{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-06T21:43:51Z", "providers": [ "Codex" ], "missingProviders": [ "Grok" ], "pass": 2, "cost": { "grok": { "usd": null, "turns": null, "seconds": 2.2, "error": "Error: Internal error: {\n \"message\": \"API error (status 402 Payment Required): Grok Build usage balance exhausted\",\n \"http_status\": 402\n}", "retried": true }, "codex": { "seconds": 59.4, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a078ac-9901-7632-a678-02ed3683638f\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: immunity\nRegistry id: vr.tr.immunity\nPlane / domain: PHY / PHY.OBJ\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA Vercy" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T11:00:00Z", "ingestedAt": "2026-10-06T08:02:29+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners" ] }, "revisions": [ { "at": "2026-10-07T11:03:58+00:00", "engine": "codex", "fields": [ "agent_conduct", "definition", "distinguishing_features", "in_scope", "out_of_scope", "owners", "purpose", "scope_statement" ], "answering_review": "2381ac288d6065ee852a6f420cca8d77c3cdadf8ae589d80e256884f74356fac" } ] }, "metaModel": { "id": "THING-Q1059", "registryId": "vr.tr.immunity", "name": "immunity", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.OBJ" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1059/", "model": { "registry_id": "vr.tr.immunity", "name": "immunity", "purpose": "Enable an AI agent to recognise the immune system, explain its components and defensive functions, assess the limits of evidence about immune responses and protection, and identify decisions requiring qualified clinical judgement.", "definition": "In the supplied sense, immunity refers to the immune system, the biological system of cells, tissues, organs and molecules that coordinates innate and adaptive responses to pathogens and other threats.", "scope_statement": "This model owns the immune system as a biological system, including its components, organization, innate and adaptive functions, regulation, memory and relationships to protective outcomes; immunity as a protective capacity is an outcome of system activity rather than the system's identity.", "in_scope": [ "Immune cells, tissues, organs and molecules and their relationships within a host are in scope.", "Innate and adaptive immune functions and their coordination are in scope.", "Immune recognition, response regulation, tolerance and memory are in scope.", "Responses to exposure, immunisation and passive transfer are in scope.", "Evidence about immune function and the limits of laboratory or observational indicators of protection are in scope.", "Changes in immune function over time and under altered host or challenge conditions are in scope.", "Immune dysfunction, including immunodeficiency, allergy and autoimmunity, is in scope at a general explanatory level." ], "out_of_scope": [ "Legal, diplomatic or institutional immunity is outside this model.", "Pathogen identity, evolution and transmission beyond their relevance to immune system function are outside this model.", "Diagnosis and treatment of infections, allergies, autoimmune disease or immunodeficiency are outside this model.", "Vaccine and medicinal-product manufacture, prescribing and administration are outside this model.", "Population-level herd protection and epidemic dynamics are outside this model." ], "distinguishing_features": [ "The immune system is an organized biological system of interacting components, while immunity to a specified challenge describes a protective capacity.", "Innate and adaptive mechanisms contribute to immune defence through distinct but coordinated functions.", "Immune recognition and regulation support defence while limiting inappropriate responses against the host.", "A detectable immune response does not by itself establish protection against infection or disease.", "Absence of illness without evidence of exposure or protective capacity does not establish immunity.", "This biological system concerns host defence; exemption from a rule, jurisdiction or obligation belongs to a different sense of the term." ], "characteristics": [ { "name": "Host and protected compartment", "kind": "relation", "unit_or_values": "Host reference and relevant tissue, organ, mucosal surface or systemic compartment", "why_it_matters": "Locates the capacity and prevents evidence from one compartment being assumed to establish protection everywhere." }, { "name": "Challenge specificity", "kind": "relation", "unit_or_values": "Challenge reference, relevant variant or antigen, and known limits of cross-protection", "why_it_matters": "Defines what the immunity claim concerns and where extrapolation needs evidence." }, { "name": "Protective endpoint", "kind": "category", "unit_or_values": "Acquisition prevention; replication or burden control; disease prevention; severity reduction; other specified endpoint", "why_it_matters": "Makes the meaning of protection explicit." }, { "name": "Mechanistic contribution", "kind": "category", "unit_or_values": "Innate; adaptive humoral; adaptive cellular; mixed; unresolved", "why_it_matters": "Separates proposed mechanisms from demonstrated protective outcomes." }, { "name": "Acquisition route", "kind": "category", "unit_or_values": "Constitutive defence; prior exposure; immunisation; passive transfer; mixed; unknown", "why_it_matters": "Supports interpretation of onset, persistence and possible immune memory." }, { "name": "Protective evidence status", "kind": "state", "unit_or_values": "Supported for a specified endpoint; partially supported; conflicting; unsupported; unassessed", "why_it_matters": "Prevents an unqualified immune or nonimmune label from replacing the evidence." }, { "name": "Immune indicator result", "kind": "measurement", "unit_or_values": "Assay-specific value, unit, specimen, method, collection time and interpretation reference", "why_it_matters": "Preserves what was actually measured without treating different assays as interchangeable." }, { "name": "Protection estimate", "kind": "measurement", "unit_or_values": "Endpoint-specific probability or relative effect, with exposure context, time horizon, uncertainty and estimation method; unknown when unavailable", "why_it_matters": "Expresses graded protection only where the evidence supports quantification." }, { "name": "Temporal applicability", "kind": "state", "unit_or_values": "Assessment date, observed follow-up, supported applicability interval and reassessment triggers", "why_it_matters": "Distinguishes past evidence from a justified claim about present protection." } ], "affordances": [ "Formulate a bounded immunity claim for a host, challenge, compartment and protective endpoint.", "Attach exposure history, immune measurements and outcome evidence to the claim.", "Compare assessments only after checking endpoint, assay, challenge and temporal compatibility.", "Flag unsupported extrapolation from immune markers to protection or from one challenge to another.", "Identify missing evidence and conditions that warrant reassessment.", "Record how an immunity claim supports or limits a proposed action, referring clinical decisions to applicable guidance and qualified review." ], "agent_conduct": { "may": [ "Explain immune system components, functions and their relationship to protection in general terms from medical sources.", "Point people to clinicians and public health advice for vaccination and testing." ], "must_not": [ "Tell a person they are immune from a single result or past illness.", "Spread false claims about vaccines or natural immunity.", "Use immunity status to exclude people beyond lawful public health rules.", "Disclose a person's immune status without consent." ], "requires_human": [ "Decisions on vaccination or immune treatment for a person require qualified human judgement." ] }, "ethics": { "considerations": [ "Immunity status has been used to grant or deny access to work and travel.", "Misinformation about immunity puts vulnerable people at risk." ], "affected_parties": [ "Immunocompromised people", "Children", "Health workers" ] }, "owners": { "steward": "No organization owns the immune system as a biological concept; health services steward individual clinical records.", "master_systems": [ "Clinical records document individual assessments of immune function.", "Vaccination registries record immunisation history." ] }, "failure_modes_and_hazards": [ "False sense of protection leading to infection.", "Waning immunity that goes unnoticed." ], "what_it_is_for": [ "Immunity is studied in biology and healthcare to understand how a host resists infection or other biological challenges.", "Its specificity, strength and duration inform interpretation of vaccination history, previous infection and laboratory evidence of protection.", "Evidence of immunity must be interpreted for the particular host and challenge because protection can be incomplete or change over time." ], "facets_not_applicable": { "interfaces": "No single standard, law or official classification applies universally to biological immunity itself.", "recognition": "Immunity cannot be identified visually because protection is inferred from biological history, functional evidence and relevant testing." } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1059: immune system", "url": "https://www.wikidata.org/wiki/Q1059", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Immune system", "url": "https://en.wikipedia.org/wiki/Immune_system", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "protection-claim", "name": "Protection claim", "description": "Defines whose immunity is being described, against what and with which meaning of protection.", "rationale": "Immunity cannot be assessed as an unrestricted property detached from a host, challenge and endpoint.", "layers": [ { "id": "host-and-challenge", "name": "Host and challenge", "description": "Establishes the biological bearer and target of the claim.", "findings": [ { "id": "bounded-immunity-target", "name": "Bounded immunity target", "description": "Record the host, relevant compartment and challenge at the specificity justified by evidence.", "questions": [ { "text": "Which host and anatomical compartment carry the claimed immunity?", "kind": "definition", "id": "bounded-immunity-target-q01" }, { "text": "Which challenge, variant or antigen is covered, and which related challenges remain outside the claim?", "kind": "boundary", "id": "bounded-immunity-target-q02" } ] } ] }, { "id": "protected-outcomes", "name": "Protected outcomes", "description": "Separates different meanings and degrees of protection.", "findings": [ { "id": "endpoint-specific-protection", "name": "Endpoint-specific protection", "description": "Record whether the claim concerns prevention, control or reduced harm, with any supported degree of protection.", "questions": [ { "text": "Does protection mean preventing infection, controlling burden, preventing disease or reducing severity?", "kind": "definition", "id": "endpoint-specific-protection-q01" }, { "text": "Under what exposure conditions and over what observation period was this outcome assessed?", "kind": "measurement", "id": "endpoint-specific-protection-q02" } ] } ] } ] }, { "id": "defence-and-acquisition", "name": "Defence and acquisition", "description": "Records the contributions and origins proposed to account for protection.", "rationale": "Similar protective outcomes may arise through different mechanisms and acquisition routes with different implications.", "layers": [ { "id": "immune-contributions", "name": "Immune contributions", "description": "Identifies relevant innate, humoral and cellular contributions without requiring a complete immune-system model.", "findings": [ { "id": "supported-defence-mechanisms", "name": "Supported defence mechanisms", "description": "Separate observed immune activity from mechanisms inferred to contribute to protection.", "questions": [ { "text": "Which innate or adaptive contributions are observed, inferred or unresolved for this protection claim?", "kind": "definition", "id": "supported-defence-mechanisms-q01" }, { "text": "What evidence links each recorded contribution to the specified protective endpoint?", "kind": "provenance", "id": "supported-defence-mechanisms-q02" } ] } ] }, { "id": "acquisition-and-memory", "name": "Acquisition and memory", "description": "Distinguishes sources of protection and evidence of a retained response capacity.", "findings": [ { "id": "origin-of-protective-capacity", "name": "Origin of protective capacity", "description": "Record relevant exposure, immunisation or transfer history, keeping acquisition history separate from demonstrated immunity.", "questions": [ { "text": "Which documented events or constitutive defences are proposed to explain this immunity?", "kind": "provenance", "id": "origin-of-protective-capacity-q01" }, { "text": "What evidence distinguishes immune memory from currently present effectors or passively acquired components?", "kind": "measurement", "id": "origin-of-protective-capacity-q02" } ] } ] } ] }, { "id": "evidence-and-inference", "name": "Evidence and inference", "description": "Connects immunity claims to measurements, observed outcomes and explicit inference limits.", "rationale": "An immune response, a history of exposure and demonstrated protection provide different kinds of evidence.", "layers": [ { "id": "immune-measurements", "name": "Immune measurements", "description": "Preserves the context needed to interpret an immune indicator.", "findings": [ { "id": "interpretable-assay-evidence", "name": "Interpretable assay evidence", "description": "Record assay identity, specimen, timing, result and the basis for any protective interpretation.", "questions": [ { "text": "What was measured, in which specimen, by which method, at what time and in which units?", "kind": "measurement", "id": "interpretable-assay-evidence-q01" }, { "text": "What source supports using this indicator or threshold to infer protection for this host context, challenge and endpoint?", "kind": "provenance", "id": "interpretable-assay-evidence-q02" } ] } ] }, { "id": "outcome-based-support", "name": "Outcome-based support", "description": "Assesses whether observed outcomes justify the claimed protection.", "findings": [ { "id": "protection-inference-limits", "name": "Protection inference limits", "description": "Record directness of evidence, alternative explanations and uncertainty when applying outcomes to a host.", "questions": [ { "text": "What exposure and outcome evidence supports protection, and could limited exposure or another factor explain the outcome?", "kind": "provenance", "id": "protection-inference-limits-q01" }, { "text": "Does the evidence concern this host or a reference population, and what limits transfer between them?", "kind": "boundary", "id": "protection-inference-limits-q02" } ] } ] } ] }, { "id": "persistence-and-context", "name": "Persistence and context", "description": "Tracks how the applicability of an immunity claim depends on time, host condition and challenge conditions.", "rationale": "A past assessment does not by itself settle protection after relevant conditions change.", "layers": [ { "id": "temporal-course", "name": "Temporal course", "description": "Records observed onset, persistence and changes in evidence of protection.", "findings": [ { "id": "time-bounded-protection", "name": "Time-bounded protection", "description": "Distinguish measured change, inferred persistence and periods lacking evidence.", "questions": [ { "text": "When was protective capacity assessed, and what repeated observations establish its course?", "kind": "measurement", "id": "time-bounded-protection-q01" }, { "text": "Beyond which date or follow-up interval would continued protection be an unsupported extrapolation?", "kind": "boundary", "id": "time-bounded-protection-q02" } ] } ] }, { "id": "changed-protection-conditions", "name": "Changed protection conditions", "description": "Identifies changes that may invalidate an earlier assessment.", "findings": [ { "id": "reassessment-triggers", "name": "Reassessment triggers", "description": "Record relevant changes in host condition, treatment, challenge identity or exposure context.", "questions": [ { "text": "Which host or challenge conditions differ from those under which protection was established?", "kind": "boundary", "id": "reassessment-triggers-q01" }, { "text": "Which documented change should trigger reassessment, and what evidence would resolve it?", "kind": "action", "id": "reassessment-triggers-q02" } ] } ] } ] }, { "id": "decision-use-and-limits", "name": "Decision use and limits", "description": "Makes the consequences and limits of relying on an immunity claim explicit.", "rationale": "An agent needs to distinguish an evidence-supported assessment from authorization to change precautions or clinical care.", "layers": [ { "id": "claim-dependent-actions", "name": "Claim-dependent actions", "description": "Connects a proposed action to the precise protection it requires.", "findings": [ { "id": "action-evidence-fit", "name": "Action evidence fit", "description": "Record the decision, its required protective endpoint and the authority governing its use.", "questions": [ { "text": "What action depends on immunity, and does the available evidence address the endpoint and time horizon that action requires?", "kind": "action", "id": "action-evidence-fit-q01" }, { "text": "Which applicable guidance or qualified decision-maker determines whether that evidence is sufficient?", "kind": "provenance", "id": "action-evidence-fit-q02" } ] } ] }, { "id": "unresolved-or-discordant-status", "name": "Unresolved or discordant status", "description": "Handles missing evidence, conflicting indicators and outcomes inconsistent with the claim.", "findings": [ { "id": "uncertainty-resolution", "name": "Uncertainty resolution", "description": "Preserve disagreement and define an appropriate route to clarify immunity without silently converting uncertainty into a binary status.", "questions": [ { "text": "Which measurements, histories or observed outcomes conflict, and which part of the protection claim remains unresolved?", "kind": "boundary", "id": "uncertainty-resolution-q01" }, { "text": "What additional record, validated assessment or qualified review could resolve the uncertainty relevant to the proposed action?", "kind": "action", "id": "uncertainty-resolution-q02" } ] } ] } ] } ] }, "openQuestions": [ "Does vr.tr.immunity intend biological immunity, and how should its placement in PHY.OBJ represent a capacity borne by a host?", "Does an existing Vercy world model already own this concept, requiring a registry link instead of a separate publication?", "Should this entry cover immunity across animals, plants and microorganisms, or should its initial applicability be explicitly narrower?", "Where should the boundary lie between immunity, constitutive physical barriers, disease tolerance and noninfectious immune targets?", "Which authoritative sources establish usable correlates of protection, interpretation limits and reassessment criteria for each supported host-challenge pair?" ], "statistics": { "bundles": 5, "layers": 10, "findings": 10, "questions": 20 } }