{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:42:25Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 21.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09534-ca76-71d1-acfe-f9741f12154e\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: kahweol\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 registe", "usd": 0.0, "recall": true }, "codex": { "seconds": 85.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09534-ca68-7421-88f8-320f2703a02b\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: kahweol\nRegistry id: vr.tr.kahweol\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContext " } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:56:51+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T12:16:29+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q1721243", "registryId": "vr.tr.kahweol", "name": "kahweol", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1721243/", "model": { "registry_id": "vr.tr.kahweol", "name": "kahweol", "purpose": "Enable an agent to identify kahweol, assess the composition and condition of kahweol-bearing material, and decide whether it is suitable for a specified analytical or experimental use.", "definition": "Kahweol is a naturally occurring furan-containing diterpenoid alcohol found in coffee oils, both free and esterified with fatty acids, and is closely related to cafestol.", "scope_statement": "This model owns vr.tr.kahweol in PHY / PHY.MAT: the chemically defined kahweol molecule, its identity evidence, and the material attributes needed to interpret samples and proposed uses.", "in_scope": [ "Molecular identity, stereochemistry and identifiers for kahweol", "Free kahweol content, purity and accompanying diterpenoids", "Distinction between free kahweol and kahweol measured after ester hydrolysis", "Sample provenance, physical condition and storage history", "Analytical suitability and evidence supporting handling or experimental use" ], "out_of_scope": [ "Coffee beans, coffee oil and brewed coffee as complete materials or products", "Cafestol and other chemically distinct diterpenoids", "Kahweol esters as independently defined chemical substances", "Extraction, roasting and brewing processes as operational systems", "Disease models, clinical treatment recommendations and population dietary advice" ], "distinguishing_features": [ "Match the stereochemically specified structure, not merely the name: kahweol is C20H26O3, CAS 6894-43-5 and PubChem CID 114778. [PubChem: Kahweol](https://pubchem.ncbi.nlm.nih.gov/compound/Kahweol)", "Separate kahweol from cafestol by structure-sensitive analysis: cafestol has formula C20H28O3, so a combined coffee-diterpene result cannot establish kahweol content. [PubChem: Cafestol](https://pubchem.ncbi.nlm.nih.gov/compound/108052)", "Determine whether the analyte is free kahweol or a derivative: kahweol palmitate has its own molecular identity and must not be treated as a synonym. [PubChem: Kahweol palmitate](https://pubchem.ncbi.nlm.nih.gov/compound/Kahweol-palmitate)", "Require analyte-specific identification and quantification before treating a coffee extract or mixed diterpene preparation as a kahweol sample of known purity." ], "characteristics": [ { "name": "Molecular identity", "kind": "category", "unit_or_values": "C20H26O3; stereochemical structure matched, partially specified or unresolved", "why_it_matters": "Formula alone cannot distinguish stereoisomers or establish that the registered molecule is present." }, { "name": "Identifier alignment", "kind": "relation", "unit_or_values": "vr.tr.kahweol linked to verified CAS, PubChem, ChEBI and jurisdictional records", "why_it_matters": "Prevents supplier names and derivative records from silently changing the substance being modeled." }, { "name": "Free kahweol assay", "kind": "measurement", "unit_or_values": "mg/g or mass %, with analytical method, uncertainty and as-received or dry-mass basis", "why_it_matters": "Determines the actual amount of kahweol available for weighing, dilution or comparison." }, { "name": "Reported analyte basis", "kind": "category", "unit_or_values": "Free kahweol; identified ester; hydrolysis-derived kahweol equivalents; unresolved", "why_it_matters": "Measurements made before and after hydrolysis need different interpretations." }, { "name": "Cafestol and other impurities", "kind": "measurement", "unit_or_values": "mg/g or mass % by identified component, with detection and quantification limits", "why_it_matters": "Accompanying diterpenoids can compromise attribution of analytical signals or experimental effects." }, { "name": "Material presentation", "kind": "state", "unit_or_values": "Isolated solid, solution or matrix-bound material; temperature in °C and solvent composition where applicable", "why_it_matters": "Supports appropriate sampling, dissolution and interpretation of material condition." }, { "name": "Thermal behavior", "kind": "measurement", "unit_or_values": "Melting or decomposition range in °C; boiling data only with pressure and supporting evidence", "why_it_matters": "Allows condition checks without assuming that an unverified thermal constant applies to the sample." }, { "name": "Solubility and solution concentration", "kind": "measurement", "unit_or_values": "mg/mL or mol/L, with solvent, temperature and dissolved-versus-nominal basis", "why_it_matters": "A nominally prepared solution may not deliver the intended dissolved kahweol concentration." }, { "name": "Storage and stability evidence", "kind": "state", "unit_or_values": "Storage temperature, duration, light and atmosphere exposure; measured remaining assay and impurity changes", "why_it_matters": "Determines whether a stored lot or stock solution remains fit for its intended use." }, { "name": "Hazard and use status", "kind": "category", "unit_or_values": "Source-dated classification, jurisdiction, material form, applicable exposure limits and permitted-use evidence; unknown where unverified", "why_it_matters": "Prevents missing hazard information or a research label from being interpreted as demonstrated safety." } ], "affordances": [ "Reconcile a sample label and structural evidence with the registered kahweol identity.", "Select an analytical method that distinguishes kahweol from cafestol and relevant derivatives.", "Calculate kahweol mass or solution concentration from a verified assay and an explicit analyte basis.", "Assess whether a lot or stored stock is suitable for a stated analytical or experimental purpose.", "Compare kahweol measurements only after reconciling matrix, preparation, units and hydrolysis status.", "Identify missing evidence before attributing a biological effect or authorizing a material-specific use." ], "agent_conduct": { "may": [ "Identify kahweol by name, identifiers and its coffee oil source, citing sources.", "Report research findings on its effects with their limits." ], "must_not": [ "Present research effects as proven health benefits or harms for coffee drinkers.", "Recommend supplements or coffee habits to a particular person on the basis of it.", "Mislabel extract content." ], "requires_human": [ "Making health claims for products sold to the public." ] }, "ethics": { "considerations": [ "Health claims about everyday foods spread easily and can mislead." ], "affected_parties": [ "Coffee drinkers", "Consumers of supplements", "Researchers" ] }, "owners": { "steward": "Nobody owns the substance; producers answer for products that contain it.", "master_systems": [] }, "visual_identification": [ "Identity rests on labels and analysis, not appearance.", "Present in coffee oils, often as fatty acid esters." ], "failure_modes_and_hazards": [ "Overstated health claims.", "Mislabelled or degraded research extracts." ], "what_it_is_for": [ "Kahweol is encountered in coffee oils and extracts, where it is studied alongside related diterpenoids.", "Analytical laboratories measure it to characterize coffee-derived materials and investigate how processing affects their composition.", "Isolated kahweol is also used in experimental research, with interpretation depending on purity and whether the material contains free or esterified forms." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides criteria for assessing and communicating hazards of isolated kahweol supplied as a chemical.", "ISO 17034, issued by the International Organization for Standardization, applies to reference material producers when kahweol is supplied as a reference material." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1721243: kahweol", "url": "https://www.wikidata.org/wiki/Q1721243", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Kahweol", "url": "https://en.wikipedia.org/wiki/Kahweol", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "kahweol-identity", "name": "Kahweol identity", "description": "Establish which molecular entity the registry entry and physical sample denote.", "rationale": "Kahweol must remain distinguishable from related coffee diterpenoids and chemically modified forms.", "layers": [ { "id": "structure-and-identifiers", "name": "Structure and identifiers", "description": "Connect the registered name to a stereochemically defined molecular reference.", "findings": [ { "id": "identity-concordance", "name": "Identity concordance", "description": "Record whether label identifiers and structural evidence agree on kahweol.", "questions": [ { "text": "Which stereochemically explicit structure defines kahweol for this record?", "kind": "definition", "id": "identity-concordance-q01" }, { "text": "Which authoritative records and sample documents support the identifier mapping?", "kind": "provenance", "id": "identity-concordance-q02" } ] } ] }, { "id": "related-compound-boundaries", "name": "Related compound boundaries", "description": "Separate the parent molecule from cafestol, esters and unresolved mixtures.", "findings": [ { "id": "parent-versus-related-material", "name": "Parent versus related material", "description": "Require an explicit relationship when a record concerns a derivative or a kahweol-containing mixture.", "questions": [ { "text": "Does this record describe free kahweol, a kahweol ester or material containing several diterpenoids?", "kind": "boundary", "id": "parent-versus-related-material-q01" }, { "text": "What evidence excludes cafestol or another compound as the assigned kahweol signal?", "kind": "measurement", "id": "parent-versus-related-material-q02" } ] } ] } ] }, { "id": "kahweol-origin-and-composition", "name": "Kahweol origin and composition", "description": "Describe the source and actual composition of the material being evaluated.", "rationale": "An origin claim or supplier purity label alone does not establish how much free kahweol a sample contains.", "layers": [ { "id": "lot-and-preparation-history", "name": "Lot and preparation history", "description": "Preserve material history relevant to identity and interpretation.", "findings": [ { "id": "traceable-kahweol-material", "name": "Traceable kahweol material", "description": "Link the evaluated sample to its lot, source and preparation history without modeling the production process itself.", "questions": [ { "text": "Which supplier lot, isolation record or synthesis record identifies this sample?", "kind": "provenance", "id": "traceable-kahweol-material-q01" }, { "text": "Was the sample hydrolyzed, derivatized or otherwise chemically transformed before evaluation?", "kind": "provenance", "id": "traceable-kahweol-material-q02" } ] } ] }, { "id": "assay-and-impurities", "name": "Assay and impurities", "description": "Distinguish measured kahweol content from other material in the sample.", "findings": [ { "id": "usable-kahweol-fraction", "name": "Usable kahweol fraction", "description": "Record free kahweol assay separately from chromatographic area purity, residual solvents and accompanying compounds.", "questions": [ { "text": "What is the free kahweol mass fraction, and does the reported purity represent mass fraction or detector area?", "kind": "measurement", "id": "usable-kahweol-fraction-q01" }, { "text": "How much cafestol, esterified material, residual solvent and unidentified impurity is present or unresolved?", "kind": "measurement", "id": "usable-kahweol-fraction-q02" } ] } ] } ] }, { "id": "kahweol-analytical-interpretation", "name": "Kahweol analytical interpretation", "description": "Make kahweol identification and quantification interpretable across analytical preparations.", "rationale": "Free-analyte measurements and results following ester hydrolysis cannot be compared without stating their basis.", "layers": [ { "id": "selectivity-and-reference", "name": "Selectivity and reference", "description": "Establish whether the method specifically identifies and measures kahweol.", "findings": [ { "id": "kahweol-signal-assignment", "name": "Kahweol signal assignment", "description": "Tie the assigned signal to reference evidence and separation from relevant interferents.", "questions": [ { "text": "Which reference material and chromatographic or spectroscopic evidence support kahweol identification?", "kind": "provenance", "id": "kahweol-signal-assignment-q01" }, { "text": "How does the method resolve or otherwise distinguish kahweol from cafestol and matrix interferents?", "kind": "measurement", "id": "kahweol-signal-assignment-q02" } ] } ] }, { "id": "hydrolysis-and-reporting-basis", "name": "Hydrolysis and reporting basis", "description": "Preserve the chemical and numerical meaning of a reported kahweol concentration.", "findings": [ { "id": "comparable-kahweol-results", "name": "Comparable kahweol results", "description": "Require explicit preparation, recovery and reporting basis before combining concentration results.", "questions": [ { "text": "Does the result quantify native free kahweol or kahweol released by hydrolysis, and in which units and matrix basis?", "kind": "definition", "id": "comparable-kahweol-results-q01" }, { "text": "What recovery, hydrolysis-completeness evidence, calibration and uncertainty support the reported amount?", "kind": "measurement", "id": "comparable-kahweol-results-q02" } ] } ] } ] }, { "id": "kahweol-material-condition", "name": "Kahweol material condition", "description": "Assess physical presentation, solution behavior and changes during storage.", "rationale": "Kahweol identity alone does not establish the concentration or condition of material delivered to an assay.", "layers": [ { "id": "physical-and-solution-state", "name": "Physical and solution state", "description": "Describe the material under the conditions of preparation and use.", "findings": [ { "id": "available-dissolved-kahweol", "name": "Available dissolved kahweol", "description": "Distinguish weighed or nominal kahweol from the amount demonstrably dissolved in the working medium.", "questions": [ { "text": "What physical form, solvent composition and temperature characterize the sample?", "kind": "measurement", "id": "available-dissolved-kahweol-q01" }, { "text": "What evidence confirms dissolution and concentration after dilution into the intended working medium?", "kind": "measurement", "id": "available-dissolved-kahweol-q02" } ] } ] }, { "id": "storage-and-change", "name": "Storage and change", "description": "Evaluate whether handling or storage has altered the material.", "findings": [ { "id": "kahweol-condition-acceptance", "name": "Kahweol condition acceptance", "description": "Base continued use on lot-relevant stability evidence rather than an assumed universal shelf life.", "questions": [ { "text": "What temperature, light, atmosphere and elapsed storage time has the solid or stock solution experienced?", "kind": "provenance", "id": "kahweol-condition-acceptance-q01" }, { "text": "Which assay or impurity changes require retesting, replacement or rejection for the intended use?", "kind": "action", "id": "kahweol-condition-acceptance-q02" } ] } ] } ] }, { "id": "kahweol-use-and-evidence", "name": "Kahweol use and evidence", "description": "Connect intended actions to applicable handling information and interpretable experimental evidence.", "rationale": "Coffee origin and reported biological activity do not independently establish the suitability of isolated kahweol for a particular use.", "layers": [ { "id": "handling-and-regulatory-identity", "name": "Handling and regulatory identity", "description": "Determine which substance-specific and preparation-specific requirements govern an action.", "findings": [ { "id": "supported-kahweol-handling", "name": "Supported kahweol handling", "description": "Record applicable classifications and restrictions with their source, date, jurisdiction and material scope.", "questions": [ { "text": "Which current safety data and jurisdictional records apply to this kahweol material and its solvent or mixture?", "kind": "provenance", "id": "supported-kahweol-handling-q01" }, { "text": "What handling, storage and disposal measures follow from those records for the proposed operation?", "kind": "action", "id": "supported-kahweol-handling-q02" } ] } ] }, { "id": "experimental-effect-attribution", "name": "Experimental effect attribution", "description": "Keep claims about kahweol tied to the tested preparation and experimental conditions.", "findings": [ { "id": "kahweol-specific-evidence", "name": "Kahweol-specific evidence", "description": "Require sufficient material and study detail to distinguish kahweol-specific findings from effects of mixed preparations.", "questions": [ { "text": "Was the tested agent verified kahweol, an ester, a cafestol mixture or a coffee extract?", "kind": "boundary", "id": "kahweol-specific-evidence-q01" }, { "text": "Which concentration, exposure duration, experimental system, vehicle controls and purity evidence support attribution to kahweol?", "kind": "measurement", "id": "kahweol-specific-evidence-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge, not a source-verified record.", "Verify stereochemical identifiers, purity-dependent physical constants, and current hazard classifications before laboratory use.", "Quantitative occurrence and health claims require evidence distinguishing coffee species, brewing methods, free versus esterified kahweol, and cafestol co-exposure." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "582-28-5", "note": "Identifies kahweol; fatty-acid esters have separate chemical identities." }, { "scheme": "Molecular formula", "value_or_pattern": "C20H26O3", "note": "Describes elemental composition but does not uniquely identify structure or stereochemistry." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Analyte in studies of coffee composition and the effects of roasting and brewing.", "Research compound in experimental studies of biological activity.", "Component measured alongside cafestol when assessing exposure to coffee diterpenes." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "314.42", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Diterpene-rich unfiltered coffee can raise serum cholesterol; the contribution of kahweol should be distinguished from that of co-occurring cafestol.", "Biological effects observed in cell or animal experiments do not establish therapeutic efficacy or safety in humans.", "Measurements can be misleading if they do not distinguish free kahweol from total kahweol measured after hydrolysis of its esters." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Exposure varies with local brewing practices because paper filtration removes much of the coffee oil carrying diterpenes." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "cafestol", "difference": "Cafestol is a related coffee diterpenoid with two additional hydrogen atoms; kahweol has an additional carbon-carbon double bond." }, { "name": "kahweol fatty-acid esters", "difference": "These derivatives have a kahweol hydroxyl group esterified with a fatty acid and are chemically distinct from free kahweol." }, { "name": "coffee oil", "difference": "Coffee oil is a mixture containing lipids and diterpenes; kahweol is an individual chemical constituent." }, { "name": "caffeine", "difference": "Caffeine is a nitrogen-containing methylxanthine alkaloid, whereas kahweol is a nitrogen-free diterpenoid." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of kahweol this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative EC or other jurisdictional identifiers, hazard classifications and occupational exposure limits, if any, apply specifically to kahweol?", "Which experimentally supported melting, decomposition and solubility measurements are reliable for structurally verified kahweol under stated conditions?", "What storage conditions and stability data support shelf lives for isolated kahweol and commonly used stock solutions?", "Which validated methods reliably distinguish free kahweol from ester-derived totals while controlling hydrolysis recovery and cafestol interference?", "Which reported biological effects are attributable to kahweol alone, and what evidence supports their relevance beyond the tested experimental system?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 17, "questions": 27 } }