{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-13T05:44:29Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 3,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T10:00:00Z",
      "ingestedAt": "2026-10-06T07:10:13+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:54+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q14860867",
    "registryId": "vr.tr.fatty-acid-metabolic-process",
    "name": "fatty acid metabolic process",
    "version": "0.2.0-wave.3",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q14860867/",
  "model": {
    "registry_id": "vr.tr.fatty-acid-metabolic-process",
    "name": "fatty acid metabolic process",
    "purpose": "Let an agent explain fatty acid metabolism and its main pathways, relay enzymes, regulation and disorders from biochemistry and clinical references, describe roles in energy and signalling, and distinguish fatty acid metabolism from triglyceride, cholesterol and carbohydrate metabolism.",
    "definition": "The set of chemical reactions and pathways by which cells synthesise, modify and break down fatty acids, including fatty acid biosynthesis from acetyl-CoA by fatty acid synthase, elongation and desaturation, fatty acid catabolism chiefly by beta-oxidation in mitochondria and peroxisomes, long-chain fatty acid metabolism, oxidative pathways such as the lipoxygenase pathway that produce signalling lipids, and related pathways such as lipoate metabolism; fatty acid metabolism supplies energy and membrane lipids and its disorders cause inherited and acquired diseases.",
    "what_it_is_for": "Not applicable; a metabolic process.",
    "affordances": [
      "explain pathways",
      "relay enzymes and regulation",
      "describe disorders",
      "distinguish related metabolism"
    ],
    "distinguishing_features": [
      "Anabolic and catabolic arms",
      "Acetyl-CoA hub",
      "Mitochondrial and peroxisomal sites",
      "Signalling lipid production"
    ],
    "appearance": "Not a visible object; biochemical pathways.",
    "visual_identification": [
      "Synthesis and breakdown of fatty acids",
      "Fatty acid biosynthesis, beta-oxidation, long-chain fatty acid metabolism, lipoxygenase pathway, lipoate metabolism",
      "Triglyceride metabolism handles storage lipids; cholesterol metabolism is a separate sterol pathway"
    ],
    "physical_properties": [
      {
        "quantity": "beta-oxidation yield",
        "typical_range": "about 106",
        "unit": "ATP per palmitate",
        "note": "approximate"
      },
      {
        "quantity": "key synthesis enzyme",
        "typical_range": "fatty acid synthase",
        "unit": "enzyme",
        "note": ""
      },
      {
        "quantity": "key catabolic step",
        "typical_range": "carnitine shuttle",
        "unit": "note",
        "note": "mitochondrial entry"
      }
    ],
    "families_and_kinds": [
      "fatty acid biosynthetic process",
      "fatty acid catabolic process including beta-oxidation",
      "long-chain and very long-chain fatty acid metabolism",
      "fatty acid oxidation in peroxisomes and omega-oxidation",
      "eicosanoid pathways including the lipoxygenase pathway",
      "related cofactor pathways such as lipoate metabolism"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cellular lipid metabolic process",
        "why": "in registry terms"
      },
      {
        "relation": "is a kind of",
        "target": "monocarboxylic acid metabolic process",
        "why": "in registry terms"
      },
      {
        "relation": "includes",
        "target": "beta oxidation",
        "why": "as the main catabolic route"
      },
      {
        "relation": "is catalysed by",
        "target": "fatty acid synthase",
        "why": "in biosynthesis"
      }
    ],
    "identifiers": [
      {
        "scheme": "GO",
        "value_or_pattern": "GO:0006631",
        "note": "fatty acid metabolic process"
      },
      {
        "scheme": "KEGG",
        "value_or_pattern": "map00071 and map00061",
        "note": "fatty acid degradation and biosynthesis"
      }
    ],
    "standards_and_regulation": [
      "Gene Ontology and KEGG pathway definitions",
      "Newborn screening programmes for fatty acid oxidation disorders"
    ],
    "failure_modes_and_hazards": [
      "Confusing fatty acid with triglyceride or cholesterol metabolism",
      "Agents giving personal medical or dietary advice",
      "Oversimplifying regulation"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain the pathways of fatty acid synthesis and breakdown, citing biochemistry sources.",
        "Relay what disorders of these pathways are, citing medical references."
      ],
      "must_not": [
        "Diagnose metabolic disorders in a person.",
        "Recommend diets or supplements as treatment for a person's metabolic condition.",
        "Overstate preliminary research as clinical fact."
      ],
      "requires_human": [
        "Any advice affecting care of a person with an inherited metabolic disorder."
      ]
    },
    "ethics": {
      "considerations": [
        "Some disorders of fatty acid metabolism are life-threatening in infants and need specialist care.",
        "Diet misinformation can harm people."
      ],
      "affected_parties": [
        "Patients with metabolic disorders",
        "Parents of affected infants"
      ]
    },
    "owners": {
      "steward": "Nobody owns the process; it belongs to biology.",
      "master_systems": [
        "Gene ontology databases"
      ]
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q14860867: fatty acid metabolic process",
      "url": "https://www.wikidata.org/wiki/Q14860867",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Fatty acid metabolism",
      "url": "https://en.wikipedia.org/wiki/Fatty_acid_metabolism",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What fatty acid metabolism is.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is fatty acid metabolism, and how does it differ from triglyceride, cholesterol and carbohydrate metabolism?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about the process in general, a pathway or a disorder?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "pathways",
            "name": "Pathways",
            "description": "Pathways.",
            "findings": [
              {
                "id": "pathways-finding",
                "name": "Pathways",
                "description": "Pathways.",
                "questions": [
                  {
                    "text": "How do biosynthesis, elongation, desaturation, beta-oxidation and the lipoxygenase pathway work?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific pathway?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "regulation",
        "name": "Regulation",
        "description": "Regulation.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "control",
            "name": "Control",
            "description": "Control.",
            "findings": [
              {
                "id": "control-finding",
                "name": "Control",
                "description": "Control.",
                "questions": [
                  {
                    "text": "How are fatty acid synthesis and oxidation regulated by hormones, malonyl-CoA and transcription factors?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "tissues",
            "name": "Tissues",
            "description": "Tissues.",
            "findings": [
              {
                "id": "tissues-finding",
                "name": "Tissues",
                "description": "Tissues.",
                "questions": [
                  {
                    "text": "How do liver, adipose, muscle and heart differ in fatty acid metabolism, including during fasting and exercise?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "medicine",
        "name": "Medicine",
        "description": "Disorders.",
        "rationale": "Clinical.",
        "layers": [
          {
            "id": "inherited",
            "name": "Inherited",
            "description": "Inherited disorders.",
            "findings": [
              {
                "id": "inherited-finding",
                "name": "Inherited",
                "description": "Inherited.",
                "questions": [
                  {
                    "text": "What are fatty acid oxidation disorders such as MCAD deficiency, and how are they screened, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own or a child s condition, which needs a clinician?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "acquired",
            "name": "Acquired",
            "description": "Acquired conditions.",
            "findings": [
              {
                "id": "acquired-finding",
                "name": "Acquired",
                "description": "Acquired.",
                "questions": [
                  {
                    "text": "How is fatty acid metabolism involved in fatty liver, diabetes and heart disease, as research describes?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits metabolic syndrome?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Signalling and history.",
        "rationale": "Context.",
        "layers": [
          {
            "id": "signalling",
            "name": "Signalling",
            "description": "Signalling lipids.",
            "findings": [
              {
                "id": "signalling-finding",
                "name": "Signalling",
                "description": "Signalling.",
                "questions": [
                  {
                    "text": "How do lipoxygenase and related pathways produce eicosanoids and other signalling lipids?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits eicosanoid?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "history",
            "name": "History",
            "description": "History.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How were beta-oxidation and fatty acid synthesis discovered, from Knoop to Lynen?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the history of biochemistry?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should beta-oxidation and fatty acid synthesis be separate primary entries?",
    "How should biochemistry references be linked?",
    "The registry entry has merged aliases naming Gene Ontology subterms; should they be split off?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}