{ "model": { "rank": 17194, "code": "thing-q938107", "model_id": "vr.tr.hypogonadism", "name": "hypogonadism", "purpose": "Let an agent explain hypogonadism and its main forms in general terms, relay diagnosis and treatment information from endocrinology guidelines, and route personal symptoms, results and treatment questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q938107/", "tier": 2, "score": 31, "payload": { "layer": "wikidata", "aliases": [ "Isolated hypogonadotropic hypogonadism", "gonadal dysgenesis", "hydrocephalus-obesity-hypogonadism syndrome", "hypogonadotropic hypogonadism associated with other endocrinopathies", "isolated congenital hypogonadotropic hypogonadism", "Gonadotropin-releasing hormone insensitivity", "embryonic testicular regression syndrome", "gonadal agenesis", "sexual infantilism", "46 XX gonadal dysgenesis", "hypergonadotropic hypogonadism", "deafness-hypogonadism syndrome", "ovarian dysgenesis 9", "ovarian dysgenesis 10", "ovarian dysgenesis 1", "ovarian dysgenesis 2", "ovarian dysgenesis 3", "ovarian dysgenesis 4", "ovarian dysgenesis 5", "ovarian dysgenesis 6", "ovarian dysgenesis 7", "ovarian dysgenesis 8", "hypergonadotropic hypogonadism-cataract syndrome", "primary hypergonadotropic hypogonadism-partial alopecia syndrome", "male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome", "hypogonadism-mitral valve prolapse-intellectual disability syndrome", "Mikati-Najjar-Sahli syndrome", "hypogonadotropic hypogonadism 12 with or without anosmia", "hypogonadotropic hypogonadism 24 without anosmia", "hypogonadotropic hypogonadism 9 with or without anosmia", "hypogonadotropic hypogonadism 2 with or without anosmia", "hypogonadotropism", "hypogonadotropic hypogonadism", "Hypogenitalism", "hypogonadism, male", "hypogonadotropic hypogonadism 16 with or without anosmia", "hypogonadotropic hypogonadism 17 with or without anosmia", "hypogonadotropic hypogonadism 20 with or without anosmia", "hypogonadotropic hypogonadism 21 with or without anosmia", "hypogonadotropic hypogonadism 15 with or without anosmia" ], "aliasCount": 45, "merged": 45, "knownIn": 31, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q938107", "url": "https://www.wikidata.org/wiki/Q938107", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T20:21:37Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q938107", "registryId": "vr.tr.hypogonadism", "name": "hypogonadism", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q938107/", "model": { "registry_id": "vr.tr.hypogonadism", "name": "hypogonadism", "purpose": "Let an agent explain hypogonadism and its main forms in general terms, relay diagnosis and treatment information from endocrinology guidelines, and route personal symptoms, results and treatment questions to clinicians.", "definition": "A condition in which the gonads, the testes or ovaries, produce little or no sex hormones and, in many cases, few or no gametes, either because of a problem in the gonads themselves or because the pituitary and hypothalamus fail to stimulate them; it can be congenital or acquired, presents as delayed puberty, infertility or hormone deficiency symptoms, and is managed with hormone replacement and treatment of the cause.", "what_it_is_for": "Not applicable; a medical condition.", "affordances": [ "explain forms and causes in general terms", "relay diagnosis and treatment information from guidelines", "explain effects on puberty, fertility and health", "route personal questions to clinicians" ], "distinguishing_features": [ "Deficient gonadal hormone production", "Primary versus secondary causes", "Congenital and acquired forms", "Treated by hormone replacement" ], "appearance": "Not visible as an object; signs vary with age and sex, from delayed puberty to hormone deficiency symptoms.", "visual_identification": [ "Low sex hormone levels confirmed by tests", "Primary in the gonads or secondary in the pituitary and hypothalamus", "Normal age-related hormone decline and infertility from other causes are distinguished" ], "physical_properties": [], "families_and_kinds": [ "primary hypogonadism from gonadal failure, including Klinefelter and Turner syndromes", "secondary or hypogonadotropic hypogonadism, including Kallmann syndrome", "congenital and acquired forms", "hypogonadism in men and in women", "late-onset hypogonadism, whose definition is debated" ], "related_models": [ { "relation": "is a kind of", "target": "gonadal disease", "why": "the category" }, { "relation": "affects", "target": "puberty", "why": "delayed or absent" }, { "relation": "is treated by", "target": "hormone replacement therapy", "why": "the main treatment" }, { "relation": "is related to", "target": "infertility", "why": "a common consequence" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "E23.0, E28.3, E29.1", "note": "by cause" }, { "scheme": "ICD-11", "value_or_pattern": "5A61, 5A80", "note": "by cause" } ], "standards_and_regulation": [ "Endocrinology society guidelines on diagnosis and treatment", "Medicines regulation for hormone therapies", "Rare disease frameworks for genetic forms" ], "failure_modes_and_hazards": [ "Missed diagnosis of delayed puberty", "Bone loss and other effects of untreated deficiency", "Misuse of testosterone outside clinical indication", "Agents giving personal medical advice" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What hypogonadism is.", "rationale": "General information.", "layers": [ { "id": "forms", "name": "Forms", "description": "Forms and causes.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are primary and secondary hypogonadism, and what causes each?", "kind": "definition" }, { "text": "Is the user asking about their own symptoms or results, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "effects", "name": "Effects", "description": "Effects.", "findings": [ { "id": "effects-finding", "name": "Effects", "description": "Effects.", "questions": [ { "text": "How does the condition affect puberty, fertility, bone and general health?", "kind": "definition" }, { "text": "Which entry fits puberty?", "kind": "action" } ] } ] } ] }, { "id": "diagnose", "name": "Diagnose", "description": "Diagnosis.", "rationale": "Clinical.", "layers": [ { "id": "tests", "name": "Tests", "description": "Investigations.", "findings": [ { "id": "tests-finding", "name": "Tests", "description": "Tests.", "questions": [ { "text": "How is hypogonadism diagnosed, and which tests distinguish the forms, in general terms?", "kind": "provenance" }, { "text": "Which entry fits endocrine testing?", "kind": "action" } ] } ] }, { "id": "debate", "name": "Debate", "description": "Debated definitions.", "findings": [ { "id": "debate-finding", "name": "Debate", "description": "Debate.", "questions": [ { "text": "What debates exist about late-onset hypogonadism and testosterone prescribing, with positions attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral?", "kind": "boundary" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment and support.", "rationale": "Care.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do guidelines describe, including hormone replacement and fertility treatment?", "kind": "provenance" }, { "text": "Is the presentation free of personal treatment advice?", "kind": "boundary" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What support exists for people with congenital forms and fertility concerns?", "kind": "provenance" }, { "text": "Which entry fits patient support?", "kind": "action" } ] } ] } ] }, { "id": "study", "name": "Study", "description": "Research and teaching.", "rationale": "Study.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What is known about genetics and new treatments, with findings attributed?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "teach", "name": "Teach", "description": "Teaching.", "findings": [ { "id": "teach-finding", "name": "Teach", "description": "Teaching.", "questions": [ { "text": "How is hypogonadism taught in endocrinology?", "kind": "action" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should primary and secondary forms be separate entries?", "How should guidelines be linked?", "The registry entry has merged aliases for rare syndromes; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hypogonadism, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain hypogonadism and its main forms in general terms, relay diagnosis and treatment information from endocrinology guidelines, and route personal symptoms, results and treatment questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Isolated hypogonadotropic hypogonadism, gonadal dysgenesis, hydrocephalus-obesity-hypogonadism syndrome, hypogonadotropic hypogonadism associated with other endocrinopathies, isolated congenital hypogonadotropic hypogonadism, Gonadotropin-releasing hormone insensitivity, embryonic testicular regression syndrome, gonadal agenesis, sexual infantilism, 46 XX gonadal dysgenesis, hypergonadotropic hypogonadism, deafness-hypogonadism syndrome.", "45 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 31 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hypogonadism, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Isolated hypogonadotropic hypogonadism", "gonadal dysgenesis", "hydrocephalus-obesity-hypogonadism syndrome", "hypogonadotropic hypogonadism associated with other endocrinopathies", "isolated congenital hypogonadotropic hypogonadism", "Gonadotropin-releasing hormone insensitivity", "embryonic testicular regression syndrome", "gonadal agenesis", "sexual infantilism", "46 XX gonadal dysgenesis", "hypergonadotropic hypogonadism", "deafness-hypogonadism syndrome" ] } ], "standing": "Described in 31 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 45 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hypogonadism from another, and a hypogonadism from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hypogonadism sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hypogonadism from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hypogonadism passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hypogonadism between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hypogonadism, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hypogonadism is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What hypogonadism is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of hypogonadism are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is hypogonadism operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of hypogonadism and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of hypogonadism?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as hypogonadism?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hypogonadism came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hypogonadism and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hypogonadism is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hypogonadism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hypogonadism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hypogonadism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }