{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-14T02:02:46Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T11:00:00Z",
      "ingestedAt": "2026-10-06T07:44:44+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:54+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q1640860",
    "registryId": "vr.tr.hyperaldosteronism",
    "name": "hyperaldosteronism",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "XCT.STA"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q1640860/",
  "model": {
    "registry_id": "vr.tr.hyperaldosteronism",
    "name": "hyperaldosteronism",
    "purpose": "Let an agent explain hyperaldosteronism in general terms, relay primary and secondary forms, causes, diagnosis and treatment approaches from endocrinology sources, describe the named forms and flag the loosely filed Cushing aliases, route urgent symptoms, and distinguish hyperaldosteronism from Cushing syndrome, phaeochromocytoma, essential hypertension and Addison disease, without diagnosing individuals.",
    "definition": "A group of conditions in which the adrenal glands produce too much of the hormone aldosterone, causing the body to retain sodium and lose potassium, leading to high blood pressure and sometimes low potassium; primary hyperaldosteronism, or Conn syndrome, arises from the adrenal glands themselves, often from an aldosterone-producing adenoma or bilateral hyperplasia, while secondary hyperaldosteronism responds to other causes, and familial forms exist, as registry aliases name. Some Cushing syndrome aliases listed involve cortisol excess rather than aldosterone and appear loosely filed. Primary hyperaldosteronism is an under-recognised cause of high blood pressure, and diagnosis and treatment belong to doctors; severe symptoms such as muscle weakness, paralysis or very high blood pressure need urgent care.",
    "what_it_is_for": "Not applicable; a hormonal disorder.",
    "affordances": [
      "explain forms and causes",
      "relay diagnosis and treatment approaches",
      "describe named forms",
      "route urgent symptoms"
    ],
    "distinguishing_features": [
      "Excess aldosterone",
      "Sodium retention and potassium loss",
      "Under-recognised hypertension cause",
      "Primary and secondary forms"
    ],
    "appearance": "Not visible; identified through blood pressure, blood tests and imaging.",
    "visual_identification": [
      "Excess aldosterone production",
      "Aldosterone-producing adenoma, familial hyperaldosteronism, familial hyperaldosteronism type 2, Cushing syndrome due to macronodular hyperplasia, ectopic Cushing syndrome, aldosterone-producing adenoma with seizures",
      "Cushing syndrome is cortisol excess; phaeochromocytoma is adrenaline-secreting; essential hypertension has no single cause; Addison disease is adrenal insufficiency"
    ],
    "physical_properties": [
      {
        "quantity": "primary form",
        "typical_range": "Conn syndrome",
        "unit": "note",
        "note": ""
      },
      {
        "quantity": "effects",
        "typical_range": "high blood pressure, low potassium",
        "unit": "list",
        "note": ""
      },
      {
        "quantity": "registry parent",
        "typical_range": "adrenal gland hyperfunction",
        "unit": "note",
        "note": ""
      }
    ],
    "families_and_kinds": [
      "primary hyperaldosteronism or Conn syndrome",
      "aldosterone-producing adenoma",
      "bilateral adrenal hyperplasia",
      "familial hyperaldosteronism",
      "secondary hyperaldosteronism"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "adrenal gland hyperfunction",
        "why": "in registry terms"
      },
      {
        "relation": "causes",
        "target": "hypertension",
        "why": ""
      },
      {
        "relation": "is contrasted with",
        "target": "Cushing syndrome",
        "why": ""
      },
      {
        "relation": "is contrasted with",
        "target": "Addison s disease",
        "why": ""
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Endocrine Society guidelines on primary aldosteronism"
    ],
    "failure_modes_and_hazards": [
      "Missed diagnosis in resistant hypertension",
      "Severe low potassium",
      "Loosely filed Cushing aliases"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain what hyperaldosteronism is and how primary and secondary forms differ.",
        "Suggest asking a clinician about screening for people with hard-to-control blood pressure."
      ],
      "must_not": [
        "Diagnose hyperaldosteronism from symptoms or a single test result.",
        "Advise stopping or changing blood pressure or potassium medicines.",
        "Confuse hyperaldosteronism with Cushing syndrome because of loosely filed aliases.",
        "Recommend potassium supplements in doses for a person."
      ],
      "requires_human": [
        "Any decision on testing, medication or adrenal surgery."
      ]
    },
    "ethics": {
      "considerations": [
        "The condition is underdiagnosed; missed cases suffer avoidable strokes and heart damage.",
        "Self-treating low potassium can be dangerous."
      ],
      "affected_parties": [
        "Patients with high blood pressure",
        "Their families",
        "Clinicians"
      ]
    },
    "owners": {
      "steward": "The person affected, with their clinical team; nobody owns the condition.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q1640860: hyperaldosteronism",
      "url": "https://www.wikidata.org/wiki/Q1640860",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Hyperaldosteronism",
      "url": "https://en.wikipedia.org/wiki/Hyperaldosteronism",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What hyperaldosteronism is.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "Is there severe muscle weakness, paralysis, palpitations or very high blood pressure, in which case seek urgent medical care?",
                    "kind": "boundary"
                  },
                  {
                    "text": "What is hyperaldosteronism, and how does it differ from Cushing syndrome, phaeochromocytoma, essential hypertension and Addison disease?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          },
          {
            "id": "forms",
            "name": "Forms",
            "description": "Named forms.",
            "findings": [
              {
                "id": "forms-finding",
                "name": "Forms",
                "description": "Forms.",
                "questions": [
                  {
                    "text": "What are Conn syndrome, aldosterone-producing adenoma, bilateral hyperplasia and familial forms, and why are the Cushing aliases different?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific form?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "mechanism",
        "name": "Mechanism",
        "description": "Mechanism.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "aldosterone",
            "name": "Aldosterone",
            "description": "Aldosterone effects.",
            "findings": [
              {
                "id": "aldosterone-finding",
                "name": "Aldosterone",
                "description": "Aldosterone.",
                "questions": [
                  {
                    "text": "How does excess aldosterone raise blood pressure and lower potassium?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "causes",
            "name": "Causes",
            "description": "Primary and secondary.",
            "findings": [
              {
                "id": "causes-finding",
                "name": "Causes",
                "description": "Causes.",
                "questions": [
                  {
                    "text": "How do primary and secondary hyperaldosteronism differ in cause?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "clinical",
        "name": "Clinical",
        "description": "Diagnosis and treatment.",
        "rationale": "Attribution.",
        "layers": [
          {
            "id": "diagnosis",
            "name": "Diagnosis",
            "description": "Diagnosis.",
            "findings": [
              {
                "id": "diagnosis-finding",
                "name": "Diagnosis",
                "description": "Diagnosis.",
                "questions": [
                  {
                    "text": "How is primary aldosteronism screened for and confirmed?",
                    "kind": "measurement"
                  },
                  {
                    "text": "Is the information current?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "treatment",
            "name": "Treatment",
            "description": "Treatment approaches.",
            "findings": [
              {
                "id": "treatment-finding",
                "name": "Treatment",
                "description": "Treatment.",
                "questions": [
                  {
                    "text": "What general treatment approaches such as surgery or aldosterone blockers do guidelines describe, with recommendations attributed?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits spironolactone?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Awareness.",
        "rationale": "Attribution.",
        "layers": [
          {
            "id": "hypertension",
            "name": "Hypertension",
            "description": "Under-recognition.",
            "findings": [
              {
                "id": "hypertension-finding",
                "name": "Hypertension",
                "description": "Hypertension.",
                "questions": [
                  {
                    "text": "Why do guidelines note primary aldosteronism as under-recognised in hypertension, with findings attributed?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the presentation neutral and attributed?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "data",
            "name": "Data quality",
            "description": "Misfiled aliases.",
            "findings": [
              {
                "id": "data-finding",
                "name": "Data quality",
                "description": "Data quality.",
                "questions": [
                  {
                    "text": "Why should Cushing syndrome aliases be separated from hyperaldosteronism?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits Cushing syndrome?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "The registry Cushing syndrome aliases should be moved to cortisol-excess entries",
    "Should familial forms be separate entries?",
    "How should guidelines be linked and kept current?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}