{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T05:29:43Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:07:00+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:54+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1269288", "registryId": "vr.tr.dysmelia", "name": "dysmelia", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1269288/", "model": { "registry_id": "vr.tr.dysmelia", "name": "dysmelia", "purpose": "Let an agent explain dysmelia and its types in neutral clinical terms, relay causes, diagnosis and management from medical and genetic sources, describe support and adaptive approaches respectfully, and route families and individuals to specialist clinicians and support organisations.", "definition": "A group of congenital limb malformations in which limbs or parts of limbs are missing, shortened or malformed, including amelia with absent limbs, meromelia with partial absence, phocomelia with shortened proximal segments, mesomelia and mesomelic dysplasias affecting the middle segments, acromelia and acromicria affecting the hands and feet, and split hand-foot malformation, arising from genetic causes, teratogens such as thalidomide or vascular disruption during development; management involves multidisciplinary care, prosthetics and surgery.", "what_it_is_for": "Not applicable; a group of conditions.", "affordances": [ "explain types and causes", "relay diagnosis and management", "describe support", "route to specialists" ], "distinguishing_features": [ "Congenital origin", "Classified by segment", "Genetic, teratogenic or vascular causes", "Multidisciplinary care" ], "appearance": "Not a visible object as a category; limb differences of many forms.", "visual_identification": [ "Congenital limb absence or malformation", "Amelia, meromelia, phocomelia, mesomelia, acromelia, acromicria, split hand-foot malformation, lower extremity deformities", "Acquired amputation is not congenital; skeletal dysplasias may affect the whole skeleton" ], "physical_properties": [ { "quantity": "limb reduction defects", "typical_range": "about 1 in 2000", "unit": "births", "note": "estimates" }, { "quantity": "thalidomide affected children", "typical_range": "about 10000", "unit": "count", "note": "late 1950s and early 1960s" } ], "families_and_kinds": [ "amelia and meromelia", "phocomelia", "mesomelia and mesomelic dysplasias such as the Camera type", "acromelia and acromicria", "split hand-foot malformation", "congenital lower extremity deformities such as fibular hemimelia" ], "related_models": [ { "relation": "is a kind of", "target": "congenital limb deformity", "why": "in registry terms" }, { "relation": "is a kind of", "target": "congenital abnormality", "why": "in registry terms" }, { "relation": "can be caused by", "target": "thalidomide", "why": "as a teratogen" }, { "relation": "is managed with", "target": "prosthesis", "why": "and surgery when appropriate" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "LB98", "note": "reduction defects of limbs, related codes" }, { "scheme": "MeSH", "value_or_pattern": "D017880", "note": "limb deformities, congenital" } ], "standards_and_regulation": [ "Congenital anomaly surveillance registries", "Teratogen regulation including thalidomide controls", "Disability rights and prosthetic provision rules" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Stigmatising language", "Missing associated syndromes" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain the types and known causes of congenital limb malformations, citing medical sources.", "Point people to support organizations and specialist services." ], "must_not": [ "Use stigmatizing language about people with limb differences.", "Diagnose a person or unborn child from images or descriptions.", "Publish images or details of identifiable people with limb differences without consent." ], "requires_human": [ "Any advice that bears on prenatal or treatment decisions for a particular person." ] }, "ethics": { "considerations": [ "People with limb differences face stigma and barriers more than limits from the condition itself.", "Some causes, such as drug exposure in pregnancy, involved serious failures of medicine regulation." ], "affected_parties": [ "People with limb differences", "Parents and families" ] }, "owners": { "steward": "Nobody owns the condition; each person's care is with their clinicians.", "master_systems": [ "Congenital anomaly registers" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1269288: dysmelia", "url": "https://www.wikidata.org/wiki/Q1269288", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Dysmelia", "url": "https://en.wikipedia.org/wiki/Dysmelia", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Care and support first.", "rationale": "Safety.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis and care.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "Why do prenatal findings or a limb difference at birth need assessment by specialist teams in genetics, orthopaedics and rehabilitation?", "kind": "action" }, { "text": "Is the user asking about a specific pregnancy, child or themselves, which needs clinicians?", "kind": "boundary" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What support organisations and peer networks exist for people with limb differences?", "kind": "provenance" }, { "text": "Is the presentation respectful and person-first?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The conditions.", "rationale": "Clinical.", "layers": [ { "id": "types", "name": "Types", "description": "Types.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What are amelia, meromelia, phocomelia, mesomelia, acromelia and split hand-foot malformation?", "kind": "definition" }, { "text": "Is the question about a congenital limb difference or an acquired amputation?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What genetic, teratogenic and vascular causes lead to dysmelia, in general terms?", "kind": "definition" }, { "text": "Which entry fits the specific cause?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Management.", "rationale": "Clinical.", "layers": [ { "id": "management", "name": "Management", "description": "Management.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "How are limb differences managed with prosthetics, surgery, therapy and adaptive approaches, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "living", "name": "Living", "description": "Living with limb difference.", "findings": [ { "id": "living-finding", "name": "Living", "description": "Living.", "questions": [ { "text": "How do people with limb differences describe their lives and needs, in their own words?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "History and research.", "rationale": "Context.", "layers": [ { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "What was the thalidomide tragedy, and how did it change drug regulation, as historians describe?", "kind": "provenance" }, { "text": "Which entry fits thalidomide?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research explores limb development genes and new prosthetics?", "kind": "provenance" }, { "text": "Which entry fits limb development?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should phocomelia and split hand-foot malformation be separate primary entries?", "How should medical and genetic sources be linked?", "The registry entry has merged aliases naming distinct conditions; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }