{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-12T03:00:56Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 2,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-05T23:55:00Z",
      "ingestedAt": "2026-10-05T20:53:47+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:56+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q189101",
    "registryId": "vr.tr.cell-population-proliferation",
    "name": "cell population proliferation",
    "version": "0.2.0-wave.2",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q189101/",
  "model": {
    "registry_id": "vr.tr.cell-population-proliferation",
    "name": "cell population proliferation",
    "purpose": "Let an agent explain cell proliferation and its regulation, describe its roles in development, repair and immunity, relate proliferation to cancer and therapy in general terms, and support learning in cell biology.",
    "definition": "The multiplication of cells resulting in the expansion of a cell population, through cell division and survival, occurring in development, tissue growth and repair, immune responses and blood cell formation, in specific cell types such as fibroblasts, myoblasts, mesenchymal cells, Leydig cells, hemocytes and inner cell mass cells, and in cell culture; proliferation is regulated by growth factors and cell cycle controls, and its dysregulation underlies cancer.",
    "what_it_is_for": "Multiplication of cells expanding a population.",
    "affordances": [
      "explain proliferation and regulation",
      "describe roles",
      "relate to cancer generally",
      "support learning"
    ],
    "distinguishing_features": [
      "Cell division",
      "Population increase",
      "Regulation",
      "Cancer link"
    ],
    "appearance": "Not visible; measured in culture and tissue.",
    "visual_identification": [
      "Increase in cell number by division",
      "Regulated by growth factors and cell cycle",
      "Cell growth is increase in size; differentiation is change in type"
    ],
    "physical_properties": [],
    "families_and_kinds": [
      "proliferation in development",
      "proliferation in tissue repair",
      "immune cell proliferation",
      "proliferation of specific cell types such as fibroblasts and myoblasts",
      "proliferation in cell culture"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cellular process or phenomenon",
        "why": "category"
      },
      {
        "relation": "is related to",
        "target": "epithelium",
        "why": "renewing tissues"
      },
      {
        "relation": "is related to",
        "target": "adenoma",
        "why": "abnormal proliferation"
      },
      {
        "relation": "is related to",
        "target": "gestation",
        "why": "embryonic proliferation"
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Cell biology nomenclature and ontologies",
      "Laboratory standards for proliferation assays",
      "Research ethics for cell and tissue work"
    ],
    "failure_modes_and_hazards": [
      "Agents giving medical advice on cancer",
      "Confusing proliferation with growth or differentiation",
      "Assay artefacts"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain cell proliferation in development, healing, immunity and disease.",
        "Analyse proliferation data in research it is authorized to work on."
      ],
      "must_not": [
        "Present laboratory proliferation findings as proof of a cure.",
        "Interpret a person's test results as a cancer diagnosis.",
        "Promote unproven products that claim to control cell growth.",
        "Fabricate or selectively report experimental data."
      ],
      "requires_human": [
        "Using research findings in decisions about a patient's treatment."
      ]
    },
    "ethics": {
      "considerations": [
        "Uncontrolled proliferation is cancer; false hope from overstated results harms patients.",
        "Cell lines and samples come from people whose consent must be respected."
      ],
      "affected_parties": [
        "Patients",
        "Tissue donors",
        "Researchers"
      ]
    },
    "owners": {
      "steward": "Nobody owns the process; researchers answer for their data and samples.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q189101: cell population proliferation",
      "url": "https://www.wikidata.org/wiki/Q189101",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Cell proliferation",
      "url": "https://en.wikipedia.org/wiki/Cell_proliferation",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What proliferation is.",
        "rationale": "Cell biology.",
        "layers": [
          {
            "id": "concept",
            "name": "Concept",
            "description": "Concept and cell cycle.",
            "findings": [
              {
                "id": "concept-finding",
                "name": "Concept",
                "description": "Concept.",
                "questions": [
                  {
                    "text": "What is cell proliferation, and how do the cell cycle and its checkpoints control it?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which cell type or context is meant?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "regulation",
            "name": "Regulation",
            "description": "Regulation.",
            "findings": [
              {
                "id": "regulation-finding",
                "name": "Regulation",
                "description": "Regulation.",
                "questions": [
                  {
                    "text": "How do growth factors, signalling pathways and contact inhibition regulate proliferation?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits cell signalling?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "roles",
        "name": "Roles",
        "description": "Roles in organisms.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "development",
            "name": "Development",
            "description": "Development and repair.",
            "findings": [
              {
                "id": "development-finding",
                "name": "Development",
                "description": "Development.",
                "questions": [
                  {
                    "text": "How does proliferation drive embryonic development, tissue renewal and wound repair?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits a specific tissue?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "immune",
            "name": "Immune",
            "description": "Immune and blood cells.",
            "findings": [
              {
                "id": "immune-finding",
                "name": "Immune",
                "description": "Immune.",
                "questions": [
                  {
                    "text": "How do lymphocytes and blood cell precursors proliferate in immune responses and haematopoiesis?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits immunology?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "disease",
        "name": "Disease",
        "description": "Disease and research.",
        "rationale": "General information.",
        "layers": [
          {
            "id": "cancer",
            "name": "Cancer",
            "description": "Proliferation and cancer.",
            "findings": [
              {
                "id": "cancer-finding",
                "name": "Cancer",
                "description": "Cancer.",
                "questions": [
                  {
                    "text": "How does dysregulated proliferation cause cancer, and how do therapies target it, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own treatment, which needs a clinician?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "assays",
            "name": "Assays",
            "description": "Measuring proliferation.",
            "findings": [
              {
                "id": "assays-finding",
                "name": "Assays",
                "description": "Assays.",
                "questions": [
                  {
                    "text": "How is proliferation measured in research and diagnostics?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits a specific assay?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "learn",
        "name": "Learn",
        "description": "History and teaching.",
        "rationale": "Education.",
        "layers": [
          {
            "id": "history",
            "name": "History",
            "description": "History.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How were cell division and its regulation discovered?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "teach",
            "name": "Teach",
            "description": "Teaching.",
            "findings": [
              {
                "id": "teach-finding",
                "name": "Teach",
                "description": "Teaching.",
                "questions": [
                  {
                    "text": "How can proliferation be taught in cell biology?",
                    "kind": "action"
                  },
                  {
                    "text": "Which misconceptions arise?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should the cell cycle be a separate entry?",
    "How should ontologies be linked?",
    "How should cancer resources be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}