{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-14T01:02:47Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T11:00:00Z", "ingestedAt": "2026-10-06T07:41:07+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:53+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1088163", "registryId": "vr.tr.pre-malignant-neoplasm", "name": "pre-malignant neoplasm", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.QLT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1088163/", "model": { "registry_id": "vr.tr.pre-malignant-neoplasm", "name": "pre-malignant neoplasm", "purpose": "Let an agent explain pre-malignant neoplasms in general terms, relay grading, examples, screening and management approaches from pathology and cancer prevention sources, describe the named lesions and flag the contradictory registry parent, and distinguish precancers from cancer in situ as defined by staging systems, invasive cancer, benign tumours and risk factors, without diagnosing or interpreting individual results.", "definition": "An abnormal growth of cells that is not cancer but has an increased risk of becoming cancer, also called a precancerous lesion, often graded by dysplasia or intraepithelial neoplasia, with examples the registry aliases name such as squamous intraepithelial lesions of the cervix, prostatic intraepithelial neoplasia, glandular and transitional cell intraepithelial neoplasms, conjunctival intraepithelial neoplasia and precancerous lesions of the eyelid skin; others include actinic keratosis, Barrett oesophagus and colorectal adenomas. The registry parent neoplastic malignancy contradicts the concept, since these lesions are by definition not malignant. Screening programmes detect many precancers so they can be monitored or treated, and people should follow screening guidance and discuss results with clinicians.", "what_it_is_for": "Not applicable; a category of lesions with cancer risk.", "affordances": [ "explain the concept and grading", "relay examples", "relay screening", "flag the contradictory registry parent" ], "distinguishing_features": [ "Increased cancer risk", "Graded dysplasia", "Found by screening", "Often treatable" ], "appearance": "Varies; often invisible, found by screening tests, biopsies or as skin patches.", "visual_identification": [ "Non-cancerous lesion with increased cancer risk", "Glandular cell intraepithelial neoplasm, transitional cell intraepithelial neoplasm, prostatic intraepithelial neoplasia, cervical squamous intraepithelial lesion, precancerous eyelid lesion, conjunctival intraepithelial neoplasm", "Carcinoma in situ is classed differently by systems; invasive cancer spreads into tissue; benign tumours lack malignant potential; risk factors are exposures" ], "physical_properties": [ { "quantity": "Bethesda System", "typical_range": "1988", "unit": "year", "note": "cervical cytology, revised" }, { "quantity": "HPV vaccination", "typical_range": "prevents many cervical precancers", "unit": "note", "note": "attributed to trials" }, { "quantity": "registry parent", "typical_range": "neoplastic malignancy", "unit": "note", "note": "contradictory" } ], "families_and_kinds": [ "cervical precancers", "skin precancers", "gastrointestinal precancers", "prostatic and urothelial intraepithelial neoplasia", "ocular surface precancers" ], "related_models": [ { "relation": "is a kind of", "target": "disease of cellular proliferation", "why": "in registry terms" }, { "relation": "includes", "target": "cervical intraepithelial neoplasia", "why": "" }, { "relation": "is detected by", "target": "cancer screening", "why": "" }, { "relation": "is contrasted with", "target": "cancer", "why": "registry parent contradictory" } ], "identifiers": [], "standards_and_regulation": [ "WHO Classification of Tumours", "National screening programmes", "Bethesda and LAST terminology" ], "failure_modes_and_hazards": [ "Missed follow-up after abnormal results", "Overtreatment of low-grade lesions", "Anxiety from misunderstanding results" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain in general terms what a precancerous lesion is and why follow-up matters.", "Remind people with abnormal screening results to keep their follow-up appointments.", "Summarise screening guidance from named health authorities with dates." ], "must_not": [ "Tell a person their lesion is harmless or certainly cancer.", "Advise skipping, delaying or replacing recommended follow-up or treatment.", "Recommend unproven remedies as a way to reverse a precancerous lesion.", "Disclose a person's screening or biopsy results without consent." ], "requires_human": [ "Any decision to treat, remove or watch a particular lesion.", "Delivering an abnormal result to a patient." ] }, "ethics": { "considerations": [ "Missed follow-up lets preventable cancers develop, while overtreatment causes avoidable harm.", "Abnormal results cause anxiety, and some lesions carry stigma, such as those linked to infections." ], "affected_parties": [ "Patients with abnormal results", "Their families", "Screening programmes" ] }, "owners": { "steward": "The treating clinician answers for each patient; screening programmes run the call and recall systems.", "master_systems": [ "Cancer screening registries" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1088163: pre-malignant neoplasm", "url": "https://www.wikidata.org/wiki/Q1088163", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Precancerous condition", "url": "https://en.wikipedia.org/wiki/Precancerous_condition", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What a precancer is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is a pre-malignant neoplasm, and how does it differ from carcinoma in situ, invasive cancer, benign tumours and risk factors?", "kind": "definition" }, { "text": "Has someone received an abnormal screening result, in which case their clinician should explain it and follow-up should not be skipped?", "kind": "boundary" } ] } ] }, { "id": "lesions", "name": "Lesions", "description": "Named lesions.", "findings": [ { "id": "lesions-finding", "name": "Lesions", "description": "Lesions.", "questions": [ { "text": "What are cervical SIL, PIN, glandular and transitional cell intraepithelial neoplasms and conjunctival and eyelid precancers?", "kind": "definition" }, { "text": "Which entry fits the specific lesion?", "kind": "action" } ] } ] } ] }, { "id": "pathology", "name": "Pathology", "description": "Pathology.", "rationale": "Science.", "layers": [ { "id": "dysplasia", "name": "Dysplasia", "description": "Grading.", "findings": [ { "id": "dysplasia-finding", "name": "Dysplasia", "description": "Dysplasia.", "questions": [ { "text": "How are low-grade and high-grade lesions graded?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "progression", "name": "Progression", "description": "Progression risk.", "findings": [ { "id": "progression-finding", "name": "Progression", "description": "Progression.", "questions": [ { "text": "Why do many precancers regress while some progress, as studies report?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "prevention", "name": "Prevention", "description": "Screening and prevention.", "rationale": "Attribution.", "layers": [ { "id": "screening", "name": "Screening", "description": "Screening.", "findings": [ { "id": "screening-finding", "name": "Screening", "description": "Screening.", "questions": [ { "text": "How do cervical and colorectal screening programmes find precancers, with guidance checked against current sources?", "kind": "provenance" }, { "text": "Is the information current?", "kind": "boundary" } ] } ] }, { "id": "hpv", "name": "HPV", "description": "HPV vaccination.", "findings": [ { "id": "hpv-finding", "name": "HPV", "description": "HPV.", "questions": [ { "text": "What do health agencies report about HPV vaccination and cervical precancer rates?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Management.", "rationale": "Attribution.", "layers": [ { "id": "management", "name": "Management", "description": "Management approaches.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "What general approaches such as surveillance or excision do guidelines describe?", "kind": "provenance" }, { "text": "Which entry fits colposcopy?", "kind": "action" } ] } ] }, { "id": "overdiagnosis", "name": "Overdiagnosis", "description": "Overdiagnosis debate.", "findings": [ { "id": "overdiagnosis-finding", "name": "Overdiagnosis", "description": "Overdiagnosis.", "questions": [ { "text": "What do researchers argue about overdiagnosis and overtreatment of precancers, with positions attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] } ] } ] }, "openQuestions": [ "The registry parent neoplastic malignancy should be corrected", "Should each named lesion be a separate entry?", "How should screening guidelines be linked and kept current?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }