{ "model": { "rank": 11422, "code": "thing-q938205", "model_id": "vr.tr.neuroblastoma", "name": "neuroblastoma", "purpose": "Let an agent explain neuroblastoma in general terms from paediatric oncology guidelines, describe risk groups, treatment and outcomes, distinguish it from other childhood tumours, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q938205/", "tier": 2, "score": 42, "payload": { "layer": "wikidata", "aliases": [ "adrenal gland ganglioneuroblastoma", "extracranial neuroblastoma", "differentiating neuroblastoma", "adrenal neuroblastoma", "relapsed neuroblastoma", "regional neuroblastoma", "localized resectable neuroblastoma", "localized unresectable neuroblastoma", "disseminated neuroblastoma", "ganglioneuroblastoma", "Pleomorphic anaplastic neuroblastoma", "nodular ganglioneuroblastoma", "intermixed schwannian stroma-rich ganglioneuroblastoma", "peripheral nervous system ganglioneuroblastoma" ], "aliasCount": 14, "merged": 14, "knownIn": 42, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q938205", "url": "https://www.wikidata.org/wiki/Q938205", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T03:46:20Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q938205", "registryId": "vr.tr.neuroblastoma", "name": "neuroblastoma", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q938205/", "model": { "registry_id": "vr.tr.neuroblastoma", "name": "neuroblastoma", "purpose": "Let an agent explain neuroblastoma in general terms from paediatric oncology guidelines, describe risk groups, treatment and outcomes, distinguish it from other childhood tumours, and route personal questions to clinicians.", "definition": "A cancer of immature nerve cells of the sympathetic nervous system, the most common solid tumour outside the brain in children, arising most often in the adrenal glands and along the spine as adrenal or extracranial neuroblastoma, ranging from localized and regional disease that may regress or differentiate to high-risk metastatic and relapsed disease, with the intermediate ganglioneuroblastoma showing partial maturation; treatment depends on risk group and combines surgery, chemotherapy, radiotherapy, stem cell transplant and immunotherapy.", "what_it_is_for": "Not applicable; a cancer.", "affordances": [ "explain the disease and risk groups", "relay treatment and outcomes", "distinguish from other tumours", "route personal questions" ], "distinguishing_features": [ "Sympathetic nervous system origin", "Early childhood", "Risk-stratified treatment", "Spontaneous regression in some infants" ], "appearance": "Not a visible object; a tumour in the adrenal gland or along the sympathetic chain.", "visual_identification": [ "Childhood cancer of sympathetic nerve cells", "Adrenal, extracranial, localized, regional, metastatic, relapsed and differentiating neuroblastoma; ganglioneuroblastoma", "Wilms tumour is a kidney cancer; neuroblastoma is not a brain tumour despite the name" ], "physical_properties": [ { "quantity": "share of childhood cancers", "typical_range": "about 6-8", "unit": "percent", "note": "" }, { "quantity": "median age at diagnosis", "typical_range": "about 18", "unit": "months", "note": "" }, { "quantity": "high-risk five-year survival", "typical_range": "about 50", "unit": "percent", "note": "improving" } ], "families_and_kinds": [ "adrenal neuroblastoma", "extracranial neuroblastoma along the sympathetic chain", "localized and regional neuroblastoma", "metastatic and stage 4S neuroblastoma", "relapsed neuroblastoma", "differentiating neuroblastoma and ganglioneuroblastoma", "MYCN-amplified high-risk disease" ], "related_models": [ { "relation": "is a kind of", "target": "neuroblastic tumor", "why": "in registry terms" }, { "relation": "is a kind of", "target": "autonomic nervous system neoplasm", "why": "in registry terms" }, { "relation": "is a kind of", "target": "paediatric oncology", "why": "in registry terms, as a paediatric cancer" }, { "relation": "is stratified by", "target": "MYCN", "why": "amplification and other markers" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "2A00.2", "note": "neuroblastoma" }, { "scheme": "MeSH", "value_or_pattern": "D009447", "note": "neuroblastoma" } ], "standards_and_regulation": [ "International Neuroblastoma Risk Group classification", "Paediatric oncology protocols such as COG and SIOPEN", "Cancer registration standards" ], "failure_modes_and_hazards": [ "Delayed diagnosis", "Agents giving personal medical advice", "Confusing neuroblastoma with brain tumours", "Overgeneralising outcomes across risk groups" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Getting help first.", "rationale": "Safety.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What signs in a child, such as an abdominal mass, bone pain or unexplained bruising around the eyes, need prompt assessment?", "kind": "action" }, { "text": "Is the user describing such signs in a child, which need a clinician promptly?", "kind": "boundary" } ] } ] }, { "id": "care", "name": "Care", "description": "Specialist care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "How is neuroblastoma diagnosed and staged by paediatric oncology teams, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own child diagnosis, which needs the oncology team?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "Clinical.", "layers": [ { "id": "disease", "name": "Disease", "description": "Disease and biology.", "findings": [ { "id": "disease-finding", "name": "Disease", "description": "Disease.", "questions": [ { "text": "What is neuroblastoma, where does it arise, and why can it regress or mature?", "kind": "definition" }, { "text": "Is the question about neuroblastoma or another childhood tumour?", "kind": "boundary" } ] } ] }, { "id": "risk", "name": "Risk", "description": "Risk groups.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Risk.", "questions": [ { "text": "How are low, intermediate and high-risk groups defined by stage, age, MYCN and histology?", "kind": "provenance" }, { "text": "Which entry fits the specific risk group or stage?", "kind": "action" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments do protocols use for each risk group, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "outcomes", "name": "Outcomes", "description": "Outcomes and survivorship.", "findings": [ { "id": "outcomes-finding", "name": "Outcomes", "description": "Outcomes.", "questions": [ { "text": "What outcomes are seen, and what late effects and follow-up exist for survivors?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and support.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses immunotherapy, targeted therapy and relapsed disease, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits paediatric cancer research?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What organisations support families affected by neuroblastoma?", "kind": "provenance" }, { "text": "Which entry fits the specific organisation?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should ganglioneuroblastoma be a separate entry?", "How should paediatric oncology guidelines be linked?", "The registry entry has merged aliases naming stages and sites; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a neuroblastoma, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain neuroblastoma in general terms from paediatric oncology guidelines, describe risk groups, treatment and outcomes, distinguish it from other childhood tumours, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: adrenal gland ganglioneuroblastoma, extracranial neuroblastoma, differentiating neuroblastoma, adrenal neuroblastoma, relapsed neuroblastoma, regional neuroblastoma, localized resectable neuroblastoma, localized unresectable neuroblastoma, disseminated neuroblastoma, ganglioneuroblastoma, Pleomorphic anaplastic neuroblastoma, nodular ganglioneuroblastoma.", "14 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 42 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a neuroblastoma, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "adrenal gland ganglioneuroblastoma", "extracranial neuroblastoma", "differentiating neuroblastoma", "adrenal neuroblastoma", "relapsed neuroblastoma", "regional neuroblastoma", "localized resectable neuroblastoma", "localized unresectable neuroblastoma", "disseminated neuroblastoma", "ganglioneuroblastoma", "Pleomorphic anaplastic neuroblastoma", "nodular ganglioneuroblastoma" ] } ], "standing": "Described in 42 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 14 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one neuroblastoma from another, and a neuroblastoma from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a neuroblastoma sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a neuroblastoma from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a neuroblastoma passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a neuroblastoma between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a neuroblastoma, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a neuroblastoma is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What neuroblastoma is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of neuroblastoma are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is neuroblastoma operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of neuroblastoma and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of neuroblastoma?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as neuroblastoma?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a neuroblastoma came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a neuroblastoma and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a neuroblastoma is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a neuroblastoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a neuroblastoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a neuroblastoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }