{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-13T15:04:03Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T11:00:00Z",
      "ingestedAt": "2026-10-06T07:34:19+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:55+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q187640",
    "registryId": "vr.tr.cell-adhesion",
    "name": "cell adhesion",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q187640/",
  "model": {
    "registry_id": "vr.tr.cell-adhesion",
    "name": "cell adhesion",
    "purpose": "Let an agent explain cell adhesion and its molecular basis, relay adhesion molecule families, mechanisms and roles in development and disease from cell biology sources, describe the Gene Ontology sub-processes the registry aliases name, and distinguish cell adhesion from cell junctions as structures, from cell migration and from aggregation of non-living particles.",
    "definition": "The process by which cells attach to each other or to the extracellular matrix through adhesion molecules such as cadherins, integrins, selectins and immunoglobulin superfamily proteins, comprising cell-cell adhesion and cell-substrate adhesion, including integrin-mediated adhesion, and contributing to development in processes such as heart morphogenesis, prostatic bud elongation and retrograde extension of neurons, as annotated in the Gene Ontology; cell adhesion underlies tissue structure, immunity, wound healing and cancer metastasis.",
    "what_it_is_for": "Not applicable; a cellular process.",
    "affordances": [
      "explain the process",
      "relay molecular mechanisms",
      "describe developmental roles",
      "distinguish related concepts"
    ],
    "distinguishing_features": [
      "Adhesion molecules",
      "Cell-cell and cell-matrix",
      "Developmental roles",
      "Disease relevance"
    ],
    "appearance": "Not a visible object; cells attached to each other or to a matrix.",
    "visual_identification": [
      "Attachment of cells to cells or matrix",
      "Cell-cell adhesion, cell-substrate adhesion, integrin-mediated adhesion, adhesion in heart morphogenesis and prostatic bud elongation",
      "Junctions are the structures; migration is movement; particle aggregation is non-living"
    ],
    "physical_properties": [
      {
        "quantity": "major molecule families",
        "typical_range": "cadherins, integrins, selectins, Ig superfamily",
        "unit": "list",
        "note": ""
      },
      {
        "quantity": "Gene Ontology term",
        "typical_range": "GO:0007155",
        "unit": "note",
        "note": "cell adhesion"
      },
      {
        "quantity": "integrin heterodimers, human",
        "typical_range": "24",
        "unit": "count",
        "note": ""
      }
    ],
    "families_and_kinds": [
      "cell-cell adhesion via cadherins and others",
      "cell-substrate adhesion via integrins",
      "selectin-mediated leukocyte adhesion",
      "adhesion in morphogenesis such as heart and prostate development",
      "adhesion in neuronal extension",
      "adhesion in cancer and immunity"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cellular process or phenomenon",
        "why": "in registry terms"
      },
      {
        "relation": "is mediated by",
        "target": "cell adhesion molecule",
        "why": "such as cadherins and integrins"
      },
      {
        "relation": "forms",
        "target": "cell junction",
        "why": "as structures"
      },
      {
        "relation": "is annotated in",
        "target": "Gene Ontology",
        "why": "as GO:0007155"
      }
    ],
    "identifiers": [
      {
        "scheme": "GO",
        "value_or_pattern": "GO:0007155",
        "note": "cell adhesion"
      },
      {
        "scheme": "MeSH",
        "value_or_pattern": "D002448",
        "note": "Cell Adhesion"
      }
    ],
    "standards_and_regulation": [
      "Gene Ontology annotation standards"
    ],
    "failure_modes_and_hazards": [
      "Confusing adhesion with junction structures",
      "Registry aliases naming narrow GO sub-terms",
      "Overgeneralising from one molecule family"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain cell adhesion and its main molecule families in general terms, citing sources.",
        "Summarise research on adhesion in disease, such as cancer spread, with references."
      ],
      "must_not": [
        "Present laboratory findings as proven treatments for people.",
        "Misstate or fabricate experimental data on adhesion molecules.",
        "Promote unapproved therapies based on adhesion research."
      ],
      "requires_human": [
        "Using research results to make clinical decisions."
      ]
    },
    "ethics": {
      "considerations": [
        "Research on adhesion feeds cancer and immune treatments; overstated findings raise false hope.",
        "Animal and human tissue research needs proper consent and oversight."
      ],
      "affected_parties": [
        "Patients",
        "Researchers",
        "Research animals"
      ]
    },
    "owners": {
      "steward": "Nobody owns the process; the scientific community studies it.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q187640: cell adhesion",
      "url": "https://www.wikidata.org/wiki/Q187640",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Cell adhesion",
      "url": "https://en.wikipedia.org/wiki/Cell_adhesion",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What cell adhesion is.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is cell adhesion, and how does it differ from junctions, migration and particle aggregation?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about molecules, mechanisms, development, disease or ontology terms?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "kinds",
            "name": "Kinds",
            "description": "Kinds.",
            "findings": [
              {
                "id": "kinds-finding",
                "name": "Kinds",
                "description": "Kinds.",
                "questions": [
                  {
                    "text": "What are cell-cell, cell-substrate and integrin-mediated adhesion, and the developmental sub-processes named in the Gene Ontology?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific kind?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "molecules",
        "name": "Molecules",
        "description": "Molecules and mechanisms.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "families",
            "name": "Families",
            "description": "Molecule families.",
            "findings": [
              {
                "id": "families-finding",
                "name": "Families",
                "description": "Families.",
                "questions": [
                  {
                    "text": "How do cadherins, integrins, selectins and Ig superfamily molecules bind?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "signalling",
            "name": "Signalling",
            "description": "Signalling.",
            "findings": [
              {
                "id": "signalling-finding",
                "name": "Signalling",
                "description": "Signalling.",
                "questions": [
                  {
                    "text": "How does adhesion signal into the cell and connect to the cytoskeleton?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "biology",
        "name": "Biology",
        "description": "Development and disease.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "development",
            "name": "Development",
            "description": "Development.",
            "findings": [
              {
                "id": "development-finding",
                "name": "Development",
                "description": "Development.",
                "questions": [
                  {
                    "text": "How does adhesion drive morphogenesis, such as heart formation and prostatic bud elongation?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits morphogenesis?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "disease",
            "name": "Disease",
            "description": "Disease.",
            "findings": [
              {
                "id": "disease-finding",
                "name": "Disease",
                "description": "Disease.",
                "questions": [
                  {
                    "text": "How do adhesion changes contribute to metastasis, inflammation and genetic disorders?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits metastasis?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Methods and history.",
        "rationale": "Context.",
        "layers": [
          {
            "id": "methods",
            "name": "Methods",
            "description": "Methods.",
            "findings": [
              {
                "id": "methods-finding",
                "name": "Methods",
                "description": "Methods.",
                "questions": [
                  {
                    "text": "How is cell adhesion measured in the laboratory?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits cell adhesion assay?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "history",
            "name": "History",
            "description": "History.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How did Holtfreter, Steinberg and later molecular work establish the field?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the history of cell biology?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should cell-cell and cell-substrate adhesion be separate primary entries?",
    "How should cell biology sources be linked?",
    "The registry entry has merged aliases naming specific GO sub-processes; should they be grouped?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}