{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-13T15:18:08Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T11:00:00Z",
      "ingestedAt": "2026-10-06T07:36:56+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:53+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q1233526",
    "registryId": "vr.tr.osteosclerosis",
    "name": "osteosclerosis",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "XCT.STA"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q1233526/",
  "model": {
    "registry_id": "vr.tr.osteosclerosis",
    "name": "osteosclerosis",
    "purpose": "Let an agent explain osteosclerosis and its causes, relay imaging findings, differential diagnosis and the sclerosing bone dysplasias from radiology and genetics sources in general terms, describe the rare syndromes the registry aliases name, and distinguish osteosclerosis from osteopetrosis as one cause, from osteoarthritis-related sclerosis and from osteopenia, routing people to clinicians.",
    "definition": "Abnormal hardening and increased density of bone, seen on X-ray as increased opacity, occurring in many conditions from localised sclerosis around infection or injury to generalised sclerosing bone dysplasias such as osteopetrosis, melorheostosis, craniometaphyseal dysplasia, hyperostosis cranialis interna, and rare syndromes including osteopathia striata with pigmentary dermopathy and white forelock, osteosclerosis with ichthyosis and premature ovarian failure, and endosteal sclerosis with cerebellar hypoplasia; osteosclerosis is the opposite of osteopenia. The model gives general information and routes people to clinicians.",
    "what_it_is_for": "Not applicable; a bone finding and condition.",
    "affordances": [
      "explain the finding",
      "relay causes and imaging",
      "route to clinicians",
      "distinguish related conditions"
    ],
    "distinguishing_features": [
      "Increased density",
      "Many causes",
      "Localised or generalised",
      "Rare genetic forms"
    ],
    "appearance": "Not a visible object; dense bone on X-ray.",
    "visual_identification": [
      "Increased bone density and hardening",
      "Melorheostosis, craniometaphyseal dysplasia, hyperostosis cranialis interna, osteopathia striata syndromes, endosteal sclerosis syndromes",
      "Osteopetrosis is one cause; subchondral sclerosis is localised in arthritis; osteopenia is reduced density"
    ],
    "physical_properties": [
      {
        "quantity": "radiological sign",
        "typical_range": "increased opacity",
        "unit": "note",
        "note": ""
      },
      {
        "quantity": "sclerosing bone dysplasias",
        "typical_range": "dozens",
        "unit": "count",
        "note": "classified by Nosology"
      },
      {
        "quantity": "melorheostosis",
        "typical_range": "flowing candle wax appearance",
        "unit": "note",
        "note": ""
      }
    ],
    "families_and_kinds": [
      "localised reactive osteosclerosis",
      "generalised osteosclerosis in metabolic and haematological disease",
      "sclerosing bone dysplasias such as osteopetrosis and melorheostosis",
      "craniometaphyseal dysplasia and hyperostosis cranialis interna",
      "rare syndromes combining osteosclerosis with skin, ovarian or cerebellar features"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "bone remodeling disease",
        "why": "in registry terms"
      },
      {
        "relation": "is contrasted with",
        "target": "osteopenia",
        "why": "reduced density"
      },
      {
        "relation": "is exemplified by",
        "target": "osteopetrosis",
        "why": "a generalised form"
      },
      {
        "relation": "is detected by",
        "target": "radiography",
        "why": "as increased opacity"
      }
    ],
    "identifiers": [
      {
        "scheme": "MeSH",
        "value_or_pattern": "D010026",
        "note": "Osteosclerosis"
      },
      {
        "scheme": "ICD-10",
        "value_or_pattern": "M85.8",
        "note": "other specified disorders of bone density and structure"
      }
    ],
    "standards_and_regulation": [
      "Nosology of genetic skeletal disorders",
      "Radiology reporting guidelines"
    ],
    "failure_modes_and_hazards": [
      "Agents giving personal medical advice",
      "Confusing finding with a specific disease",
      "Registry aliases naming very rare syndromes"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain osteosclerosis and its causes in general terms, citing medical sources.",
        "Help a radiologist by flagging areas of increased bone density on images under their direction."
      ],
      "must_not": [
        "Diagnose the cause of osteosclerosis in a specific person.",
        "Tell a patient that findings on an image are harmless or serious.",
        "Share imaging or genetic findings without consent."
      ],
      "requires_human": [
        "Any diagnosis or treatment decision.",
        "Disclosing an inherited bone condition to relatives."
      ]
    },
    "ethics": {
      "considerations": [
        "Some sclerosing bone disorders are inherited, so findings affect whole families.",
        "Rare diseases are often missed, delaying care for years."
      ],
      "affected_parties": [
        "Patients",
        "Families with inherited conditions",
        "Clinicians"
      ]
    },
    "owners": {
      "steward": "The treating clinician answers for diagnosis and care.",
      "master_systems": [
        "Patient health records",
        "Rare disease registries"
      ]
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q1233526: osteosclerosis",
      "url": "https://www.wikidata.org/wiki/Q1233526",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Osteosclerosis",
      "url": "https://en.wikipedia.org/wiki/Osteosclerosis",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What osteosclerosis is.",
        "rationale": "Clinical.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is osteosclerosis, and how does it differ from osteopetrosis, arthritis-related sclerosis and osteopenia?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the user asking about a personal imaging result or symptoms, which need a clinician?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "causes",
            "name": "Causes",
            "description": "Causes.",
            "findings": [
              {
                "id": "causes-finding",
                "name": "Causes",
                "description": "Causes.",
                "questions": [
                  {
                    "text": "What are the localised, metabolic, haematological and genetic causes, including the syndromes the registry names?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific cause?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "imaging",
        "name": "Imaging",
        "description": "Imaging and diagnosis.",
        "rationale": "Clinical.",
        "layers": [
          {
            "id": "signs",
            "name": "Signs",
            "description": "Signs.",
            "findings": [
              {
                "id": "signs-finding",
                "name": "Signs",
                "description": "Signs.",
                "questions": [
                  {
                    "text": "How does osteosclerosis appear on X-ray, CT and bone scan, as radiologists describe?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "differential",
            "name": "Differential",
            "description": "Differential diagnosis.",
            "findings": [
              {
                "id": "differential-finding",
                "name": "Differential",
                "description": "Differential.",
                "questions": [
                  {
                    "text": "How do clinicians distinguish causes of dense bone?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "genetics",
        "name": "Genetics",
        "description": "Sclerosing dysplasias.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "dysplasias",
            "name": "Dysplasias",
            "description": "Dysplasias.",
            "findings": [
              {
                "id": "dysplasias-finding",
                "name": "Dysplasias",
                "description": "Dysplasias.",
                "questions": [
                  {
                    "text": "What are melorheostosis, craniometaphyseal dysplasia and hyperostosis cranialis interna, and what genes are involved?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the specific dysplasia?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "syndromes",
            "name": "Syndromes",
            "description": "Syndromes.",
            "findings": [
              {
                "id": "syndromes-finding",
                "name": "Syndromes",
                "description": "Syndromes.",
                "questions": [
                  {
                    "text": "What are the osteopathia striata, osteosclerosis-ichthyosis and endosteal sclerosis syndromes, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the specific syndrome?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Management and history.",
        "rationale": "Context.",
        "layers": [
          {
            "id": "management",
            "name": "Management",
            "description": "Management.",
            "findings": [
              {
                "id": "management-finding",
                "name": "Management",
                "description": "Management.",
                "questions": [
                  {
                    "text": "How are sclerosing conditions managed, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits bone disease?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "history",
            "name": "History",
            "description": "History.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How were the sclerosing bone dysplasias described and classified?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the history of radiology?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should melorheostosis and craniometaphyseal dysplasia be separate primary entries?",
    "How should radiology and genetics sources be linked?",
    "The registry entry has merged aliases naming rare syndromes; should they be split off?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}