{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T14:03:52Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:37:18+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:54+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1640998", "registryId": "vr.tr.hyperkeratosis", "name": "hyperkeratosis", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1640998/", "model": { "registry_id": "vr.tr.hyperkeratosis", "name": "hyperkeratosis", "purpose": "Let an agent explain hyperkeratosis as a skin sign, relay causes, patterns and management from dermatology references in general terms, describe the specific conditions the registry aliases name, and distinguish hyperkeratosis from keratosis in general, from psoriasis and from warts, routing people with skin concerns to clinicians.", "definition": "Thickening of the outer layer of the skin, the stratum corneum, occurring as a response to friction, pressure or inflammation as in calluses, lichenification from chronic scratching and the prayer bump on the forehead of some worshippers, as a feature of dermatitis such as hyperkeratotic hand eczema, and in rarer conditions such as confluent and reticulated papillomatosis, hyperkeratosis lenticularis perstans and certain vascular malformations; hyperkeratosis is a sign rather than a single disease.", "what_it_is_for": "Not applicable; a skin sign.", "affordances": [ "explain the sign and causes", "relay patterns and management", "describe named conditions", "distinguish related conditions" ], "distinguishing_features": [ "Stratum corneum thickening", "Sign not disease", "Mechanical and inflammatory causes", "Rare named forms" ], "appearance": "Thickened, rough or scaly skin.", "visual_identification": [ "Thickened outer skin layer", "Calluses, lichenification, prayer bump, hyperkeratotic hand dermatitis, confluent and reticulated papillomatosis, hyperkeratosis lenticularis perstans", "Keratosis is a broader term; psoriasis is an inflammatory disease; warts are viral" ], "physical_properties": [ { "quantity": "stratum corneum", "typical_range": "outermost epidermal layer", "unit": "note", "note": "" }, { "quantity": "prayer bump", "typical_range": "callus from repeated prostration", "unit": "note", "note": "zebibah" }, { "quantity": "Flegel disease", "typical_range": "hyperkeratosis lenticularis perstans", "unit": "note", "note": "rare" } ], "families_and_kinds": [ "friction and pressure hyperkeratosis such as calluses and the prayer bump", "lichenification from chronic scratching", "hyperkeratotic dermatitis of hands and feet", "follicular and inherited hyperkeratoses", "rare conditions such as confluent and reticulated papillomatosis and Flegel disease", "hyperkeratosis in vascular malformations" ], "related_models": [ { "relation": "is a kind of", "target": "keratosis", "why": "in registry terms" }, { "relation": "affects", "target": "stratum corneum", "why": "the outer epidermis" }, { "relation": "is exemplified by", "target": "callus", "why": "a common form" }, { "relation": "is contrasted with", "target": "psoriasis", "why": "an inflammatory disease" } ], "identifiers": [ { "scheme": "MeSH", "value_or_pattern": "D017488", "note": "Keratosis" }, { "scheme": "ICD-10", "value_or_pattern": "L85", "note": "other epidermal thickening" } ], "standards_and_regulation": [ "Dermatology clinical guidelines", "Occupational health rules for friction and chemical skin exposure" ], "failure_modes_and_hazards": [ "Missing underlying disease", "Agents giving personal medical advice", "Registry aliases naming distinct conditions" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain hyperkeratosis and its common forms, such as calluses, in general terms.", "Advise seeing a physician for skin changes that are new, spreading or painful." ], "must_not": [ "Diagnose a skin condition from a description or photo.", "Recommend cutting or removing thickened skin at home for people with diabetes or poor circulation.", "Treat distinct conditions named in aliases as the same disease.", "Comment on a worshipper's prayer mark in a way that mocks their faith." ], "requires_human": [ "Any treatment decision for a patient." ] }, "ethics": { "considerations": [ "Skin changes can signal underlying disease that is missed if dismissed.", "Visible skin conditions cause stigma." ], "affected_parties": [ "Patients", "People with diabetes", "Workers with friction injuries" ] }, "owners": { "steward": "The patient and their physicians.", "master_systems": [] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1640998: hyperkeratosis", "url": "https://www.wikidata.org/wiki/Q1640998", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Hyperkeratosis", "url": "https://en.wikipedia.org/wiki/Hyperkeratosis", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What hyperkeratosis is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and causes.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is hyperkeratosis, and how does it differ from keratosis, psoriasis and warts?", "kind": "definition" }, { "text": "Is the user asking about their own skin, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are calluses, lichenification, the prayer bump, hyperkeratotic hand dermatitis, confluent and reticulated papillomatosis and Flegel disease?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Assessment and management.", "rationale": "Clinical.", "layers": [ { "id": "assessment", "name": "Assessment", "description": "Assessment.", "findings": [ { "id": "assessment-finding", "name": "Assessment", "description": "Assessment.", "questions": [ { "text": "How do clinicians assess hyperkeratosis and identify underlying causes?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "management", "name": "Management", "description": "Management.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "What treatments exist, from emollients and keratolytics to treating the cause, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "science", "name": "Science", "description": "Skin biology.", "rationale": "Science.", "layers": [ { "id": "biology", "name": "Biology", "description": "Keratinisation.", "findings": [ { "id": "biology-finding", "name": "Biology", "description": "Biology.", "questions": [ { "text": "How does the epidermis form the stratum corneum, and what goes wrong in hyperkeratosis?", "kind": "provenance" }, { "text": "Which entry fits keratinocyte?", "kind": "action" } ] } ] }, { "id": "rare", "name": "Rare", "description": "Rare conditions.", "findings": [ { "id": "rare-finding", "name": "Rare", "description": "Rare.", "questions": [ { "text": "What is known about the rare conditions named in the registry?", "kind": "provenance" }, { "text": "Which entry fits the specific condition?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Culture and occupation.", "rationale": "Context.", "layers": [ { "id": "culture", "name": "Culture", "description": "Prayer bump.", "findings": [ { "id": "culture-finding", "name": "Culture", "description": "Culture.", "questions": [ { "text": "What is the prayer bump, and how is it regarded in Muslim communities, described respectfully?", "kind": "provenance" }, { "text": "Is the presentation respectful?", "kind": "boundary" } ] } ] }, { "id": "occupation", "name": "Occupation", "description": "Occupational skin.", "findings": [ { "id": "occupation-finding", "name": "Occupation", "description": "Occupation.", "questions": [ { "text": "How do work and sport cause calluses and hand dermatitis, and how are they prevented?", "kind": "provenance" }, { "text": "Which entry fits occupational dermatitis?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should callus, lichenification and the rare conditions be separate primary entries?", "How should dermatology references be linked?", "The registry entry has merged aliases naming distinct conditions and a religious callus; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }