{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T18:38:43Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "codex", "producedAt": "2026-10-08T12:00:00Z", "ingestedAt": "2026-10-08T18:55:14+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-08T18:56:44+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q123619", "registryId": "vr.tr.nucleic-acids", "name": "nucleic acids", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q123619/", "model": { "registry_id": "vr.tr.nucleic-acids", "name": "nucleic acids", "purpose": "Let an agent explain nucleic acids and their functions, relay structure, types and laboratory uses from molecular biology sources, describe the analogues and concepts the registry aliases name, and distinguish nucleic acids from nucleotides, genes, chromosomes and proteins.", "definition": "Biopolymers made of nucleotide monomers, DNA and RNA, that store and transmit genetic information and catalyse and regulate cellular processes, along with synthetic analogues called xeno nucleic acids such as hexitol and glycol nucleic acids; related concepts in the registry aliases include nucleic acid probes used to detect sequences, episomes, which are DNA elements that replicate independently or integrate into chromosomes, R-loops, three-stranded DNA-RNA hybrid structures, and nucleic acid nomenclature conventions.", "what_it_is_for": "Storing and expressing genetic information.", "affordances": [ "explain structure and types", "relay functions and methods", "describe analogues and concepts", "distinguish related molecules" ], "distinguishing_features": [ "Nucleotide polymers", "Genetic information", "Base pairing", "Natural and synthetic forms" ], "appearance": "Not a visible object; long molecular chains, visible as white strands when precipitated.", "visual_identification": [ "Polymers of nucleotides", "DNA, RNA, hexitol and glycol nucleic acids, probes, episomes, R-loops", "Nucleotides are monomers; genes are functional segments; chromosomes are packaged DNA; proteins are amino acid polymers" ], "physical_properties": [ { "quantity": "DNA double helix described", "typical_range": "1953", "unit": "year", "note": "Watson, Crick, Franklin, Wilkins" }, { "quantity": "nucleic acid discovered", "typical_range": "1869", "unit": "year", "note": "Friedrich Miescher" }, { "quantity": "human genome", "typical_range": "about 3.1", "unit": "billion base pairs", "note": "" } ], "families_and_kinds": [ "DNA", "RNA including mRNA, tRNA and rRNA", "xeno nucleic acids such as HNA and GNA", "nucleic acid probes", "episomes and plasmids", "structures such as R-loops" ], "related_models": [ { "relation": "is a kind of", "target": "macromolecule", "why": "in registry terms" }, { "relation": "is a kind of", "target": "polynucleotide", "why": "in registry terms" }, { "relation": "includes", "target": "DNA", "why": "" }, { "relation": "is composed of", "target": "nucleotide", "why": "" } ], "identifiers": [ { "scheme": "MeSH", "value_or_pattern": "D009696", "note": "Nucleic Acids" } ], "standards_and_regulation": [ "IUPAC-IUBMB nucleic acid nomenclature", "Biosafety rules for recombinant nucleic acids" ], "failure_modes_and_hazards": [ "Confusing nucleic acids with genes", "Registry aliases mixing molecules, tools and structures", "Overstating synthetic biology claims" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain the informational, regulatory and catalytic roles of DNA and RNA.", "Describe documented nucleic acid records while distinguishing natural molecules from synthetic analogues." ], "must_not": [ "Disclose identifying sequence information from a person's biological material without authorization.", "Claim that detecting a nucleic acid sequence alone establishes a viable organism or active disease.", "Represent a synthetic nucleic acid analogue as interchangeable with DNA or RNA without supporting evidence.", "Assist in using nucleic acids to cause infection or other biological harm." ], "requires_human": [ "An authorized custodian must decide whether human nucleic acid material or identifying sequence data may be reused.", "A qualified clinician must decide the clinical significance of a nucleic acid finding." ] }, "ethics": { "considerations": [ "Nucleic acid records can reveal sensitive inherited or health information beyond the purpose of collection.", "Unsupported claims about sequence detection can cause stigma or inappropriate care." ], "affected_parties": [ "People whose biological material or sequence data are used.", "Patients and communities affected by interpretations of nucleic acid findings." ] }, "owners": { "steward": "The authorized custodian of the biological material or sequence record.", "master_systems": [ "Public nucleotide sequence archives." ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q123619: nucleic acids", "url": "https://www.wikidata.org/wiki/Q123619", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Nucleic acid", "url": "https://en.wikipedia.org/wiki/Nucleic_acid", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What nucleic acids are.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What are nucleic acids, and how do they differ from nucleotides, genes, chromosomes and proteins?", "kind": "definition" }, { "text": "Is the question about structure, a type, a laboratory method or synthetic biology?", "kind": "boundary" } ] } ] }, { "id": "concepts", "name": "Concepts", "description": "Related concepts.", "findings": [ { "id": "concepts-finding", "name": "Concepts", "description": "Concepts.", "questions": [ { "text": "What are hexitol and glycol nucleic acids, probes, episomes, R-loops and nucleic acid nomenclature?", "kind": "definition" }, { "text": "Which entry fits the specific concept?", "kind": "action" } ] } ] } ] }, { "id": "biology", "name": "Biology", "description": "Structure and function.", "rationale": "Science.", "layers": [ { "id": "structure", "name": "Structure", "description": "Structure.", "findings": [ { "id": "structure-finding", "name": "Structure", "description": "Structure.", "questions": [ { "text": "How do DNA and RNA structures and base pairing work?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "function", "name": "Function", "description": "Function.", "findings": [ { "id": "function-finding", "name": "Function", "description": "Function.", "questions": [ { "text": "How do nucleic acids store, copy and express genetic information?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "laboratory", "name": "Laboratory", "description": "Methods and synthetic biology.", "rationale": "Application.", "layers": [ { "id": "methods", "name": "Methods", "description": "Methods.", "findings": [ { "id": "methods-finding", "name": "Methods", "description": "Methods.", "questions": [ { "text": "How are probes, sequencing and PCR used to study nucleic acids?", "kind": "provenance" }, { "text": "Which entry fits DNA sequencing?", "kind": "action" } ] } ] }, { "id": "xna", "name": "XNA", "description": "Xeno nucleic acids.", "findings": [ { "id": "xna-finding", "name": "XNA", "description": "XNA.", "questions": [ { "text": "What are xeno nucleic acids, and what research uses do they have?", "kind": "provenance" }, { "text": "Which entry fits xeno nucleic acid?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "History.", "rationale": "Context.", "layers": [ { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did Miescher, Avery, Franklin, Watson and Crick contribute?", "kind": "provenance" }, { "text": "Which entry fits the history of molecular biology?", "kind": "action" } ] } ] }, { "id": "structures", "name": "Structures", "description": "R-loops and episomes.", "findings": [ { "id": "structures-finding", "name": "Structures", "description": "Structures.", "questions": [ { "text": "What are R-loops and episomes, and why do they matter?", "kind": "provenance" }, { "text": "Which entry fits R-loop?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should xeno nucleic acids and R-loops be separate primary entries?", "How should molecular biology sources be linked?", "The registry entry has merged aliases naming tools, elements and structures; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }