{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-10-06T10:46:19Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 56, "engine": "claude", "gate": { "passed": true, "version": "1.0", "at": "2026-10-09T07:29:59+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q14906548", "registryId": "vr.tr.ctsg", "name": "CTSG", "version": "0.2.0-wave.56", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.LIV" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q14906548/", "model": { "registry_id": "vr.tr.ctsg", "name": "CTSG", "purpose": "Let an agent explain the CTSG gene and its product cathepsin G, relay function, location and disease associations from curated genomic sources, and keep the gene apart from its protein, from the cysteine cathepsins and from other neutrophil proteases.", "definition": "CTSG is the human protein-coding gene for cathepsin G, a serine protease stored in the azurophilic granules of neutrophils that is released at sites of inflammation and helps kill engulfed microbes and remodel tissue; the gene lies in a cluster of related protease genes on chromosome 14.", "what_it_is_for": "Encoding cathepsin G, which takes part in the immune defence and inflammatory functions of neutrophils.", "affordances": [ "identify the gene and its official symbol", "relay the function of the encoded protein", "relate it to neighbouring protease genes", "relay curated disease and research associations", "point to authoritative gene records" ], "distinguishing_features": [ "A serine protease, unlike most cathepsins, which are cysteine proteases", "The gene is not the protein: CTSG names the gene, cathepsin G the enzyme", "Distinct from neutrophil elastase (ELANE) and proteinase 3 (PRTN3), other granule serine proteases", "Human gene, distinct from its orthologues in other species" ], "appearance": null, "visual_identification": [ "Official HGNC symbol CTSG in human gene records", "Protein named cathepsin G", "Located on chromosome 14 near the granzyme gene cluster" ], "physical_properties": [ { "quantity": "kind", "typical_range": "protein-coding gene", "unit": "note", "note": "" }, { "quantity": "organism", "typical_range": "Homo sapiens", "unit": "note", "note": "" }, { "quantity": "product", "typical_range": "cathepsin G, a serine protease", "unit": "note", "note": "" } ], "families_and_kinds": [ "chymotrypsin-like serine protease family", "neutrophil granule serine proteases", "orthologues in other mammals" ], "related_models": [ { "relation": "is a kind of", "target": "protein-coding gene", "why": "" }, { "relation": "is confused with", "target": "cysteine cathepsins", "why": "share the cathepsin name but differ in mechanism" }, { "relation": "is confused with", "target": "ELANE", "why": "another neutrophil serine protease gene" }, { "relation": "is confused with", "target": "cathepsin G (protein)", "why": "the product, not the gene" } ], "identifiers": [ { "scheme": "Wikidata", "value_or_pattern": "Q14906548", "note": "registry item" }, { "scheme": "HGNC symbol", "value_or_pattern": "CTSG", "note": "official human gene symbol" }, { "scheme": "HGNC ID", "value_or_pattern": "HGNC: followed by digits", "note": "look up in the HGNC database" }, { "scheme": "NCBI Gene ID", "value_or_pattern": "digits only", "note": "look up in NCBI Gene" } ], "standards_and_regulation": [ "HGNC gene nomenclature rules", "Genetic data protection under health and privacy law" ], "failure_modes_and_hazards": [ "Confusing the gene with the protein or with cysteine cathepsins", "Overstating disease associations from single studies", "Misusing personal genetic data" ], "agent_conduct": { "may": [ "Relay the gene's function and associations from curated databases and cite them.", "Explain the difference between the gene, its protein and a variant." ], "must_not": [ "Interpret a person's genetic test result as a diagnosis.", "Disclose or infer a named person's genetic data without consent.", "State a variant is disease-causing without a curated classification." ], "requires_human": [ "Clinical interpretation of a variant found in a patient.", "Any genetic counselling decision." ] }, "ethics": { "considerations": [ "Genetic data is sensitive and identifying.", "Overstated associations can mislead patients and research." ], "affected_parties": [ "People who have their genes tested", "Their relatives", "Researchers" ] }, "owners": { "steward": "Nobody owns the gene; the gene nomenclature authority maintains its official name and symbol.", "master_systems": [ "HGNC", "NCBI Gene", "Ensembl", "UniProt" ] }, "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q14906548: CTSG", "url": "https://www.wikidata.org/wiki/Q14906548", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Cathepsin G", "url": "https://en.wikipedia.org/wiki/Cathepsin_G", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "gene-identity", "name": "Gene identity", "description": "Symbol, name and location.", "rationale": "Gene records are anchored by the official symbol and locus.", "layers": [ { "id": "nomenclature", "name": "Nomenclature", "description": "Symbol and aliases.", "findings": [ { "id": "nomenclature-finding", "name": "Nomenclature", "description": "Symbol and aliases.", "questions": [ { "text": "What is the official symbol and name, and which aliases are in use?", "kind": "definition" }, { "text": "Which database holds the authoritative record?", "kind": "provenance" } ] } ] }, { "id": "locus", "name": "Locus", "description": "Chromosomal location.", "findings": [ { "id": "locus-finding", "name": "Locus", "description": "Chromosomal location.", "questions": [ { "text": "Where on chromosome 14 does CTSG lie, and which genes neighbour it?", "kind": "provenance" }, { "text": "Which genome assembly is the location given against?", "kind": "measurement" } ] } ] } ] }, { "id": "protein", "name": "Protein", "description": "Cathepsin G.", "rationale": "The gene matters through what its product does.", "layers": [ { "id": "enzyme-class", "name": "Enzyme class", "description": "Serine protease.", "findings": [ { "id": "enzyme-class-finding", "name": "Enzyme class", "description": "Serine protease.", "questions": [ { "text": "What class of enzyme is cathepsin G, and how does it differ from cysteine cathepsins?", "kind": "boundary" }, { "text": "Which substrates does it act on?", "kind": "provenance" } ] } ] }, { "id": "expression", "name": "Expression", "description": "Where it is made and stored.", "findings": [ { "id": "expression-finding", "name": "Expression", "description": "Where it is made and stored.", "questions": [ { "text": "In which cells is it expressed, and where is it stored?", "kind": "provenance" }, { "text": "When is it released?", "kind": "definition" } ] } ] } ] }, { "id": "function", "name": "Function", "description": "Role in immunity and inflammation.", "rationale": "Its biological role is what research asks about.", "layers": [ { "id": "host-defence", "name": "Host defence", "description": "Killing microbes.", "findings": [ { "id": "host-defence-finding", "name": "Host defence", "description": "Killing microbes.", "questions": [ { "text": "How does cathepsin G contribute to killing engulfed microbes?", "kind": "provenance" }, { "text": "Which evidence supports this role?", "kind": "provenance" } ] } ] }, { "id": "inflammation", "name": "Inflammation", "description": "Tissue effects.", "findings": [ { "id": "inflammation-finding", "name": "Inflammation", "description": "Tissue effects.", "questions": [ { "text": "How does it affect tissue and signalling at sites of inflammation?", "kind": "provenance" }, { "text": "Which effects are shown in humans and which in models?", "kind": "boundary" } ] } ] } ] }, { "id": "associations", "name": "Associations", "description": "Disease and research links.", "rationale": "Associations must be traced to curated sources.", "layers": [ { "id": "disease-links", "name": "Disease links", "description": "Reported associations.", "findings": [ { "id": "disease-links-finding", "name": "Disease links", "description": "Reported associations.", "questions": [ { "text": "Which diseases have been linked to CTSG or cathepsin G, and how strong is the evidence?", "kind": "provenance" }, { "text": "Is the link to the gene, the protein level or autoantibodies?", "kind": "boundary" } ] } ] }, { "id": "variants", "name": "Variants", "description": "Genetic variation.", "findings": [ { "id": "variants-finding", "name": "Variants", "description": "Genetic variation.", "questions": [ { "text": "Are any CTSG variants classified in curated clinical databases?", "kind": "provenance" }, { "text": "Who may interpret a variant found in a patient?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "How strong are the reported disease associations?", "Should the protein have its own linked entry?", "How should orthologues in other species be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }