{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-12T20:28:17Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 3,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T10:00:00Z",
      "ingestedAt": "2026-10-06T07:02:23+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:56+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q189092",
    "registryId": "vr.tr.cell-migration",
    "name": "cell migration",
    "version": "0.2.0-wave.3",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q189092/",
  "model": {
    "registry_id": "vr.tr.cell-migration",
    "name": "cell migration",
    "purpose": "Let an agent explain cell migration and its modes, relay mechanisms and roles in development, immunity, healing and disease from cell biology sources, and route clinical questions about cancer spread to clinicians.",
    "definition": "The directed movement of cells from one place to another, essential to embryonic development, immune responses, wound healing and tissue maintenance, and involved in cancer spread; cells migrate by crawling on surfaces or through tissues using the cytoskeleton, adhesion and signalling cues, in modes such as amoeboid, mesenchymal and collective migration.",
    "what_it_is_for": "Moving cells to where they are needed in development, defence and repair.",
    "affordances": [
      "explain mechanisms and modes",
      "describe roles in development, immunity and healing",
      "explain involvement in cancer metastasis in general terms",
      "relay methods used to study migration"
    ],
    "distinguishing_features": [
      "Active, directed cell movement",
      "Driven by cytoskeleton and adhesion",
      "Guided by chemical and physical cues",
      "Central to development, immunity and metastasis"
    ],
    "appearance": "Not visible to the eye; under the microscope cells extending protrusions and crawling.",
    "visual_identification": [
      "Cells moving directionally",
      "Modes: amoeboid, mesenchymal, collective",
      "Passive transport in blood and cell division are different processes"
    ],
    "physical_properties": [
      {
        "quantity": "speed",
        "typical_range": "about 0.1-20",
        "unit": "micrometres per minute",
        "note": "immune cells fastest"
      }
    ],
    "families_and_kinds": [
      "leukocyte migration",
      "neuronal and glial migration in the developing brain",
      "germ cell migration",
      "collective migration of cell sheets",
      "amoeboid and mesenchymal single-cell migration",
      "cancer cell invasion"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cell motility",
        "why": "the general category"
      },
      {
        "relation": "is part of",
        "target": "morphogenesis",
        "why": "a developmental role"
      },
      {
        "relation": "is used by",
        "target": "immune system",
        "why": "leukocyte trafficking"
      },
      {
        "relation": "is related to",
        "target": "metastasis",
        "why": "cancer cell spread"
      }
    ],
    "identifiers": [
      {
        "scheme": "Gene Ontology",
        "value_or_pattern": "GO:0016477",
        "note": "cell migration"
      }
    ],
    "standards_and_regulation": [
      "Gene Ontology definitions",
      "Research ethics rules for animal and human tissue studies"
    ],
    "failure_modes_and_hazards": [
      "Metastasis when cancer cells migrate",
      "Developmental disorders from failed migration",
      "Agents giving clinical advice"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain cell migration in development, immunity, wound healing and cancer spread.",
        "Report research findings with their limits."
      ],
      "must_not": [
        "Present laboratory findings as treatments for cancer.",
        "Promote unproven therapies claimed to stop cancer spread.",
        "Give a person a prognosis based on cell migration research."
      ],
      "requires_human": [
        "Use of human cells or tissue in research."
      ]
    },
    "ethics": {
      "considerations": [
        "Cancer patients are vulnerable to overstated claims.",
        "Human cells come from donors who must consent."
      ],
      "affected_parties": [
        "Cancer patients",
        "Tissue donors",
        "Researchers"
      ]
    },
    "owners": {
      "steward": "Nobody owns the process; it belongs to biology.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q189092: cell migration",
      "url": "https://www.wikidata.org/wiki/Q189092",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Cell migration",
      "url": "https://en.wikipedia.org/wiki/Cell_migration",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "mechanism",
        "name": "Mechanism",
        "description": "How cells move.",
        "rationale": "Mechanism.",
        "layers": [
          {
            "id": "machinery",
            "name": "Machinery",
            "description": "Cytoskeleton and adhesion.",
            "findings": [
              {
                "id": "machinery-finding",
                "name": "Machinery",
                "description": "Machinery.",
                "questions": [
                  {
                    "text": "How do the cytoskeleton, adhesions and membrane protrusions move a cell?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about active migration or passive transport?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "guidance",
            "name": "Guidance",
            "description": "Guidance cues.",
            "findings": [
              {
                "id": "guidance-finding",
                "name": "Guidance",
                "description": "Guidance.",
                "questions": [
                  {
                    "text": "How do chemical gradients, stiffness and other cues direct migration?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits chemotaxis?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "modes",
        "name": "Modes",
        "description": "Kinds of migration.",
        "rationale": "Kinds.",
        "layers": [
          {
            "id": "single",
            "name": "Single",
            "description": "Single-cell modes.",
            "findings": [
              {
                "id": "single-finding",
                "name": "Single",
                "description": "Single.",
                "questions": [
                  {
                    "text": "How do amoeboid and mesenchymal migration differ?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits a specific cell type?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "collective",
            "name": "Collective",
            "description": "Collective migration.",
            "findings": [
              {
                "id": "collective-finding",
                "name": "Collective",
                "description": "Collective.",
                "questions": [
                  {
                    "text": "How do groups of cells migrate together in development and healing?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "roles",
        "name": "Roles",
        "description": "Roles in biology and disease.",
        "rationale": "Function.",
        "layers": [
          {
            "id": "normal",
            "name": "Normal",
            "description": "Development, immunity, healing.",
            "findings": [
              {
                "id": "normal-finding",
                "name": "Normal",
                "description": "Normal.",
                "questions": [
                  {
                    "text": "What roles does migration play in development, immune responses and wound healing?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits wound healing?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "disease",
            "name": "Disease",
            "description": "Disease.",
            "findings": [
              {
                "id": "disease-finding",
                "name": "Disease",
                "description": "Disease.",
                "questions": [
                  {
                    "text": "How does migration contribute to metastasis and developmental disorders, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own diagnosis, which needs a clinician?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "study",
        "name": "Study",
        "description": "Methods and teaching.",
        "rationale": "Study.",
        "layers": [
          {
            "id": "methods",
            "name": "Methods",
            "description": "Methods.",
            "findings": [
              {
                "id": "methods-finding",
                "name": "Methods",
                "description": "Methods.",
                "questions": [
                  {
                    "text": "How is migration studied, from live imaging to migration assays and modelling?",
                    "kind": "provenance"
                  },
                  {
                    "text": "How is migration measured?",
                    "kind": "measurement"
                  }
                ]
              }
            ]
          },
          {
            "id": "teach",
            "name": "Teach",
            "description": "Teaching.",
            "findings": [
              {
                "id": "teach-finding",
                "name": "Teach",
                "description": "Teaching.",
                "questions": [
                  {
                    "text": "How is cell migration taught in cell biology?",
                    "kind": "action"
                  },
                  {
                    "text": "Which misconceptions arise?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should each migration mode be a separate entry?",
    "How should Gene Ontology terms be linked?",
    "The registry entry has merged aliases for specific cell types; should they be split off?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}