{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-14T01:02:47Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T11:00:00Z", "ingestedAt": "2026-10-06T07:41:07+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:54+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1504713", "registryId": "vr.tr.leiomyosarcoma", "name": "leiomyosarcoma", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1504713/", "model": { "registry_id": "vr.tr.leiomyosarcoma", "name": "leiomyosarcoma", "purpose": "Let an agent explain leiomyosarcoma in general terms, relay sites, diagnosis, treatment approaches and research from oncology sources, route to specialist care, describe the named variants and flag the stage alias, and distinguish leiomyosarcoma from leiomyoma, gastrointestinal stromal tumour, other sarcomas and carcinomas, without diagnosing or advising individual treatment.", "definition": "A rare malignant tumour of smooth muscle cells, a type of soft tissue sarcoma that can arise in the uterus, retroperitoneum, blood vessel walls such as the inferior vena cava and pulmonary artery, skin and other sites, with site-based and histological variants the registry aliases name including colon, fallopian tube, central nervous system and pulmonary artery leiomyosarcomas, granular cell leiomyosarcoma and metastatic leiomyosarcoma, which is a disease stage rather than a kind; treatment is usually surgery, with chemotherapy or radiotherapy in some cases, planned by specialist sarcoma teams, and outcomes depend on site, grade and spread. People with a growing lump or unexplained symptoms should see a doctor, and specialist centres are recommended.", "what_it_is_for": "Not applicable; a cancer.", "affordances": [ "explain sites and features", "relay diagnosis and treatment approaches", "describe named variants", "route to specialist care" ], "distinguishing_features": [ "Smooth muscle origin", "Many sites", "Rare", "Specialist multidisciplinary care" ], "appearance": "A firm mass that may be found on imaging or as a lump; diagnosed by biopsy.", "visual_identification": [ "Malignant smooth muscle tumour", "Metastatic leiomyosarcoma, granular cell leiomyosarcoma, fallopian tube leiomyosarcoma, central nervous system leiomyosarcoma, pulmonary artery leiomyosarcoma, colon leiomyosarcoma", "Leiomyomas are benign; GISTs arise from interstitial cells; other sarcomas come from other connective tissues; carcinomas come from epithelium" ], "physical_properties": [ { "quantity": "soft tissue sarcomas", "typical_range": "about 1 percent of adult cancers", "unit": "note", "note": "attributed" }, { "quantity": "leiomyosarcoma share of soft tissue sarcomas", "typical_range": "roughly 10-20 percent", "unit": "note", "note": "estimates vary" }, { "quantity": "registry parent", "typical_range": "smooth muscle cancer", "unit": "note", "note": "" } ], "families_and_kinds": [ "uterine leiomyosarcoma", "retroperitoneal leiomyosarcoma", "vascular leiomyosarcoma", "cutaneous leiomyosarcoma" ], "related_models": [ { "relation": "is a kind of", "target": "soft tissue sarcoma", "why": "related" }, { "relation": "is contrasted with", "target": "leiomyoma", "why": "" }, { "relation": "is contrasted with", "target": "gastrointestinal stromal tumor", "why": "" }, { "relation": "is treated by", "target": "sarcoma surgery", "why": "approach" } ], "identifiers": [], "standards_and_regulation": [ "ESMO and NCCN sarcoma guidelines", "WHO Classification of Soft Tissue and Bone Tumours" ], "failure_modes_and_hazards": [ "Delayed specialist referral", "Misdiagnosis as fibroid", "Stage alias treated as kind" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain what leiomyosarcoma is and where it can arise, in general terms.", "Encourage people with suspected sarcoma to seek a specialist sarcoma centre.", "Summarise guidance from named cancer bodies with dates." ], "must_not": [ "Diagnose leiomyosarcoma or rule it out, including distinguishing it from a fibroid.", "Recommend specific treatments, doses or trials for a particular patient.", "Promote unproven cures or discourage evidence-based treatment.", "State survival odds for an individual as if they were certain." ], "requires_human": [ "Any decision about surgery, chemotherapy or palliative care for a patient.", "Breaking news of a sarcoma diagnosis or recurrence." ] }, "ethics": { "considerations": [ "Rare cancers are often diagnosed late, and misplaced reassurance can cost lives.", "Patients facing a grave diagnosis are vulnerable to false hope and exploitation." ], "affected_parties": [ "Patients and survivors", "Families and carers", "Specialist clinicians" ] }, "owners": { "steward": "The treating oncology team answers for each patient; nobody owns the disease.", "master_systems": [ "Cancer registries" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1504713: leiomyosarcoma", "url": "https://www.wikidata.org/wiki/Q1504713", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Leiomyosarcoma", "url": "https://en.wikipedia.org/wiki/Leiomyosarcoma", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What leiomyosarcoma is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is leiomyosarcoma, and how does it differ from leiomyoma, GIST, other sarcomas and carcinomas?", "kind": "definition" }, { "text": "Does someone have a growing lump or a diagnosis, in which case a specialist sarcoma team should guide care?", "kind": "boundary" } ] } ] }, { "id": "variants", "name": "Variants", "description": "Named variants.", "findings": [ { "id": "variants-finding", "name": "Variants", "description": "Variants.", "questions": [ { "text": "What are colon, fallopian tube, CNS, pulmonary artery and granular cell leiomyosarcomas, and what does metastatic mean?", "kind": "definition" }, { "text": "Which entry fits the specific variant?", "kind": "action" } ] } ] } ] }, { "id": "clinical", "name": "Clinical", "description": "Diagnosis.", "rationale": "Science.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How are imaging and biopsy used to diagnose leiomyosarcoma?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "uterine", "name": "Uterine", "description": "Uterine leiomyosarcoma.", "findings": [ { "id": "uterine-finding", "name": "Uterine", "description": "Uterine.", "questions": [ { "text": "Why can uterine leiomyosarcoma be hard to tell from fibroids before surgery?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment approaches.", "rationale": "Attribution.", "layers": [ { "id": "approaches", "name": "Approaches", "description": "Approaches.", "findings": [ { "id": "approaches-finding", "name": "Approaches", "description": "Approaches.", "questions": [ { "text": "What general approaches do sarcoma guidelines describe, with recommendations attributed?", "kind": "provenance" }, { "text": "Is the information current?", "kind": "boundary" } ] } ] }, { "id": "centres", "name": "Centres", "description": "Specialist centres.", "findings": [ { "id": "centres-finding", "name": "Centres", "description": "Centres.", "questions": [ { "text": "Why do guidelines recommend treatment at sarcoma centres?", "kind": "provenance" }, { "text": "Which entry fits sarcoma?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and support.", "rationale": "Attribution.", "layers": [ { "id": "research", "name": "Research", "description": "Clinical trials.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research directions are reported for leiomyosarcoma, checked against current sources?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] }, { "id": "support", "name": "Support", "description": "Patient support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What do sarcoma patient organisations offer?", "kind": "provenance" }, { "text": "Which entry fits Sarcoma UK?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "The registry alias metastatic leiomyosarcoma should be treated as a stage, not a kind", "Should site variants be separate entries?", "How should sarcoma guidelines be linked and kept current?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }