{ "model": { "rank": 6341, "code": "thing-reaction-act", "model_id": "vr.tr.reaction-act", "name": "reaction", "purpose": "a bodily process occurring due to the effect of some antecedent stimulus or agent", "family": "Thing Registry", "category": "Activities and processes", "status": "research-draft", "kind": "thing", "plane": "ACT", "domain": "ACT.ACT", "industry": "", "version": "", "url": "/models/thing/reaction-act/", "tier": 2, "score": 61, "payload": { "layer": "wordnet", "aliases": [ "accommodation reflex", "belch", "belching", "burp", "burping", "eructation", "blink", "eye blink", "blinking", "wink", "winking", "nictitation", "nictation", "blush", "flush", "vomit", "vomiting", "emesis", "regurgitation", "disgorgement", "puking", "rumination", "hematemesis", "haematemesis", "hyperemesis", "hyperemesis gravidarum", "defecation reflex", "rectal reflex", "yawn", "yawning", "oscitance", "oscitancy", "electric shock", "electrical shock", "shock", "fart", "farting", "flatus", "wind", "breaking wind" ], "aliasCount": 135, "merged": 61, "knownIn": 0, "facets": { "substance": "activity", "origin": "conceptual", "agency": "inert", "mobility": "not-applicable", "scale": "not-applicable", "affordances": [ "observable" ] }, "markers": [], "lexicalClass": "noun.act", "senseRank": 2, "alsoRegisteredAs": null, "source": { "dataset": "oewn:2024", "synset": "oewn-00860679-n", "ili": "i39914", "license": "CC BY 4.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T13:56:28Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.0102544, "turns": 1, "seconds": 164, "error": null }, "codex": { "seconds": 63.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07c23-271e-7d53-89e9-4340c65289b9\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: reaction\nRegistry id: vr.tr.reaction-act\nPlane / domain: ACT / ACT.ACT\nRegistry definition: a bodily process occurring due to the effect of some ante" } } }, "metaModel": { "id": "THING-REACTION-ACT", "registryId": "vr.tr.reaction-act", "name": "reaction", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "ACT.ACT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/reaction-act/", "model": { "registry_id": "vr.tr.reaction-act", "name": "reaction", "purpose": "Enable an AI agent to recognise a bodily reaction, assess its course and significance, and identify justified observations or actions without treating a suspected trigger as a proven cause.", "definition": "A reaction in this sense is an organism-level physiological or pathological process elicited by a prior stimulus or exogenous agent and mediated by neural, immune, endocrine, or local tissue mechanisms, ranging from a normal reflex or homeostatic response to hypersensitivity and other adverse effects.", "scope_statement": "This model owns an episode of bodily process understood as occurring because of an antecedent stimulus or agent, including its manifestations, attributed trigger, temporal course, contextual dependencies and action-relevant uncertainty.", "in_scope": [ "The bodily process constituting the reaction and the organism or body region in which it occurs", "The antecedent stimulus or agent and evidence connecting it to the reaction", "Observable manifestations and reported bodily experiences", "Onset, progression, resolution and recurrence of the reaction", "Context affecting interpretation and constraints on observation or intervention" ], "out_of_scope": [ "The identity and lifecycle of the stimulus or causal agent independently of this reaction", "Diseases, injuries and persistent conditions beyond their relationship to the episode", "Deliberate actions and decisions considered independently of bodily reactions", "Emotional appraisals, opinions and social responses without a bodily process in scope", "Chemical reactions considered independently of a bodily process", "Treatment protocols and clinical decisions owned by appropriate care models" ], "distinguishing_features": [ "Identify a bodily process, rather than relying on the word 'reaction' to denote an opinion, decision or social response.", "Identify an antecedent stimulus or agent, or explicitly record that one is hypothesised but unidentified; a bodily change alone does not establish the causal relationship.", "Distinguish the reaction episode from its manifestations: a sign or sensation can indicate a reaction without defining the entire process.", "Distinguish the episode from a persistent condition that may predispose to, result from or resemble it.", "Record whether intentional behaviour accompanies the process without assuming that intention either establishes or excludes a bodily reaction." ], "characteristics": [ { "name": "Reacting organism and bodily locus", "kind": "relation", "unit_or_values": "Organism reference; body region or system; localisation uncertain", "why_it_matters": "Establishes whose bodily process is being described and where its manifestations occur." }, { "name": "Antecedent stimulus or agent", "kind": "relation", "unit_or_values": "Stimulus, exposure or agent reference; unidentified; multiple candidates", "why_it_matters": "Connects the episode to the antecedent required by the registry definition." }, { "name": "Causal attribution status", "kind": "category", "unit_or_values": "Unassessed; suspected; supported; disputed; unresolved", "why_it_matters": "Separates observed sequence from the strength of the explanation connecting trigger and process." }, { "name": "Manifestation", "kind": "category", "unit_or_values": "Described bodily change, with observed, instrument-detected or subject-reported basis", "why_it_matters": "Makes the reaction recognisable without requiring an established mechanism." }, { "name": "Onset latency", "kind": "measurement", "unit_or_values": "Elapsed time from a specified antecedent event, in seconds, minutes, hours or days; interval estimate; unknown", "why_it_matters": "Records temporal fit while preserving uncertainty about exposure and onset." }, { "name": "Episode duration", "kind": "measurement", "unit_or_values": "Elapsed time with explicit start and end criteria; ongoing; unknown", "why_it_matters": "Supports comparison and distinguishes completed observations from an episode still unfolding." }, { "name": "Manifestation magnitude", "kind": "measurement", "unit_or_values": "Manifestation-specific physical unit or named rating scale, including baseline and uncertainty", "why_it_matters": "Avoids treating unlike bodily changes as if they shared a universal intensity measure." }, { "name": "Course", "kind": "state", "unit_or_values": "Onset; increasing; stable; decreasing; fluctuating; resolved; unknown", "why_it_matters": "Supports decisions about further observation and review." }, { "name": "Functional consequence", "kind": "relation", "unit_or_values": "Affected bodily function or activity, with described change and evidence", "why_it_matters": "Distinguishes detectable change from consequences relevant to the organism." } ], "affordances": [ "Recognise and delimit a candidate reaction episode from bodily observations and antecedent context.", "Associate candidate triggers with the episode while retaining competing explanations.", "Track manifestations against an appropriate baseline and identify changes in course.", "Compare repeated episodes without assuming identical triggers or mechanisms.", "Identify missing observations and request review when recorded criteria warrant it.", "Record authorised responses and subsequent changes without treating improvement as proof of causation." ] }, "sources": [ { "id": "wordnet-reaction-process", "title": "WordNet 3.1, synset reaction (noun: bodily process)", "url": "https://wordnet.princeton.edu/", "what_it_supports": "The exact gloss used as the research sense, and the grouping of physiological response with examples such as a bad reaction to a medicine.", "url_status": "blocked" }, { "id": "ich-e2a", "title": "ICH Harmonised Guideline E2A: Clinical Safety Data Management - Definitions and Standards for Expedited Reporting", "url": "https://database.ich.org/sites/default/files/E2A_Guideline.pdf", "what_it_supports": "Regulatory distinction between adverse event and adverse (drug) reaction, causality, and expedited reporting of serious unexpected reactions.", "url_status": "live" }, { "id": "edwards-aronson-2000", "title": "Adverse drug reactions: definitions, diagnosis, and management", "url": "", "what_it_supports": "Clinical definition of ADR, Type A versus Type B classification, diagnosis, and management as used in pharmacovigilance and therapeutics. The Lancet, 2000, Edwards and Aronson." }, { "id": "gell-coombs", "title": "Clinical Aspects of Immunology", "url": "", "what_it_supports": "The Gell and Coombs Types I-IV classification that still structures how clinicians name hypersensitivity reactions. Blackwell Scientific Publications, Gell and Coombs." }, { "id": "go-0050896", "title": "Gene Ontology term GO:0050896, response to stimulus", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050896", "what_it_supports": "The organism- and cell-level biological-process identifier for a change elicited by a stimulus, the closest controlled-vocabulary neighbour to this sense.", "url_status": "live" }, { "id": "sampson-anaphylaxis-2006", "title": "Second symposium on the definition and management of anaphylaxis: summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium", "url": "", "what_it_supports": "Clinical diagnostic criteria used for anaphylaxis as a life-threatening systemic reaction. Journal of Allergy and Clinical Immunology, 2006, Sampson et al." }, { "id": "who-pharmacovigilance-2002", "title": "The Importance of Pharmacovigilance: Safety Monitoring of Medicinal Products", "url": "", "what_it_supports": "WHO operational definition of adverse reaction, spontaneous reporting, and the international drug-monitoring programme (VigiBase / Uppsala Monitoring Centre)." } ], "structure": { "bundles": [ { "id": "bodily-episode", "name": "Bodily episode", "description": "Establishes the bodily process being treated as a reaction and the limits of its episode.", "rationale": "A reaction must be distinguishable from a label, an isolated manifestation and an ongoing condition.", "layers": [ { "id": "process-identification", "name": "Process identification", "description": "Identifies the reacting organism and the bodily change under consideration.", "findings": [ { "id": "candidate-bodily-process", "name": "Candidate bodily process", "description": "Records what bodily process is proposed as the reaction and the observations supporting its recognition.", "questions": [ { "text": "What bodily process is occurring, in which organism and at which known or suspected bodily locus?", "kind": "definition", "id": "candidate-bodily-process-q01" }, { "text": "What observation or report supports recognising this process, and who or what supplied it?", "kind": "provenance", "id": "candidate-bodily-process-q02" } ] } ] }, { "id": "episode-boundaries", "name": "Episode boundaries", "description": "Separates one reaction episode from background processes and neighbouring episodes.", "findings": [ { "id": "episode-membership", "name": "Episode membership", "description": "Makes explicit why particular manifestations belong to one episode rather than separate or persistent processes.", "questions": [ { "text": "What criteria mark the start and end of this episode?", "kind": "boundary", "id": "episode-membership-q01" }, { "text": "What supports grouping these manifestations into one reaction rather than several reactions or an ongoing condition?", "kind": "boundary", "id": "episode-membership-q02" } ] } ] } ] }, { "id": "antecedent-attribution", "name": "Antecedent attribution", "description": "Connects the bodily process to candidate antecedent stimuli or agents without overstating causation.", "rationale": "Dependence on an antecedent is central to this registry entry, but temporal sequence alone leaves the explanation unsettled.", "layers": [ { "id": "stimulus-contact", "name": "Stimulus contact", "description": "Describes the antecedent event and how it could have affected the organism.", "findings": [ { "id": "antecedent-event", "name": "Antecedent event", "description": "Records candidate stimuli or agents, timing and relevant contact or exposure circumstances.", "questions": [ { "text": "Which stimulus or agent preceded the bodily process, and how did it reach or affect the organism?", "kind": "definition", "id": "antecedent-event-q01" }, { "text": "What is known about its timing, duration and magnitude, and which details were measured rather than inferred?", "kind": "measurement", "id": "antecedent-event-q02" } ] } ] }, { "id": "causal-support", "name": "Causal support", "description": "Assesses the basis and limits of assigning the reaction to an antecedent.", "findings": [ { "id": "trigger-hypothesis", "name": "Trigger hypothesis", "description": "Keeps evidence for the proposed connection separate from alternative explanations and unknown mechanisms.", "questions": [ { "text": "What evidence beyond temporal order supports attributing this bodily process to the proposed antecedent?", "kind": "provenance", "id": "trigger-hypothesis-q01" }, { "text": "Which alternative triggers, coincident processes or missing observations leave that attribution uncertain?", "kind": "boundary", "id": "trigger-hypothesis-q02" } ] } ] } ] }, { "id": "bodily-expression", "name": "Bodily expression", "description": "Describes how the reaction presents and what changes it produces in bodily function.", "rationale": "Recognition and assessment require concrete manifestations, not an unexplained reaction label or universal severity score.", "layers": [ { "id": "manifestation-evidence", "name": "Manifestation evidence", "description": "Separates measured changes, externally observed signs and reported sensations.", "findings": [ { "id": "manifestation-profile", "name": "Manifestation profile", "description": "Records the location, character and magnitude of each manifestation with its observation basis.", "questions": [ { "text": "Which bodily changes were observed, instrument-detected or reported, and where did each occur?", "kind": "definition", "id": "manifestation-profile-q01" }, { "text": "How was each change measured or described, against what baseline and with what uncertainty?", "kind": "measurement", "id": "manifestation-profile-q02" } ] } ] }, { "id": "functional-effect", "name": "Functional effect", "description": "Identifies consequences of the reaction for bodily function and activity.", "findings": [ { "id": "consequence-assessment", "name": "Consequence assessment", "description": "Distinguishes manifestation magnitude from experienced burden and functional impact.", "questions": [ { "text": "Which bodily functions or activities changed during the episode, and how was the change assessed?", "kind": "measurement", "id": "consequence-assessment-q01" }, { "text": "What evidence links those consequences to the reaction rather than a pre-existing or concurrent condition?", "kind": "provenance", "id": "consequence-assessment-q02" } ] } ] } ] }, { "id": "reaction-course", "name": "Reaction course", "description": "Tracks the reaction through time and relates repeated episodes to their circumstances.", "rationale": "An agent must distinguish an emerging reaction, a resolving episode and an apparent recurrence before interpreting its state.", "layers": [ { "id": "within-episode-dynamics", "name": "Within-episode dynamics", "description": "Tracks latency, progression, fluctuation and observed resolution.", "findings": [ { "id": "temporal-trajectory", "name": "Temporal trajectory", "description": "Records changes over time while distinguishing observed endpoints from gaps in observation.", "questions": [ { "text": "When did manifestations begin relative to the antecedent, and how have their magnitude and distribution changed?", "kind": "measurement", "id": "temporal-trajectory-q01" }, { "text": "Does the latest observation support resolution, persistence or an unknown state because observation ended?", "kind": "boundary", "id": "temporal-trajectory-q02" } ] } ] }, { "id": "recurrence-context", "name": "Recurrence context", "description": "Compares episodes with attention to changes in antecedents and organism state.", "findings": [ { "id": "cross-episode-comparison", "name": "Cross-episode comparison", "description": "Records similarities and differences without presuming a shared mechanism.", "questions": [ { "text": "Have comparable manifestations followed comparable antecedents before, and what records support the comparison?", "kind": "provenance", "id": "cross-episode-comparison-q01" }, { "text": "Which differences in exposure, baseline bodily state or concurrent conditions limit comparison between episodes?", "kind": "boundary", "id": "cross-episode-comparison-q02" } ] } ] } ] }, { "id": "response-and-reassessment", "name": "Response and reassessment", "description": "Connects the reaction's observed state to justified monitoring, review and authorised responses.", "rationale": "A useful model must support decisions while avoiding unsupported treatment choices or deliberate trigger testing.", "layers": [ { "id": "observation-and-review", "name": "Observation and review", "description": "Identifies what needs to be observed next and when an appropriate reviewer is needed.", "findings": [ { "id": "next-assessment", "name": "Next assessment", "description": "Records observation priorities and externally established criteria for escalation or specialist assessment.", "questions": [ { "text": "Which additional observation would clarify whether the reaction is progressing, resolving or affecting function?", "kind": "action", "id": "next-assessment-q01" }, { "text": "Which applicable review criteria have been supplied by an appropriate authority, and do current observations meet them?", "kind": "action", "id": "next-assessment-q02" } ] } ] }, { "id": "response-outcome", "name": "Response outcome", "description": "Records actions affecting the episode and the evidence needed to assess their consequences.", "findings": [ { "id": "action-linked-reassessment", "name": "Action-linked reassessment", "description": "Relates authorised actions to subsequent observations without assuming that sequence demonstrates effectiveness.", "questions": [ { "text": "What response is authorised within the agent's role, and what instruction or decision establishes that authority?", "kind": "action", "id": "action-linked-reassessment-q01" }, { "text": "What changed after the response, and what concurrent changes or natural progression limit attributing that outcome to the action?", "kind": "measurement", "id": "action-linked-reassessment-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Neural reflex (stretch, withdrawal, and autonomic reflexes)", "Immediate (Type I) hypersensitivity / IgE-mediated allergic reaction", "Delayed-type (Type IV) hypersensitivity", "Adverse drug reaction (Type A/augmented versus Type B/idiosyncratic)", "Anaphylaxis and anaphylactoid/non-IgE immediate systemic reaction", "Transfusion reaction (haemolytic, febrile non-haemolytic, TRALI, allergic)", "Local and systemic injection or vaccine reactogenicity", "Acute-phase inflammatory reaction to injury, infection, or toxin" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "WordNet 3.1 sense key", "value_or_pattern": "reaction%1:22:00::", "note": "Noun process sense matching the gloss 'a bodily process occurring due to the effect of some antecedent stimulus or agent'." }, { "scheme": "Gene Ontology", "value_or_pattern": "GO:0050896", "note": "response to stimulus; parent biological process, not a clinical diagnosis." }, { "scheme": "SNOMED CT", "value_or_pattern": "281647001", "note": "Adverse reaction (disorder); many more specific descendants exist (drug, vaccine, transfusion, allergic)." }, { "scheme": "MeSH", "value_or_pattern": "D064420", "note": "Drug-Related Side Effects and Adverse Reactions." }, { "scheme": "ICD-10", "value_or_pattern": "T78", "note": "Adverse effects, not elsewhere classified; related codes include T80 (infusion/transfusion) and T88.7 (unspecified adverse effect of drug)." }, { "scheme": "Wikidata", "value_or_pattern": "Q45959", "note": "adverse drug reaction; the general physiological 'reaction' sense is not a single stable Wikidata item." }, { "scheme": "MedDRA", "value_or_pattern": "SOC/HLGT hierarchy (e.g. Immune system disorders; HLGT Allergic conditions)", "note": "Individual reactions are coded as Preferred Terms, not as one code for the kind 'reaction'." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "ICH E2A (International Council for Harmonisation): definitions of adverse event versus adverse reaction and rules for expedited safety reporting.", "ICH E2B(R3) (ICH): electronic transmission of individual case safety reports.", "MedDRA (ICH / MedDRA MSSO): mandatory terminology for coding reactions in many regulatory submissions.", "EMA Good Pharmacovigilance Practices, Module VI (European Medicines Agency): management and reporting of adverse reactions in the EU.", "21 CFR 312.32 and 21 CFR 314.80 (US FDA): IND safety reporting and postmarketing reporting of adverse drug experiences.", "WHO Programme for International Drug Monitoring / CIOMS reporting form (World Health Organization and CIOMS): international spontaneous reporting of suspected reactions.", "ISO 14155 (ISO): clinical investigation of medical devices, including adverse event and adverse device-effect definitions.", "NIAID/FAAN (and later WAO/EAACI) anaphylaxis criteria: clinical diagnostic standard for a life-threatening systemic reaction, not a statute." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Documenting a patient's reaction after a new drug, radiocontrast agent, anaesthetic, or biologic infusion.", "Allergy-clinic skin-prick, intradermal, and patch testing to identify the eliciting agent.", "Emergency treatment of anaphylaxis with intramuscular adrenaline and observation for biphasic recurrence.", "Spontaneous reports of suspected ADRs to national centres (FAERS, Yellow Card, EudraVigilance) and onward to VigiBase.", "Trial and programme recording of vaccine reactogenicity (local swelling, fever, systemic symptoms).", "Pre-transfusion matching and bedside monitoring for haemolytic and non-haemolytic transfusion reactions.", "Measuring simple and choice reaction time in neurology, occupational toxicology, and human-factors assessment.", "Protocolised monitoring of cytokine-release and infusion reactions during monoclonal-antibody and CAR-T therapy." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Simple visual reaction time (healthy adult)", "typical_range": "180-250", "unit": "ms" }, { "quantity": "Acute serum tryptase rise supporting anaphylaxis", "typical_range": "peak ≥ (1.2 × baseline + 2); many labs treat baseline 95th percentile as about 11", "unit": "μg/L" }, { "quantity": "Skin-prick test mean wheal diameter versus negative control", "typical_range": "positive if ≥3", "unit": "mm" }, { "quantity": "CTCAE reaction/event severity", "typical_range": "1-5 (5 = death)", "unit": "grade" }, { "quantity": "Naranjo adverse-drug-reaction probability score", "typical_range": "0-13 (definite typically ≥9)", "unit": "score" }, { "quantity": "Systolic blood-pressure change in anaphylaxis definitions", "typical_range": "fall ≥30% from baseline, or absolute hypotension", "unit": "mmHg or %" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Anaphylactic shock, airway obstruction, and death.", "Severe cutaneous adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS).", "Haemolytic transfusion reaction from ABO incompatibility.", "Cytokine-release syndrome and delayed neurotoxicity after cellular or T-cell-engaging therapy.", "Missed or delayed identification of the causal agent, allowing re-exposure.", "False 'allergy' labels (especially penicillin) that block first-line therapy and drive broader-spectrum antibiotics.", "Under-reporting and incomplete case details in spontaneous pharmacovigilance.", "Paradoxical, withdrawal, and cross-reactive reactions that do not match the expected pharmacology." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Specialists in Europe (EAACI and related bodies) more strictly reserve 'allergy' for immune-mediated disease; US clinical and lay use often folds in non-immune intolerance.", "National reporting channels differ: FDA FAERS (United States), MHRA Yellow Card (United Kingdom), EudraVigilance (EU), PMDA (Japan), all feeding WHO VigiBase in Uppsala.", "East Asian dermatology still leans on Japanese morphological classifications of drug eruption alongside Gell-Coombs types.", "Adrenaline autoinjector products, licensed doses, school-carry rules, and public-access laws for anaphylaxis vary widely by country.", "Traditional-medicine products are in routine pharmacovigilance in China and parts of South and East Asia but are often coded poorly or omitted in Western ADR datasets." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "chemical reaction", "difference": "A molecular transformation that does not require a living body; test whether the system is an organism responding to a stimulus rather than reactants forming products." }, { "name": "adverse event", "difference": "Any untoward medical occurrence temporally associated with a product, causal or not; ICH/CIOMS causality (certain, probable, possible, unlikely, unrelated) is what promotes an event to a suspected reaction." }, { "name": "side effect", "difference": "Usually an expected, often dose-related labelled effect (Type A); a 'reaction' in clinical safety language more often implies a suspected causal, sometimes unexpected, response." }, { "name": "intolerance", "difference": "Non-immune mechanism (metabolic, pharmacologic, or irritant), as in lactose intolerance; separate by absence of specific immune markers (sIgE, basophil activation, T-cell assays) and by reproducible dose-related physiology." }, { "name": "reflex", "difference": "A stereotyped, neurally mediated subclass of reaction; separate by short latency, a defined spinal or brainstem pathway, and independence from immune or drug-metabolic mediators." }, { "name": "adaptation / acclimatization", "difference": "A slower, often compensatory adjustment to a sustained condition; separate by time course (days to weeks versus seconds to hours) and by reduced rather than expressed effect of the stimulus." }, { "name": "symptom", "difference": "A reported experience, not the bodily process itself; a reaction can be observed or measured (wheal, tryptase, reflex latency) without a verbal report." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of reaction this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend this entry to cover bodily reactions across all organisms, and how should organism-specific extensions be bounded?", "How should this entry relate to neighbouring concepts such as reflex, physiological response, symptom and adverse reaction without duplicating their models?", "What minimum evidence permits classification as a reaction when the antecedent or causal mechanism remains unidentified?", "Which episode-boundary conventions are appropriate for delayed, overlapping, sustained or repeatedly triggered bodily processes?", "Which manifestation-specific measures and authoritative review criteria should be incorporated through specialised extensions?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched.", "facetsInferred": false, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a reaction, record what state it is in, and decide what may be done with it.", "whatItIs": "a bodily process occurring due to the effect of some antecedent stimulus or agent", "characteristics": { "substance": "activity", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: accommodation reflex, belch, belching, burp, burping, eructation, blink, eye blink, blinking, wink, winking, nictitation.", "61 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a reaction, and on what evidence are they told apart?" ], "whatItIsMadeOf": "something that happens over time", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "accommodation reflex", "belch", "belching", "burp", "burping", "eructation", "blink", "eye blink", "blinking", "wink", "winking", "nictitation" ] } ], "standing": "61 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one reaction from another, and a reaction from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a reaction sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a reaction from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a reaction passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a reaction between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a reaction, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a reaction is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "process-and-outcome", "name": "Process, inputs and outcome", "description": "How a reaction proceeds, what it needs and what it leaves behind.", "rationale": "An activity is known by its steps and its results, and both have to be recordable while it is still running.", "layers": [ { "id": "steps-and-sequence", "name": "Steps and sequence", "description": "The steps of a reaction, their order and what may run in parallel.", "findings": [ { "id": "steps-and-preconditions", "name": "Steps, preconditions and completion", "description": "What has to be true before each step of a reaction and what marks it done.", "questions": [ { "id": "steps-and-preconditions-q01", "text": "What identifies and describes a step of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "steps-and-preconditions-q02", "text": "Who or what asserted this about a step of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "steps-and-preconditions-q03", "text": "What may an agent decide or do once a step of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "inputs-and-results", "name": "Inputs, resources and results", "description": "What a reaction consumes and what it produces.", "findings": [ { "id": "inputs-and-outputs", "name": "Inputs, outputs and side effects", "description": "The resources a reaction takes and the results it leaves, wanted or not.", "questions": [ { "id": "inputs-and-outputs-q01", "text": "What identifies and describes the inputs and results of a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "inputs-and-outputs-q02", "text": "Who or what asserted this about the inputs and results of a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "inputs-and-outputs-q03", "text": "What may an agent decide or do once the inputs and results of a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What reaction is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of reaction are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is reaction operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of reaction and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of reaction?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as reaction?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a reaction came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a reaction and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a reaction is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a reaction, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a reaction, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a reaction is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }