{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:12:28Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 17.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e2-813c-7500-ad20-c12064863ac6\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: diosmetin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regis", "usd": 0.0, "recall": true }, "codex": { "seconds": 82.0, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e2-8143-78d2-84cb-0ee876990c36\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: diosmetin\nRegistry id: vr.tr.diosmetin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCont" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:55:52+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:26+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1649664", "registryId": "vr.tr.diosmetin", "name": "diosmetin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1649664/", "model": { "registry_id": "vr.tr.diosmetin", "name": "diosmetin", "purpose": "Enable an agent to recognise diosmetin, assess the identity and condition of a particular sample, and determine its suitability for a documented analytical or research use.", "definition": "Diosmetin is a naturally occurring O-methylated flavone, specifically 3',5,7-trihydroxy-4'-methoxyflavone, that forms the aglycone of the flavonoid glycoside diosmin.", "scope_statement": "This model owns vr.tr.diosmetin in PHY / PHY.MAT: the chemical identity of diosmetin and the composition, physical state, provenance, handling constraints and evidence needed to evaluate samples represented as that substance.", "in_scope": [ "Molecular identity, substitution pattern and identifier reconciliation", "Sample purity, related compounds, residual solvents and water content", "Solid form, solution behaviour and condition-dependent physical measurements", "Preparation provenance, storage history and analytical traceability", "Evidence supporting handling decisions and research suitability" ], "out_of_scope": [ "Diosmin and other diosmetin glycosides as independent substances", "Plant species and extracts containing diosmetin", "Finished medicines, supplements and formulated products", "Manufacturing processes and laboratory equipment as independent models", "Clinical treatment protocols, dosing recommendations and disease models" ], "distinguishing_features": [ "Require the flavone structure with hydroxyl groups at 5, 7 and 3' and a methoxy group at 4'; diosmetin is luteolin's 4'-O-methyl ether. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Diosmetin)", "Reconcile the proposed identity with molecular formula C16H12O6, CAS 520-34-3 and PubChem CID 5281612; matching a name alone is insufficient. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Diosmetin)", "Distinguish the free aglycone from diosmin or another glycoside by establishing whether a sugar substituent is present. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Diosmetin)", "Require structural evidence locating the methoxy group; molecular formula or precursor mass alone cannot establish its position.", "Distinguish a diosmetin sample from an extract or formulation by measuring its composition rather than treating detection of diosmetin as proof of substance purity." ], "characteristics": [ { "name": "Molecular identity", "kind": "category", "unit_or_values": "Structure representation and identifiers consistent with diosmetin", "why_it_matters": "Prevents confusion with glycosides, positional isomers and similarly named flavonoids." }, { "name": "Diosmetin content", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g, with method, uncertainty and as-is or dry basis", "why_it_matters": "Supports preparation of known amounts and assessment of lot suitability." }, { "name": "Chromatographic purity", "kind": "measurement", "unit_or_values": "% peak area, with detector, wavelength, separation method and integration rules", "why_it_matters": "Describes the measured impurity profile without equating detector response with mass fraction." }, { "name": "Related compounds and preparation residues", "kind": "measurement", "unit_or_values": "Identified species in % or mg/kg; unknown peaks and detection limits recorded separately", "why_it_matters": "Residual precursors, glycosides or solvents may affect analysis and research interpretation." }, { "name": "Solid and hydration state", "kind": "state", "unit_or_values": "Observed crystalline or amorphous state; hydrate or solvate evidence; water content", "why_it_matters": "Allows physical measurements and weighed quantities to be interpreted for the actual material." }, { "name": "Thermal behaviour", "kind": "measurement", "unit_or_values": "Melting interval and decomposition onset in °C, with method, heating rate and atmosphere", "why_it_matters": "Separates observed melting from decomposition and supports comparisons between lots." }, { "name": "Solution behaviour", "kind": "measurement", "unit_or_values": "Solubility in mg/mL or mol/L at specified solvent composition, pH and temperature", "why_it_matters": "Determines whether a nominal preparation delivers dissolved diosmetin." }, { "name": "Stability under use conditions", "kind": "measurement", "unit_or_values": "% diosmetin remaining and impurity change over time under specified conditions", "why_it_matters": "Supports storage, retesting and interpretation of experiments using aged solutions." }, { "name": "Lot and reference-material lineage", "kind": "relation", "unit_or_values": "Supplier or preparer, lot, preparation route, certificate and analytical reference", "why_it_matters": "Connects identity and composition claims to the material actually used." }, { "name": "Hazard and regulatory assessment", "kind": "category", "unit_or_values": "Source-dated jurisdiction-specific classification, applicable restrictions or explicitly unresolved status", "why_it_matters": "Supports handling decisions without inferring safety from natural occurrence." } ], "affordances": [ "Match a labelled sample to diosmetin using reconciled identifiers and structural evidence.", "Accept, quarantine or reject a lot against documented analytical requirements.", "Calculate a preparation amount from measured content and verify that diosmetin remains dissolved.", "Select storage and retesting conditions supported by evidence for the relevant material or solution.", "Compare research observations while accounting for purity, vehicle, concentration and analytical specificity." ], "agent_conduct": { "may": [ "Describe diosmetin and its relation to diosmin from chemical and pharmacological sources.", "Report the status of evidence on its effects without overstating it." ], "must_not": [ "Claim it treats cancer or other diseases on the basis of laboratory studies alone.", "Recommend doses of supplements containing it to a person.", "Confuse it with diosmin when stating approved medicinal uses." ], "requires_human": [ "Advising a person to take a product containing it alongside other medicines." ] }, "ethics": { "considerations": [ "Flavonoid supplements are often sold with claims that outrun the evidence.", "Patients may delay proper care on the strength of such claims." ], "affected_parties": [ "Supplement buyers", "Patients" ] }, "owners": { "steward": "Nobody owns the compound; makers answer for products that contain it.", "master_systems": [] }, "visual_identification": [ "A yellowish crystalline powder; identity is confirmed by laboratory analysis." ], "failure_modes_and_hazards": [ "Supplements may be mislabelled or interact with medicines." ], "what_it_is_for": [ "Diosmetin is encountered in natural product chemistry and research on flavonoid metabolism.", "Documented samples are used as analytical reference materials or research reagents when their identity and purity meet the requirements of the study." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides the framework for assessing and communicating chemical hazards where implemented, without establishing a specific hazard classification for diosmetin." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1649664: diosmetin", "url": "https://www.wikidata.org/wiki/Q1649664", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Diosmetin", "url": "https://en.wikipedia.org/wiki/Diosmetin", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "identity-and-neighbour-boundaries", "name": "Identity and neighbour boundaries", "description": "Establish which molecular entity a diosmetin claim denotes.", "rationale": "Diosmetin must remain distinct from its glycosides and other flavonoids even when labels or analytical signals overlap.", "layers": [ { "id": "structure-and-identifiers", "name": "Structure and identifiers", "description": "Reconcile the named substance with an explicit molecular structure.", "findings": [ { "id": "substitution-pattern-confirmation", "name": "Substitution pattern confirmation", "description": "Record evidence sufficient to establish the flavone scaffold and placement of hydroxyl and methoxy substituents.", "questions": [ { "text": "What structure representation defines diosmetin, and which authoritative identifiers resolve to that structure?", "kind": "definition", "id": "substitution-pattern-confirmation-q01" }, { "text": "Which analytical observations establish the methoxy position rather than merely matching molecular mass?", "kind": "measurement", "id": "substitution-pattern-confirmation-q02" } ] } ] }, { "id": "aglycone-and-containing-materials", "name": "Aglycone and containing materials", "description": "Separate diosmetin itself from chemically linked derivatives and mixtures.", "findings": [ { "id": "free-versus-derived-diosmetin", "name": "Free versus derived diosmetin", "description": "Preserve the distinction between diosmetin originally present and diosmetin generated during sample preparation.", "questions": [ { "text": "Does the record describe free diosmetin, a glycoside, or a mixture containing diosmetin?", "kind": "boundary", "id": "free-versus-derived-diosmetin-q01" }, { "text": "Did hydrolysis or another preparation step generate the diosmetin being measured?", "kind": "provenance", "id": "free-versus-derived-diosmetin-q02" } ] } ] } ] }, { "id": "lot-composition-and-traceability", "name": "Lot composition and traceability", "description": "Describe what a particular diosmetin sample contains and how its claims were established.", "rationale": "A substance name does not establish usable content, analytical purity or absence of preparation residues.", "layers": [ { "id": "content-and-related-compounds", "name": "Content and related compounds", "description": "Separate quantitative diosmetin content from method-dependent purity measures.", "findings": [ { "id": "assay-basis-and-impurity-profile", "name": "Assay basis and impurity profile", "description": "Capture content, chromatographic response and impurity evidence without treating them as interchangeable.", "questions": [ { "text": "Is reported purity a calibrated mass fraction or chromatographic area percentage, and what basis and uncertainty apply?", "kind": "measurement", "id": "assay-basis-and-impurity-profile-q01" }, { "text": "Which related flavonoids, residual glycosides, solvents and unknown components were measured, and at what detection limits?", "kind": "measurement", "id": "assay-basis-and-impurity-profile-q02" } ] } ] }, { "id": "preparation-and-reference-lineage", "name": "Preparation and reference lineage", "description": "Connect the sample to its preparation history and identity standards.", "findings": [ { "id": "lot-specific-evidence", "name": "Lot-specific evidence", "description": "Attach certificates and analytical records to the relevant diosmetin lot rather than transferring claims between suppliers or batches.", "questions": [ { "text": "Was this lot isolated, synthesised or prepared from a glycoside, and which records document that route?", "kind": "provenance", "id": "lot-specific-evidence-q01" }, { "text": "Which reference material and analytical records support this lot's identity and assigned content?", "kind": "provenance", "id": "lot-specific-evidence-q02" } ] } ] } ] }, { "id": "physical-state-and-solution-preparation", "name": "Physical state and solution preparation", "description": "Record the material conditions that determine weighing, dissolution and physical-property interpretation.", "rationale": "Diosmetin measurements and preparations require evidence tied to solid state, solvent and experimental conditions.", "layers": [ { "id": "solid-form-and-thermal-response", "name": "Solid form and thermal response", "description": "Characterise the actual solid rather than assigning an unqualified catalogue constant.", "findings": [ { "id": "conditioned-solid-characterisation", "name": "Conditioned solid characterisation", "description": "Keep water content, form evidence and thermal events attached to the measured sample.", "questions": [ { "text": "What evidence establishes the sample's crystallinity, hydration or solvation state and water content?", "kind": "measurement", "id": "conditioned-solid-characterisation-q01" }, { "text": "Does the reported thermal event represent melting, solvent loss or decomposition, and under what conditions?", "kind": "measurement", "id": "conditioned-solid-characterisation-q02" } ] } ] }, { "id": "dissolution-and-delivered-concentration", "name": "Dissolution and delivered concentration", "description": "Evaluate diosmetin concentration in the final working medium.", "findings": [ { "id": "verified-dissolved-dose", "name": "Verified dissolved concentration", "description": "Distinguish nominal addition from measured dissolved diosmetin after preparation and dilution.", "questions": [ { "text": "What solubility was measured at the relevant solvent composition, pH, temperature and equilibration time?", "kind": "measurement", "id": "verified-dissolved-dose-q01" }, { "text": "How will the agent verify concentration and detect precipitation after a stock is diluted into the working medium?", "kind": "action", "id": "verified-dissolved-dose-q02" } ] } ] } ] }, { "id": "stability-and-handling-decisions", "name": "Stability and handling decisions", "description": "Determine whether diosmetin remains fit for use and what handling evidence applies.", "rationale": "Storage claims, hazard classifications and use restrictions must be evaluated for the relevant sample and conditions.", "layers": [ { "id": "storage-and-in-use-integrity", "name": "Storage and in-use integrity", "description": "Track chemical integrity of solid material and prepared solutions separately.", "findings": [ { "id": "evidence-based-retest-state", "name": "Evidence-based retest state", "description": "Base continued use on applicable stability evidence and observed composition changes.", "questions": [ { "text": "What measurements establish diosmetin stability under the actual light, temperature, atmosphere, pH and storage duration?", "kind": "measurement", "id": "evidence-based-retest-state-q01" }, { "text": "Which excursion, age or analytical change requires retesting or rejection of this lot or solution?", "kind": "action", "id": "evidence-based-retest-state-q02" } ] } ] }, { "id": "hazard-and-jurisdiction", "name": "Hazard and jurisdiction", "description": "Resolve safety information for diosmetin and distinguish it from solvent or formulation hazards.", "findings": [ { "id": "applicable-handling-evidence", "name": "Applicable handling evidence", "description": "Record current source-backed classifications and unresolved gaps without treating missing data as evidence of safety.", "questions": [ { "text": "Which current SDS and jurisdictional records apply to this diosmetin material, and do their identifiers agree?", "kind": "provenance", "id": "applicable-handling-evidence-q01" }, { "text": "What handling, containment and disposal measures follow from the applicable evidence and the sample's physical form?", "kind": "action", "id": "applicable-handling-evidence-q02" } ] } ] } ] }, { "id": "research-use-and-evidence-boundaries", "name": "Research use and evidence boundaries", "description": "Determine what conclusions a diosmetin experiment or measurement can support.", "rationale": "An agent must distinguish effects attributed to the aglycone from results involving derivatives, mixtures or inadequately characterised exposure.", "layers": [ { "id": "analytical-measurand", "name": "Analytical measurand", "description": "Define precisely which form of diosmetin a method reports.", "findings": [ { "id": "free-and-post-hydrolysis-results", "name": "Free and post-hydrolysis results", "description": "Preserve sample-treatment context when interpreting diosmetin measurements.", "questions": [ { "text": "Does the method quantify free diosmetin or diosmetin released by a specified hydrolysis procedure?", "kind": "definition", "id": "free-and-post-hydrolysis-results-q01" }, { "text": "How were recovery, matrix effects and separation from related compounds established?", "kind": "measurement", "id": "free-and-post-hydrolysis-results-q02" } ] } ] }, { "id": "biological-claim-attribution", "name": "Biological claim attribution", "description": "Attach any reported biological observation to its tested material and experimental context.", "findings": [ { "id": "exposure-and-inference-limits", "name": "Exposure and inference limits", "description": "Evaluate whether a result supports a claim about diosmetin under the proposed conditions of use.", "questions": [ { "text": "Was the tested material characterised diosmetin, a glycoside, an extract or a formulation, and what exposure was verified?", "kind": "provenance", "id": "exposure-and-inference-limits-q01" }, { "text": "What controls address vehicle effects, precipitation and assay interference, and which conclusions remain outside the evidence?", "kind": "boundary", "id": "exposure-and-inference-limits-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled information; no sources were consulted.", "Verify physical constants, quantitative solubility and hazard classifications against records for the specific material and purity.", "Distinguish evidence about isolated diosmetin from evidence about diosmin, mixtures and metabolites." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "520-34-3", "note": "Identifier for diosmetin." }, { "scheme": "Molecular formula", "value_or_pattern": "C16H12O6", "note": "Describes elemental composition but does not distinguish structural isomers." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Reference compound for identifying and quantifying diosmetin in analytical chemistry.", "Analyte in studies of diosmin metabolism and pharmacokinetics.", "Experimental compound in laboratory studies of flavonoid biological activity." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "300.26", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Low aqueous solubility can complicate preparation of solutions and interpretation of biological assays.", "Confusing diosmetin with diosmin can lead to incorrect analytical assignments or unsupported transfer of evidence between the compounds.", "Laboratory biological activity does not establish clinical efficacy or a safe human dose." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Diosmin", "difference": "Diosmin is diosmetin 7-O-rutinoside; diosmetin lacks the attached sugar group." }, { "name": "Luteolin", "difference": "Luteolin has a hydroxyl group at the 4' position where diosmetin has a methoxy group." }, { "name": "Chrysoeriol", "difference": "Chrysoeriol has a 3'-methoxy and 4'-hydroxyl substitution pattern, reversing those substituents relative to diosmetin." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of diosmetin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which EC identifier, jurisdiction-specific GHS classifications and substance-specific exposure limits, if any, are supported by current authoritative records?", "Which solid forms and melting or decomposition ranges have been experimentally established, and is a boiling-point value physically meaningful and supported?", "What measured solubility, ionisation and stability data apply to the intended solvents, pH values and temperatures?", "Which reference materials and validated methods best distinguish diosmetin from positional isomers, residual glycosides and preparation-derived impurities?", "Which proposed research uses have evidence for characterised free diosmetin at verified exposure, and which rely on glycosides, mixtures or indirect inference?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 16, "questions": 26 } }