{ "model": { "rank": 13873, "code": "thing-q846316", "model_id": "vr.tr.aplastic-anemia", "name": "aplastic anemia", "purpose": "Let an agent explain aplastic anaemia and its causes in neutral clinical terms, relay diagnosis, severity grading and treatment in general from haematology sources, distinguish it from other marrow failure and anaemia types listed as aliases, and route people with symptoms or diagnoses to haematologists.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q846316/", "tier": 2, "score": 36, "payload": { "layer": "wikidata", "aliases": [ "Revesz syndrome", "Refractory anemia with ring sideroblasts", "drug induced aplastic anemia", "severe aplastic anemia", "sideroblastic anaemia P", "myelophthisic anemia", "erythroblastopenia", "congenital hypoplastic anemia", "acquired aplastic anemia", "pyridoxine-responsive sideroblastic anemia", "Hereditary sideroblastic anemia", "secondary sideroblastic anemia", "Transient erythroblastopenia of childhood", "WT limb-blood syndrome", "hereditary isolated aplastic anemia" ], "aliasCount": 15, "merged": 15, "knownIn": 36, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q846316", "url": "https://www.wikidata.org/wiki/Q846316", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T06:18:08Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q846316", "registryId": "vr.tr.aplastic-anemia", "name": "aplastic anemia", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q846316/", "model": { "registry_id": "vr.tr.aplastic-anemia", "name": "aplastic anemia", "purpose": "Let an agent explain aplastic anaemia and its causes in neutral clinical terms, relay diagnosis, severity grading and treatment in general from haematology sources, distinguish it from other marrow failure and anaemia types listed as aliases, and route people with symptoms or diagnoses to haematologists.", "definition": "A rare, serious condition in which the bone marrow fails to produce enough red cells, white cells and platelets, causing anaemia, infections and bleeding, most often from autoimmune destruction of stem cells, sometimes drug-induced or caused by toxins, viruses or inherited syndromes such as Fanconi anaemia and the telomere disorder Revesz syndrome, and graded as non-severe, severe and very severe; the registry aliases also list distinct marrow disorders such as sideroblastic anaemia, refractory anaemia with ring sideroblasts and myelophthisic anaemia, which have different causes; treatment includes immunosuppression and stem cell transplantation.", "what_it_is_for": "Not applicable; a disease.", "affordances": [ "explain causes and grading", "relay diagnosis and treatment", "distinguish related disorders", "route to specialists" ], "distinguishing_features": [ "Empty marrow", "Pancytopenia", "Mostly immune-mediated", "Curable by transplant in many" ], "appearance": "Not a visible object; pallor, bruising and infections.", "visual_identification": [ "Bone marrow failure with pancytopenia", "Acquired, drug-induced and severe aplastic anaemia; inherited forms such as Revesz syndrome", "Sideroblastic anaemia and refractory anaemia with ring sideroblasts are different marrow disorders; myelophthisic anaemia is marrow replacement" ], "physical_properties": [ { "quantity": "incidence", "typical_range": "about 2", "unit": "per million per year", "note": "Western countries, higher in East Asia" }, { "quantity": "main treatments", "typical_range": "immunosuppression, stem cell transplant", "unit": "list", "note": "" }, { "quantity": "severity criteria", "typical_range": "Camitta criteria", "unit": "note", "note": "" } ], "families_and_kinds": [ "acquired immune-mediated aplastic anaemia", "drug-induced aplastic anaemia", "aplastic anaemia after hepatitis or toxins", "inherited bone marrow failure such as Fanconi anaemia, dyskeratosis congenita and Revesz syndrome", "severe and very severe aplastic anaemia", "distinct disorders listed as aliases such as sideroblastic anaemia, refractory anaemia with ring sideroblasts and myelophthisic anaemia" ], "related_models": [ { "relation": "is a kind of", "target": "bone marrow failure", "why": "in registry terms" }, { "relation": "is a kind of", "target": "congenital anemia", "why": "in registry terms, though most cases are acquired" }, { "relation": "is treated by", "target": "hematopoietic stem cell transplantation", "why": "in eligible patients" }, { "relation": "is contrasted with", "target": "myelodysplastic syndrome", "why": "a clonal marrow disorder" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "3A70", "note": "aplastic anaemia" }, { "scheme": "MeSH", "value_or_pattern": "D000741", "note": "anemia, aplastic" }, { "scheme": "Orphanet", "value_or_pattern": "ORPHA:88", "note": "acquired aplastic anemia" } ], "standards_and_regulation": [ "Haematology guidelines such as those of the British Society for Haematology", "Transplant and blood transfusion standards", "Drug safety monitoring for marrow toxicity" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Confusing aplastic anaemia with other anaemias listed as aliases", "Delayed diagnosis of infections and bleeding" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Care first.", "rationale": "Safety.", "layers": [ { "id": "urgent", "name": "Urgent", "description": "Urgent signs.", "findings": [ { "id": "urgent-finding", "name": "Urgent", "description": "Urgent.", "questions": [ { "text": "Why do fever, unusual bleeding, severe fatigue or unexplained bruising need urgent medical assessment?", "kind": "action" }, { "text": "Is the user describing their own symptoms or results, which needs a clinician now?", "kind": "boundary" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What patient organisations and support exist for people with aplastic anaemia?", "kind": "provenance" }, { "text": "Which entry fits the specific organisation?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and causes.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is aplastic anaemia, and what immune, drug, toxin, viral and inherited causes exist?", "kind": "definition" }, { "text": "Is the question about aplastic anaemia or a different marrow or anaemia disorder listed as an alias?", "kind": "boundary" } ] } ] }, { "id": "related", "name": "Related", "description": "Related disorders.", "findings": [ { "id": "related-finding", "name": "Related", "description": "Related.", "questions": [ { "text": "How do sideroblastic anaemia, refractory anaemia with ring sideroblasts, myelophthisic anaemia and Revesz syndrome differ from aplastic anaemia?", "kind": "definition" }, { "text": "Which entry fits the specific disorder?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis and grading.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is aplastic anaemia diagnosed by blood counts and marrow biopsy, and how is severity graded?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How is aplastic anaemia treated with immunosuppression, transplantation and supportive care, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and history.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses eltrombopag, transplant outcomes and telomere biology, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits bone marrow failure research?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How was aplastic anaemia described by Ehrlich and how did treatment develop?", "kind": "provenance" }, { "text": "Which entry fits the history of haematology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should inherited marrow failure and sideroblastic anaemia be separate primary entries?", "How should haematology sources be linked?", "The registry entry has merged aliases naming distinct disorders; should they be moved?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a aplastic anemia, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain aplastic anaemia and its causes in neutral clinical terms, relay diagnosis, severity grading and treatment in general from haematology sources, distinguish it from other marrow failure and anaemia types listed as aliases, and route people with symptoms or diagnoses to haematologists.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Revesz syndrome, Refractory anemia with ring sideroblasts, drug induced aplastic anemia, severe aplastic anemia, sideroblastic anaemia P, myelophthisic anemia, erythroblastopenia, congenital hypoplastic anemia, acquired aplastic anemia, pyridoxine-responsive sideroblastic anemia, Hereditary sideroblastic anemia, secondary sideroblastic anemia.", "15 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 36 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a aplastic anemia, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Revesz syndrome", "Refractory anemia with ring sideroblasts", "drug induced aplastic anemia", "severe aplastic anemia", "sideroblastic anaemia P", "myelophthisic anemia", "erythroblastopenia", "congenital hypoplastic anemia", "acquired aplastic anemia", "pyridoxine-responsive sideroblastic anemia", "Hereditary sideroblastic anemia", "secondary sideroblastic anemia" ] } ], "standing": "Described in 36 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 15 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one aplastic anemia from another, and a aplastic anemia from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a aplastic anemia sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a aplastic anemia from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a aplastic anemia passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a aplastic anemia between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a aplastic anemia, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a aplastic anemia is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What aplastic anemia is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of aplastic anemia are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is aplastic anemia operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of aplastic anemia and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of aplastic anemia?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as aplastic anemia?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a aplastic anemia came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a aplastic anemia and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a aplastic anemia is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a aplastic anemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a aplastic anemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a aplastic anemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }