{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T20:58:16Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-05T23:50:00Z", "ingestedAt": "2026-10-05T20:46:52+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:53+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q11081", "registryId": "vr.tr.alzheimer-s-disease", "name": "Alzheimer's disease", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q11081/", "model": { "registry_id": "vr.tr.alzheimer-s-disease", "name": "Alzheimer's disease", "purpose": "Let an agent give accurate general information on Alzheimer's disease, recognise changes needing assessment, explain diagnosis, care and research with evidence, and point to specialist care and support for people and carers without individual medical advice.", "definition": "A progressive neurodegenerative disease and the most common cause of dementia, characterised by accumulation of amyloid plaques and tau tangles in the brain, leading to memory loss, cognitive decline and changes in behaviour, usually in older age but with rarer early-onset and inherited forms; it is diagnosed by clinical assessment, imaging and biomarkers, and managed with supportive care and, increasingly, disease-modifying therapies.", "what_it_is_for": "A neurodegenerative disease requiring diagnosis, care and support.", "affordances": [ "explain the disease and its stages in general terms", "recognise changes needing assessment", "explain diagnosis, treatment and research", "find specialist services and carer support" ], "distinguishing_features": [ "Most common dementia", "Amyloid and tau pathology", "Progressive", "Late and early-onset forms" ], "appearance": "Not physical; progressive memory and cognitive changes.", "visual_identification": [ "Progressive memory loss and cognitive decline", "Amyloid and tau pathology", "Other dementias have different patterns and causes" ], "physical_properties": [], "families_and_kinds": [ "late-onset Alzheimer's disease", "early-onset Alzheimer's disease", "inherited autosomal dominant forms", "mixed dementia with vascular changes", "preclinical and prodromal stages" ], "related_models": [ { "relation": "is a kind of", "target": "tauopathy", "why": "category" }, { "relation": "is a kind of", "target": "aging-associated disease", "why": "category" }, { "relation": "is a", "target": "neurodegeneration", "why": "neurodegenerative disease" }, { "relation": "affects", "target": "brain", "why": "organ" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines from neurology and dementia bodies", "Medicines regulation for disease-modifying therapies", "Care standards and dementia strategies" ], "failure_modes_and_hazards": [ "Missing treatable causes of cognitive change", "Agents diagnosing", "Unproven treatments and scams targeting people with dementia" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain Alzheimer's disease, its stages and care options from health authorities.", "Support people living with dementia and carers with reminders and information they have chosen." ], "must_not": [ "Diagnose Alzheimer's disease in a specific person.", "Promote unproven cures or supplements.", "Take advantage of a person's impaired memory or judgement, such as in finances or consent.", "Speak to or about people with dementia in ways that strip their dignity." ], "requires_human": [ "Decisions on care, capacity, finances or living arrangements for a person with dementia." ] }, "ethics": { "considerations": [ "People with dementia are at high risk of abuse and exploitation.", "Dignity and the person's own wishes matter at every stage." ], "affected_parties": [ "People with dementia", "Family carers", "Care workers" ] }, "owners": { "steward": "The person affected and their legal representatives; clinicians answer for diagnosis and care.", "master_systems": [] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q11081: Alzheimer's disease", "url": "https://www.wikidata.org/wiki/Q11081", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Alzheimer's disease", "url": "https://en.wikipedia.org/wiki/Alzheimer%27s_disease", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "assess", "name": "Assess", "description": "Changes to check.", "rationale": "Assessment first.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning changes.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Warning changes.", "questions": [ { "text": "Are there progressive memory or thinking changes that affect daily life and warrant assessment?", "kind": "boundary" }, { "text": "Should the person see a doctor for evaluation, including of treatable causes?", "kind": "action" } ] } ] }, { "id": "urgent", "name": "Urgent", "description": "Urgent situations.", "findings": [ { "id": "urgent-finding", "name": "Urgent", "description": "Urgent situations.", "questions": [ { "text": "Is there sudden confusion, a wandering person at risk or another emergency?", "kind": "boundary" }, { "text": "Which service should be contacted now?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "General information.", "layers": [ { "id": "mechanism", "name": "Mechanism", "description": "What happens in the brain.", "findings": [ { "id": "mechanism-finding", "name": "Mechanism", "description": "Mechanism.", "questions": [ { "text": "What is known about the causes and brain changes of Alzheimer's disease, according to research?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis or test results?", "kind": "boundary" } ] } ] }, { "id": "risk", "name": "Risk", "description": "Risk and genetics.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Risk.", "questions": [ { "text": "What do health authorities say about risk factors, protective factors and inherited forms?", "kind": "provenance" }, { "text": "Who is eligible for genetic counselling?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Treatment and support.", "rationale": "Evidence-based care.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Care options.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Care options.", "questions": [ { "text": "Which treatments and supportive care exist, in general terms, and what is the evidence for new disease-modifying therapies?", "kind": "provenance" }, { "text": "Which questions should be asked of the specialist?", "kind": "action" } ] } ] }, { "id": "unproven", "name": "Unproven", "description": "Unproven treatments.", "findings": [ { "id": "unproven-finding", "name": "Unproven", "description": "Unproven treatments.", "questions": [ { "text": "Does this offered treatment or supplement have regulatory approval and evidence?", "kind": "boundary" }, { "text": "What do regulators warn about?", "kind": "provenance" } ] } ] } ] }, { "id": "support", "name": "Support", "description": "People and carers.", "rationale": "Support for all.", "layers": [ { "id": "orgs", "name": "Organisations", "description": "Support organisations.", "findings": [ { "id": "orgs-finding", "name": "Organisations", "description": "Support.", "questions": [ { "text": "Which organisations support people with Alzheimer's disease and their carers here?", "kind": "provenance" }, { "text": "Which planning tools, such as advance care planning, exist?", "kind": "provenance" } ] } ] }, { "id": "research", "name": "Research", "description": "Research participation.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "Which trials and registries are recruiting, according to registries?", "kind": "provenance" }, { "text": "How can someone discuss participation with their team?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should each form be a separate entry?", "How should guidelines be linked?", "How should support services be localised?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }