": { "registry_id": "vr.tr.multiple-sclerosis", "name": "multiple sclerosis", "purpose": "Let an agent explain multiple sclerosis and its courses and mechanisms, relay general information on diagnosis, treatment and living with the condition from health bodies, support patients and families in understanding care, and route personal medical questions to clinicians.", "definition": "A chronic autoimmune disease of the central nervous system in which the immune system damages the myelin sheath of nerve fibres, causing lesions in the brain and spinal cord and symptoms such as fatigue, vision problems, numbness, weakness, balance and cognitive difficulties, in courses classified as relapsing-remitting, primary progressive and secondary progressive, with rarer variants and paediatric forms; multiple sclerosis is diagnosed by clinical and imaging criteria and managed with disease-modifying therapies, symptom treatment and rehabilitation.", "what_it_is_for": "Autoimmune demyelinating disease of the central nervous system.", "affordances": [ "explain courses and mechanisms", "relay diagnosis and treatment information", "support understanding of care", "route personal questions" ], "distinguishing_features": [ "Demyelination", "Course types", "Imaging-based diagnosis", "Disease-modifying therapy" ], "appearance": "Not physical as a concept; lesions seen on imaging.", "visual_identification": [ "Autoimmune damage to myelin in brain and spinal cord", "Relapsing or progressive courses", "Neuromyelitis optica and other demyelinating diseases are distinct" ], "physical_properties": [], "families_and_kinds": [ "relapsing-remitting multiple sclerosis", "primary progressive multiple sclerosis", "secondary progressive multiple sclerosis", "paediatric multiple sclerosis", "rare variants such as Balo concentric sclerosis" ], "related_models": [ { "relation": "is a kind of", "target": "autoimmune disease of central nervous system", "why": "category" }, { "relation": "is a kind of", "target": "demyelinating disease of central nervous system", "why": "category" }, { "relation": "is related to", "target": "neurology", "why": "the specialty treating it" }, { "relation": "is related to", "target": "innate immune response", "why": "immune mechanisms involved" } ], "identifiers": [], "standards_and_regulation": [ "Diagnostic criteria for multiple sclerosis", "Clinical guidelines for disease-modifying therapy", "Disability rights and support law" ], "failure_modes_and_hazards": [ "Agents giving personal diagnostic or treatment advice", "Outdated treatment information", "Unproven therapies marketed to patients" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What multiple sclerosis is.", "rationale": "General information.", "layers": [ { "id": "mechanism", "name": "Mechanism", "description": "Mechanism and causes.", "findings": [ { "id": "mechanism-finding", "name": "Mechanism", "description": "Mechanism.", "questions": [ { "text": "How does immune damage to myelin cause symptoms, and what do researchers say about causes and risk factors?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "courses", "name": "Courses", "description": "Courses and variants.", "findings": [ { "id": "courses-finding", "name": "Courses", "description": "Courses.", "questions": [ { "text": "How do relapsing-remitting, primary and secondary progressive courses and rare variants differ?", "kind": "definition" }, { "text": "Which entry fits a specific course?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Guidelines.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is multiple sclerosis diagnosed with clinical criteria, imaging and other tests, according to guidelines?", "kind": "provenance" }, { "text": "Which entry fits neuroimaging?", "kind": "action" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What disease-modifying therapies, symptom treatments and rehabilitation exist, in general terms?", "kind": "provenance" }, { "text": "Is urgent care needed now, for example during a severe relapse?", "kind": "boundary" } ] } ] } ] }, { "id": "live", "name": "Live", "description": "Living with the condition.", "rationale": "Support.", "layers": [ { "id": "daily", "name": "Daily", "description": "Daily life.", "findings": [ { "id": "daily-finding", "name": "Daily", "description": "Daily.", "questions": [ { "text": "How do people manage fatigue, work, mobility and family life, according to patient organisations and clinicians?", "kind": "provenance" }, { "text": "Which entry fits disability support?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Support and rights.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What support organisations, benefits and rights exist?", "kind": "provenance" }, { "text": "Is someone in crisis, needing urgent help?", "kind": "boundary" } ] } ] } ] }, { "id": "learn", "name": "Learn", "description": "Research and history.", "rationale": "Education.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is under way on causes, remyelination and new therapies, and which findings are uncertain?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How was multiple sclerosis described and understood historically?", "kind": "provenance" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should each course type be a separate entry?", "How should guidelines be linked?", "How should patient organisations be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a multiple sclerosis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain multiple sclerosis and its courses and mechanisms, relay general information on diagnosis, treatment and living with the condition from health bodies, support patients and families in understanding care, and route personal medical questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Idiopathic inflammatory demyelinating disease, pediatric multiple sclerosis, Balo concentric sclerosis, primary progressive multiple sclerosis, progressive relapsing multiple sclerosis, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, chronic progressive multiple sclerosis, clinically isolated syndrome, multiple sclerosis, susceptibility to, disseminated sclerosis with narcolepsy, tumefactive multiple sclerosis.", "12 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 81 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a multiple sclerosis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Idiopathic inflammatory demyelinating disease", "pediatric multiple sclerosis", "Balo concentric sclerosis", "primary progressive multiple sclerosis", "progressive relapsing multiple sclerosis", "relapsing-remitting multiple sclerosis", "secondary progressive multiple sclerosis", "chronic progressive multiple sclerosis", "clinically isolated syndrome", "multiple sclerosis, susceptibility to", "disseminated sclerosis with narcolepsy", "tumefactive multiple sclerosis" ] } ], "standing": "Described in 81 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 12 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one multiple sclerosis from another, and a multiple sclerosis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a multiple sclerosis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a multiple sclerosis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a multiple sclerosis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a multiple sclerosis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a multiple sclerosis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a multiple sclerosis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of multiple sclerosis a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define multiple sclerosis, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover multiple sclerosis, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How multiple sclerosis develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does multiple sclerosis typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for multiple sclerosis, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a multiple sclerosis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a multiple sclerosis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a multiple sclerosis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a multiple sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a multiple sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a multiple sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }